Digital Commons Network^™

Aquatic Ecosystems Of The Anthropocene: Limnology And Microbial Ecology Of Mine Pit Lakes, Melanie L. Blanchette, Mark A. Lund

Research outputs 2014 to 2021

Mine pit lakes (‘pit lakes’) are new aquatic ecosystems of the Anthropocene. Potentially hundreds of meters deep, these lakes are prominent in the landscape and in the public consciousness. However, the ecology of pit lakes is underrepresented in the literature. The broad goal of this research was to determine the environmental drivers of pelagic microbe assemblages in Australian coal pit lakes. The overall experimental design was four lakes sampled three times, top and bottom, in 2019. Instrument chains were installed in lakes and measurements of in situ water quality and water samples for metals, metalloids, nutrients and microbe assemblage were …

Impact Of Internal Integration, Supply Chain Partnership, Supply Chain Agility, And Supply Chain Resilience On Sustainable Advantage, Zeplin Jiwa Husada Tarigan, Hotlan Siagian, Ferry Jie

Research outputs 2014 to 2021

The global order has suddenly changed due to the COVID-19 pandemic. Many countries, including Indonesia, have applied lockdown policies to stop the spread of COVID-19. Lockdown policies have disrupted the supply of raw materials and the demand for finished goods. The manufacturing industry is one of the sectors that has suffered most in this situation, and they have struggled to reconfigure their internal and external supply chain network and partnership. This study examined the impact of internal integration, supply chain partnership, supply chain agility, and supply chain resilience on sustainable advantage. The participants of this study were from manufacturing companies …

Validity And Test-Retest Reliability Of The Jumpo App For Jump Performance Measurement, Amilton Vieira, Anthony J. Blazevich, Alexandre Souza Da Costa, James J. Tufano, Martim Bottaro

Research outputs 2014 to 2021

International Journal of Exercise Science 14(7): 677-686, 2021. The vertical jump test is one of the simplest and most prevalent physical tests used in practice and research. This study investigated the validity and reliability of a new mobile application (Jumpo) for measuring jump performance on Android devices. University-aged students (n = 10; 20 ± 3 years; 176 ± 6 cm; 68 ± 9 kg) reported to the laboratory on three occasions (2-7 days apart): to be familiarized with the jump performance measurements and then for test-retest reliability assessments. Participants performed countermovement jumps (CMJ), squat jumps (SJ), and right and left …

Glycosylation Of Igg Associates With Hypertension And Type 2 Diabetes Mellitus Comorbidity In The Chinese Muslim Ethnic Minorities And The Han Chinese, Xiaoni Meng, Manshu Song, Marija Vilaj, Jerko Štambuk, Mamatyusupu Dolikun, Jie Zhang, Di Liu, Hao Wang, Xiaoyu Zhang, Jinxia Zhang, Weijie Cao, Ana Momčilović, Irena Trbojević-Akmačić, Xingang Li, Deqiang Zheng, Lijuan Wu, Xiuhua Guo, Youxin Wang, Gordan Lauc, Wei Wang

Research outputs 2014 to 2021

Objectives: Hypertension and type 2 diabetes mellitus comorbidity (HDC) is common, which confers a higher risk of cardiovascular disease than the presence of either condition alone. Describing the underlying glycomic changes of immunoglobulin G (IgG) that predispose individuals to HDC may help develop novel protective immune-targeted and anti-inflammatory therapies. Therefore, we investigated glycosylation changes of IgG associated with HDC. Methods: The IgG N-glycan profiles of 883 plasma samples from the three northwestern Chinese Muslim ethnic minorities and the Han Chinese were analyzed by ultra-performance liquid chromatography instrument. Results: We found that 12 and six IgG N-glycan traits showed significant associations …

Exploring The Key Challenges Facing Company Secretaries In A Two-Tier Board Context, Stefan Peij, Pieter-Jan Bezemer

Research outputs 2014 to 2021

Purpose: This study aims to examine the core challenges facing company secretaries in a two-tier board context. This study focuses on the key factors contributing to these challenges and how company secretaries can effectively address them.

Design/methodology/approach: An analysis of the narratives provided by 291 Dutch company secretaries in response to a series of open-ended questionnaire questions led to insights into the key challenges company secretaries face in their day-to-day work.

Findings: Company secretaries perceive a myriad of factors contributing to pressures on their time, the need to work for multiple organizational bodies and the processing of information. They believe …

Breaking The Silence: Insights From Wa Services Working With Aboriginal/ Lgbtiq+ People: Organisations Summary Report 2021, Braden Hill, Bep Uink, Jenny Dodd, Dameyon Bronson, Anne-Marie Eades, Sian Bennett

Research outputs 2014 to 2021

The ‘Breaking the Silence’ research project is one of the first to focus on the unique experiences of Aboriginal and/or Torres Strait Islander LGBTIQ+ people living in Western Australia. The report presents the first phase of a twopart research project that explores how a range of health, social support and education organisations respond to the needs of Aboriginal and/or Torres Strait Islander people, living in Western Australia and identifying as LGBTIQ+. This report presents the findings of focus groups, interviews and surveys with staff employed within a range of organisations that work closely with Aboriginal and/or LGBTIQ+ individuals. The discussion …

Non-Traditional Systemic Risk Contagion Within The Chinese Banking Industry, Tonmoy Choudhury, Simone Scagnelli, Jaime L.P. Yong, Zhaoyong Zhang Prof

Research outputs 2014 to 2021

Systemic risk contagion is a key issue in the banking sector in maintaining financial system stability. This study is among the first few to use three different distance-to-risk measures to empirically assess the domestic interbank linkages and systemic contagion risk of the Chinese banking industry, by using bivariate dynamic conditional correlation GARCH model on data collected from eight prominent Chinese banks for the period 2006–2018. The results show a relatively high correlation among almost all the banks, suggesting an interconnectedness among the banks. We found evidence that the banking system is exposed to significant domestic contagion risks arising from systemic …

The Prospective Applicability Of The Strengths-Based Approach To Managing And Developing Employees In Small Businesses, Chamila Kumudunee Wijekuruppu, Alan Coetzer, Pattanee Susomrith

Research outputs 2014 to 2021

Purpose: The strength-based approach is promulgated as a management practice that improves individual productivity and performance. This study's purpose is to explore the prospective applicability of the strengths-based approach to managing and developing employees in small businesses. The study focuses on four domains of practice: selection, training, performance evaluation and task assignment.

Design/methodology/approach: The study employed semi-structured, face-to-face interviews to obtain data. The units of analysis were managers and employees of small businesses. Eleven managers and 19 employees were interviewed. Data analysis involved thematic analysis with the NVivo 12 software program.

Findings: First, the small businesses used a strengths-based approach …

Effect Of Occupational Therapy Home Visit Discharge Planning On Participation After Stroke: Protocol For The Home Rehab Trial, Natasha A. Lannin, Lindy Clemson, Avril Drummond, Mandy Stanley, Leonid Churilov, Kate Laver, Sophie O'Keefe, Ian Cameron, Maria Crotty, Tim Usherwood, Nadine E. Andrew, Laura Jolliffe, Dominique A. Cadilhac

Research outputs 2014 to 2021

Introduction: After first stroke, the transition from rehabilitation to home can be confronting and fraught with challenges. Although stroke clinical practice guidelines recommend predischarge occupational therapy home visits to ensure safe discharge and provision of appropriate equipment, there is currently limited evidence to support this recommendation. Methods and analysis: The HOME Rehab trial is a national, multicentre, phase III randomised controlled trial with concealed allocation, blinded assessment and intention-to-treat analysis being conducted in Australia. The trial aim is to determine the effect and potential cost-effectiveness of an enhanced occupational therapy discharge planning intervention that involves pre and postdischarge home visits, …

Bridging The Research To Practice Gap: A Systematic Scoping Review Of Implementation Of Interventions For Cancer-Related Fatigue Management, Oluwaseyifunmi Andi Agbejule, Nicolas H. Hart, Stuart Ekberg, Koczwara Bogda, Rahul Ladwa, Camilla Simonsen, Elizabeth P. Pinkham, Raymond Javan Chan

Research outputs 2014 to 2021

Background: Cancer-related fatigue (CRF) is one of the most common and distressing symptoms in people with cancer. Although efficacy of interventions for CRF have been extensively investigated, less has been done to ensure successful translation into routine clinical practice. The aim of this systematic scoping review was to synthesise knowledge surrounding the implementation of CRF interventions, summarise the processes and outcomes of implementation strategies used, and identify opportunities for further research. Methods: PubMed, Cochrane CENTRAL, EMBASE and CINAHL databases were searched (up to December 2020). The Cochrane Effective Practice and Organisation of Care (EPOC) Group taxonomy and the RE-AIM Framework …

Putative Factors Influencing Knowledge And Behavioural Practices Of Health Science Undergraduate Students Towards Covid-19 Infection Ahead Of Re-Opening Universities In Ghana, Emmanuel Acheampong, Evans Asamoah Adu, Enoch O. Anto, Yaa Obirikorang, Eric Adua, Sylvester Yao Lopko, Emmanuella Nsenbah Acheampong, Agartha Odame Anto, Vivian Baah, Christian Obirikorang

Research outputs 2014 to 2021

Background: The coronavirus disease 2019 (COVID-19) virus is a global pandemic affecting daily activities and delaying the reopening of several institutions such as universities. As a result, precautionary and preventive measures are being implemented to curtail the spread of the virus. However, knowledge and compliance measures are essential for adequate preparedness to reopen the universities amidst the pandemic. Methods: This cross-sectional study evaluated knowledge, attitudes, and practices (KAP) along with factors influencing Health Science undergraduate students toward the COVID-19 infection pandemic in Ghana. A total of 606 students provided information regarding KAP of COVID-19 infection using an online questionnaire designed …

Quantifying 210po/210pb Disequilibrium In Seawater: A Comparison Of Two Precipitation Methods With Differing Results, Montserrat Roca-Martí, Viena Puigcorbé, Maxi Castrillejo, Núria Casacuberta, Jordi Garcia-Orellana, J. Kirk Cochran, Pere Masqué

Research outputs 2014 to 2021

The disequilibrium between lead-210 (210Pb) and polonium-210 (210Po) is increasingly used in oceanography to quantify particulate organic carbon (POC) export from the upper ocean. This proxy is based on the deficits of 210Po typically observed in the upper water column due to the preferential removal of 210Po relative to 210Pb by sinking particles. Yet, a number of studies have reported unexpected large 210Po deficits in the deep ocean indicating scavenging of 210Po despite its radioactive mean life of ∼ 200 days. Two precipitation methods, Fe(OH)3 and Co-APDC, are typically used to concentrate Pb and Po from seawater samples, and deep …

Maintaining Weight Loss In Obese Men With Prostate Cancer Following A Supervised Exercise And Nutrition Program—A Pilot Study, Rebekah L. Wilson, Dennis R. Taaffe, Robert U. Newton, Nicolas H. Hart, Philippa Lyons-Wall, Daniel A. Galvão

Research outputs 2014 to 2021

Supervised exercise and nutrition programs can mitigate or reverse androgen deprivation therapy (ADT) induced fat mass (FM) gain, lean mass (LM) loss, and impaired physical function. It is unclear whether these benefits are retained following transition to self-management. This study examined the effect of a home-based weight maintenance program on body composition and physical function in obese men with prostate cancer (PCa) on ADT following a 12-week supervised weight loss intervention. Eleven obese PCa patients (74 ± 5 years, 40.0 ± 4.9% body fat) on ADT ( > 6 months) com-pleted a 12-week self-managed home-based weight maintenance program consisting of 150 …

Major Genetic Discontinuity And Novel Toxigenic Species In Clostridioides Difficile Taxonomy, Daniel R. Knight, Korakrit Imwattana, Brian Kullin, Enzo Guerrero-Araya, Daniel Paredes-Sabja, Xavier Didelot, Kate E. Dingle, David W. Eyre, César Rodríguez, Thomas V. Riley

Research outputs 2014 to 2021

Clostridioides difficile infection (CDI) remains an urgent global One Health threat. The genetic heterogeneity seen across C. difficile underscores its wide ecological versatility and has driven the significant changes in CDI epidemiology seen in the last 20 years. We analysed an international collection of over 12,000 C. difficile genomes spanning the eight currently defined phylogenetic clades. Through whole-genome average nucleotide identity, and pangenomic and Bayesian analyses, we identified major taxonomic incoherence with clear species boundaries for each of the recently described cryptic clades CI–III. The emergence of these three novel genomospecies predates clades C1–5 by millions of years, rewriting the …

Supervision In Initial Teacher Education: A Scoping Review, Madlen Griffiths, Mandie Shean, Denise Jackson

Research outputs 2014 to 2021

Supervision in initial teacher education is a pivotal component of professional experience, widely considered to be the most valued aspect of preservice teacher learning. Key to these experiences is the work of the university appointed supervisors who mentor the novices during their in-classroom learning. This is a dichotomous and often under-rated role, fraught with challenges, yet remains under-theorised and underresearched. Situated in a framework of readiness for teaching, this literature review provides a synopsis of the challenges facing the provision of quality teacher education programs and the supervision of preservice teachers and details the myriad of tasks undertaken by these …

Estimated Financial Impacts Of Inaccurate Obese Patient Data Recorded By The Western Australian Country Health Service, Kim Mcclean, Martyn Cross, Sue Reed

Research outputs 2014 to 2021

Purpose: Pressure on Australia’s healthcare system is increasing annually due to corresponding increases in chronic diseases such as obesity and rapidly ageing population growth across Australia, resulting in requirements for increased funding. This study investigates the financial impact to hospitals due to inaccurate obese patient recording and coding.

Background: Australian healthcare organisations receive Activity-Based Funding (ABF) which provides reimbursement of costs relating to the type of patient care delivered and the resources required for the patient treatment. Accurate healthcare data are essential to ensure accuracy of ABF and appropriate reimbursement of costs incurred by hospitals that manage obese patients. Managing …

Influence Of Rock Wettability On Thf Hydrate Saturation And Distribution In Sandstones, Ghazanfer Raza Abbasi, Ahmed Al-Yaseri, Abubakar Isah, Alireza Keshavarz, Sefan Iglauer

Research outputs 2014 to 2021

Natural gas trapped in hydrate deposits is a potentially enormous source of energy which can in principle be extracted from the underground reservoir structures. These reserves can potentially also catastrophically release very large quantities of greenhouse gases to the atmosphere. One key parameter which is well known to strongly influence fluid distribution, saturation, and production is rock wettability. However, the effect of wettability on gas hydrate in sediments has not been investigated yet. We thus used nuclear magnetic resonance (NMR) spectrometry to measure relaxation times (T₂ and T₁) and the corresponding surface relaxivity of tetrahydrofuran hydrate …

Co-Creating Visual Representations Of Safe Spaces With Mental Health Service Users Using Photovoice And Zoom, Julie Dare, Helen Seiver, Lesley Andrew, David A. Coall, Shantha Karthigesu, Moira Sim, Kathy Boxall

Research outputs 2014 to 2021

This paper examines methodological issues related to an innovative online qualitative research project that explored ‘safe spaces’ with mental health service users. The project used photovoice and focus groups conducted via Zoom videoconferencing software. Eleven participants shared photographs, discussing their meaning and significance in relation to ‘safe spaces’. The photographs were then synthesised into an artist's impression of a safe space and transcripts of the online photovoice discussion analysed thematically and triangulated with the artist's impression. The paper provides a reflexive discussion of the research process and explores methodological and ethical implications of conducting sensitive qualitative research in online spaces.

Questionnaires To Measure Process And Structure Of Quality Indicators For Pediatric Nursing, Maria Forsner, Evalotte Mörelius, Lena Hanberger

Research outputs 2014 to 2021

Introduction The quality of nursing care has a significant impact on the outcomes of care. The specific needs of children requiring hospital care make it essential to monitor and compare data not only on the medically oriented outcome measure but also on nursing care, structure, and process, requiring perspectives from registered nurses (RNs) and nurse managers (NMs). Thus, this project aimed to evaluate the structure and process of nursing quality indicators in pediatric hospital care with questionnaires distributed to RN and NM. Methods We developed separate questionnaires for NMs and RNs to assess the process and structure of the quality …

Molecular Analyses Reveal Consistent Food Web Structure With Elevation In Rainforest Drosophila – Parasitoid Communities, Christopher T. Jeffs, J. Christopher D. Terry, Megan Higgie, Anna Jandová, Hana Konvičková, Joel J. Brown, Chia H. Lue, Michele Schiffer, Eleanor K. O'Brien, Jon Bridle, Jan Hrček, Owen T. Lewis

Research outputs 2014 to 2021

The analysis of interaction networks across spatial environmental gradients is a powerful approach to investigate the responses of communities to global change. Using a combination of DNA metabarcoding and traditional molecular methods we built bipartite Drosophila – parasitoid food webs from six Australian rainforest sites across gradients spanning 850 m in elevation and 5°C in mean temperature. Our cost-effective hierarchical approach to network reconstruction separated the determination of host frequencies from the detection and quantification of interactions. The food webs comprised 5–9 host and 5–11 parasitoid species at each site, and showed a lower incidence of parasitism at high elevation. …

Associations Between Fruit Intake And Risk Of Diabetes In The Ausdiab Cohort, Nicola P. Bondonno, Raymond J. Davey, Kevin Murray, Simone Radavelli-Bagatini, Catherine P. Bondonno, Lauren C. Blekkenhorst, Marc Sim, Dianna J. Magliano, Robin M. Daly, Jonathan E. Shaw, Joshua R. Lewis, Jonathan M. Hodgson

Research outputs 2014 to 2021

Context

Fruit, but not fruit juice, intake is inversely associated with type 2 diabetes mellitus (T2DM). However, questions remain about the mechanisms by which fruits may confer protection. Objective The aims of this work were to examine associations between intake of fruit types and 1) measures of glucose tolerance and insulin sensitivity and 2) diabetes at follow-up.

Methods

Among participants of the Australian Diabetes, Obesity and Lifestyle Study, fruit and fruit juice intake was assessed by food frequency questionnaire at baseline. Associations between fruit and fruit juice intake and 1) fasting plasma glucose, 2-hour postload plasma glucose, updated homeostasis model …

Parents And Teachers’ Perceptions Of The Tone And Emotional Impact Of Education News Coverage, Kathryn Shine, Shane L. Rogers

Research outputs 2014 to 2021

This study examines Australian teachers (n = 268) and parents’ (n = 206) self-reported perceptions of education news coverage and how the coverage affects them. Overall, the participants reported a perception that news coverage of teachers, schools, the education system and standardised testing was generally negative in tone. Participants reported typically feeling demoralised by negative stories and inspired by positive stories. A high importance was placed upon the public perception of education by participants. However, trust in the media reporting of educational issues was low. An exception to this general pattern of findings was that participants did not place as …

Co2 – Brine – Sandstone Wettability Evaluation At Reservoir Conditions Via Nuclear Magnetic Resonance Measurements, Auby Baban, Ahmed Al-Yaseri, Alireza Keshavarz, R. Amin, Stefan Iglauer

Research outputs 2014 to 2021

CO₂-rock wettability is a key parameter which governs CO₂ trapping capacities and containment security in the context of CO₂ geo-sequestration schemes. However, significant uncertainties still exist in terms of predicting CO₂ rock wettability at true reservoir conditions. This study thus reports on wettability measurements via independent Nuclear Magnetic Resonance (NMR) experiments on sandstone (CO₂–brine systems) to quantify Wettability Indices (WI) using the United States Bureau of Mines (USBM) scale. The results show that CO₂ (either molecularly dissolved or as a separate supercritical phase) significantly reduced the hydrophilicity of the sandstone from strongly …

Neutron Scattering: A Subsurface Application Review, Mirhasan Hosseini, Muhammad Arif, Alireza Keshavarz, Stefan Iglauer

Research outputs 2014 to 2021

Geomaterials and filling fluids properties that are pertinent to a geologic porous media can be characterized using a range of methods, such as nuclear magnetic resonance, X-rays, infrared spectroscopy, and neutron scattering (NS). In this context, NS features as an important tool elucidate key properties of a porous medium, which has recently gained significant attention. Key rock properties that can be measured by NS include: rock texture (i.e. crystallographic preferred orientation), mechanical properties (i.e. stress and strain) as well as porous medium properties (pore porosity, pore size and connectivity). In addition, NS imaging can help elucidate the phase behaviour of …

A Review Of Security Standards And Frameworks For Iot-Based Smart Environments, Nickson M. Karie, Nor Masri Sahri, Wencheng Yang, Craig Valli, Victor R. Kebande

Research outputs 2014 to 2021

Assessing the security of IoT-based smart environments such as smart homes and smart cities is becoming fundamentally essential to implementing the correct control measures and effectively reducing security threats and risks brought about by deploying IoT-based smart technologies. The problem, however, is in finding security standards and assessment frameworks that best meets the security requirements as well as comprehensively assesses and exposes the security posture of IoT-based smart environments. To explore this gap, this paper presents a review of existing security standards and assessment frameworks which also includes several NIST special publications on security techniques highlighting their primary areas of …

Cross-Education And Detraining Effects Of Eccentric Vs. Concentric Resistance Training Of The Elbow Flexors, Shigeru Sato, Riku Yoshida, Ryosuke Kiyono, Kaoru Yahata, Koki Yasaka, Kazunori (Ken) Nosaka, Masatoshi Nakamura

Research outputs 2014 to 2021

Background: Unilateral resistance training increases the strength of the contralateral non-trained homologous muscles known as the cross-education effect. We tested the hypothesis that unilateral eccentric resistance training (ET) would induce greater and longer-lasting cross-education effect when compared with concentric resistance training (CT). Methods: Young (20–23 y) participants were allocated to ET (5 males, 4 females) or CT (5 males, 4 females) group that performed unilateral progressive ET or CT of the elbow flexors, twice a week for 5 weeks (10 sessions) followed by a 5-week detraining, and control group (7 males, 6 females) that did not perform any training. Maximum …

Proteome And Nutritional Shifts Observed In Hordein Double-Mutant Barley Lines, Utpal Bose, Angéla Juhász, Ronald Yu, Mahya Bahmani, Keren Byrne, Malcolm Blundell, James A. Broadbent, Crispin A. Howitt, Michelle L. Colgrave

Research outputs 2014 to 2021

Lysine is the most limiting essential amino acid in cereals, and efforts have been made over the decades to improve the nutritional quality of these grains by limiting storage protein accumulation and increasing lysine content, while maintaining desired agronomic traits. The single lys3 mutation in barley has been shown to significantly increase lysine content but also reduces grain size. Herein, the regulatory effect of the lys3 mutation that controls storage protein accumulation as well as a plethora of critically important processes in cereal seeds was investigated in double mutant barley lines. This was enabled through the generation of three hordein …

Biometrics For Internet‐Of‐Things Security: A Review, Wencheng Yang, Song Wang, Nor Masri Sahri, Nickson M. Karie, Mohiuddin Ahmed, Craig Valli

Research outputs 2014 to 2021

The large number of Internet‐of‐Things (IoT) devices that need interaction between smart devices and consumers makes security critical to an IoT environment. Biometrics offers an interesting window of opportunity to improve the usability and security of IoT and can play a significant role in securing a wide range of emerging IoT devices to address security challenges. The purpose of this review is to provide a comprehensive survey on the current biometrics research in IoT security, especially focusing on two important aspects, authentication and encryption. Regarding authentication, contemporary biometric‐based authentication systems for IoT are discussed and classified based on different biometric …

Kinematic And Neuromuscular Measures Of Intensity During Drop Jumps In Female Volleyball Players, Maximiliano Torres-Banduc, Rodrigo Ramirez-Campillo, David Cristobal Andrade, Julio Calleja-González, Pantelis Theo Nikolaidis, John J. Mcmahon, Paul Comfort

Research outputs 2014 to 2021

The aim of this study was to assess drop jump (DJ) performance variables (jump height, contact time, and reactive strength index) concomitant to surface electromyography (sEMG) of lower limb muscles during DJs from different drop heights (intensities). The eccentric and concentric phase sEMG from the gastrocnemius medialis, biceps femoris, and vastus medialis muscles were assessed during all tests, with sEMG activity normalized to maximal voluntary isometric contraction (MVIC). In a cross-sectional, study, 10 amateur female volleyball players (age 22.1 ± 1.8 years; body mass 72.9 ± 15.2 kg; height 1.70 ± 0.08 m) completed DJs from six heights [15-90 cm …

Pattern And Degree Of Individual Brain Atrophy Predicts Dementia Onset In Dominantly Inherited Alzheimer's Disease, Ophir Keret, Adam M. Staffaroni, John M. Ringman, Yann Cobigo, Sheng-Yang M. Goh, Amy Wolf, Isabel Elaine Allen, Stephen Salloway, Jasmeer Chhatwal, Adam M. Brickman, Dolly Reyes-Dumeyer, Randal J. Bateman, Tammie L.S. Benzinger, John C. Morris, Beau M. Ances, Nelly Joeseph-Mathurin, Richard J. Perrin, Brian A. Gordon, Johannes Levin, Jonathan Voglein, Mathias Jucker, Christian La Fougere, Ralph N. Martins, Hamid R. Sohrabi, Kevin Taddei, Victor L. Villemagne, Peter R. Schofield, William S. Brooks, Michael Fulham, Colin L. Masters, Bernardino Ghetti, Andrew J. Saykin, Clifford R. Jack, Neill R. Graff-Radford, Michael Weiner, David M. Cash, Ricardo F. Allegri, Patricio Chrem, Su Yi, Bruce L. Miller, Gil D. Rabinovici, Howard J. Rosen, Dominantly Inherited Alzheimer Network

Research outputs 2014 to 2021

Introduction: Asymptomatic and mildly symptomatic dominantly inherited Alzheimer's disease mutation carriers (DIAD-MC) are ideal candidates for preventative treatment trials aimed at delaying or preventing dementia onset. Brain atrophy is an early feature of DIAD-MC and could help predict risk for dementia during trial enrollment. Methods: We created a dementia risk score by entering standardized gray-matter volumes from 231 DIAD-MC into a logistic regression to classify participants with and without dementia. The score's predictive utility was assessed using Cox models and receiver operating curves on a separate group of 65 DIAD-MC followed longitudinally. Results: Our risk score separated asymptomatic versus demented …