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2021

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The Impact Of Ocean‐Wave Coupling On The Upper Ocean Circulation During Storm Events, D. Bruciaferri, M. Tonani, H. W. Lewis, J. R. Siddorn, A. Saulter, Sanchez Jm Castillo, N. G. Valiente, D. Conley, P. Sykes, I. Ascione, N. Mcconnell Jan 2021

The Impact Of Ocean‐Wave Coupling On The Upper Ocean Circulation During Storm Events, D. Bruciaferri, M. Tonani, H. W. Lewis, J. R. Siddorn, A. Saulter, Sanchez Jm Castillo, N. G. Valiente, D. Conley, P. Sykes, I. Ascione, N. Mcconnell

School of Biological and Marine Sciences

Many human activities rely on accurate knowledge of the sea surface dynamics. This is especially true during storm events, when wave-current interactions might represent a leading order process of the upper ocean. In this study, we assess and analyze the impact of including three wave-dependent processes in the ocean momentum equation of the Met Office North West European Shelf ocean-wave forecasting system on the accuracy of the simulated surface circulation. The analysis is conducted using ocean currents and Stokes drift data produced by different implementations of the coupled forecasting systems to simulate the trajectories of surface (iSphere) and 15 m …


Spatial Variation In The Gastrointestinal Microbiome, Diet, And Nutritional Condition Of A Juvenile Flatfish Among Coastal Habitats, Marc T. Morris, Chris Hauton, Alison J. Baylay, Luca Peruzza, Timothy E. Targett, Benjamin J. Ciotti Jan 2021

Spatial Variation In The Gastrointestinal Microbiome, Diet, And Nutritional Condition Of A Juvenile Flatfish Among Coastal Habitats, Marc T. Morris, Chris Hauton, Alison J. Baylay, Luca Peruzza, Timothy E. Targett, Benjamin J. Ciotti

School of Biological and Marine Sciences

No abstract provided.


Plasticity Of Thermal Performance Curves In A Narrow Range Endemic Water Beetle, Susana Pallarés, Wilco C.E.P. Verberk, David T. Bilton Jan 2021

Plasticity Of Thermal Performance Curves In A Narrow Range Endemic Water Beetle, Susana Pallarés, Wilco C.E.P. Verberk, David T. Bilton

School of Biological and Marine Sciences

No abstract provided.


The Interacion Between Humans And Buildings For Energy Efficiency: A Critical Review, T Harputlugil, P De Wilde Jan 2021

The Interacion Between Humans And Buildings For Energy Efficiency: A Critical Review, T Harputlugil, P De Wilde

School of Art, Design and Architecture

Buildings consume energy for different purposes. One core function is to provide healthy and comfortable living conditions for the humans that inhabit these buildings. The associated energy use is significant: taken together, buildings are responsible for roughly 40% of the world's total annual energy consumption. This large percentage makes the built environment an important target for researchers, policy makers, innovators and others who aim to decrease energy consumption and the associated emissions of Greenhouse Gases (GHG). Unfortunately, the significant body of research on energy efficient buildings conducted since the 1970s has had only a limited impact on the overall energy …


Trait Evaluations Of Faces And Voices: Comparing Within- And Between-Person Variability, Nadine Lavan, Mila Mileva, Andrew W. Young, A. Mike Burton, Carolyn Mcgettigan Jan 2021

Trait Evaluations Of Faces And Voices: Comparing Within- And Between-Person Variability, Nadine Lavan, Mila Mileva, Andrew W. Young, A. Mike Burton, Carolyn Mcgettigan

School of Psychology

Human faces and voices are rich sources of information that can vary in many different ways. Most of the literature on face/voice perception has focused on understanding how people look and sound different to each other (between-person variability). However, recent studies highlight the ways in which the same person can look and sound different on different occasions (within-person variability). Across three experiments, we examined how within- and between-person variability relate to one another for social trait impressions by collecting trait ratings attributed to multiple face images and voice recordings of the same people. We find that within-person variability in social …


Multiple-Image Arrays In Face Matching Tasks With And Without Memory, Kay L. Ritchie, Robin S.S. Kramer, Mila Mileva, Adam Sandford, A. Mike Burton Jan 2021

Multiple-Image Arrays In Face Matching Tasks With And Without Memory, Kay L. Ritchie, Robin S.S. Kramer, Mila Mileva, Adam Sandford, A. Mike Burton

School of Psychology

No abstract provided.


Young Children’S Understanding Of Justifications For Breaking A Promise, Patricia Kanngiesser, Maria Mammen, Michael Tomasello Jan 2021

Young Children’S Understanding Of Justifications For Breaking A Promise, Patricia Kanngiesser, Maria Mammen, Michael Tomasello

School of Psychology

There are sometimes legitimate reasons for breaking a promise when circumstances change. We investigated 3- and 5-year-old German children’s understanding of promise breaking in prosocial (helping someone else) and selfish (playing with someone else) conditions. In Study 1 (n = 80, 50% girls), preschoolers initially kept their own promise in all conditions. When they eventually broke their promise, 3-year-olds’ justifications mostly referenced salient events, whereas 5-year-olds also referenced social norms. In Study 2 (n = 65, 49% girls), 5-year-olds preferred others’ promise-breaking more in prosocial than selfish conditions; 3-year-olds showed the reverse pattern. Three-year-olds’ justifications focused on desires, whereas 5-year-olds …


Chitosan Inhibits Septin‐Mediated Plant Infection By The Rice Blast Fungus Magnaporthe Oryzae In A Protein Kinase C And Nox1 Nadph Oxidase‐Dependent Manner, F Lopez‐Moya, M Martin‐Urdiroz, M Oses‐Ruiz, Vincent M. Were, Mark D. Fricker, George Littlejohn, Lv Lopez‐Llorca, Nicholas J. Talbot Jan 2021

Chitosan Inhibits Septin‐Mediated Plant Infection By The Rice Blast Fungus Magnaporthe Oryzae In A Protein Kinase C And Nox1 Nadph Oxidase‐Dependent Manner, F Lopez‐Moya, M Martin‐Urdiroz, M Oses‐Ruiz, Vincent M. Were, Mark D. Fricker, George Littlejohn, Lv Lopez‐Llorca, Nicholas J. Talbot

School of Biological and Marine Sciences

No abstract provided.


Transport, Weathering And Pollution Of Plastic From Container Losses At Sea: Observations From A Spillage Of Inkjet Cartridges In The North Atlantic Ocean, Andrew Turner, Tracey Williams, Tom Pitchford Jan 2021

Transport, Weathering And Pollution Of Plastic From Container Losses At Sea: Observations From A Spillage Of Inkjet Cartridges In The North Atlantic Ocean, Andrew Turner, Tracey Williams, Tom Pitchford

School of Geography, Earth and Environmental Sciences

No abstract provided.


A Novel Method For Assessing Design Fidelity In Web-Based Behavioral Interventions., Jeffrey D. Lambert, Lewis R. Elliott, Adrian H. Taylor, Paul Farrand, Anne M. Haase, Colin J. Greaves Jan 2021

A Novel Method For Assessing Design Fidelity In Web-Based Behavioral Interventions., Jeffrey D. Lambert, Lewis R. Elliott, Adrian H. Taylor, Paul Farrand, Anne M. Haase, Colin J. Greaves

Peninsula Medical School

No abstract provided.


Divergent Trajectories Of Cellular Bioenergetics, Intermediary Metabolism And Systemic Redox Status In Survivors And Non-Survivors Of Critical Illness, Helen T. Mckenna, Ka O’Brien, Bernadette O. Fernandez, Magdalena Minnion, Adam Tod, Ben D. Mcnally, James A. West, Julian L. Griffin, Michael P. Grocott, Michael G. Mythen, Martin Feelisch, Andrew J. Murray, Daniel S. Martin Jan 2021

Divergent Trajectories Of Cellular Bioenergetics, Intermediary Metabolism And Systemic Redox Status In Survivors And Non-Survivors Of Critical Illness, Helen T. Mckenna, Ka O’Brien, Bernadette O. Fernandez, Magdalena Minnion, Adam Tod, Ben D. Mcnally, James A. West, Julian L. Griffin, Michael P. Grocott, Michael G. Mythen, Martin Feelisch, Andrew J. Murray, Daniel S. Martin

Peninsula Medical School

BackgroundNumerous pathologies result in multiple-organ failure, which is thought to be a direct consequence of compromised cellular bioenergetic status. Neither the nature of this phenotype nor its relevance to survival are well understood, limiting the efficacy of modern life-support.MethodsTo explore the hypothesis that survival from critical illness relates to changes in cellular bioenergetics, we combined assessment of mitochondrial respiration with metabolomic, lipidomic and redox profiling in skeletal muscle and blood, at multiple timepoints, in 21 critically ill patients and 12 reference patients.ResultsWe demonstrate an end-organ cellular phenotype in critical illness, characterized by preserved total energetic capacity, greater coupling efficiency and …


Evaluation Of A Primary Care-Based Collaborative Care Model (Partners2) For People With Diagnoses Of Schizophrenia, Bipolar, Or Other Psychoses: Study Protocol For A Cluster Randomised Controlled Trial, Humera Plappert, Charley Hobson-Merrett, Bliss Gibbons, Elina Baker, Sheridan Bevan, Michael Clark, Siobhan Creanor, Linda Davies, Rebecca Denyer, Julia Frost, Linda Gask, John Gibson, Laura Gill, Ruth Gwernan-Jones, Pollyanna Hardy, Joanne Hosking, Peter Huxley, Alison Jeffrey, Benjamin Jones, Steven Marwaha, Vanessa Pinold, Claire Planner, Tim Rawcliffe, Siobhan Reilly, Debra Richards, Lynsey Williams, Max Birchwood, Richard Byng Jan 2021

Evaluation Of A Primary Care-Based Collaborative Care Model (Partners2) For People With Diagnoses Of Schizophrenia, Bipolar, Or Other Psychoses: Study Protocol For A Cluster Randomised Controlled Trial, Humera Plappert, Charley Hobson-Merrett, Bliss Gibbons, Elina Baker, Sheridan Bevan, Michael Clark, Siobhan Creanor, Linda Davies, Rebecca Denyer, Julia Frost, Linda Gask, John Gibson, Laura Gill, Ruth Gwernan-Jones, Pollyanna Hardy, Joanne Hosking, Peter Huxley, Alison Jeffrey, Benjamin Jones, Steven Marwaha, Vanessa Pinold, Claire Planner, Tim Rawcliffe, Siobhan Reilly, Debra Richards, Lynsey Williams, Max Birchwood, Richard Byng

Peninsula Medical School

BackgroundCurrent NHS policy encourages an integrated approach to provision of mental and physical care for individuals with long term mental health problems. The ‘PARTNERS2’ complex intervention is designed to support individuals with psychosis in a primary care setting.AimThe trial will evaluate the clinical and cost-effectiveness of the PARTNERS2 intervention.Design & settingThis is a cluster randomised controlled superiority trial comparing collaborative care (PARTNERS2) with usual care, with an internal pilot to assess feasibility. The setting will be primary care within four trial recruitment areas: Birmingham & Solihull, Cornwall, Plymouth, and Somerset. GP practices are randomised 1:1 to either (a) the PARTNERS2 …


Exenatide Once Weekly Over 2 Years As A Potential Disease-Modifying Treatment For Parkinson’S Disease: Protocol For A Multicentre, Randomised, Double Blind, Parallel Group, Placebo Controlled, Phase 3 Trial: The ‘Exenatide-Pd3’ Study, Nirosen Vijiaratnam, Christine Girges, Grace Auld, Marisa Chau, Kate Maclagan, Alexa King, Simon Skene, Kashfia Chowdhury, Steve Hibbert, Huw Morris, Patricia Limousin, Dilan Athauda, Camille B. Carroll, Michele T. Hu, Monty Silverdale, Gordon W. Duncan, Ray Chaudhuri, Christine Lo, Din S Del, Alison J. Yarnall, Lynn Rochester, Rachel Gibson, John Dickson, Rachael Hunter, Vincenzo Libri, Thomas Foltynie Jan 2021

Exenatide Once Weekly Over 2 Years As A Potential Disease-Modifying Treatment For Parkinson’S Disease: Protocol For A Multicentre, Randomised, Double Blind, Parallel Group, Placebo Controlled, Phase 3 Trial: The ‘Exenatide-Pd3’ Study, Nirosen Vijiaratnam, Christine Girges, Grace Auld, Marisa Chau, Kate Maclagan, Alexa King, Simon Skene, Kashfia Chowdhury, Steve Hibbert, Huw Morris, Patricia Limousin, Dilan Athauda, Camille B. Carroll, Michele T. Hu, Monty Silverdale, Gordon W. Duncan, Ray Chaudhuri, Christine Lo, Din S Del, Alison J. Yarnall, Lynn Rochester, Rachel Gibson, John Dickson, Rachael Hunter, Vincenzo Libri, Thomas Foltynie

Peninsula Medical School

IntroductionParkinson’s disease (PD) is a common neurodegenerative disorder with substantial morbidity. No disease-modifying treatments currently exist. The glucagon like peptide-1 receptor agonist exenatide has been associated in single-centre studies with reduced motor deterioration over 1 year. The aim of this multicentre UK trial is to confirm whether these previous positive results are maintained in a larger number of participants over 2 years and if effects accumulate with prolonged drug exposure.Methods and analysisThis is a phase 3, multicentre, double-blind, randomised, placebo-controlled trial of exenatide at a dose of 2 mg weekly in 200 participants with mild to moderate PD. Treatment duration …


Clarifying Realist Analytic And Interdisciplinary Consensus Processes In A Complex Health Intervention: A Worked Example Of Judgemental Rationality In Action, Sarah Rybczynska-Bunt, Lauren Weston, Richard Byng, Alex Stirzaker, Charlotte Lennox, Mark Pearson, Sarah Brand, Mike Maguire, Graham Durcan, Jonathan Graham, Sarah Leonard, Jenny Shaw, Tim Kirkpatrick, Christabel Owens, Cath Quinn Jan 2021

Clarifying Realist Analytic And Interdisciplinary Consensus Processes In A Complex Health Intervention: A Worked Example Of Judgemental Rationality In Action, Sarah Rybczynska-Bunt, Lauren Weston, Richard Byng, Alex Stirzaker, Charlotte Lennox, Mark Pearson, Sarah Brand, Mike Maguire, Graham Durcan, Jonathan Graham, Sarah Leonard, Jenny Shaw, Tim Kirkpatrick, Christabel Owens, Cath Quinn

Peninsula Medical School

Judgemental rationality is infrequently referenced within discussions of Realist Evaluations. Judgemental rationality refers to researchers’ capacity to assess which, potential, meanings provide the most credible explanations. In evaluation work, rationale for analysis is provided, though rarely do we see how an evaluator made judgements between competing theories, and which theories were discarded and why. We provide a worked example of the application of judgemental rationality. The Engager intervention offered support to prison leavers with common mental health problems. The data for 24, purposively sampled, participants from the intervention arm of the trial were integrated. Bhaskar’s DREIC, a five-step analytical procedure, …