Digital Commons Network^™

Guide To Sources For The Study Of The 1971 Alaska Native Claims Settlement Act: Volume 2 Bibliography, Sue Sherif, Joan Antonson

AHS ANCSA Committee

The Alaska Native Claims Settlement Act (43 USC 1601-1624) -- Public Law 92-203, approved December 18, 1971 (85 Stat. 688) has been the subject of a number of bibliographies compiled since the act was passed in 1971. They include stand-alone publications and ones that are in published books about the act. The bibliography that follows was initiated for commemoration of the 50th anniversary of the passage of the landmark legislation, especially to add sources published since the 40th anniversary and to be helpful for a researcher initiating a study. The first publications generally provided background historical context and summarized the …

Dissecting The Molecular Mechanism Of Familial Cardiomyopathies, Sarah Ruth Clippinger Schulte

Arts & Sciences Graduate Student Theses and Dissertations

Familial cardiomyopathies, including hypertrophic (HCM), restrictive (RCM) and dilated cardiomyopathy (DCM), are the leading cause of sudden cardiac death in young people. These diseases, which are characterized by altered cardiac contractility and remodeling of the heart, can lead to heart failure. These diseases are primarily caused by point mutations in sarcomeric proteins that generate or regulate heart contraction, such as troponin T. In the heart, the troponin complex together with tropomyosin lie along the actin filament and regulate myosin’s ability to bind actin and produce force. Here I show how mutations in troponin T affect contractility at the molecular level …

A Study On The Hormonal Regulation And Novel Role Of Na+ Leak Channel, Non-Selective (Nalcn) In Human Myometrial Smooth Muscle Cells, Chinwendu Amazu

Arts & Sciences Graduate Student Theses and Dissertations

During pregnancy, the uterus transitions from a quiescent state to an excitable, highly contractile state to deliver the fetus. Two important contributors essential for this transition are progesterone (P4) and estrogen (E2), which promote quiescence or contraction, respectively, by acting on the myometrial smooth muscle cells (MSMCs). While these hormones regulate uterine contractions, it is unclear how they affect electrical activity of MSMCs, which underlies uterine contractile activity. Our lab recently identified Na+ leak channel, non-selective (NALCN) as a component of the leak current in human MSMCs and showed that mice lacking NALCN in the uterus have dysfunctional labor. In …

Computational Methods For Analysis Of Data For Conformational And Phase Equilibria Of Disordered Proteins, Jared Michael M Lalmansingh

Arts & Sciences Graduate Student Theses and Dissertations

Intrinsically disordered proteins and regions (IDPs / IDRs) are a class of proteins with diverse conformational heterogeneity that do not fold into a tertiary structure due to the lack of a native structural state. Consequently, disordered proteins are remarkably flexible and exhibit multivalent properties that enable them to adopt myriad functional roles within the cell such as: signaling transduction, transcription, enzymatic catalysis, translation, and many more. Due to their multivalency, some IDPs undergo monomeric and heterotypic interactions which can drive phase separation. Such IDPs can form membraneless organelles with specific regulatory roles within the cell which include, but are not …

Quantitative Characterization Of Microbial Ecologies In Dysbiosis And Infection, Eric Keen

Arts & Sciences Graduate Student Theses and Dissertations

In 1973, Theodosius Dobzhansky famously wrote that nothing in biology makes sense except in the light of evolution. Today, nearly 50 years later, little in microbiology – or in biology, for that matter – makes sense except in the light of genomics. Microbial genomics populates the field with innumerable testable hypotheses for evaluation in vitro and in vivo, allows us to monitor microbial populations in real time and at a massive scale, and underpins our approach to entire domains of microbiology, including microbial evolution. In this Thesis, I present three studies from my graduate research united by their common theme …

Moby-Dick As Corporate Catastrophe: Law, Ethics, And Redemption, David Yosifon

Faculty Publications

Herman Melville’s Moby-Dick serves here as a vehicle through which to interrogate core features of American corporate law and excavate some of the deeper lessons about the human soul that lurk behind the pasteboard mask of the law’s black letter. The inquiry yields an illuminating vantage on the ethical consequences of corporate capital structure, the law of corporate purpose, the meaning of voluntarism, the ethical stakes of corporate fiduciary obligations, and the role of lawyers in preventing or facilitating corporate catastrophe. No prior familiarity with the novel or corporate law is required.

Satirizing Empire: Comparing Ancient China And Rome, Di Wang

Arts & Sciences Graduate Student Theses and Dissertations

Comparative scholars of the ancient Mediterranean and East Asian worlds have recently taken a serious interest in the unprecedented and simultaneous emergence of two classical empires: Rome and China. The trend, invigorated by the contemporary geopolitical development of China’s rise as a world empire challenging the post-World War II Western hegemony, has yielded new insights into the many divergences and convergences of the world’s two most enduring political and cultural systems. However, preoccupied with describing the political, cultural institutions and grand narratives of empire, scholarship has largely ignored the detractors of empire, whose ingenious expressions are as enduring as these …

Slo2.1 Channels: A New Molecular Mechanism To Regulate Uterine Excitability, Juan Jose Ferreira

Arts & Sciences Graduate Student Theses and Dissertations

At the end of pregnancy, the uterus transitions from a non-contractile state to a highly contractile state. Two processes primarily drive this transition. First, from the 28th week of pregnancy until labor, the resting membrane potential of uterine (myometrial) smooth muscle cells (MSMCs) gradually becomes more positive (depolarizes) (Parkington et al. 1999). Second, at the end of pregnancy, MSMCs express more oxytocin receptors and become more sensitive to oxytocin (Kimura et al. 1996). However, the detailed mechanisms by which these processes occur have not been determined. My central hypothesis was that the Na+-activated K+ channel SLO2.1 plays a key role …

Surveillance And Dynamics Of Bacteria And Resistance Genes In Humans And Hospitals, Alaric Wences D'Souza

Arts & Sciences Graduate Student Theses and Dissertations

Bacteria live in, on, and around us. These bacteria affect human health through beneficial commensal interactions that promote normal development and through harmful infections or perturbations leading to disease. Understanding the prevalence, spread, and resilience of these bacteria in humans and human environments is critical to clinical medicine and epidemiology. I investigated environmental and human resident bacteria to understand dynamics in bacterial communities and how these dynamics may impact human health.Hospitals are one critical location of human-bacterial interactions. Bacteria can contaminate hospital surfaces from patients or environmental sources and subsequently transmit from surfaces to vulnerable patients. I analyzed bacteria from …

The Role Of Neuronal Atp-Sensitive Potassium Channels In Learning And Memory, Shaul Vladimir Yahil

Arts & Sciences Graduate Student Theses and Dissertations

ATP-sensitive potassium (KATP) channels link cellular metabolism and membrane excitability in many tissues, including brain and pancreas. Gain-of-function (GOF) mutations to KATP channels cause neonatal diabetes, with some patients exhibiting developmental delay, epilepsy, and neonatal diabetes (DEND) syndrome. Diabetic symptoms have been attributed to loss of membrane excitability and insulin secretion in pancreatic β-cells, though the origin of neurological deficits and the effects of neuronal KATP-GOF mutations more generally remain elusive. In this dissertation, I will present evidence that mice expressing KATP-GOF mutations pan-neuronally (nKATP-GOF) demonstrated sensorimotor and cognitive deficits, whereas hippocampus-specific hKATP-GOF mice exhibited predominantly learning and memory deficits. …

Detecting Apple Crop Pest Insects From Eptesicus Fuscus (Big Brown Bat) Feces Using Metabarcoding In Southern Michigan Apple Orchards, Randi Lesagonicz

Masters Projects

Michigan is ranked third in the U.S. for apple production. Michigan State University identified 78 pest insect species that cause damage to Michigan’s crop. Orchards using conventional and integrated pest management (IPM) spend thousands of dollars on pest control substances, which are hazardous to the environment and human health, and do not prevent 100% of crop damage and losses. The public’s increasing desire for “cleaner” foods has led to studies on how to incorporate more naturally occurring pest biocontrol agents. Bats have been recognized as pest insect biocontrol agents in numerous U.S. agroecosystems like corn, cotton, and pecans; however, little …

Smoking, Alcohol Consumption, And Depression In Association With Incidence Of Type 2 Diabetes Among Mexican Americans In Starr County, Texas, Gabriela Rubannelsonkumar

Honors Program Theses and Research Projects

Previous studies on conditions like obesity, hypertension, and type 2 diabetes mellitus (T2DM) have explored the correlations between them and various other human conditions, including aortic stiffness, left ventricular hypertrophy and sleep apnea, as they predict possibilities of developing certain diseases in Mexican Americans. This study aims to observe the correlation between lifestyle decisions that could relate to the onset of the depression in normal, prediabetic, and diabetic individuals. These include smoking habits and alcohol consumption. Many papers have previously conducted research on these lifestyle habits as they relate to obesity, hypertension, diabetes, however, have done so in a singular …

Sex Differences In Treatment Strategy For Coronary Artery Aneurysms: Insights From The International Coronary Artery Aneurysm Registry, F Arslan, I. J. Núñez-Gil, R Rodríguez-Olivares, E Cerrato, M Bollati, L Nombela-Franco, B Terol, E Alfonso-Rodríguez, S. J. Camacho Freire, Pedro A. Villablanca, I. J. Amat Santos, J. M. De La Torre Hernández, I Pascual, C Liebetrau, M Alkhouli, A Fernández-Ortiz

Cardiology Articles

INTRODUCTION: Sex disparities exist in coronary artery disease (CAD) in terms of risk profile, clinical management and outcome. It is unclear if differences are also present in coronary aneurysms, a rare variant of CAD.

METHODS: Patients were selected from the international Coronary Artery Aneurysm Registry (CAAR; ClinicalTrials.gov: NCT02563626), and differences between groups were analysed according to sex. The CAAR database is a prospective multicentre registry of 1565 patients with coronary aneurysms (336 females). Kaplan-Meier method was used for event-free survival analysis for death, major adverse cardiac events (MACE: composite endpoint of death, heart failure and acute coronary syndrome) and bleeding. …

Leadership Conversion: From Command-And-Control To People-Centered Approach, Elli Unt

Student Theses and Dissertations

Leadership style is often recognized as the most important factor in determining workforce productivity and in establishing an organizational environment. In the last century, researchers have observed a significant shift in the approach organizational leaders take to communicate with their teams. This paper explores the gap between the leadership models of the last century (top-down approach) and more modern leadership practices (collaborative approach) in respect to economic and technological changes faced by organizations today. Through the analysis of knowledge and understanding about the subject shared by professionals from different fields, this paper proposes new ideas on how to better adapt …

How Did Covid-19 Impact The Aviation Industry, Theresa Sonntag

Student Theses and Dissertations

The ongoing coronavirus pandemic (COVID-19) has been impacted the whole world. One of the hardest-hit industries in the aviation industry. This research investigates how COVID-19 challenged this sector. It focuses especially on how American Airlines and Lufthansa Group got impacted and what they tried to do to recover from this crisis. This paper’s primary focus is on how those two airlines changed their communication strategy and their marketing to regain customer trust and their reputation. It looks at different researchers and their theories to overcome such a crisis like this and discusses different airlines and what they did when they …

Unlocking The “Opportunity” In Opportunity Zones: A Proposal To Revolutionize The Opportunity Zone Tax Program, Andrew Jacobs

Seton Hall Journal of Legislation and Public Policy

No abstract provided.

Eliminating The Haze: A Federal Proposal For Antihazing Compliance Regulations, Gabrielle Bamberski

Seton Hall Journal of Legislation and Public Policy

No abstract provided.

The Right Side Of The Coin: State Approaches In Regulating Virtual Currencies, Zachary Miller

Seton Hall Journal of Legislation and Public Policy

No abstract provided.

The Ncaa’S Historical Challenges With Antitrust Issues And Its Current Battle For Continued Relevance, Andrew Bondarowicz

Seton Hall Journal of Legislation and Public Policy

No abstract provided.

The Cost Of A Bundle Of Wood: Video Games And In-App Purchases, Amory R. Blank

Seton Hall Journal of Legislation and Public Policy

No abstract provided.

Is Official League Data A Safe Bet: Benefits And Concerns With Requiring Sportsbooks To Purchase League Data Feeds, Robert J. Sheran

Seton Hall Journal of Legislation and Public Policy

No abstract provided.

Democracy And The Media: The Year In C-Span Archives Research, Volume 7, Robert X. Browning

The Year in C-SPAN Archives Research

Volume 7 of The Year in C-SPAN Archives Research series focuses on the relationship between democracy and the media. Using the extensive collection of the C-SPAN Video Library, chapters cover Trump political rallies, congressional references of late-night comedy, responses of African American congresswomen to COVID-19 bills, and congressional attacks on the media through floor speeches in the House of Representatives and Senate.

The C-SPAN Video Library is unique because there is no other research collection that is based on video research of contemporary politics. Methodologically distinctive, much of the research uses new techniques to analyze video, text, and spoken words …

From Inspiration To Actualization: Designing An Mba That Can Deliver The Goods, Rodolfo P. Ang

Journal of Management for Global Sustainability

This invited essay continues the conversation on the International Association of Jesuit Universities’ (IAJU) white paper entitled “An Inspirational Paradigm for Jesuit Business Education.” Mr. Rodolfo P. Ang, one of the members of the Task Force that developed the white paper, talks about his experience of leading the Ateneo de Manila University Graduate School of Business toward the actualization of the paradigm.

A Rapid Screening Method For Ecological Risks Posed By Different Land Use Intensities: Case Study Of Marikina City’S River System, Maria Aileen Leah Guzman, Charlotte Kendra Gotangco Gonzales, Rene Juna Claveria, Philippe Joshua Evardo, Jean Jardeleza Mijares

Journal of Management for Global Sustainability

Land use plays an important role in environmental and sustainability research because of its potential contribution to ecosystem protection or degradation. However, most risk maps used in comprehensive land use planning only identify areas at risk, for example, to various geophysical or climate- and weather-related hazards. It would also be useful to identify land areas that pose a risk to ecological systems. In this study, a simplified method adapted from the source-habitat approach and the relative risk model was used to explore the potential ecological risk of exposure to water pollutants posed by land uses on the river system in …

Demography, Comorbidities, Biomarkers, And Severity Of Infection In Admitted Covid-19 Patients: Experience From A Tertiary Care Hospital In South India, Indira Kedlaya, Yashas V. Kedlaya, Saad H. Usmani

Manipal Journal of Medical Sciences

Introduction: This retrospective study analyses the demographics, clinical features, and comorbidities of patients admitted with COVID-19. The study also evaluates the association of two biomarkers namely D-dimer and CRP (C-reactive protein) with the severity of the infection. Methods: Data of COVID-19 patients admitted from 1 June 2020 to 31 August 2020 was collected based on age, sex, date of admission and discharge, the severity of infection, final disposition, treatment, biomarkers (C-reactive protein and D-dimer), other associated presentations, and comorbidities through a chart review. The severity of infection was categorized into asymptomatic, mild, moderate, or severe, based on WHO criteria. Results: …

Pharmacotherapy For Non-Alcoholic Steatohepatitis - Current Status And Future Prospects, Ganesh Bhat

Manipal Journal of Medical Sciences

Non-alcoholic Steatohepatitis (NASH) is emerging as a leading cause of cirrhosis worldwide. Weight reduction through lifestyle modification is accepted first line treatment for these patients. Histological improvement in highrisk patient is the primary target of pharmacotherapy in NASH patients. Even though currently many drugs are available for these high-risk patients, none of them has been approved USA Food and Drug Administration (FDA) until now. Among these, vitamin E and pioglitazone has been approved by AASLD (American Association for the Study of Liver Diseases) in selected group of patients. There are more than a dozen drug targeting different pathways in NASH …

Malabar Pit Viper Envenomation Presenting With Symptomatic Hyperkalaemia In A Tertiary Care Centre In South Karnataka, Vrinda Lath

Manipal Journal of Medical Sciences

A 25-year-old male was bitten by a pit viper over the foot and presented with a tender and oedematous bitten limb a day after the bite. He had received anti-snake venom (ASV) at a local centre and developed anaphylaxis. He was admitted for observation and developed sudden onset hyperkalaemia and hemodynamic instability which responded to anti-hyperkalemic measures. We highlight envenomation by a species not known to cause any life-threatening complications, and emphasize the need for intensive monitoring and discuss the importance of species identification, knowledge of regional herpetofauna and treatment modalities including the need for a species-specific antivenin.

A Rare Case Of Chorioretinitis Sclopetaria- A Pellet In A Haystack, Yogish Kamath

Manipal Journal of Medical Sciences

Chorioretinitis sclopetaria is a rare event with a poor visual prognosis, with less than a hundred cases reported worldwide. We report a case of an 8-year-old boy who presented with swelling and decreased vision in the left eye after an alleged fall. On examination, the affected eye showed periorbital ecchymosis, ptosis, subconjunctival haemorrhage, hyphema, and an afferent pupillary defect. A CT scan showed a foreign object lodged in the left orbit which was removed surgically. This case report intends to describe the rare occurrence of chorioretinitis sclopetaria in a child, wherein the history of gun pellet injury, elicited in retrospect, …

The Haunting Of Her House: How Virginia Law Punishes Women Who Become Mothers Through Rape, Jordan S. Miceli

Washington and Lee Law Review Online

If a rape victim becomes pregnant following the attack, she has three options: abort the pregnancy, place the child for adoption, or keep and raise the child. However, by requiring proof of conviction of rape to terminate the parental rights of the man who fathered that child through his rape, the Commonwealth of Virginia imposes a substantial burden on a victim weighing those options. To obtain a conviction under the current scheme, a victim, through her local prosecutor, has to prove to a jury that the accused committed the rape beyond a reasonable doubt. The Commonwealth requires proof of conviction …

An Investigation Into The Relationship Between Obstetric Racism And Postpartum Depression In Black Women, Miguel A. Claxton Iii

University Honors Theses

Postpartum depression is the most common postpartum mood disorder, with 13% of new mothers reporting symptoms within the first year. Adverse birth outcomes, such as low birth weight and preterm birth co-index with the development of postpartum depression. This correlation is particularly alarming considering that Black women have about a 60% higher rate of preterm birth and an 88% higher rate of low birth weight infants than Caucasian women. By utilizing theories of stratified reproduction, necropolitics, and obstetric racism, this paper aims to situate postpartum depression in Black women as a psychological response to systems of medicolegal control and domination. …