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Calliope, Georgia Southern University

Calliope Magazine

Volume 38

Human Cortical Serotonin 2a Receptor Occupancy By Psilocybin Measured Using [11c]Mdl 100,907 Dynamic Pet And A Resting-State Fmri-Based Brain Parcellation, Frederick S Barrett, Yun Zhou, Theresa M Carbonaro, Joshua M Roberts, Gwenn S Smith, Roland R Griffiths, Dean F Wong

2020-Current year OA Pubs

Psilocybin (a serotonin 2A, or 5-HT

Advance (Spring 2021), Georgia Southern Division Of Continuing And Professional Education

Division of Continuing & Professional Education

No abstract provided.

Jiann-Ping Hsu College Of Public Health Magazine, Georgia Southern University

College of Public Health: News & Publications

• Message from the Dean: Stuart H. Tedders, PhD
• One-On-One: Building a POD from the ground up!
• Our Community: Making a Difference
• The COVID-19 Pivot: Teaching, Outreach, Research
• One Year Later: Reflections
• Dr. James Stephens
• Zoom made the world smaller
• Creating space where everyone belongs
• Center for Addiction Recovery Growth in a new normal—the pandemic year
• Karl E. Peace Center for Biostatistics and Survey Research Working together: biostatistics collaborations
• Center for Public Health Practice and Research Making real impacts with training, assessments and more
• Faculty and Students
• Office of Practice and Research
• Research
• College
• Photos

Homotopic Functional Connectivity Disruptions In Glioma Patients Are Associated With Tumor Malignancy And Overall Survival, Andy G S Daniel, Carl D Hacker, John J Lee, Donna Dierker, Joseph B Humphries, Joshua S Shimony, Eric C Leuthardt

2020-Current year OA Pubs

BACKGROUND: Gliomas exhibit widespread bilateral functional connectivity (FC) alterations that may be associated with tumor grade. Limited studies have examined the connection-level mechanisms responsible for these effects. Given the typically strong FC observed between mirroring/homotopic brain regions in healthy subjects, we hypothesized that homotopic connectivity (HC) is altered in low-grade and high-grade glioma patients and the extent of disruption is associated with tumor grade and predictive of overall survival (OS) in a cohort of

METHODS: We used a mirrored FC-derived cortical parcellation to extract blood-oxygen-level-dependent (BOLD) signals and to quantify FC differences between homotopic pairs in normal-appearing brain in a …

Analysis Of Turbulence Model Uncertainty For Canonical Flow Problems Including Shock Wave Boundary Layer Interaction Simulations, Aaron James Erb

Doctoral Dissertations

"The purpose of this research is to present results of an uncertainty and sensitivity analysis study of commonly used turbulence models in Reynolds-Averaged Navier-Stokes (RANS) codes due to the epistemic uncertainty in closure coefficients for a set of turbulence model validation cases that represent the structure of several canonical flow problems. The study focuses on the analysis of a 2D zero pressure gradient flat plate, a 2D wall mounted hump, and an axisymmetric shock wave boundary layer interaction, all of which are well documented on the NASA Langley Research Center Turbulence Modeling Resource website. The Spalart-Allmaras (SA), the Wilcox (2006) …

Thermomechanical Simulation And Process Optimization For Hot Rolling Of Steel, Shouvik Ganguly

Doctoral Dissertations

"Hot rolling is a manufacturing process that involves large material deformation, complicated geometries, contact conditions and non-uniform temperature gradients. Steel industries are motivated to prevent hot rolled steel products to be defect free and with desired shape and size. In order to simulate the process accurately, it is essential that the material model for steel accounts for the viscoplasticity and changes in properties that occur in steel at elevated temperatures as grain growth and recrystallization.

The healing of existing voids during hot rolling was investigated using finite element simulations. Voids are highly undesirable as they not only degrade the product …

Spatiotemporal Variations Of Upper Crustal Anisotropy Along The San Jacinto Fault Zone In Southern California And The Fairview Region In Central Oklahoma, Enyuan Jiang

Doctoral Dissertations

"To discern spatial and explore the possible existence of temporal variations of upper crustal anisotropy along an ~15 km section of the San Jacinto Fault Zone (SJFZ) in California, and in the Fairview, Oklahoma, region, we conduct systematic shear wave splitting (SWS) investigations using local S-wave data recorded by seismic stations. Strong spatial variations in crustal anisotropy are revealed by 1694 and 405 pairs of splitting parameters (including the fast polarization orientation and the splitting time), respectively. For both areas, for raypaths traveling through the fault zones, the fast orientations are parallel to the faults and may be attributed to …

Convective-Diffusive Transport In Krogh Cylinders: A Model For Pharmacokinetics, Xianjie Qiu

Doctoral Dissertations

"Drug delivery to inside of the tumor is the important problem. The dynamics of drug delivery is presented here. Previously and particularly for directed delivery, a stirred tank model has been used, which appears to have worked well when compared to experiments. However, the stirred tank models do not include all the mass transfer resistances and towards that end we have used a distributed system called Krogh cylinder. This study focuses on the Krogh cylinder model simulation, both on the fluid flow and the mass transfer. The capillary network is broken down into cylindrical cells, each containing a capillary and …

Integrating Snp Data And Imputation Methods Into The Dna Methylation Analysis Framework, Yuqing Su

Doctoral Dissertations

"DNA methylation is a widely studied epigenetic modification that can influence the expression and regulation of functional genes, especially those related to aging, cancer and other diseases. The common goal of methylation studies is to find differences in methylation levels between samples collected under different conditions. Differences can be detected at the site level, but regulated methylation targets are most commonly clustered into short regions. Thus, identifying differentially methylated regions (DMRs) between different groups is of prime interest. Despite advanced technology that enables measuring methylation genome-wide, misinterpretations in the readings can arise due to the existence of single nucleotide polymorphisms …

Pdn Modeling For High-Speed Multilayer Pcb Boards And Decap Optimization Using Machine Learning Techniques, Ling Zhang

Doctoral Dissertations

"In power distribution networks (PDN), there are two main challenges nowadays. One challenge is how to efficiently model and calculate the impedance for arbitrary-shape and multi-layer PDN systems. The second challenge is the optimization of decoupling capacitors in the pre-layout stage. This dissertation proposes novel solutions to these two challenges. To tackle the first challenge, a boundary element method (BEM) is utilized to calculate the quasi-static inductances between vertical vias for arbitrary-shape planes. Then a specialized circuit solver is developed to solve the equivalent circuit of inductances and capacitances for multi-layer PDN structures. Also, a contour integral method (CIM) is …

Crustal And Upper Mantle Structure Beneath The Southeastern United States From Joint Inversion Of Rayleigh Wave Dispersion And Receiver Functions, Qiuyue Yang

Doctoral Dissertations

"In spite of numerous geophysical investigations have been conducted in southeastern United States, the structure and evolution of the crust and lithospheric mantle remain controversial due the thick sedimentary covers atop the crust of the coastal plains there. In this study, we use data from 186 broadband seismic stations belonging to the USArray Transportable Array to construct a 3-D shear wave velocity model for the southeastern United States for the top 180 km by a joint inversion of Rayleigh wave phase velocity dispersion and receiver functions. Our results show a clear spatial correspondence with major surficial geological features. A prominent …

Quantum Inspired Concepts In Decision Making, Qizi Zhang

Doctoral Dissertations

"In this study, several new applications of quantum-inspired techniques are presented to advance the state of the art in decision making. In the first part, a quantum boost scheme for multiple-model filters based on extended Grover’s algorithm is presented for fault detection and parameter estimation. The quantum boost scheme accelerates the convergence of the posterior probabilities in the multiple-model filter. Stability proofs for the quantum boost scheme is presented and its performance is analyzed using benchmark examples. In the second part, the scope of application is extended to modeling human decision making. The open quantum system cognition model is applied …

Receiver Function Imaging Of The 410 And 660 Km Discontinuities And Seismic Azimuthal Anisotropy Revealed By Shear Wave Splitting Beneath The Australian Continent, Kailun Ba

Doctoral Dissertations

"The Australian continent is composed the of Precambrian cratons in the west and Phanerozolc orogens in the east. Despite numerous seismological studies, controversies remain regarding the structure, evolution, and dynamics of the crust and mantle beneath Australia. In this study, we used two techniques, receiver functions and shear wave splitting analyses, to investigate the topography of the mantle transition zone (MTZ) discontinuities and mantle seismic azimuthal anisotropy, respectively. We utilized P-to-S receiver functions to map the 410 and 660 km discontinuities bordering the MTZ. The discontinuity depths obtained show a systematic apparent uplifting for both discontinuities in central and western …

Protection Of Modern Distribution Systems, Fahd Amin Hariri

Doctoral Dissertations

“Motivated by the potential for improvements in the electric distribution system’s protection schemes, this work examined the challenges facing protection schemes due to the integration of Distributed Generators (DGs). Traditional protection schemes for radial distribution systems were designed based on the unidirectional power flow from the source down to the loads. Protective devices typically use are overcurrent relays, autoreclosers, fuses, and circuit breakers. However, these protective schemes may no longer be sufficient to ensure correct operation in the new era of distribution systems integrated by DGs. This research investigated the impact of DGs that might mislead the protection schemes in …

Emi Characterization For Power Supplies And Machine Learning Based Modeling In Emc/Si, Jiayi He

Doctoral Dissertations

"Signal integrity (SI) and electromagnetic interference (EMI) are essential for consumer electronics and high-speed server applications. It is necessary to do EMI and SI modeling at the design stage. In this research, several modeling approaches for EMI and SI problems are proposed. By using measurement-based modeling method, the mechanism of conducted emissions (CE) on ac to dc power supplies in an LED TV is analyzed. A system-level transient simulation model is built to predict the conducted emission (CE). To characterize the equivalent dipole moment sources in RFI and EMI problems, a dipole source reconstruction method based on machine learning techniques …

Gis And Remote Sensing Groundwater Potentiality Investigation Of Gulu District, Uganda Using Synthetic Aperture Radar And Magnetic Geophysics, Rachel Ann Jones

Doctoral Dissertations

“Developing countries have few resources for ground-based hydrological investigations to determine optimal placement of boreholes for community water access. Remote sensing data are available at a variety of resolutions and sense different parameters, and are useful inputs for hydrologic models, but these data are rarely obtainable in developing countries with the parameters or resolutions necessary for hydrologic applications. This research seeks to use and improve existing remote sensing and GIS techniques to identify areas of optimal water supply in locations with limited geologic or hydrologic information, such as Gulu District, Uganda. Fusing different remotely sensed data sets can produce higher …

Contributions To The Performance Of Thin Film Capacitors For High Reliability Applications, Daniel Krueger

Doctoral Dissertations

"Capacitors are critical devices in microelectronic assemblies that must be incorporated into electronic systems through a variety of ways such as integrated or discrete devices. This work has developed new thin film capacitors deposited directly onto multichip module or printed circuit board surfaces to benefit from closer integration that enhances system performance for use in high reliability applications. The capacitors serve as filters or provide tuning and energy storage functions. Unexpected performance was observed during development that included low adhesion of the films to the substrates, higher effective dielectric constants than reported in literature, and low yields. Three publications resulted …

Proper Orthogonal Decomposition: New Approximation Theory And A New Computational Approach, Sarah Katherine Locke

Doctoral Dissertations

“Proper orthogonal decomposition (POD) projection errors and error bounds for POD reduced order models of partial differential equations have been studied by many. In this research we obtain new results regarding POD data approximation theory and present a new difference quotient (DQ) approach for computing the POD modes of the data.

First, we improve on earlier results concerning POD projection errors by extending to a more general framework that allows for non-orthogonal POD projections and seminorms. We obtain new exact error formulas and convergence results for POD data approximation errors, and also prove new pointwise convergence results and error bounds …

Computational Studies Of Carbon Nanocluster Solidification, Chathuri Chandani Silva

Doctoral Dissertations

“A subset of micron-size meteoritic carbon particles formed in red giant atmospheres show a core-rim structure, likely condensed from a vapor phase into super-cooled carbon droplets that nucleated graphene sheets (~40Å) on randomly oriented 5-atom loops during solidification, followed by coating with a graphite rim. Similar particles form during slow cooling of carbon vapor in the lab.

Here we investigate the nucleation and growth of carbon rings and graphene sheets using density functional theory (DFT). Our objectives: (1). explore different computational techniques in DFT-VASP for various carbon structures and compare the results with literature, (2). investigate the nucleation and growth …

Mantle Flow Systems Associated With Slab Subduction And Absolute Plate Motion In Alaska Constrained By Shear Wave Splitting Analyses, Yuchen Yang

Doctoral Dissertations

"Alaska has long been recognized as a geologically complex region with a sharp contrast in tectonic activity between southern and northern Alaska. While the former is characterized by the subduction of the geometrically varying Pacific-Yakutat plate beneath the North American plate, the latter has a mostly stable cratonic setting. To investigate the mantle flow fields beneath Alaska and understand the influence of the subduction process on regional mantle dynamics, a total of 2790 pairs of well-defined teleseismic shear wave splitting (SWS) measurements recorded from 379 stations are obtained and analyzed. In addition, 247 pairs of SWS results from local earthquake …

The Pilot Knob Magnetite, Pilot Knob Hematite, And Shepherd Mountain Iron Oxide Deposits In Southeast Missouri -- Local Expressions Of A Magmatic-Hydrothermal Plumbing System?, Bolorchimeg N. Tunnell

Doctoral Dissertations

“The Southeast Missouri Iron Metallogenic Province in the Midwestern USA contains seven major and several minor IOA/IOCG-type deposits, all of which are spatially associated with the early Mesoproterozoic (1.50-1.44 Ga) magmatism in the St. Francois Mountains terrane. This Ph.D. project focuses on the Pilot Knob deposits, i.e., the deeper largely massive Pilot Knob Magnetite (PKM) and the shallower Pilot Knob Hematite (PKH) deposits, and the Shepherd Mountain deposit that are located less than 2.1 km distance from one another. The first precise age for the formation of the PKM ore is constrained at 1438±5.8 Ma using apatite U-Pb method. Petrographic …

Sensor Data Based Adaptive Models For Assembly Worker Training In Cyber Manufacturing, Md. Al-Amin

Doctoral Dissertations

“Production innovations are occurring faster than ever leading conventional production systems towards cyber manufacturing. Manufacturing workers thus need to frequently learn new methods and skills. In fast-changing, largely uncertain production systems, manufacturers with the ability to comprehend workers’ behavior and assess their operational performance in near real-time will achieve better performance than peers. Recognizing worker actions in near real-time while performing the assembly can serve this purpose. However, reliably recognizing the assembly actions performed by the workers is challenging, because the actions for assembly are complex and workers are not only heterogeneous but sensitive to the variation of the work …

Multimodal Neuroscience Data Modeling And Inference, Sima Azizi

Doctoral Dissertations

“Mathematical models can be combined with deep learning and machine learning methods to provide new insights in neuroscience. The field of neuroscience is characterized by rich datasets that include fluid biomarkers, EEG signals, and advanced neuroimages. Recent advances in natural language processing have led to the opportunity to gain additional insights from rapidly growing text databases as well as electronic health records. In this research, we focus on applying computational intelligence methods to the analysis of three different complex data sources: blood levels of disease biomarkers, EEG signals from schizophrenic patients, and disease phenotypes encoded in electronic health records. First, …

Semi-Empirical Modeling Of Liquid Carbon's Containerless Solidification, Philip C. Chrostoski

Doctoral Dissertations

“Elemental carbon has important structural diversity, ranging from nanotubes through graphite to diamond. Previous studies of micron-size core/rim carbon spheres extracted from primitive meteorites suggest they formed around such stars via the solidification of condensed carbon-vapor droplets, followed by gas-to-solid carbon coating to form the graphite rims. Similar core/rim particles result from the slow cooling of carbon vapor in the lab. The long-range carbon bond-order potential was used to computationally study liquid-like carbon in (1.8 g/cm³) periodic boundary (tiled-cube supercell) and containerless (isolated cluster) settings. Relaxations via conjugate-gradient and simulated-annealing nucleation and growth simulations using molecular dynamics were …

Cooperative Navigation Of Small Satellites In The Deep Space Environment, Jill Christine Davis

Doctoral Dissertations

“The continued development of small satellites (SmallSats) has made them an increasingly viable mission alternative to traditional monolithic spacecraft. Constellations, swarms, and formations of these small spacecraft have the potential to fill unique gaps in the space systems architecture, while reducing overall mission costs and increasing mission redundancy. Cooperative navigation between spacecraft within swarms and formations is critical to mission success, but poses many challenges for SmallSats due to their size, mass, power, and computing constraints. While Earth orbiting missions can rely on GNSS data for high-accuracy inertial and relative navigation, deep space missions require new navigation techniques. In this …

Reduced Calibration Uncertainties For The Global Network Of Gravitational-Wave Observatories And The Impact On Sky Localization Of Burst-Like Sources, Dripta Bhattacharjee

Doctoral Dissertations

The Advanced Laser Interferometer Gravitational-wave Observatory (LIGO) is a science facility in the United States devoted to the observation of gravitational waves (GWs). It comprises two kilometer-scale laser interferometers. It is a part of a global ground-based GW detector network that also includes Virgo in Italy and KAGRA in Japan. Calibration of the LIGO detectors is achieved using displacement fiducials generated by radiation pressure based systems called Photon Calibrators (Pcals). The first part of this research described here details the developments implemented during the third LIGO-Virgo-KAGRA (LVK) observation run, O3, in the propagation of laser power calibration via transfer standards …

Mining Haul Road Defect Detection -- Advancement In Automated Road Extent And Response Calibration For Improved Maintenance, Alexander David Douglas

Doctoral Dissertations

Mine haul roads degrade rapidly due to extremely heavy loads on sub optimal construction materials. This research tests two methods of defect detection to determine limitations to current technology: optical detection and vehicle vibration response. Optical defect detection was found to have the least significant limitations for surface defect detection and vehicle vibration response modeling has the least significant limitations for subsurface defects. This research proposes novel methods to eliminate the critical limitations of both technologies.

Unmanned Aerial Vehicles (UAV) equipped with GPS and a high-resolution camera is used to create a 3-D point cloud using a structure-from-motion algorithm. This …

Dynamic Behavior And Interactions Of Ferrofluid Droplets Under Magnetic Fields In Low Reynolds Number Flows, Md Rifat Hassan

Doctoral Dissertations

Digital microfluidics in combination with emulsion microfluidics are crucial building blocks of droplet-based microfluidics, which are prevalent in a wide variety of industrial and biomedical applications, including polymer processing, food production, drug delivery, inkjet printing, and cell-based assays. Therefore, understanding the dynamics and interactions of droplets as well as the interactions between the droplets and solid surfaces are of great importance in order to improve the performance or product in these applications.

Recently, several studies in the literature have demonstrated the potential of magnetic fields in controlling the behavior of droplets in microscale; however, the fundamental mechanism behind the interesting …

Investigation Of Anomalous Data Trends During Coal Dust Explosibilty Testing, Jacob Lee Miller

Doctoral Dissertations

Coal dust explosibility is a health and safety concern that has been a recognized hazard for over 100 years. Initial testing by the Author using a Siwek 20L apparatus recorded a secondary maximum pressure at higher dust concentrations (1,000-7,000g/m³) with Pulverized Pittsburgh Coal (PCC). Higher dust concentrations are beyond the typical ASTM E1226 testing procedure but are possible in mining and processing scenarios. No reference documents have been discovered that show a secondary maximum pressure at higher dust concentrations. Literature reviewed identified that once a coal dust concertation generates a peak pressure, the pressure remains constant or decreases …