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2021

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High Calorie Diet With A Combination Of Intermittent Restriction Affects The Reproductive Cycle And The Uterine Weight Of Mice (Mus Musculus), Anggraeni Dyah Kumalasari, Lilik Herawati, Raden Argarini, Lina Lukitasari, Zulhabri Othman, Astika Gita Ningrum Dec 2021

High Calorie Diet With A Combination Of Intermittent Restriction Affects The Reproductive Cycle And The Uterine Weight Of Mice (Mus Musculus), Anggraeni Dyah Kumalasari, Lilik Herawati, Raden Argarini, Lina Lukitasari, Zulhabri Othman, Astika Gita Ningrum

Folia Medica Indonesiana

Highlight: • High-calorie diet influence with interval restrictions combination on the reproductive cycle and weight of the uterus in mice were analyzed. • Calories balance impact for female reproductive health. Abstract : Balanced calories affected for body health and daily activities. Lose of energy can disturb the health and daily activities, while over calorie for diets also causes disorders such as metabolic. When there are excess calories in the body will be involved. It can be an obesity risk, diabetes mellitus, fertility disorder, cancer, and cardiovascular disease. Furthermore, in women there can be an increase in menstrual disorders and fertility …


State V. Preston Respondent's Brief Dckt. 48841 Dec 2021

State V. Preston Respondent's Brief Dckt. 48841

Not Reported

No abstract provided.


Combining Community Wastewater Genomic Surveillance With State Clinical Surveillance: A Framework For Sars-Cov-2 Public Health Practice., Ted Smith, Rochelle H. Holm, Ray Yeager, Joseph B. Moore Iv, Eric C. Rouchka, Kevin J. Sokoloski, Daymond Talley, Vaneet Arora, Sarah Moyer, Aruni Bhatnagar Dec 2021

Combining Community Wastewater Genomic Surveillance With State Clinical Surveillance: A Framework For Sars-Cov-2 Public Health Practice., Ted Smith, Rochelle H. Holm, Ray Yeager, Joseph B. Moore Iv, Eric C. Rouchka, Kevin J. Sokoloski, Daymond Talley, Vaneet Arora, Sarah Moyer, Aruni Bhatnagar

Faculty and Staff Scholarship

Study objective: To garner a framework for combining community wastewater surveillance with state clinical surveillance that influence confirmation of SARS-CoV-2 variants within the community, and recommend how the flow of such research evidence could be expanded and employed for public health response. Design, setting, and participants: This work involved analyzing wastewater samples collected weekly from 17 geographically resolved locations in Louisville/Jefferson County, Kentucky from February 10 to November 29, 2021. Genomic surveillance and RT-qPCR platforms were used as screening to identify SARS-CoV-2 in wastewater, and state clinical surveillance was used for confirmation. Main results: The results demonstrate increased epidemiological value …


Deep Brain Stimulation: A Treatment Option For Parkinson's, Michael D. Staudt Dec 2021

Deep Brain Stimulation: A Treatment Option For Parkinson's, Michael D. Staudt

Conference Presentation Abstracts

No abstract provided.


Exposure To Prenatal Maternal Distress And Infant White Matter Neurodevelopment, Catherine H. Demers, Maria M. Bagonis, Khalid Al-Ali, Sarah E. Garcia, Martin A. Styner, John H. Gilmore, M. Camille Hoffman, Benjamin L. Hankin, Elysia Poggi Davis Dec 2021

Exposure To Prenatal Maternal Distress And Infant White Matter Neurodevelopment, Catherine H. Demers, Maria M. Bagonis, Khalid Al-Ali, Sarah E. Garcia, Martin A. Styner, John H. Gilmore, M. Camille Hoffman, Benjamin L. Hankin, Elysia Poggi Davis

Psychology: Faculty Scholarship

The prenatal period represents a critical time for brain growth and development. These rapid neurological advances render the fetus susceptible to various influences with life-long implications for mental health. Maternal distress signals are a dominant early life influence, contributing to birth outcomes and risk for offspring psychopathology. This prospective longitudinal study evaluated the association between prenatal maternal distress and infant white matter microstructure. Participants included a racially and socioeconomically diverse sample of 85 mother–infant dyads. Prenatal distress was assessed at 17 and 29 weeks’ gestational age (GA). Infant structural data were collected via diffusion tensor imaging (DTI) at 42–45 weeks’ …


A Highly Versatile Fungal Glucosyltransferase For Specific Production Of Quercetin-7-O-Β-D-Glucoside And Quercetin-3-O-Β-D-Glucoside In Different Hosts, Jie Ren, Wenzhu Tang, Caleb Don Barton, Owen M. Price, Mark Wayne Mortensen, Alexandra Phillips, Banner Wald, Simon Elgin Hulme, Logan Powell Stanley, Joan Hevel, Jixun Zhan Dec 2021

A Highly Versatile Fungal Glucosyltransferase For Specific Production Of Quercetin-7-O-Β-D-Glucoside And Quercetin-3-O-Β-D-Glucoside In Different Hosts, Jie Ren, Wenzhu Tang, Caleb Don Barton, Owen M. Price, Mark Wayne Mortensen, Alexandra Phillips, Banner Wald, Simon Elgin Hulme, Logan Powell Stanley, Joan Hevel, Jixun Zhan

Biological Engineering Faculty Publications

Glycosylation is an effective way to improve the water solubility of natural products. In this work, a novel glycosyltransferase gene (BbGT) was discovered from Beauveria bassiana ATCC 7159 and heterologously expressed in Escherichia coli. The purified enzyme was functionally characterized through in vitro enzymatic reactions as a UDP-glucosyltransferase, converting quercetin to five monoglucosylated and one diglucosylated products. The optimal pH and temperature for BbGT are 35 ℃ and 8.0, respectively. The activity of BbGT was stimulated by Ca2+, Mg2+, and Mn2+, but inhibited by Zn2+. BbGT enzyme is flexible and can glycosylate a variety of substrates such as curcumin, …


2021-12-07 Newsletter, Morehead State University. Staff Congress. Dec 2021

2021-12-07 Newsletter, Morehead State University. Staff Congress.

Staff Congress Records

Staff Congress newsletter from December 7, 2021.


2021-12-07 Minutes, Morehead State University. Staff Congress. Dec 2021

2021-12-07 Minutes, Morehead State University. Staff Congress.

Staff Congress Records

Staff Congress meeting minutes from December 7, 2021.


Point Absorber Limits To Future Gravitational-Wave Detectors, Wenxuan Jia, Hiroaki Yamamoto, Kevin Kuns, Anamaria Effler, Matthew Evans, Peter Fritschel, R. Abbott, C. Adams, R. Adhikari, Karla E. Ramirez Dec 2021

Point Absorber Limits To Future Gravitational-Wave Detectors, Wenxuan Jia, Hiroaki Yamamoto, Kevin Kuns, Anamaria Effler, Matthew Evans, Peter Fritschel, R. Abbott, C. Adams, R. Adhikari, Karla E. Ramirez

Physics & Astronomy Faculty Publications

High-quality optical resonant cavities require low optical loss, typically on the scale of parts per million. However, unintended micron-scale contaminants on the resonator mirrors that absorb the light circulating in the cavity can deform the surface thermoelastically, and thus increase losses by scattering light out of the resonant mode. The point absorber effect is a limiting factor in some highpower cavity experiments, for example, the Advanced LIGO gravitational wave detector. In this Letter, we present a general approach to the point absorber effect from first principles and simulate its contribution to the increased scattering. The achievable circulating power in current …


Hypothalamic Steroid Receptor Coactivator-2 Regulates Adaptations To Fasting And Overnutrition, Yongjie Yang, Yanlin He, Hailan Liu, Wenjun Zhou, Chunmei Wang, Pingwen Xu, Xing Cai, Hesong Liu, Kaifan Yu, Zhou Pei, Ilirjana Hyseni, Makoto Fukuda, Qingchun Tong, Jianming Xu, Zheng Sun, Bert W O'Malley, Yong Xu Dec 2021

Hypothalamic Steroid Receptor Coactivator-2 Regulates Adaptations To Fasting And Overnutrition, Yongjie Yang, Yanlin He, Hailan Liu, Wenjun Zhou, Chunmei Wang, Pingwen Xu, Xing Cai, Hesong Liu, Kaifan Yu, Zhou Pei, Ilirjana Hyseni, Makoto Fukuda, Qingchun Tong, Jianming Xu, Zheng Sun, Bert W O'Malley, Yong Xu

Faculty, Staff and Students Publications

The neuroendocrine system coordinates metabolic and behavioral adaptations to fasting, including reducing energy expenditure, promoting counterregulation, and suppressing satiation and anxiety to engage refeeding. Here, we show that steroid receptor coactivator-2 (SRC-2) in pro-opiomelanocortin (POMC) neurons is a key regulator of all these responses to fasting. POMC-specific deletion of SRC-2 enhances the basal excitability of POMC neurons; mutant mice fail to efficiently suppress energy expenditure during food deprivation. SRC-2 deficiency blunts electric responses of POMC neurons to glucose fluctuations, causing impaired counterregulation. When food becomes available, these mutant mice show insufficient refeeding associated with enhanced satiation and discoordination of anxiety …


Remote Teaching In Nepalese Higher Education During Covid-19: Teachers' Perspectives, Suman Laudari, Sojen Pradhan, Sanjay Lama Dec 2021

Remote Teaching In Nepalese Higher Education During Covid-19: Teachers' Perspectives, Suman Laudari, Sojen Pradhan, Sanjay Lama

Higher Learning Research Communications

Objectives: The purpose of the study was to examine the factors that supported or inhibited teacher participation in remote teaching. Teaching and learning in Nepal was predominantly face-to-face prior to the pandemic, and the previous studies showed that the use of educational technology in higher education was limited.

Method: This exploratory case study draws on data derived from focus group discussions with teachers in higher education. Thematic analysis was employed to explore the impacts of different factors in sudden transition to remote teaching.

Findings: Findings show that personal factors such as teachers’ sense of duty and their attitude towards technology …


A Brief History Of Writing From The Perspective Of Restoration Scripture, Noel B. Reynolds Dec 2021

A Brief History Of Writing From The Perspective Of Restoration Scripture, Noel B. Reynolds

Faculty Publications

This paper brings together selected insights of modern epigraphers who study the languages and texts of the ancient near east to illuminate how we should understand the composition and history of central texts in the Bible and the Book of Mormon.


Ethical Hacking, Mollie Brogdon Dec 2021

Ethical Hacking, Mollie Brogdon

Culture, Society, and Praxis

No abstract provided.


Chronic Conditions And Pediatric Healthcare Utilization During Warm Weather Days In New York City, Li Niu, Maria Teresa Herrera, Blean Girma, Bian Liu, Jeffrey Glassberg, Leah Schinasi, Jane E. Clougherty, Perry Sheffield Dec 2021

Chronic Conditions And Pediatric Healthcare Utilization During Warm Weather Days In New York City, Li Niu, Maria Teresa Herrera, Blean Girma, Bian Liu, Jeffrey Glassberg, Leah Schinasi, Jane E. Clougherty, Perry Sheffield

Journal of Applied Research on Children: Informing Policy for Children at Risk

Background: While literature on the overall health burden of high temperature exposures on children continues to grow, little is known about whether children with chronic diseases are particularly vulnerable to the adverse health impacts of extreme heat.

Methods: We used New York Statewide Planning and Research Cooperative System (SPARCS) data on children aged 0-18 years admitted to emergency department and hospitals during the warm months (May-September) from 2005 to 2011. We identified children with specific chronic diseases or conditions that plausibly enhance susceptibility to heat (i.e., asthma, obesity, cerebral palsy, cystic fibrosis, sickle cell disease, sickle cell trait, and mental …


Book Reviews, Florida Historical Society Dec 2021

Book Reviews, Florida Historical Society

Florida Historical Quarterly

TORIES, DONS, AND REBELS: THE AMERICAN REVOLUTION IN BRITISH WEST FLORIDA, by J. Barton Starr, reviewed by Aubrey C. Land; ZORA NEALE HURSTON: A LITERARY BIOGRAPHY, by Robert E. Hemenway, reviewed by Kevin M. McCarthy; THE LIVING DOCK AT PANACEA, by Jack Rudloe, reviewed by Wyatt Blassingame; FEARLESS AND FREE: THE SEMINOLE INDIAN WAR, 1835-1842, by George Walton, reviewed by Frank Laumer; AFRICANS AND SEMINOLES: FROM REMOVAL TO EMANCIPATION, by Daniel F. Littlefield, Jr., reviewed by James W. Covington; RELIGION IN THE OLD SOUTH, by Donald G. Mathews, reviewed by Walter B. Posey; ADAMS AND JEFFERSON: A REVOLUTIONARY DIALOGUE, by …


Torment Of Pestilence: Yellow Fever Epidemics In Pensacola, George F. Pearce Dec 2021

Torment Of Pestilence: Yellow Fever Epidemics In Pensacola, George F. Pearce

Florida Historical Quarterly

For more than a century, yellow fever epidemics intermittently swept over Pensacola, Florida, producing a high mortality, disrupting its economic and social life, dividing community leaders and medical authorities over courses of action in combatting them, causing untold numbers to flee, some permanently, and keeping those who remained in a state of demoralizing terror. The approach of summer each year invariably brought with it the fear of a repetition of the dreadful experience. This atmosphere of apprehension and utter helplessness was nourished by ignorance about the origin, transmission, and prevention of the disease. It was not until 1900 that medical …


Book Reviews, Florida Historical Society Dec 2021

Book Reviews, Florida Historical Society

Florida Historical Quarterly

THE ENTERPRISE OF FLORIDA: PEDRO MENENDEZ DE AVILES AND THE SPANISH CONQUEST OF 1565-1568, by Eugene Lyon, reviewed by Michael V. Gannon; FLORIDA POLITICS IN THE GILDED AGE, 1877-1893, by Edward C. Williamson, reviewed by Charlton W. Tebeau; OGLETHORPE IN AMERICA, by Phinizy Spalding, reviewed by Jack P. Greene; COLONIAL GEORGIA, A HISTORY, by Kenneth Coleman, reviewed by David R. Chesnutt; THE PAPERS OF GENERAL NATHANAEL GREENE, VOLUME I, DECEMBER 1766-DECEMBER 1776, edited by Richard K. Showman, Margaret Cobb, and Robert E. McCarthy, reviewed by Kenneth Coleman; THIS AFFAIR OF LOUISIANA, by Alexander DeConde, reviewed by Gilbert C. Din; THE …


Career Of A "Carpetbagger": Malachi Martin In Florida, Mildred L. Fryman Dec 2021

Career Of A "Carpetbagger": Malachi Martin In Florida, Mildred L. Fryman

Florida Historical Quarterly

The epithet "carpetbagger" holds such a solid place in the vocabulary of American history that it would be difficult to describe the nation’s Reconstruction experience without utilizing it. In 1868, the editors of a Pensacola newspaper expressed the attitude towards “carpetbaggers” which prevailed among white Southerners. “While crushed beneath a grinding military despotism, hireling spies and impudent adventurers have swarmed upon . . . [us] taking a despicable advantage of . . . [our] weakness, misfortunes and suffering to traduce, vilify and malign . . . [us]. . . . Upstarts, without name, character or position in their own land, …


Book Reviews, Florida Historical Society Dec 2021

Book Reviews, Florida Historical Society

Florida Historical Quarterly

CRACKER MESSIAH: GOVERNOR SIDNEY J. CATTS OF FLORIDA, by Wayne Flynt, reviewed by Dewey W. Grantham; FLORIDA TERRITORY IN 1844: THE DIARY OF MASTER EDWARD C. ANDERSON, UNITED STATES NAVY, edited by W. Stanley Hoole, reviewed by George E. Buker; PROCEEDINGS OF THE GULF COAST HISTORY AND HUMANITIES CONFERENCE, VOLUME VI, THE CULTURAL LEGACY OF THE GULF COAST, 1870-1940, edited by Lucius F. Ellsworth and Linda V. Ellsworth, reviewed by Gloria Jahoda; GOLD, GALLEONS AND ARCHAEOLOGY: A HISTORY OF THE 1715 SPANISH PLATE FLEET AND THE TRUE STORY OF THE GREAT FLORIDA TREASURE FIND, by Robert F. Burgess and Carl …


Book Reviews, Florida Historical Society Dec 2021

Book Reviews, Florida Historical Society

Florida Historical Quarterly

HOPES, DREAMS, AND PROMISES: A HISTORY OF VOLUSIA COUNDY, FLORIDA, by Michael G. Schene, reviewed by Thomas Graham; THE EMERGENCE OF A CITY IN THE MODERN SOUTH: PENSACOLA, 1900-1945, by James R. McGovern, reviewed by Wayne Flynt; THE UNIVERSITY OF MIAMI: A GOLDEN ANNIVERSARY HISTORY, 1926-1976, by Charlton W. Tebeau, reviewed by Thelma Peters; THE SOUND OF BELLS: THE EPISCOPAL CHURCH IN SOUTH FLORIDA, 1892-1969, by Joseph D. Cushman, Jr., reviewed by Samuel S. Hill, Jr.; CONFUSION TO THE ENEMY: A BIOGRAPHY OF EDWARD BALL, by Raymond K. Mason and Virginia Harrison, reviewed by William M. Goza; THE FLEDGLING PROVINCE: …


Turmoil At Big Cypress: Seminole Deer And The Florida Cattle Tick Controversy, Kenneth R. Philip Dec 2021

Turmoil At Big Cypress: Seminole Deer And The Florida Cattle Tick Controversy, Kenneth R. Philip

Florida Historical Quarterly

Indian Commissioner John Collier and Secretary of the Interior Harold L. Ickes, who was accompanied by his wife and son, left Washington, D.C., during the early spring of 1935 to meet with representatives of approximately 600 Seminole Indians who lived on three reservations and on scattered plots of land in Florida. Their purpose was to honor the one-hundredth anniversary of the beginning of the Second Seminole War and to conclude an informal peace treaty with these native Americans. After their arrival at West Palm Beach on March 18, Commissioner Collier requested that officials from the Dania Seminole Agency take them …


Frederic Remington In Florida, Julian M. Pleasants Dec 2021

Frederic Remington In Florida, Julian M. Pleasants

Florida Historical Quarterly

Of the many writers and artists who have glorified the western experience, few have been more singularly devoted, more prolific, or more enduring than Frederic Sackrider Remington. Through his painting, sculpture, illustrations, and literary works, Remington preserved for posterity the essence of a wild and colorful epoch in American history. To a rare and satisfying degree, he captured the Old West-reconstructing its vividness and the vitality of the men, animals, and the scenes that characterized its picturesque history. Other artists drew and painted cowboys, Indians, and the western scene, and many have done so since, but as one critic noted, …


The Tampa Flogging Case, Urban Vigiliantism, Robert P. Ingalls Dec 2021

The Tampa Flogging Case, Urban Vigiliantism, Robert P. Ingalls

Florida Historical Quarterly

On November 30, 1935, at about nine o'clock in the evening, a group of Tampa policemen, without a warrant, entered a home at 307 East Palm Avenue and seized six men who were holding a political meeting. Four of the six were members of the Socialist party. All belonged to the Modern Democrats, a new local party that had run candidates in the recent municipal election on a platform containing socialist ideas. Now, almost a month after their candidates had been defeated by incumbents, these leaders of the Modern Democrats were being taken to police headquarters for questioning about their …


Mass Spectra Of Mesonic Molecules At Finite Temperature, Arezu Jahanshir, Mohammad Reza Soltani Dec 2021

Mass Spectra Of Mesonic Molecules At Finite Temperature, Arezu Jahanshir, Mohammad Reza Soltani

Karbala International Journal of Modern Science

At a finite temperature, exotic hadronic systems, mass spectrum was studied using the quark structure and the radial Schrödinger equation with the Cornell interaction potential representing the hadronic interaction. The projective unitary representation has been used in the study of hadronic ground states in physics. A relativistic bound state's mass spectrum with temperature dependence is shown to have a unique feature. The resulting values are compared to experimental and theoretical values, and the study showed a high level of conformity with additional values wherever feasible.


Efficiency Of +Idonblender Photogrammetric Tool In Facial Prosthetics Rehabilitation – An Evaluation Study, Mohammed R. Falih, Fanar M. Abed, Rodrigo Salazar-Gamarra, Luciano Lauria Dib Dec 2021

Efficiency Of +Idonblender Photogrammetric Tool In Facial Prosthetics Rehabilitation – An Evaluation Study, Mohammed R. Falih, Fanar M. Abed, Rodrigo Salazar-Gamarra, Luciano Lauria Dib

Karbala International Journal of Modern Science

Several open-source 3D modeling software tools have recently been featured to reconstruct a 3D image-based model using Structure from Motion (SfM) algorithms such as +IDonBlender. It is, therefore, necessary to evaluate the accuracy of the models extracted from this tool to prove effectiveness for different applications. This paper aims to evaluate the +IDonBlender methodology tool in rehabilitating facial deformations. +IDonBlender is an add-on tool programmed within Blender software and designed for medical applications. In this research, two individuals from different genders have volunteered to contribute to this study, one with severe facial deformation and the other is healthy with no …


Proposed Hybrid Correlationfeatureselectionforestpanalizedattribute Approach To Advance Idss, Doaa Nteesha Mhawi, Prof. Soukaena H. Hashem Dec 2021

Proposed Hybrid Correlationfeatureselectionforestpanalizedattribute Approach To Advance Idss, Doaa Nteesha Mhawi, Prof. Soukaena H. Hashem

Karbala International Journal of Modern Science

NetworkIntrusionDetectionSystem(NIDS), widely used network infrastructure. Although many datamining has been used to increase the effectiveness of IDSs, current ID still struggle to perform well. therfore; proposed a new NIDS focused on feature_selection. The proposed CorrelationFeatureSelection_ForestPanalizedAttributes(CFS_FPA) used for dimensionality_reduction and selects the optimal_subset. based on two steps: first check each feature with a target(class) and choose only features that most effective by applying CFS filter using a statistical_method, then applied FPA to select only features will enhance ID and reduce_dimensionality. proposal tested with the NSLKDD experimental results of accuracy 0.997% and 0.004 FAR, wherein UNSWNB15_dataset accuracy and FAR are 0.995%, 0.008 …


Analysis Of Modern Communication Protocols For Iot Applications, Neerendra Kumar, Pragti Jamwal Dec 2021

Analysis Of Modern Communication Protocols For Iot Applications, Neerendra Kumar, Pragti Jamwal

Karbala International Journal of Modern Science

To facilitate increasing interactions of machines, various protocols are building up for IoT applications. Safeguarding communication among devices is necessary. In this paper, various protocols have been studied and compared using six parameters: Communication overhead, Security, Packet Loss, Throughput, Bandwidth and Support to QoS. LIDOR is found as the most successful communication protocol. A tabulated comparison of various communication protocols have been provided by comparing the parameters. Further, six star rating for the various protocols have been proposed. The study shows that LIDOR increases reliability under DoS attacks. Considering the existing literature, new research gaps and challenges have been presented.


Calculation And Comparison Of Certain Physical Properties Of Sample Irregular Galaxies With The Milky Way Galaxy, Hasanain Hassan Al-Dahlaki Msc Dec 2021

Calculation And Comparison Of Certain Physical Properties Of Sample Irregular Galaxies With The Milky Way Galaxy, Hasanain Hassan Al-Dahlaki Msc

Karbala International Journal of Modern Science

Irregular galaxies often include a mix of old and young celestial populations, as well as dust and gas. This study makes an early effort at the morphological classification of irregular galaxies. These sources have been chosen from (70) irregular galaxies data samples from a Catalogue survey. We present a statistical analysis of the physical properties for the chosen data from the database and a collection of tools that used to study the physics of galaxies and cosmology HYPERLEDA (http://atlas.obshp.fr/hyperleda/) and NASA /IPAC Extragalactic Database NED (https://ned.ipac.caltech.edu/) survey.


Prediction Of Iraqi Stock Exchange Using Optimized Based-Neural Network, Ameer Al-Haq Al-Shamery, Prof. Dr. Eman Salih Al-Shamery Dec 2021

Prediction Of Iraqi Stock Exchange Using Optimized Based-Neural Network, Ameer Al-Haq Al-Shamery, Prof. Dr. Eman Salih Al-Shamery

Karbala International Journal of Modern Science

Stock market prediction is an interesting financial topic that has attracted the attention of researchers for the last years. This paper aims at improving the prediction of the Iraq-Stock-Exchange (ISX) using a developed method of feedforward Neural-Networks based on the Quasi-Newton optimization approach. The proposed method reduces the error factor depending on the Jacobian vector and Lagrange multiplier. This improvement has led to accelerating convergence during the learning process. A sample of companies listed on ISX was selected. This includes twenty-six banks for the years from 2010 to 2020. To evaluate the proposed model, the research findings are compared with …


Biosynthesis, Characterization And Antiproliferative Activity Of Green Synthesized Gold Nanoparticles Using Lantadene A Extracted From Lantana Camara, Dawood Ali Salim Dawood, Lee Suan Chua Ph.D, Tian Swee Tan Ph.D, Ahmed F. Alshemary Ph.D Dec 2021

Biosynthesis, Characterization And Antiproliferative Activity Of Green Synthesized Gold Nanoparticles Using Lantadene A Extracted From Lantana Camara, Dawood Ali Salim Dawood, Lee Suan Chua Ph.D, Tian Swee Tan Ph.D, Ahmed F. Alshemary Ph.D

Karbala International Journal of Modern Science

This study was focused on the biosynthesis of gold nanoparticles loaded with lantadene A (LA-AuNPs) from Lantana camara extract and the antiproliferative effects on prostate cancer cells (LNCaP). The synthesized LA-AuNPs had smooth surface, and nearly spherical in shape (67.94 nm) with the zeta potential (-30.11±0.83 mV). LAAuNPs showed a dose dependent cytotoxic activity with IC50, 126.82 µg/mL against LNCaP, but non-cytotoxic to normal prostate cells. The intrinsic pathway of apoptosis was caused by the increase of caspases-3/7 and -9 activity and cell cycle arrest at the G0/G1 phase. Therefore, LA-AuNPs could be a potent lead to inhibit LNCaP