Digital Commons Network^™

Vitamin C For Sepsis Intervention: From Redox Biochemistry To Clinical Medicine, Y R. Li, Hong Zhu

Osteopathic Medicine, Jerry M. Wallace School of

Vitamin C, also known as ascorbic acid or ascorbate, is a water-soluble vitamin synthesized in plants as well as in animals except humans and several other animal species. Humans obtain vitamin C from dietary sources and via vitamin supplementation. Vitamin C possesses important biological functions, including serving as a cofactor for many enzymes, acting as an antioxidant and anti-inflammatory compound, and participating in regulating stem cell biology and epigenetics. The multifunctional nature of vitamin C contributes to its essentialness in maintaining and safeguarding physiological homeostasis, especially regulation of immunity and inflammatory responses. In this context, vitamin C has been investigated …

Benefits And Leaves Of Absence Handbook For Faculty, 2021, University Of Dayton

Faculty Handbooks

No abstract provided.

Practical Pearl: Influenza - December 2021, Ingrid Camelo

Pediatrics Practical Pearls: Referral Guidelines for Common Problems

No abstract provided.

Roots And Routes Toward Decoloniality Within And Outside Psychology Praxis, Jesica S. Fernández, Christopher C. Sonn, Ronelle Carolissen, Garth Stevens

Ethnic Studies

Recent psychology scholarship has engaged topics of decoloniality, from conferences to journal publications to edited volumes. These efforts are examples of the decolonial turn, a paradigm shift oriented to interrupting the colonial legacies of power, knowledge, and being. As critical community psychologists, we contend that decoloniality/decolonization is an epistemic and ontological process of continuously disrupting the coloniality of power that is the hegemonic Western Eurocentric approach to theory, research, and practice. To document and critically understand this process of colonial disruption—the roots and routes toward decoloniality within and outside of community psychology—we collected information at conference workshops and an open-ended …

Genetic Susceptibility To Hepatocellular Carcinoma In Chromosome 22q13.31, Findings Of A Genome-Wide Association Study., Zhanwei Wang, Anuradha S Budhu, Yi Shen, Linda Lou Wong, Brenda Y Hernandez, Maarit Tiirikainen, Xiaomei Ma, Melinda L Irwin, Lingeng Lu, Hongyu Zhao, Joseph K Lim, Tamar Taddei, Lopa Mishra, Karen Pawlish, Antoinette Stroup, Robert Brown, Mindie H Nguyen, Jill Koshiol, Maria O Hernandez, Marshonna Forgues, Hwai-I Yang, Mei-Hsuan Lee, Yu-Han Huang, Motoki Iwasaki, Atsushi Goto, Shiori Suzuki, Koichi Matsuda, Chizu Tanikawa, Yoichiro Kamatani, Dean Mann, Maria Guarnera, Kirti Shetty, Claire E Thomas, Jian-Min Yuan, Chiea Chuen Khor, Woon-Puay Koh, Harvey Risch, Xin Wei Wang, Herbert Yu

Surgery Faculty Publications

Background and Aim: Chronic hepatitis C virus (HCV) infection, long-term alcohol use, cigarette smoking, and obesity are the major risk factors for hepatocellular carcinoma (HCC) in the United States, but the disease risk varies substantially among individuals with these factors, suggesting host susceptibility to and gene-environment interactions in HCC. To address genetic susceptibility to HCC, we conducted a genome-wide association study (GWAS).

Methods: Two case-control studies on HCC were conducted in the United States. DNA samples were genotyped using the Illumian microarray chip with over 710 000 single nucleotide polymorphisms (SNPs). We compared these SNPs between 705 HCC cases and …

Accidental Ocular Rocuronium Exposure., Ayal Z Pierce, Sonal Batra, Bailey Norberg

Emergency Medicine Faculty Publications

No abstract provided.

Delegation, Administration, And Improvisation, Kevin Arlyck

Notre Dame Law Review

Nondelegation originalism is having its moment. Recent Supreme Court opinions suggest that a majority of Justices may be prepared to impose strict constitutional limits on Congress’s power to delegate policymaking authority to the executive branch. In response, scholars have scoured the historical record for evidence affirming or refuting a more stringent version of nondelegation than current Supreme Court doctrine demands. Though the debate ranges widely, sharp disputes have arisen over whether a series of apparently broad Founding-era delegations defeat originalist arguments in favor of a more demanding modern doctrine. Proponents—whom I call “nondelegationists”—argue that these historical delegations can all be …

Light Pollution Levels On Beaches: How Window Tinting Effects Disorientation Of Sea Turtles On Hilton Head Island, Kathryn (Kate) Hettiger

Biology: Student Scholarship & Creative Works

Loggerhead sea turtles, an endangered species, are decreasing at alarming rates worldwide. Artificial light from beachfront hotels on Hilton Head Island are causing disorientation in Loggerhead sea turtle hatchlings affecting their ability to successfully find the ocean. To mitigate this, exterior windows facing the ocean will be tinted using either tinting spray, which will be implemented at the Marriott Grande Ocean, or using tinting film, which will be implemented at the Marriott Westin. During the typical nesting and hatching season (May-October), sea turtle hatchling tracks will be recorded using drones to compare the effects of various levels of light pollution …

Does Psychological Well-Being Mediate The Relationship Between Parental Expectations And Academic Achievement?, Madison Marsden, Carisa Chaplin, Emma Grehan, Jai-Leah Garcia

Psychology Student Research Showcase

A Research Methods Project supervised by Dr. Laura Wilson (Fall 2021).

Sexuality And Stress, Gabe Martin, Matilda Nettey, Ellie Streeter

Psychology Student Research Showcase

A Research Methods Project supervised by Dr. David Stahlman (Fall 2021)

The Relationship Between Lifestyle And Eating Behaviors In College Students, Caitlin O’Leary, Ariana Dodge, Helena Nichols, Melanie Barron

Psychology Student Research Showcase

A Research Methods Project supervised by Dr. Laura Wilson (Fall 2021).

Stress Levels And The Relationship Of Positive And Negative Coping Strategies In College Athletes Versus Non-Athletes, Sara Roberts, Callie Poole, Am Greene-Villa

Psychology Student Research Showcase

A Research Methods Project supervised by Dr. David Stahlman (Fall 2021)

Self Esteem During Puberty: A Parent’S Guide, Sydney Thompson

Psychology Student Research Showcase

An infographic created as part of Dr. Erchull’s Social Psychology course (Fall 2021).

Students were asked to “give psychology away” through an infographic designed to educate an audience of their choice about an idea from social psychology that the group would benefit from understanding. TOPIC: self-esteem. AUDIENCE: parents.

Substance Use In Relation To Socioeconomic Status, Sarah Whitt, Sarah Kuzemchak, Emily Greer

Psychology Student Research Showcase

A Research Methods Project supervised by Dr. Laura Wilson (Fall 2021).

Early Multicenter Experience With Imipenem-Cilastatin-Relebactam For Multidrug-Resistant Gram-Negative Infections, Nicholas Rebold, Taylor Morrisette, Abdalhamid M. Lagnf, Sara Alosaimy

Faculty and Student Publications

A multicenter case series of 21 patients were treated with imipenem-cilastatin-relebactam. There were mixed infection sources, with pulmonary infections (11/21,52%) composing the majority. The primary pathogen was Pseudomonas aeruginosa (16/21, 76%), and 15/16 (94%) isolates were multidrug-resistant. Thirty-day survival occurred in 14/21 (67%) patients. Two patients experienced adverse effects.

Cryo-Em Reveals The Architecture Of Placental Malaria Var2csa And Provides Molecular Insight Into Chondroitin Sulfate Binding, Kaituo Wang, Robert Dagil, Thomas Lavstsen, Sandeep K. Misra

Faculty and Student Publications

Placental malaria can have severe consequences for both mother and child and effective vaccines are lacking. Parasite-infected red blood cells sequester in the placenta through interaction between parasite-expressed protein VAR2CSA and the glycosaminoglycan chondroitin sulfate A (CS) abundantly present in the intervillous space. Here, we report cryo-EM structures of the VAR2CSA ectodomain at up to 3.1 Å resolution revealing an overall V-shaped architecture and a complex domain organization. Notably, the surface displays a single significantly electropositive patch, compatible with binding of negatively charged CS. Using molecular docking and molecular dynamics simulations as well as comparative hydroxyl radical protein foot-printing of …

Identification Of A Solo Acylhomoserine Lactone Synthase From The Myxobacterium Archangium Gephyra, Hanan Albataineh, Maya Duke, Sandeep K. Misra, Joshua S. Sharp

Faculty and Student Publications

Considered a key taxon in soil and marine microbial communities, myxobacteria exist as coordinated swarms that utilize a combination of lytic enzymes and specialized metabolites to facilitate predation of microbes. This capacity to produce specialized metabolites and the associated abundance of biosynthetic pathways contained within their genomes have motivated continued drug discovery efforts from myxobacteria. Of all myxobacterial biosynthetic gene clusters deposited in the antiSMASH database, only one putative acylhomoserine lactone (AHL) synthase, agpI, was observed, in genome data from Archangium gephyra. Without an AHL receptor also apparent in the genome of A. gephyra, we sought to determine if AgpI …

Characterization And In Vitro And In Vivo Evaluation Of Tacrolimus-Loaded Poly(Ε-Caprolactone) Nanocapsules For The Management Of Atopic Dermatitis, Guilherme Dos Anjos Camargo, Leandro Ferreira, Diego José Schebelski, Amanda Martinez Lyra

Faculty and Student Publications

Background: Tacrolimus (TAC) is a drug of natural origin used in conventional topical dosage forms to control atopic dermatitis. However, direct application of the drug often causes adverse side effects in some patients. Hence, drug nanoencapsulation could be used as an improved novel therapy to mitigate the adverse effects and enhance bioavailability of the drug. Methods: Physicochemical properties, in vitro drug release experiments, and in vivo anti-inflammatory activity studies were performed. Results: TAC-loaded nanocapsules were successfully prepared by the interfacial deposition of preformed polymer using poly(ε-caprolactone) (PCL). The nanoparticu-late systems presented a spherical shape with a smooth and regular surface, …

Extracts From Pulsatilla Patens Target Cancer-Related Signaling Pathways In Hela Cells, Grażyna Łaska, Magdalena Maciejewska-Turska, Elwira Sieniawska, Łukasz Świątek

Faculty and Student Publications

The purpose of this study was to determine if a methanolic extract of the Pulsatilla patens (L.) Mill. can inhibit the progression of cancer through the modulation of cancer-related metabolic signaling pathways. We analyzed a panel of 13 inducible luciferase reporter gene vectors which expression is driven by enhancer elements that bind to specific transcription factors for the evaluation of the activity of cancer signaling pathways. The root extract of P. patens exhibited strong inhibition of several signaling pathways in HeLa cells, a cervical cancer cell line, and was found to be the most potent in inhibiting the activation of …

Functional Genomics Study Of Pseudomonas Putida To Determine Traits Associated With Avoidance Of A Myxobacterial Predator, Shukria Akbar, D. Cole Stevens

Faculty and Student Publications

Predation contributes to the structure and diversity of microbial communities. Predatory myxobacteria are ubiquitous to a variety of microbial habitats and capably consume a broad diversity of microbial prey. Predator–prey experiments utilizing myxobacteria have provided details into predatory mechanisms and features that facilitate consumption of prey. However, prey resistance to myxobacterial predation remains underexplored, and prey resistances have been observed exclusively from predator–prey experiments that included the model myxobacterium Myxococcus xanthus. Utilizing a predator–prey pairing that instead included the myxobacterium, Cystobacter ferrugineus, with Pseudomonas putida as prey, we observed surviving phenotypes capable of eluding predation. Comparative transcriptomics between P. putida …

Transmission Studies And The Composition Of Prokaryotic Communities Associated With Healthy And Diseased Aplysina Cauliformis Sponges Suggest That Aplysina Red Band Syndrome Is A Prokaryotic Polymicrobial Disease, Matteo Monti, Aurora Giorgi, Cole G. Easson, Deborah J. Gochfeld

Faculty and Student Publications

Aplysina cauliformis, the Caribbean purple rope sponge, is commonly affected by Aplysina Red Band Syndrome (ARBS). This transmissible disease manifests as circular lesions with red margins and results in bare spongin fibers. Leptolyngbya spp. appear to be responsible for the characteristic red coloration but transmission studies with a sponge-derived isolate failed to establish disease, leaving the etiology of ARBS unknown. To investigate the cause of ARBS, contact transmission experiments were performed between healthy and diseased sponges separated by filters with varying pore sizes. Transmission occurred when sponges were separated by filters with pore sizes ≥ 2.5 μm, suggesting a prokaryotic …

Using Multiple Mendelian Randomization Approaches And Genetic Correlations To Understand Obesity, Urate, And Gout, Charleen D. Adams, Brian B. Boutwell

Faculty and Student Publications

Observational studies suggest relationships between obesity, urate, and gout but are possibly confounded. We assessed whether genetically determined obesity, higher urate (and related traits), and gout were causal using multiple Mendelian randomization (MR) approaches and linkage disequilibrium score regression for genetic correlations (rg). For data, we used genome-wide association study summary statistics available through MR-Base. We observed that obesity increased urate (beta = 0.127; 95% CI = 0.098, 0.157; P-value = 1.2E−17; rg = 0.25 [P-value = 0.001]) and triglycerides (beta = 0.082; 95% CI = 0.065, 0.099; P-value = 1.2E−21; rg = 0.23 [P-value = 8.8E−12]) and decreased high-density …

Cognitive Determinants Of Weight Control By Dietary Patterns Among Postmenopausal Women With Osteoporosis: An Application Of Theory Of Planned Behavior, Hossein Hajizadeh, Pouria Sefidmooye Azar, Haidar Nadrian, Farhang Soltani Bejestani, Sousan Kolahi, Kritika Gupta

Faculty and Student Publications

Background: In this study, we aimed to assess the cognitive determinants of weight control behaviors by dietary patterns among postmenopausal women with osteoporosis. Methods: This cross-sectional study, based on the theory of planned behavior (TPB) was conducted from July to December 2017 among 240 postmenopausal women with osteoporosis in Tabriz, Iran. A validated and reliable TPB-based instrument, namely Weight-CuRB, and the food frequency questionnaire (FFQ) were used. Results: The results of exploratory factor analysis (EFA) indicated three dietary patterns (total variance explained = 24.44%); healthy (n = 71), mixed (n = 78), and western (n = 91). In addition, food …

The Learning Log, December 2021, Lindenwood University

Learning Log

The Learning Log is the electronic newsletter of the Lindenwood University Learning Academy.

Comments Regarding “Technical Support Document: Social Cost Of Carbon, Methane, And Nitrous Oxide Interim Estimates Under Executive Order 13990”, Lawrence G. Baxter, Jospeh E. Stiglitz, Stephanie Kelton, Jay C. Shambaugh

Regenerative Crisis Response Committee

No abstract provided.

The Case For Climate Conscious, Low Carbon Federal Procurement, Jay C. Shambaugh, Gina-Gail S. Fletcher, Jennifer M. Silvi, Hannah H. Braun, Missie Frandsen, Peter A. Bruno

Regenerative Crisis Response Committee

Purchasing practices are one of many contributors to the climate crisis. As the world’s largest purchaser of goods and services, the U.S. Federal Government is in a unique position to cut a significant portion of national emissions through the development of more responsible, sustainable, and—most importantly—climate-conscious supply chains. According to the Office of the Federal Chief Sustainability Officer, federal supply chain emissions associated with federal contracts are twice as high as Federal Scope 1 and Scope 2 emissions, combined. As such, reforming Federal procurement practices to limit direct emissions as well as emissions in supply chains can play a crucial …

Making Green Mortgages Mainstream & Accessible, Megan Greene, Adam Tooze, Jennifer M. Silva, Rohan Kocharekar, Hannah H. Braun

Regenerative Crisis Response Committee

No abstract provided.

Solution To Vessels Mismatch In Microsurgery: Vertical Arteriotomy Technique, Uthman Alamoudi, Tamer Ghanem

Otolaryngology Articles

Background: Microvascular anastomosis is the key for successful free flap transplantation. Ideally, the anastomosis should maintain the flow with minimal turbulence, disruption of endothelium, and minimizing the furrow to prevent thrombosis and failure of the flap. One of the main pitfalls of micro-anastomosis is vessels size mismatch.

Method and Result: There are many ways to overcome this issue, which includes forced mechanical dilation of the smaller vessel, oblique cuts, fish mouth cuts, interposition grafts, end-to-side anastomosis, coupling device, and others. Here, we report a simple technique with single customizable longitudinal arteriotomy of the smaller vessel to achieve an adequate size …

(R1468) Global Analysis Of An Seirs Model For Covid-19 Capturing Saturated Incidence With Treatment Response, David A. Oluyori, Helen O. Adebayo, Ángel G.C. Pérez

Applications and Applied Mathematics: An International Journal (AAM)

In this work, a new SEIRS model with saturated incidence rate and piecewise linear treatment response is proposed to describe the dynamics of COVID-19. It is assumed that the treatment response is proportional to the number of infected people as long as the incidence cases are within the capacity of the healthcare system, after which the value becomes constant, when the number of confirmed cases exceeds the carrying capacity of the available medical facilities. Thus, the basic reproduction number of the model is obtained. It is proved that the disease-free equilibrium is globally asymptotically stable when the basic reproduction number …

Litigation, Legislation, And Love: The Comparative Efficacy Of Litigation And Legislation For The Expansion Of Lesbian, Gay, And Bisexual Civil Rights, Mallory Harrington

Honors College Theses

This research examines the comparative efficacy of federal appellate court decisions and federal legislation with regards to the furtherance of civil rights on the basis of sexual orientation. The research examines efficacy based upon the number of measures which have been implemented as well as the content of each measure. The research examines federal appellate and Supreme Court decisions, as well as adopted pieces of federal legislation since 1950. It also examines the likely causes of the disparities in efficacy that are indicated in this analysis. The findings of this research indicate that litigation has been much more effective at …