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Metabolic Control Of Stem Cell Ageing And Longevity Through Caloric Restriction, Valerie Navarrete

The Yale Undergraduate Research Journal

While prior studies have identified recurring genetic patterns, gaps of knowledge still remain in existing aging mechanisms; where they originate, and how they offer insight to environmental disruptions that dictate health over time. Given the inescapability of age-related deterioration and pathology, stitching together current literature may help demystify the biological process common to all living mammals. The physiological disruption of aged tissue reflects a cellular dependence on environmental cues and historical wear. Retaining the capacity to differentiate into any cell type, a stem cell best parallels a call-and-response relationship between organ and cell. As the longest living proliferative cell in …

The Genomics Of Heart Failure: Design And Rationale Of The Hermes Consortium, R. Thomas Lumbers, Sonia Shah, Honghuang Lin, Tomasz Czuba, Albert Henry, Daniel I. Swerdlow, Anders Mälarstig, Charlotte Andersson, Niek Verweij, Michael V. Holmes, Johan Ärnlöv, Per Svensson, Harry Hemingway, Neneh Sallah, Peter Almgren, Krishna G. Aragam, Geraldine Asselin, Joshua D. Backman, Mary L. Biggs, Heather L. Bloom, Eric Boersma, Jeffrey Brandimarto, Michael R. Brown, Hans-Peter Brunner-La Rocca, David J. Carey, Mark D. Chaffin, Daniel I. Chasman, Olympe Chazara, Xing Chen, Xu Chen, Jonathan H. Chung, William Chutkow, John G.F. Cleland, James P. Cook, Simon De Denus, Abbas Dehghan, Graciela E. Delgado, Spiros Denaxas, Alexander S. Doney, Marcus Dörr, Samuel C. Dudley, Gunnar Engström, Tõnu Esko, Ghazaleh Fatemifar, Stephan B. Felix, Chris Finan, Ian Ford, Francoise Fougerousse, René Fouodjio, Mohsen Ghanbari, Sahar Ghasemi, Vilmantas Giedraitis, Franco Giulianini, John S. Gottdiener, Stefan Gross, Daníel F. Guðbjartsson, Hongsheng Gui, Rebecca Gutmann, Christopher M. Haggerty, Pim Van Der Harst, Åsa K. Hedman, Anna Helgadottir, Hans Hillege, Craig L. Hyde, Jaison Jacob, J. Wouter Jukema, Frederick Kamanu, Isabella Kardys, Maryam Kavousi, Kay-Tee Khaw, Marcus E. Kleber, Lars Køber, Andrea Koekemoer, Bill Kraus, Karoline Kuchenbaecker, Claudia Langenberg, Lars Lind, Cecilia M. Lindgren, Barry London, Luca A. Lotta, Ruth C. Lovering, Jian'an Luan, Patrik Magnusson, Anubha Mahajan, Douglas Mann, Kenneth B. Margulies, Nicholas A. Marston, Winfried März, John J.V. Mcmurray, Olle Melander, Giorgio Melloni, Ify R. Mordi, Michael P. Morley, Andrew D. Morris, Andrew P. Morris, Alanna C. Morrison, Michael W. Nagle, Christopher P. Nelson, Christopher Newton-Cheh, Alexander Niessner, Teemu Niiranen, Christoph Nowak, Michelle L. O'Donoghue, Anjali T. Owens, Colin N.A. Palmer, Guillaume Paré, Markus Perola, Louis-Philippe Lemieux Perreault, Eliana Portilla-Fernandez, Bruce M. Psaty, Kenneth M. Rice, Paul M. Ridker, Simon P.R. Romaine, Carolina Roselli, Jerome I. Rotter, Christian T. Ruff, Marc S. Sabatine, Perttu Salo, Veikko Salomaa, Jessica Van Setten, Alaa A. Shalaby, Diane T. Smelser, Nicholas L. Smith, Kari Stefansson, Steen Stender, David J. Stott, Garðar Sveinbjörnsson, Mari-Liis Tammesoo, Jean-Claude Tardif, Kent D. Taylor, Maris Teder-Laving, Alexander Teumer, Guðmundur Thorgeirsson, Unnur Thorsteinsdottir, Christian Torp-Pedersen, Stella Trompet, Danny Tuckwell, Benoit Tyl, Andre G Uitterlinden, Felix Vaura, Abirami Veluchamy, Peter M. Visscher, Uwe Völker, Adriaan A. Voors, Xiaosong Wang, Nicholas J. Wareham, Peter E. Weeke, Raul Weiss, Harvey D. White, Kerri L. Wiggins, Heming Xing, Jian Yang, Yifan Yang, Laura M. Yerges-Armstrong, Bing Yu, Faiez Zannad, Faye Zhao, Jemma B. Wilk, Hilma Holm, Naveed Sattar, Steven A. Lubitz, David E. Lanfear, Svati Shah, Michael E. Dunn, Quinn S. Wells, Folkert W. Asselbergs, Aroon D. Hingorani, Marie-Pierre Dubé, Nilesh J. Samani, Chim C. Lang, Thomas P. Cappola, Patrick T. Ellinor, Ramachandran S. Vasan, J. Gustav Smith

Cardiology Articles

AIMS: The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure.

METHODS AND RESULTS: The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and performed genome-wide genotyping of common genetic variants. The enrolment of subjects into participating studies ranged from 1948 to the present day, and the median follow-up following heart failure diagnosis ranged from 2 to 116 months. Forty-nine of 51 individual studies enrolled participants …

Another Measure Of Success: Examining The Success Sequence And Its Possible Utility In Crime Prevention, Andrew T. Heath

Liberty University Law Review

No abstract provided.

Transition Of Living Arrangement And Cognitive Impairment Status Among Chinese Older Adults: Are They Associated?, Yen-Han Lee, Chia Hung Lin, Jia Ren Chang, Ching Ti Liu, Mack Shelley, Yen Chang Chang

College of Health and Human Services

Background and Objectives: Living arrangement is a crucial factor for older adults’ health. It is even more critical for Chinese older adults due to the tradition of filial piety. With the aging of China’s population, the prevalence of cognitive impairment among older adults has increased. This study examines the association between living arrangement transition and cognitive function among Chinese older adults.

Materials and Methods: Using three waves of the Chinese Longitudinal Healthy Longevity Survey (CLHLS; 2008–2009, 2011–2012, and 2014), we analyzed data for older adults (age ≥ 65) who lived with other household members and reported good cognitive function or …

Facilitating Well-Rounded Clinical Experience For Psychiatric Nurse Practitioner Students, Joan Alviar Fraino, Nancy Selix

Nursing and Health Professions Faculty Research and Publications

There is a steady increase in demand for mental health services and a lack of providers. Recent societal changes resulting from the COVID-19 pandemic have increased these needs. Psychiatric mental health nurse practitioners (PMHNP) are well suited to offer these services. High-quality clinical PMHNP student experiences are based on well-rounded curricula in a variety of clinical settings. Meeting the need for clinical education and finding high-quality preceptors is especially challenging during the pandemic due to the lack of preceptors and access to care for in-person services. Creative approaches are needed to meet student clinical experience needs.

A Newly Identified Impairment In Both Vision And Hearing Increases The Risk Of Deterioration In Both Communication And Cognitive Performance, Dawn M. Guthrie, Nicole Williams, Jennifer Campos, Paul Mick, Joseph B. Orange, M. Kathleen Pichora-Fuller, Marie Y. Savundranayagam, Walter Wittich, Natalie A. Phillips

Health Sciences Faculty Publications

Vision and hearing impairments are highly prevalent in adults 65 years of age and older. There is a need to understand their association with multiple health-related outcomes. We analyzed data from the Resident Assessment Instrument for Home Care (RAI-HC). Home care clients were followed for up to 5 years and categorized into seven unique cohorts based on whether or not they developed new vision and/or hearing impairments. An absolute standardized difference (stdiff) of at least 0.2 was considered statistically meaningful. Most clients (at least 60%) were female and 34.9 per cent developed a new sensory impairment. Those with a new …

Ce 611 Syllabus: Development Over The Lifespan, Mary Fawcett

Counselor Education Syllabi

The purpose of this course is to promote students’ thinking and learning about human growth, adaptation, and change throughout the lifespan. Major theories, issues, eras, and trends in human development will be addressed.

Ce 640 Syllabus: Orientation To Clinical Mental Health Counseling, Mary Fawcett

Counselor Education Syllabi

This course examines the counseling profession including history, philosophy, theory, and professional issues. Emphasis is on different counseling populations, social justice and multicultural issues.

Evaluating The Role Of Gender In Dementia-Related Language Deficiencies, Kelsey Bourque

Dissertations, Theses, and Capstone Projects

Typically, about 60% of dementia patients are women. Researchers have historically dismissed this imbalance as a result of the life expectancy for women being longer, and since age is the primary risk factor associated with dementia, and women’s longer lifespan equates to a higher percentage of the dementia patient population (Mielke, 2018). While the exact cause of dementia is unknown, researchers and clinicians have historically treated male and female populations the same, asserting that there is no significant difference between the two sexes in regards to detecting dementia. The present study aims to address this potential gap in dementia research, …

Should I Stay Or Should I Go? Mexican Return Migration Across The Life Course, Mara G. Sheftel

Dissertations, Theses, and Capstone Projects

Foreign-born individuals make up a growing share of older adults in the US. Older immigrants offer an important vantage point from which to investigate integration because outcomes at older ages can be considered “final” measures providing empirical evidence for theoretical understandings of the forces impacting immigrant trajectories. However, considering the non-negligible portion of immigrants that ultimately return to their country of origin it is impossible to get the full range of immigrant outcomes without considering returnees. Further, patterns of return may differ across the life course with distinct economic, social, and health considerations at older ages. However, the impact of …

University Of Nebraska At Omaha Commencement: August 2021, University Of Nebraska At Omaha

Commencement Programs

No abstract provided.

Facilitating Aging In Place And Community By Empowering Participation In Society: A Mixed Methods Study On The Co-Development Of A Theory Of Change With Suburban-Dwelling Older Adults, Emily Balog

Doctor of Philosophy in Translational Health Sciences Dissertations

Background: Baby boomers are steadily aging in America and represent an increased population in nearly every sector. In suburban communities today, older adults make up 51% of the population. Ninety-five percent of all older adults live in community settings and have expressed a desire to avoid costly institutionalization and to remain in their homes and communities, also called aging in place. Older adults in moderate income suburban communities are increasingly at a higher risk for institutionalization should their health or finances decline as the access to their wealth is within the home in which they dwell. This process …

Inflammation In Older Adults: Stress, Depression, And Aces, Kerianne Kramer

Loma Linda University Electronic Theses, Dissertations & Projects

Studies conducted on Adverse Childhood Experiences (ACEs) have shown that childhood adversity is relatively common, likely to co-occur, and have dose-dependent relationships with mental and physical health in adulthood. People with a history of ACEs are likely to experience dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, leading to increased inflammation production, greater stress reactivity, and decreased serotonin production. This longitudinal study explored the role depression and perceived stress have in the relationship between ACEs and inflammation while controlling for demographic characteristics (e.g., age, gender, ethnicity, education, difficulty meeting expenses). The study sample included 288 (61% female, 66% white, Mage = 68, …

Health-Related Quality Of Life And Mental Well-Being Of Healthy And Diseased Persons In 8 Countries: Does Stringency Of Government Response Against Early Covid-19 Matter?, Di Long, Juanita A. Haagsma, Mathieu F. Janssen, John N. Yfantopoulos, Erica I. Lubetkin, Gouke J. Bonsel

Publications and Research

Objectives

Our study aimed to (1) assess health-related quality of life (HRQoL) and mental well-being of healthy and diseased persons in the general population during the early stage of the COVID-19 pandemic and (2) examine the relationship between HRQoL and mental well-being and individual characteristics and government response against COVID-19, as measured by the stringency index.

Methods

A web-based survey was administered to a cohort of persons from the general population of eight countries: Greece, Italy, the Netherlands, Russia, South Africa, Sweden, the United Kingdom (UK) and the United States of America (US) from April 22 to May 5 and …

Organizational Learning During Covid-19: A Qualitative Study Of Nurses' Experiences, Bret Lyman, Morgan K. Horton, Alyssa Oman

Faculty Publications

Aim: The aim of this study is to test the validity of the Organizational Learning in Hospitals model in the context of the COVID-19 pandemic.

Background: Organizational learning is especially crucial in circumstances of intense, complex, enduring change, as with the COVID-19 pandemic. Nurse managers need additional guidance for fostering organizational learning under such circumstances. The Organizational Learning in Hospitals model may be a helpful resource but requires additional validation.

Methods: Semi-structured interviews were conducted to gather 19 nurses' first-hand experiences of organizational learning during the COVID-19 pandemic. Data were analysed using deductive thematic analysis.

Results: Nurses' experiences of organizational …

Death In Genetic Algorithms, Micah Burkhardt, Roman Yampolskiy

Faculty and Staff Scholarship

Death has long been overlooked in evolutionary algorithms. Recent research has shown that death (when applied properly) can benefit the overall fitness of a population and can outperform sub-sections of a population that are “immortal” when allowed to evolve together in an environment [1]. In this paper, we strive to experimentally determine whether death is an adapted trait and whether this adaptation can be used to enhance our implementations of conventional genetic algorithms. Using some of the most widely accepted evolutionary death and aging theories, we observed that senescent death (in various forms) can lower the total run-time of genetic …

Sweetpotato Leaves Inhibit Lipopolysaccharide-Induced Inflammation In Raw 264.7 Macrophages Via Suppression Of Nf-Κb Signaling Pathway, Hyun-Dong Cho, Cindi Brownmiller, Harun Sorker, Shahidul Islam, Sun-Ok Lee

Food Science Faculty Publications and Presentations

Limited information is available regarding the health-promoting activities of sweetpotato leaves (SPL). The present study investigated antioxidant and anti-inflammatory effects, and phenolic contents in 29 SPL cultivars harvested in 2018 and 2019. Extracts showed total phenolic contents 9.4–23.1 mg gallic acid equivalent/g, and DPPH radical scavenging activity indicated 36.6–247.3 mM of Trolox equivalent/g. SPL extracts were identified to contain bioactive components such as, chlorogenic acid (11.7–22.1 μg/mg), 3,4-dicaffeoylquinic acid (16.3–59.9 μg/mg), 3,5-dicaffeoylquinic acid (50.9–72.7 μg/mg), chlorophyll B (6.1–12.3 μg/mg), lutein (1.9–4.9 μg/mg), chlorophyll A (2.7–4.3 μg/mg) and β-carotene (0.1 ≤ μg/mg). RAW 264.7 murine macrophage cells were pretreated with 100–200 …

Providing Childcare, Christine Ho, Sunha Myong

Research Collection School Of Economics

Women’s economic empowerment has been hailed as one of the most remarkable revolutions in the past 50 years. Yet, women still face the lion’s share of the burden of childcare despite major progress in their education and earnings capacity. This is particularly salient in many Asian countries. This chapter proposes a synthesis of the state of knowledge on childcare and discusses policy-relevant issues applicable to the Singapore context. Selected policies are documented and lessons from the international landscape are discussed. Raising children incurs both direct costs in the form of childcare and opportunity costs in the form of career costs. …

Promoting Patient Engagement: A Scoping Review Of Actions That Align With The Interactive Care Model, Georgia Tobiano, Teresa Jerofke-Owen, Andrea P. Marshall

College of Nursing Faculty Research and Publications

Background

Conceptual clarity for the term patient engagement is growing. However, there is variability in patient engagement in healthcare, which could be due to the absence of models to guide practice or a myriad of organisational, nurse and patient factors. The recently developed ‘Interactive Care Model’ provides guidance on how to genuinely promote individualised patient engagement. An understanding of how to action this model in nursing is required.

Aims

The aim of this scoping review was to examine actions in the published scientific literature that align with the Interactive Care Model, in the context of nursing care of hospitalised patients. …

Raps Sheet, September 2021, Retirement Association Of Portland State

RAPS Sheet: Monthly Newsletter

No abstract provided.

Maktabah Syamilah As An Information Seeking Tool For Higher Education In Islamic Studies, Asnil Aidah Ritonga

Library Philosophy and Practice (e-journal)

This study is a personal perspective from the experience of teaching Islamic Studies in a Master's Program of Islamic Higher Education. Students' limited knowledge and skills while seeking reference sources for Islamic studies serve as an obstacle in writing authentic academic works. Therefore, the use of Maktabah Syamilah as a reference tool for Islamic studies is very important for students. The skill of using Maktabah Syamilah is necessary because scientific works, including papers or research at Islamic universities, demand the use of original Arabic literature. Hence, proficiency in using this tool requires serious training and should be promoted by the …

The Relationship Between Self-Efficacy And Quality Of Life Among University Students, Reda Al-Mwadih, Majdi Adheisa, Hesham Alomyan, Ahmad Al-Badri

An-Najah University Journal for Research - B (Humanities)

Numerous studies, most of them involving adolescents and adults, have evidenced a moderately positive relationship between self-efficacy and quality of life (QoL). There are, however, a limited number of studies that have addressed the mechanisms underlying this relation. Thus, the objective of the present study was to examine the relationship between one’s perceptions of the capabilities (self-efficacy) and perceptions of one’s life and environment (QoL) among the students enrolled at the Faculty of Educational Sciences at Zarqa University. To achieve the objective of the study a sample of 120 male and female students was selected from the Faculty of Educational …

Pelaksanaan Kegiatan Promotif Santun Lansia Di Puskesmas Kecamatan Cilincing, Jakarta Utara Pada Tahun 2019, Diantri Astuti, Indra Lestari Fawzi

Jurnal Pembangunan Manusia

The elderly diseases are generally degenerative diseases, the handling requires a long time and high costs, so that it will be a very heavy burden for the government. The Puskesmas Santun Lansia is a health center that provides comprehensive health services to the elderly population, which includes promotive, curative, preventive, and rehabilitative services. Health care for the elderly give priority to quality promotion and prevention. This study aims to evaluate the process of implementing the promotional activities of Santun Lansia at the Cilincing District Health Center and what are the supporting and inhibiting factors in the implementation of this activity. …

Association Between Self-Reported Fatigue And Sarcopenia Measures Among Elderly In Selangor, Malaysia, Maria Justine, Aliff Latir, Nadhirah Noor, Angelbeth Joanny, Izzaty Iskandar, Maisarah Sakinah Amirul Faizi, Dzulhelmi Edinan

Kesmas

The association between fatigue and sarcopenia is not well understood, therefore, this study aimed to compare the sarcopenia measures among elderly with mild and severe fatigue and to determine whether fatigue severity is associated with sarcopenia measures. This was a cross-sectional study conducted on201 elderly (age = 68.45±6.30 years). The elderly was classified into either mild or severe fatigue based on the Fatigue Severity Scale (FSS), meanwhile, sarcopenia measures include SARC-F score, muscle mass (ASM/height2), calf circumference (CC), upper (handgrip) and lower limb muscle strength, as well as physical performance (gait speed). Data were analyzed using independent t-tests and logistic …

Utilizing Digital Technology To Address Loneliness And Isolation In Older Adults Through A Community-Based Connection Model: Responding To A Pandemic, Melissa A. Nagel

Doctor of Nursing Practice (DNP) Projects

Problem: Loneliness and social isolation, both of which can have serious detrimental effects on health and well-being, have become more prevalent during the recent COVID-19 pandemic, particularly in the older adult population. During part of the past year, older adults were strongly encouraged to follow strict quarantine measures because of their vulnerability to the virus. This forced isolation exacerbated the already existing issue of loneliness and social isolation in this population.

Interventions: Older adults who are members of a local non-profit community organization, focused on increasing independence and social vitality, were invited to participate in a virtual, interactive social engagement …

Senior Center Response To Covid-19: Social Engagement And Outreach, Ceara Somerville, Saralyn Collins, Caitlin Coyle, Jan Mutchler, Center For Social And Demographic Research On Aging, University Of Massachusetts Boston

Center for Social and Demographic Research on Aging Publications

Social isolation can have devastating effects on an individual’s mental and physical wellbeing. The COVID-19 outbreak has put older adults at greater risk of isolation and has pushed efforts to address isolation to the forefront of public health in Massachusetts. Senior centers have been working to end isolation in their communities long before COVID-19 and have continued that work in the face of a global pandemic. This fact sheet describes what Massachusetts senior centers are doing during the pandemic to address isolation among older community members.

Covid-19 Preparedness And The Anxiety Of Thai Citizens, Afifi Lateh, Prasopchai Pasunon, Kiflan Dolah, Panida Kongjam, Saminee Chemae, Phanupong Panomwan, Alawee Lateh

Kesmas

The outbreak of COVID-19 has brought sickness and fatality to Thai citizens. In addition, it left a tremendous psychological impact on mental health as they experienced panic and anxiety about controlling situations and preserving their physical and mental well-being. This study aimed to analyze the factors influencing COVID-19 preparedness and anxiety based on groups of Thai citizens. Online questionnaires were employed to collect data from 2,768 respondents selected through convenience sampling and snowball sampling on Facebook, having shared questionnaires with 190 other users. Data were collected from March 29 to April 3, 2020. The acquired data were analyzed using percentage …

Senior Center Response To Covid-19: Technology, Ceara Somerville, Saralyn Collins, Caitlin Coyle, Jan Mutchler, Center For Social And Demographic Research On Aging, University Of Massachusetts Boston

Center for Social and Demographic Research on Aging Publications

The COVID-19 pandemic has made the use of technology critical to remain socially connected with others while remaining physically distance. Senior centers in Massachusetts have had to think outside of the box and adapt their programs and services to be provided remotely, by phone, email, social media, and video calls. Moreover, senior centers have become responsible for helping older adults overcome their hesitations with using technology to keep them engaged and connected while physical gathering spaces have been closed.

Senior Center Response To Covid-19: Nutrition, Ceara Somerville, Saralyn Collins, Caitlin Coyle, Jan Mutchler, Center For Social And Demographic Research On Aging, University Of Massachusetts Boston

Center for Social and Demographic Research on Aging Publications

Older adults across the U.S. are at risk of malnutrition, which can have lasting effects on health. Councils on Aging (COAs) are at the forefront of meeting the nutritional needs of older adults in their communities. The COVID-19 pandemic has not only limited older adults’ access to food, but it has also affected COAs’ abilities to get nutritious food out to seniors. Despite the hurdles presented by the global pandemic, Massachusetts COAs have continued their efforts to meet the nutritional needs of older adults.

The Impact Of Readmission On Family Caregivers Of Children Following Ventricular Peritoneal Shunt Surgery, Mary Uwhuba

Theses

Family caregivers work tirelessly to ensure their loved ones don't need to return to the hospital after discharge. This study will examine the impact of readmission on family caregivers of children who have had ventricular peritoneal shunt (VPS) surgery and been readmitted by looking at the economic, social, familial, and personal strains of caregiving. This study is a descriptive study. The Impact on Family Scale survey (Stein & Jessop, 1985) was used to judge if family caregivers were affected by child's readmission.