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2021

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Pediatric Mental Health Hospitalizations And The Return To School: School-Based Provider Perspectives On Commmunication, Collaboration, And Systematic Practices, Lauren Elizabeth Carr Jan 2021

Pediatric Mental Health Hospitalizations And The Return To School: School-Based Provider Perspectives On Commmunication, Collaboration, And Systematic Practices, Lauren Elizabeth Carr

Dissertations

The provision of pediatric mental health services has changed greatly over the last several decades with more children and adolescents requiring intensive mental health treatment. Despite this increase, systemic barriers continue to prevent youth from receiving appropriate treatment following psychiatric hospitalization. An important aspect of this treatment process includes a child’s return to school, one of the most common environments for a child or adolescent outside of their home. For many children, the hospital-to-school transition team may include regular and special education teachers, school psychologists, social workers or therapists, psychiatrists, medical doctors, case managers, and nurses. Because of this, it …


Standardizing Thoracic Aortic Aneurysm Education, Marjorie Anne Gisslow Jan 2021

Standardizing Thoracic Aortic Aneurysm Education, Marjorie Anne Gisslow

Master's Projects and Capstones

Problem: Patients receive information about a new thoracic aortic aneurysm (TAA) diagnosis from their primary care providers (PCPs). As TAA is a relatively rare conditions, many PCPs have rudimentary knowledge of TAA, and need information and support from cardiac specialists to address their patients’ concerns and guide their care.

Context: In the Regional TAA Surveillance Program the TAA nurses offer educational content for patients through the information they provide to the PCPs. Currently the educational material available to PCPs is not comprehensive or easily accessible.

Intervention: Uniform, comprehensive educational content provided through recommendations in the patient’s electronic medical record at …


Wastewater Treatment Alters Microbial Colonization Of Microplastics, John J. Kelly, Maxwell G. London, Amanda R. Mccormick, Miguel Rojas, John W. Scott, Timothy J. Hoellein Jan 2021

Wastewater Treatment Alters Microbial Colonization Of Microplastics, John J. Kelly, Maxwell G. London, Amanda R. Mccormick, Miguel Rojas, John W. Scott, Timothy J. Hoellein

Biology: Faculty Publications and Other Works

Microplastics are ubiquitous contaminants in aquatic habitats globally, and wastewater treatment plants (WWTPs) are point sources of microplastics. Within aquatic habitats microplastics are colonized by microbial biofilms, which can include pathogenic taxa and taxa associated with plastic breakdown. Microplastics enter WWTPs in sewage and exit in sludge or effluent, but the role that WWTPs play in establishing or modifying microplastic bacterial assemblages is unknown. We analyzed microplastics and associated biofilms in raw sewage, effluent water, and sludge from two WWTPs. Both plants retained >99% of influent microplastics in sludge, and sludge microplastics showed higher bacterial species richness and higher abundance …


Low Medication Adherence Is Associated With Decline In Health-Related Quality Of Life: Results Of A Longitudinal Analysis Among Older Women And Men With Hypertension, Erin Peacock, Cara Joyce, Leslie S. Craig, Zachary Lenane, Elizabeth W. Holt, Paul Muntner, Marie Krousel-Wood Jan 2021

Low Medication Adherence Is Associated With Decline In Health-Related Quality Of Life: Results Of A Longitudinal Analysis Among Older Women And Men With Hypertension, Erin Peacock, Cara Joyce, Leslie S. Craig, Zachary Lenane, Elizabeth W. Holt, Paul Muntner, Marie Krousel-Wood

Biostatistics Collaborative Core: Faculty Publications and Other Works

Objective: The aim of this study was to determine the association of low antihypertensive medication adherence with decline in health-related quality of life (HRQOL) over 1 year.

Methods: We used data from older men and women with hypertension (n¼ 1525) enrolled in the Cohort Study of Medication Adherence among Older Adults. Adherence was measured using the validated self-report four-item Krousel-Wood Medication Adherence Scale (K-Wood-MAS-4) (low adherence¼ score 1) and prescription refill-based proportion of days covered (PDC) (low adherence¼ PDC< 0.80). We defined decline in HRQOL as a decrease in Mental Component Summary (MCS) or Physical Component Summary (PCS) score (from the RAND 36-Item Health Survey 1.0 administered at two time points – at the time of adherence assessment and 1 year later) equivalent to the minimal important difference (MID) for each respective summary score, calculated as the average of MID estimates derived from distribution and anchor-based approaches.

Results: The prevalence of low adherence was 38.6% using the K-Wood-MAS-4 and 23.9% using PDC. On the basis of mean MID …


The Effects Of Technological Supervision On Gig Workers: Organizational Control And Motivation Of Uber, Taxi, And Limousine Drivers, Peter Norlander, Nenad Jukic, Arup Varma, Svetlozar Nestorov Jan 2021

The Effects Of Technological Supervision On Gig Workers: Organizational Control And Motivation Of Uber, Taxi, And Limousine Drivers, Peter Norlander, Nenad Jukic, Arup Varma, Svetlozar Nestorov

School of Business: Faculty Publications and Other Works

Does supervision from technological platforms alter gig workers’ motivation and perceptions of control? We address this question with two field studies set in the passenger livery (pick up and drop off) industry. A between-subjects field survey (n = 50) finds that UberX drivers perceive significantly greater organizational control compared to taxi drivers, but do not report significantly different levels of intrinsic motivation, needs satisfaction, or enjoyment of work. In a follow-up within-subjects field experiment (n = 79), we identify the causal impact of technological supervision on drivers’ perceptions of control and motivation. Black car limousine drivers who sometimes …


Promoting Early-Adolescent Dual Language Learners' Language Use & Reading Skills, Holly Griskell Jan 2021

Promoting Early-Adolescent Dual Language Learners' Language Use & Reading Skills, Holly Griskell

Dissertations

Most studies of Dual Language Learners’ (DLLs’) literacy development focus on the early childhood years. As such, this three-study dissertation sought to advance our knowledge of DLLs’ English language and reading comprehension skills during early adolescence, a developmental stage when many students struggle with reading. Study 1, “Classroom Discussion and Early-Adolescent Dual Language Learners’ Motivation and Reading Comprehension”, considered how features of the classroom language environment promote DLLs’ reading comprehension skills. We examined relations between students’ (N = 413; M age = 11.66-years-old) engagement in high-quality classroom discussions and reading comprehension as a function of their motivation to participate in …


Elementary Principals' And Teachers' Educational Beliefs And Practices In Inclusive Schools, Dawn Hill Jan 2021

Elementary Principals' And Teachers' Educational Beliefs And Practices In Inclusive Schools, Dawn Hill

Dissertations

This qualitative study will explore the educational beliefs and practices of elementary principals and teachers in inclusive schools. Nine elementary schools in a unit district are the focus of this study given the significant gains made in closing the achievement gap between students with disabilities and their non-disabled peers. The research questions in this study are as follows: (1) How are principals’ LRE beliefs and practices related to student achievement? (2) How are teachers’ LRE beliefs and practices related to student achievement? The elementary schools included in this study not only narrowed the achievement gap between students with IEPs and …


Ethical Health Care In An African Context: Linking Conventional Medicine And Traditional Healing Practices In Igboland, Nigeria., Michael Osondu Okoro Jan 2021

Ethical Health Care In An African Context: Linking Conventional Medicine And Traditional Healing Practices In Igboland, Nigeria., Michael Osondu Okoro

Dissertations

This dissertation argues that in Nigeria’s Igboland, a health care ethic reflective of the Roman Catholic Christian faith must build links between the rightful practices of both conventional Western medicine and traditional Igbo healers. It calls such a health care ethic an “integral health care ethic” in the Nigerian Igbo context.The inspiration for this dissertation comes from the growing respect given to indigenous people and their knowledge by the Roman Catholic Church since the Second Vatican Council and, more specifically, the attention Pope Francis has given to indigenous people in his writings and speeches. For example, in his remarks on …


Files Cryptography Based On One-Time Pad Algorithm, Ahmad Mohamad Al-Smadi, Ahmad Al-Smadi, Roba Mahmoud Ali Aloglah, Nisrein Abu-Darwish, Ahed Abugabah Jan 2021

Files Cryptography Based On One-Time Pad Algorithm, Ahmad Mohamad Al-Smadi, Ahmad Al-Smadi, Roba Mahmoud Ali Aloglah, Nisrein Abu-Darwish, Ahed Abugabah

All Works

The Vernam-cipher is known as a one-time pad of algorithm that is an unbreakable algorithm because it uses a typically random key equal to the length of data to be coded, and a component of the text is encrypted with an element of the encryption key. In this paper, we propose a novel technique to overcome the obstacles that hinder the use of the Vernam algorithm. First, the Vernam and advance encryption standard AES algorithms are used to encrypt the data as well as to hide the encryption key; Second, a password is placed on the file because of the …


Deciphering Property Insurers’ Indemnification Obligations After Disasters, Pandemics And Business Interruption Losses: An Analysis Of State Supreme Courts And Federal Circuits’ Declaratory Judgments, Willy E. Rice Jan 2021

Deciphering Property Insurers’ Indemnification Obligations After Disasters, Pandemics And Business Interruption Losses: An Analysis Of State Supreme Courts And Federal Circuits’ Declaratory Judgments, Willy E. Rice

Journal of Business & Technology Law

No abstract provided.


Automatic Fall Risk Detection Based On Imbalanced Data, Yen-Hung Liu, Patrick C. K. Hung, Farkhund Iqbal, Benjamin C. M. Fung Jan 2021

Automatic Fall Risk Detection Based On Imbalanced Data, Yen-Hung Liu, Patrick C. K. Hung, Farkhund Iqbal, Benjamin C. M. Fung

All Works

In recent years, the declining birthrate and aging population have gradually brought countries into an ageing society. Regarding accidents that occur amongst the elderly, falls are an essential problem that quickly causes indirect physical loss. In this paper, we propose a pose estimation-based fall detection algorithm to detect fall risks. We use body ratio, acceleration and deflection as key features instead of using the body keypoints coordinates. Since fall data is rare in real-world situations, we train and evaluate our approach in a highly imbalanced data setting. We assess not only different imbalanced data handling methods but also different machine …


Utility Of Self-Rated Adherence For Monitoring Dietary And Physical Activity Compliance And Assessment Of Participant Feedback Of The Healthy Diet And Lifestyle Study Pilot., Holly O'Reilly, Chloe E. Panizza, Unhee Lim, Kim M. Yonemori, Lynne R. Wilkens, Yurii B. Shvetsov, Michelle N. Harvie, John Shepherd, Fengqing Maggie Zhu, Loïc Le Marchand, Carol Boushey, Kevin D. Cassel Jan 2021

Utility Of Self-Rated Adherence For Monitoring Dietary And Physical Activity Compliance And Assessment Of Participant Feedback Of The Healthy Diet And Lifestyle Study Pilot., Holly O'Reilly, Chloe E. Panizza, Unhee Lim, Kim M. Yonemori, Lynne R. Wilkens, Yurii B. Shvetsov, Michelle N. Harvie, John Shepherd, Fengqing Maggie Zhu, Loïc Le Marchand, Carol Boushey, Kevin D. Cassel

Other resources

We examined the utility of self-rated adherence to dietary and physical activity (PA) prescriptions as a method to monitor intervention compliance and facilitate goal setting during the Healthy Diet and Lifestyle Study (HDLS). In addition, we assessed participants’ feedback of HDLS. HDLS is a randomized pilot intervention that compared the effect of intermittent energy restriction combined with a Mediterranean diet (IER + MED) to a Dietary Approaches to Stop Hypertension (DASH) diet, with matching PA regimens, for reducing visceral adipose tissue area (VAT).


文理人 (Wenliren: Humanities, Science, Human), Lui Lam Jan 2021

文理人 (Wenliren: Humanities, Science, Human), Lui Lam

Faculty Publications

No abstract provided.


Rfid Adaption In Healthcare Organizations: An Integrative Framework, Ahed Abugabah, Louis Sanzogni, Luke Houghton, Ahmad Ali Alzubi, Alaa Abuqabbeh Jan 2021

Rfid Adaption In Healthcare Organizations: An Integrative Framework, Ahed Abugabah, Louis Sanzogni, Luke Houghton, Ahmad Ali Alzubi, Alaa Abuqabbeh

All Works

Radio frequency identification (RFID), also known as electronic label technology, is a non-contact automated identification technology that recognizes the target object and extracts relevant data and critical characteristics using radio frequency signals. Medical equipment information management is an important part of the construction of a modern hospital, as it is linked to the degree of diagnosis and care, as well as the hospital's benefits and growth. The aim of this study is to create an integrated view of a theoretical framework to identify factors that influence RFID adoption in healthcare, as well as to conduct an empirical review of the …


Folding Methodology For Flexible Aircraft Interiors, Aditya Venkatesh, Fengfeng (Jeff) Xi, Joon Chung Jan 2021

Folding Methodology For Flexible Aircraft Interiors, Aditya Venkatesh, Fengfeng (Jeff) Xi, Joon Chung

International Journal of Aviation, Aeronautics, and Aerospace

This paper establishes a general furniture folding methodology that is aimed at flexible aircraft cabin interiors. This methodology will allow users to modify existing furniture pieces to their liking and thereby customizing their overall travel experience. The folding methodology also includes a process to quantify the transformation of the furniture pieces. This paper also introduces two design concepts called Open-on-Demand and Reconfiguration to allow passengers to modify an otherwise rigid cabin. The advantages of the multi-functional space saving furniture pieces are also illustrated in this paper. While the general folding methodology was developed for aircraft interiors, it can be adapted …


A Model For Inhalation Of Infectious Aerosol Contaminants In An Aircraft Passenger Cabin, Bert A. Silich Jan 2021

A Model For Inhalation Of Infectious Aerosol Contaminants In An Aircraft Passenger Cabin, Bert A. Silich

International Journal of Aviation, Aeronautics, and Aerospace

Aerosol contamination of an aircraft cabin by infectious passengers is a concern of passengers, aircrew and the aviation industry. This may be especially important during a pandemic, such as COVID-19, where the full extent of aerosol transmission is not well understood. A statistical method to determine the number of infectious passengers on board along with a mathematical model estimating the contaminant concentration of aerosols in the cabin and the number of inhaled infectious particles by passengers is presented. An example is used to demonstrated how the results can be estimated during normal operations and emergency conditions with malfunctions of the …


Small Unmanned Aircraft Systems Acoustic Analysis For Noninvasive Marine Mammal Response: An Exploratory Field Study, David Thirtyacre, Gennifer Brookshire, Sarah Callan, Brittany Arvizu, Patrick Sherman Jan 2021

Small Unmanned Aircraft Systems Acoustic Analysis For Noninvasive Marine Mammal Response: An Exploratory Field Study, David Thirtyacre, Gennifer Brookshire, Sarah Callan, Brittany Arvizu, Patrick Sherman

International Journal of Aviation, Aeronautics, and Aerospace

As in countless other fields of human endeavor, small unmanned aircraft systems (sUAS) have the potential to benefit pinniped (Pinnipedia; e.g., Phocidae [seals], Otariidae [sea lions], and Odobenidae [walruses]) response efforts. The employment of sUAS could give responders a close-up look at animals in distress in order to determine their condition as well as develop a response strategy. However, unlike other subjects that are regularly inspected by sUAS (e.g., croplands and civil infrastructure) pinnipeds may respond to the distinctive sound generated by small, multirotor sUAS. This reaction may include retreating into the water en masse, which could put …


How Duty Rosters And Stress Relate To Sleep Problems And Fatigue Of International Pilots, Marion Venus, Martin Grosse Holtforth Jan 2021

How Duty Rosters And Stress Relate To Sleep Problems And Fatigue Of International Pilots, Marion Venus, Martin Grosse Holtforth

International Journal of Aviation, Aeronautics, and Aerospace

While previous research focused on pilots’ fatigue, rosters, potential performance-impairment and aviation-safety, this research investigates, how pilots’ work-related and psychosocial stress and rosters can affect their sleep and fatigue. A cross-sectional online survey was completed by 192 pilots flying for European operators, 180 Australian pilots and 34 pilots from UAE, Turkey and Asia Pacific. Pilots reported their actual duty- and flight-hours, flown sectors, standby, rest, vacation days, number of early starts, night-flights and sports-hours for the last two months. Schedule-related data, way to work, age, flight-hours on the present type of aircraft, subjective job-security and psychosocial stress were used as …


Aviation Culture: A ‘Glass Sky’ For Women Pilots - Literature Review, Ivana Gorlin, Donna Bridges Jan 2021

Aviation Culture: A ‘Glass Sky’ For Women Pilots - Literature Review, Ivana Gorlin, Donna Bridges

International Journal of Aviation, Aeronautics, and Aerospace

This paper reports on a review of literature covering gender issues in aviation. It considers the impacts of aviation culture on women pilots. The focus of the review was on empirical studies over a 25-year period (1996-2020). Two research questions underpin the review; firstly, we investigated how aviation culture impacts women pilots’ experiences, secondly, we considered its effect on women as pilots. Using a hermeneutic methodological framework, we found that cultural attitudes towards women pilots in the aviation industry are biased and discriminatory. The studies in the review overwhelming concur that the hegemonic masculine culture that dominates aviation significantly diminishes …


An Integrated Method For Airline Company Supplier Selection Based On The Entropy And Vikor Methods: A Real Case Study, Naimeh Borjalilu, Zeinab Sazvar, Sina Nayeri Jan 2021

An Integrated Method For Airline Company Supplier Selection Based On The Entropy And Vikor Methods: A Real Case Study, Naimeh Borjalilu, Zeinab Sazvar, Sina Nayeri

International Journal of Aviation, Aeronautics, and Aerospace

All certified airlines require to implement a safety and quality management system. Therefore, the quality of all services and products with critical operational domains have been challenging issues in the aviation industry. In this regard, supplier selection plays an important role to acquire competitive benefits. Flight operations is critical scope in an airline and their outputs have a direct impact on flight safety consequences. Therefore, the quality of supplier’s product and services play the main role in their flight operations process. In this research, a new decision-making framework is developed to evaluate the performance of the suppliers based on the …


Aircraft Exhaust Gas Temperature Value Mining With Rough Set Method, Mustagime Tülin Yıldırım Asst. Prof., Mehtap Taşcı Jan 2021

Aircraft Exhaust Gas Temperature Value Mining With Rough Set Method, Mustagime Tülin Yıldırım Asst. Prof., Mehtap Taşcı

International Journal of Aviation, Aeronautics, and Aerospace

Aircrafts are one of the most important means of transportation today. For aircrafts to be able to serve safely, their maintenance must be done in a timely and complete manner. In addition to regular maintenance, it may appear suddenly; there is also irregular maintenance performed in cases such as lightning strikes, bird strikes, and hard landings. Engine failures and maintenance has great importance in aircraft maintenance. Using the data recorded during the flight by flight data recorder, the engine health condition is monitored and the necessary maintenance procedures are carried out. In this study, the exhaust gas temperature was estimated …


A Relational Analysis Of The Writing Cafe: Social Learning, Participant Experiences And Tensions In Higher Education, Christie Pritchard Jan 2021

A Relational Analysis Of The Writing Cafe: Social Learning, Participant Experiences And Tensions In Higher Education, Christie Pritchard

Plymouth Institute of Education Theses

The Writing Café is a social learning space designed to support the development of academic writers within one Higher Education institution. The relationship between learning, space and practices is an emerging area for researchers and this thesis makes a productive contribution to knowledge by using Bourdieu’s relational framework to explore the game from the perspective of the players. The story of the Writing Café connects the practices within a particular sub-field to the wider institutional field and explores the pedagogical possibilities. Considering the Writing Cafe from a micro, social and cultural perspective contributes to the ambition of achieving a social …


Rare Metal Resources In Polymetallic Nodules From The Eastern Equatorial Pacific Ocean, Wycliff Tupiti Jan 2021

Rare Metal Resources In Polymetallic Nodules From The Eastern Equatorial Pacific Ocean, Wycliff Tupiti

School of Geography, Earth and Environmental Sciences Theses

The Clarion-Clipperton fracture zone (CCFZ) in the eastern equatorial Pacific is the area with the greatest interest in terms of metal resources in polymetallic nodules. The nodules are enriched (relative to crustal composition) in economically important metals such as Mn, Ni, Cu, Zn, and so-called critical metals such as Co, Rare Earth Elements and Y (REYs). This project involves the geochemical and mineralogical investigation of nodules from five box cores from the UK claim area in the CCFZ. Bulk geochemical analysis shows that the nodules formed from both hydrogenetic (precipitation from bottom oxic seawater) and diagenetic (precipitation from oxic/suboxic sediment …


Optimising Oak Woodland Establishment Into Uk Upland Pastures In The Context Of Climate Change; And The Role Of Oak Woodland In Soil Hydrological Recovery For Natural Flood Management, Thomas Murphy Jan 2021

Optimising Oak Woodland Establishment Into Uk Upland Pastures In The Context Of Climate Change; And The Role Of Oak Woodland In Soil Hydrological Recovery For Natural Flood Management, Thomas Murphy

School of Geography, Earth and Environmental Sciences Theses

Increases in the magnitude and extremity of upland (>250-300m a.s.l.) precipitation associated with anthropogenic climate change (ACC) and coinciding with soil compaction leave downstream communities at elevated flood risk. The study examines changes in upland precipitation and the impact of upland ‘Atlantic’ oak (Quercus robur, Quercus petraea) woodland establishment on the recovery of soils for natural flood management (NFM). The soil moisture, livestock grazing and dispersal constraints for potential oak woodland expansion in upland pastures are assessed. The study is located within Dartmoor National Park (DNP) and finds greater increases in precipitation in upland areas than the lowland site, …


Evaluating The Emerging Environmental Risks Of Mycotoxins In Freshwater Ecosystems., Emily Eagles Jan 2021

Evaluating The Emerging Environmental Risks Of Mycotoxins In Freshwater Ecosystems., Emily Eagles

School of Geography, Earth and Environmental Sciences Theses

Deoxynivalenol (DON) and zearalenone (ZON) are two of the prominent mycotoxins which regularly contaminate food, both of these natural toxins are produced by fungi within the Fusarium genus. With the known widespread occurrence of these toxins in cereal crops there has been rising interest into the potential transference into freshwaters. Multiple reports of mycotoxin occurrence in freshwater samples have led to their consideration as natural chemicals of emerging concern, particularly with ZON seen to act in an oestrogenic nature, yet the ecotoxicological data to support analysis of risk to freshwater ecosystems is lacking. The main aim of this work was …


The Holistic Assessment And Care Planning In Partnership (Happi) Study A Mixed Methods Feasibility Study Of A Nurse-Led Intervention For Older People Who Live With Frailty, Helen Lyndon Jan 2021

The Holistic Assessment And Care Planning In Partnership (Happi) Study A Mixed Methods Feasibility Study Of A Nurse-Led Intervention For Older People Who Live With Frailty, Helen Lyndon

School of Nursing and Midwifery Theses

Aim. This mixed-methods feasibility study aimed to identify and to develop consensus on the components of a holistic assessment and care planning intervention for frail older people in primary care and to conduct a feasibility cluster randomised, controlled trial with an embedded qualitative study to assess potential trial methods for a definitive trial.Background. Frailty is a serious but not inevitable consequence of ageing that can be managed as a long-tern condition. Frail older people are more at risk to adverse health outcomes than the non-frail, yet many do not receive evidence based management including a comprehensive geriatric assessment (CGA); a …


Across The River: Ferries As A Vehicle For Exploring Riverborderscapes, Eva Mcgrath Jan 2021

Across The River: Ferries As A Vehicle For Exploring Riverborderscapes, Eva Mcgrath

School of Geography, Earth and Environmental Sciences Theses

This thesis uses the concept of the riverborderscape to provide new understandings of watery geographies, borders and landscape. This is a spatial and conceptual term used to explore the space of the river through a holistic approach, focusing upon the materialities, experiences and narratives that shape, emerge within and construct this space. These ideas are applied in relation to three rivers that form an everyday border between places at different scales in the South West of England: the River Tamar (regional), River Torridge (district) and Helford River (parish). Research is situated on and across the river, through the routes of …


Visual Anthropological Methods In Earthquake Risk Communication: A Transdisciplinary Approach, Johanna Ickert Jan 2021

Visual Anthropological Methods In Earthquake Risk Communication: A Transdisciplinary Approach, Johanna Ickert

School of Geography, Earth and Environmental Sciences Theses

Increases in disaster losses, in combination with emerging cascading crises, are provoking a fundamental rethinking of prevailing disaster risk reduction measures, including risk communication principles and practices. The resulting paradigm shift towards participation, action, and prevention is firmly outlined in the Sendai Framework’s call for (1) more people-centred approaches and (2) the broader use of innovative information and communication technology (ICT). However, this call raises many epistemological and methodological challenges and open questions about how hazard scientists will translate these novel requirements into their daily research practice. This thesis presents a practice-led enquiry dedicated to exploring the potential of audiovisual …


Starting A New Anti-Seizure Medication In Drug-Resistant Epilepsy: Add-On Or Substitute?, Mubeen Janmohamed, Nicholas Lawn, Katrina Spilsbury, Josephine Chan, John Dunne Jan 2021

Starting A New Anti-Seizure Medication In Drug-Resistant Epilepsy: Add-On Or Substitute?, Mubeen Janmohamed, Nicholas Lawn, Katrina Spilsbury, Josephine Chan, John Dunne

IHR Papers and Journal Articles

Objectives: Randomized studies in drug-resistant epilepsy (DRE) typically involve addition of a new anti-seizure medication (ASM). However, in clinical practice, if the patient is already taking multiple ASMs, then substitution of one of the current ASMs commonly occurs, despite little evidence supporting this approach.

Methods: Longitudinal prospective study of seizure outcome after commencing a previously untried ASM in patients with DRE. Multivariable time-to-event and logistic regression models were used to evaluate outcomes by whether the new ASM was introduced by addition or substitution.

Results: A total of 816 ASM changes in 436 adult patients with DRE between 2010 and 2018 …


Parent Carer Quality Of Life And Night-Time Attendance In Non-Ambulant Youth With Neuromuscular Disorders, Vivienne Travlos, Shane Patman, Jenny Downs, Dana Hince, Andrew C. Wilson Jan 2021

Parent Carer Quality Of Life And Night-Time Attendance In Non-Ambulant Youth With Neuromuscular Disorders, Vivienne Travlos, Shane Patman, Jenny Downs, Dana Hince, Andrew C. Wilson

Physiotherapy Papers and Journal Articles

Purpose: To describe and explore carer quality of life (QoL) and night-time attendance to their child in parents of non-ambulant youth with Neuromuscular Disorders.

Methods: A cross-sectional population-based, comprehensive survey including the Adult Carer QoL (ACQoL) questionnaire, measures of social context and youths’ physical status. Associations between carerQoL or frequency of parents’ night-time attendance with independent variables were explored using linear and logistic regression models, respectively.

Results: Parents’ perceived lower carer-QoL (mean 76.5/120, SD 18.5) when they attended to their child twice a night or more (n = 17/35) and with shorter time since their child was prescribed noninvasive ventilation …