Digital Commons Network^™

Discovery Of Phosphotyrosine-Binding Oligopeptides With Supramolecular Target Selectivity, Ana S. Pina, Leonor Morgado, Krystyna L. Duncan, Sara Carvalho, Henrique F. Carvalho, Armenio J. M. Barbosa, Beatriz De P. Mariz, Ines P. Moreira, Daniela Kalafatovic, Bruno M. Morais Faustino, Vishal Narang, Tong Wang, Charalampos G. Pappas, Isabel Ferreira, A. Cecılia A. Roque, Rein V. Ulijn

Advanced Science Research Center

We demonstrate phage-display screening on self-assembled ligands that enables the identification of oligopeptides that selectively bind dynamic supramolecular targets over their unassembled counterparts. The concept is demonstrated through panning of a phage-display oligopeptide library against supramolecular tyrosine-phosphate ligands using 9-fluorenylmethoxycarbonyl-phenylalanine-tyrosine-phosphate (Fmoc-FpY) micellar aggregates as targets. The 14 selected peptides showed no sequence consensus but were enriched in cationic and proline residues. The lead peptide, KVYFSIPWRVPM-NH2 (P7) was found to bind to the Fmoc-FpY ligand exclusively in its self-assembled state with KD = 74 ± 3 μM. Circular dichroism, NMR and molecular dynamics simulations revealed that the peptide interacts with Fmoc-FpY …

Evaluating The Efficacy Of Microsurgical Training Methods In Ophthalmology Education: A Systematic Review And Meta-Analysis, Geoffrey Nguyen, Jamie Palmer, Emilie Ludeman, Moran R. Levin, Ramya Swamy, Janet Alexander

Journal of Academic Ophthalmology

Abstract

Objective The objective of our paper is to review all of the relevant literature in ophthalmology microsurgical education and identify which teaching methodologies were most effective.

Methods A systematic review and meta-analysis of the literature was conducted. Electronic databases, including Ovid MEDLINE, Cochrane CENTRAL, and EMBASE, were searched with preset terms. The search was through December 11, 2019. Eligibility criteria included studies with sufficient data for analyzing associations between surgical teaching techniques and success rates in surgical skills and the organization of the intervention as a microsurgical skills course, curriculum, or program. The articles were independently reviewed by two …

Emerging Technologies And Social Media Are Creating Environment Flexible For The Libraries: A Brief Review, Anwar Muhammad Mr

Library Philosophy and Practice (e-journal)

Purpose- The basic purpose of this paper is to find out the Library professionals how these libraries perceive the importance of social media and emerging technologies what would make the difference in the libraries and how they help libraries to create environments flexible and exclusive.

Design/methodology/approach – the survey method and qualitative research design were used to determine the data as per the set of objectives of the study.

Findings – This study revealed the perception of library professionals about the use of social media and emerging technologies is very high. The reviewed literature has identified the importance and use …

An Analysis Of The Research Productivity & Research Interests Of Library And Information Science Department Of Panjab University In Zenodo Community, Subhajit Panda, Dr. Atasi Sinhababu

Library Philosophy and Practice (e-journal)

The crisis in open access scholarly communications leads to several initiatives promoting the development of open access repositories. It reduces the repetition of research studies by minimising the cost of access and encouraging the reuse of research data. But at the same time, the contributor researchers are also concerned about the long term preservation, meta-descriptions and citation support of their research publication shard in open access repositories. Zenodo, as an open access repository, supports a wider variety of use cases, and many of them implement minimal control on the data uploaded by users. The present study discusses the research output …

The Lost Taste, Wei-En Chen

Theses

The Lost Taste is a film about a young chef named Ueda who is running a noodle bar that was passed down from his deceased father. Ueda is an excellent cook who always satisfies his customers with his secret family recipe. However, in recent years he has been having a hard time running his business, since fast-food chain restaurants are booming and one across the street is stealing his customers. Recently, only a few old loyal customers have come to visit. Worst of all, he has completely forgotten that this very day is the deadline to pay off his debt …

Understanding The Effect Of Dietary Palmitic Acid On Glycolysis During Innate Immune Memory In Macrophages, Khaleda A. Aqaei

PSU McNair Scholars Online Journal

Trained immunity is long-term innate immune memory induced by a primary stimulus, which leads to hyper-inflammation upon secondary stimulation with a homologous or heterologous ligand. Trained immunity is mediated by epigenetic and metabolic reprogramming of the target cell and leads to modification of gene expression and cellular function. Classically, trained immunity is initiated by b-glucans, an inflammatory molecule found on the exterior of fungal species. Interestingly, our lab has recently described that dietary fatty acids can initiate trained immunity, working through similar pathways as b-glucans. Specifically, our data show that a pre-treatment with a specific dietary saturated fatty acid (SFA), …

Small Mammal Community Ecology And Ectoparasite Dynamics In A Tamaulipan Thornscrub Habitat, Brandi Giles

Theses and Dissertations

Small mammals play many roles in ecosystems and are known as great indicators of overall ecosystem function and health, but they are also highly competent hosts for ticks and tick-borne disease. In this study, I gathered data on small mammal community ecology and species diversity, abundance, and overall ectoparasite (i.e., ticks) dynamics in a south Texas Tamaulipan thornscrub habitat. I also assessed differences in these parameters in edge versus interior habitats across a gradient of habitat fragmentation and species assemblage. Lastly, I assessed which host and environmental factors can be utilized for predicting parasitization of small mammals in this habitat. …

Determining The Optimal Healthcare System For America: Comparing The Current American And Universal Healthcare Systems, Tejas Kandharkar

University Honors Program

U.S. citizens ranked healthcare as the most important issue when it comes to voting (Zieff, 2020). The healthcare system’s importance is evident which is why it is important to determine what healthcare system is optimal for America. I used core indicators to compare the current American healthcare system and universal healthcare system and evaluated them for four key parameters. Based on my analysis, I conclusively determined that the universal healthcare system (Score: 8.23/10) is more optimal than the current American healthcare system (Score: 5.10/10). The American system had a somewhat better quality of care but the universal healthcare system was …

Obligations In A Global Health Emergency - Authors' Reply, Ezekiel J. Emanuel

Sturm College of Law: Faculty Scholarship

No abstract provided.

A Training Program For Staff Members Who Work With Children With Challenging Behaviors, On Suicide Risk Precautions, And/Or In Isolation In The Pediatric Acute Care Setting, Jessica S. Eady

Department of Occupational Therapy Entry-Level Capstone Projects

No abstract provided.

Project Creation Of Home Exercise Programs Utilizing Best- Practice Patient Education Techniques, Shelby M. Fleming

Department of Occupational Therapy Entry-Level Capstone Projects

No abstract provided.

Assessing And Improving Political Learning And Engagement On College Campuses, Catherine A. Copeland, Leah Murray

eJournal of Public Affairs

The American Association for State Colleges and University’s (AASCU’s) American Democracy Project (ADP) and the Institute for Democracy and Higher Education (IDHE), located at Tufts University’s Jonathan M. Tisch College of Civic Life, formed a three-year partnership to pilot a process for fostering institutional change to advance political learning and engagement on college campuses. The multidimensional approach to collecting information, deploying dialogues, and crafting interventions provided insight into the necessity of generating institutional support for civic engagement initiatives.

This article reviews the goals, plan, and process of this three-year, multi-phased initiative. We weave throughout the results of multi-stage evaluations of …

Policy Implications Of The Covid-19 Pandemic On Food Security In Rural America: Evidence From Appalachia, Kathryn M. Cardarelli, Emily M. Dewitt, Rachel Gillespie, Rachel Hogg-Graham, Heather Norman-Burgdolf, Janet T. Mullins

Dietetics and Human Nutrition Faculty Publications

Rural communities are disproportionally affected by food insecurity, making them vulnerable to the consequences of supply disruptions caused by the COVID-19 pandemic. While access to food was initially diminished due to food supply disruptions, little is known about the mechanisms through which federal emergency assistance programs impacted food access in rural populations. Through a series of five focus groups in spring 2021, we examined the impact of the COVID-19 pandemic on food access in a rural Appalachian community in Kentucky. Data were analyzed using a Grounded Theory Approach. Findings revealed the following four primary themes: food scarcity in grocery stores; …

Review Of The World: A Brief Introduction By Richard Haass (New York, Ny: Penguin Press, 2020), Steven Elliott-Gower

eJournal of Public Affairs

A review of The World: A Brief Introduction by Richard Haass (2020)

Building Capacity To Alleviate Poverty Through National Service: An Evaluation Plan Guided By Community Partner Perspectives, Laura E. Martin

eJournal of Public Affairs

This paper explores how a national service program, the Mid-South VISTA Project (MSVP), impacts community partner organizations through capacity building activities. MSVP is housed at Mid-South University and extends the community-engaged activities of campus units and while building capacity at partner organizations. The project considers dimensions of nonprofit capacity building, navigating the community-campus partnership process, and the legacy of the VISTA program. The data presented here are part of a larger case study of how programs housed at MSU’s community engagement center impact community partner organizations. Findings from interviews with fifteen VISTA supervisors guide the development of an evaluation plan …

Exercise And The Brain: What Can Fit-U Do For You?, Kaitlin R. Miller

Honors Capstones

This project was a pilot study exploring the effects of an aerobic program, FIT-U, and factors influencing cognitive outcomes for healthy aging individuals and those with neurogenic cognitive-communicative disorders. While aerobic exercise has been shown to improve cognition in both cases, this study looked into the factors that influence this phenomenon. Three regular attendees of FIT-U were given a letter fluency test before and after FIT-U, using different letters each time, but balanced in terms of difficulty. By using single subject methodology, the data were consistent with a trend towards improved VF scores following each FIT-U session for two participants. …

Burnout Among Intensive Care Nurses, Julia Brown

MSN Capstone Projects

At a time when the healthcare system is experiencing strain due to the current health crisis and nursing shortages, talking about, and addressing nursing mental health is of the utmost importance. Nurses who work in the pediatric intensive care unit (PICU) often face more stress due to the patient population they work with. These stresses can lead to burnout and moral distress if not addressed appropriately. Nurses should have a system in place at their workplace and tools readily available to support their mental health while on the job. Through a literature search, it is proposed that an initiation of …

Type 2 Diabetic Education Benchmark Study, Amy Lynd

MSN Capstone Projects

Evaluating the implementation of verbal and written education on diet for newly diagnosed type 2 diabetics.

Cyathostomin Resistance To Moxidectin And Combinations Of Anthelmintics In Australian Horses, Ghazanfar Abbas, Abdul Ghafar, John Hurley, Jenni Bauquier, Anne Beasley, Edwina J. A. Wilkes, Caroline Jacobson, Charles El-Hage, Lucy Cudmore, Peter Carrigan, Brett Tennent-Brown, Charles G. Gauci, Martin K. Nielsen, Kristopher J. Hughes, Ian Beveridge, Abdul Jabbar

Veterinary Science Faculty Publications

BACKGROUND: Cyathostomins are the most important and common parasitic nematodes of horses, with > 50 species known to occur worldwide. The frequent and indiscriminate use of anthelmintics has resulted in the development of anthelmintic resistance (AR) in horse nematodes. In this study we assessed the efficacy of commonly used anthelmintics against cyathostomins in Australian thoroughbred horses.

METHODS: Two drug efficacy trials per farm were conducted on two thoroughbred horse farms in the state of Victoria, Australia. In the first trial, the horses on Farm A were treated with single and combinations of anthelmintics, including oxfendazole (OFZ), abamectin (ABM), abamectin and morantel …

Cellular Agriculture: An Outlook On Smart And Resilient Food Agriculture Manufacturing, Salil Bapat, Vishvesh Koranne, Neha Shakelly, Aihua Huang, Michael Sealy, Kamlakar P. Rajurkar, John W. Sutherland, Ajay P. Malshe

School of Mechanical Engineering Faculty Publications

Over the centuries, the application of grassland and cutting of livestock are the primary foundations for
the production of food agriculture manufacturing. Growing human population, accelerated human
activities globally, staggering food inequity, changing climate, precise nutrition for extended life
expectancy, and more demand for protein food call for a new outlook to smartness in food agriculture
manufacturing for delivering nutritious food. Cellular agriculture, 3D printing of food, vertical urban
farming, and digital agriculture alongside traditional means are envisioned to transform food agriculture
and manufacturing systems for acceptability, availability, accessibility, affordability, and resiliency for meeting demands of food in this century …

The Montclarion, December 2, 2021, The Montclarion

The Montclarion

Student Newspaper of Montclair State University

The Mineral Composition Of Date Palm Fruits (Phoenix Dactylifera L.) Under Low To High Salinity Irrigation, Rania Dghaim, Zied Hammami, Rola Al Ghali, Linda Smail, Dalia Haroun

All Works

Adaptability to salinity varies between different varieties of date palm trees. This research aims to explore the long-term impact of different salinity irrigation levels on the mineral content of 13 date palm varieties grown in the United Arab Emirates (UAE). Date varieties were grown using three irrigation water salinity levels of 5, 10 and 15 dS m-1. The mineral composition (B, Ca, Cu, Fe, K, Mg, Na, P and Zn) of date palm fruits was determined using Inductively Coupled Plasma-Optical Emission Spectrometry (ICP-OES). High salinity levels showed no effect on the mineral content of Ajwat AlMadinah, Naghal, Barhi, Shagri, Abu …

Covid-19'S Impact On Communication Practices In The Animal Welfare Nonprofit Sector, Tiffany M. Davis

Master of Arts in Professional Writing Capstones

Historically, writing and communication practices have been vital components in the nonprofit sector. With the rise of the COVID-19 pandemic, the writing and communication practices within the nonprofit sector have been forced to adapt and change for organizations to continue disseminating their missions and continuing fundraising. Specifically, animal welfare nonprofit organizations have had to shift their communication practices in the wake of the virus. This capstone aims to answer questions about the value of writing and communication practices, and also answer research questions about the effects of COVID-19 on the animal welfare nonprofit sector. Through secondary and primary research, in …

Association Of Low-Frequency And Rare Coding Variants With Information Processing Speed, Jan Bressler, Gail Davies, Albert V Smith, Yasaman Saba, Joshua C Bis, Xueqiu Jian, Caroline Hayward, Lisa Yanek, Jennifer A Smith, Saira S Mirza, Ruiqi Wang, Hieab H H Adams, Diane Becker, Eric Boerwinkle, Archie Campbell, Simon R Cox, Gudny Eiriksdottir, Chloe Fawns-Ritchie, Rebecca F Gottesman, Megan L Grove, Xiuqing Guo, Edith Hofer, Sharon L R Kardia, Maria J Knol, Marisa Koini, Oscar L Lopez, Riccardo E Marioni, Paul Nyquist, Alison Pattie, Ozren Polasek, David J Porteous, Igor Rudan, Claudia L Satizabal, Helena Schmidt, Reinhold Schmidt, Stephen Sidney, Jeannette Simino, Blair H Smith, Stephen T Turner, Sven J Van Der Lee, Erin B Ware, Rachel A Whitmer, Kristine Yaffe, Qiong Yang, Wei Zhao, Vilmundur Gudnason, Lenore J Launer, Annette L Fitzpatrick, Bruce M Psaty, Myriam Fornage, M Arfan Ikram, Cornelia M Van Duijn, Sudha Seshadri, Thomas H Mosley, Ian J Deary

Faculty, Staff and Student Publications

Measures of information processing speed vary between individuals and decline with age. Studies of aging twins suggest heritability may be as high as 67%. The Illumina HumanExome Bead Chip genotyping array was used to examine the association of rare coding variants with performance on the Digit-Symbol Substitution Test (DSST) in community-dwelling adults participating in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. DSST scores were available for 30,576 individuals of European ancestry from nine cohorts and for 5758 individuals of African ancestry from four cohorts who were older than 45 years and free of dementia and …

Empowerment Of Farmers: The Role Of Actor And The Persistence Of Coffee Farmers In Rural Pattongko, Indonesia, A. Hasdiansyah, Sugito Sugito, Yoyon Suryono

The Qualitative Report

Many farmers' empowerment has failed because the process is rigid, instructive, and uses too many techniques that are not following the local conditions of the community. Therefore, the empowerment process must be improved to be able to make farmers empowered and independent. For this reason, it is necessary to explore how the learning process and the involvement of actor in the empowerment process are needed. The subjects of this study consisted of eight farmers and one empowerment actor. The method used is qualitative through in-depth interviews, observation, and document review. All data were transcribed, organized, then analyzed to produce conclusions. …

Written Reminiscences Of Dorothea Jansen - Oh 783, Dorothea Jansen, Covid-19 Pandemic

Winthrop University Oral History Program

These written responses were completed by Dorothea Jansen as part of Project 2020: A Collaborative Oral History. These recollections provide insight into the COVID-19 pandemic and critical year 2020, notably from the perspective of a retired American living in Lancaster County, South Carolina. Notable topics of conversation include COVID-19 virus, vaccination, masking, social isolation, education, social unrest, and disinformation.

Dorothea Jansen (b. 1947) is a native of Syosset, New York, and longtime resident of the Carolinas. She currently resides in the Legacy Park Community of Lancaster County, SC.

Spearheaded by Dr. O. Jennifer Dixon-McKnight, an Assistant Professor of History …

Exploring Personal Information Disclosure And Protective Behaviour Of Research Scholars’ When Seeking Information From The Web., Chanlang Ki Bareh

Library Philosophy and Practice (e-journal)

The collection of personal information became the most prominent threat associated with information consumption from the web. Existing research has not explored the information disclosure and protective behaviour of PhD research scholars. This investigation aimed to address the following objectives: (1) To find the Information-Seeking Behaviours of research scholars (2) To explore the research scholars’ attitudes towards personal information disclosure (3) To explore the protective behaviours of research scholars’ towards personal information disclosure. The study aims to contribute to existing knowledge in information disclosure behaviour and protective behaviour. The empirical research consists of thirty (30) PhD research scholars from the …

Mechanical Overload-Induced Muscle-Derived Extracellular Vesicles Promote Adipose Tissue Lipolysis, Ivan J. Vechetti Jr, Bailey D. Peck, Yuan Wen, R Grace Walton, Taylor R. Valentino, Alexander P. Alimov, Cory M. Dungan, Douglas W. Van Pelt, Ferdinand Von Walden, Bjorn Alkner, Charlotte A. Peterson, John J. Mccarthy

Department of Nutrition and Health Sciences: Faculty Publications

How regular physical activity is able to improve health remains poorly understood. The release of factors from skeletal muscle following exercise has been proposed as a possible mechanism mediating such systemic benefits. We describe a mechanism wherein skeletal muscle, in response to a hypertrophic stimulus induced by mechanical overload (MOV), released extracellular vesicles (EVs) containing muscle-specific miR-1 that were preferentially taken up by epidydimal white adipose tissue (eWAT). In eWAT, miR-1 promoted adrenergic signaling and lipolysis by targeting Tfap2α, a known repressor of Adrβ3 expression. Inhibiting EV release prevented the MOV-induced increase in eWAT miR-1 abundance and expression of …

Identities Development Of Adult Chinese Heritage Language Learners From Southeast Asian American Families, Feng Liang

Journal of Southeast Asian American Education and Advancement

Although linguistic and cultural varieties exist among Chinese Heritage Language Learners (CHLLs), little attention has been given to how adult CHLLs with non-Mandarin backgrounds attempt to negotiate their identities when they learned Chinese. Grounded in He’s (2008, 2016) theory of Chinese heritage language (CHL) development, this study explored the construction of identities of Chinese adults with non-Mandarin backgrounds in the process of Chinese heritage language learning. Three adult CHLLs in the United States participated in a multiple case study that lasted for six months. Data collection included interviews, journals, observations, and informal communications. Findings suggest that CHLLs of non-Mandarin backgrounds …

Holistic Well-Being And Humanitarian Workers During Covid-19: Concepts, Challenges, And Recommendations, Nicholas Sherwood

Biennial Conference: The Social Practice of Human Rights

The onset of the COVID-19 pandemic has exacerbated conflict dynamics and humanitarian disasters around the world, including Syria, Yemen, and East Africa. Humanitarian efforts designed to address these dynamics and disasters are also falling prey to the fallout of COVID, most notably increases in psychological distress experienced by humanitarian workers (HW) operating on the front lines of humanitarian zones. As such, new and innovative practices must be explored to support HW as they continue their desperately needed work; this imperative is further bolstered by calls in international human rights-based documents (e.g., Universal Declaration of Human Rights and the International Covenant …