Digital Commons Network^™

Hedgehog-Interacting Protein Is A Multimodal Antagonist Of Hedgehog Signalling, Samuel C Griffiths, Rebekka A Schwab, Kamel El Omari, Benjamin Bishop, Ellen J Iverson, Tomas Malinauskas, Ramin Dubey, Mingxing Qian, Douglas F Covey, Robert J C Gilbert, Rajat Rohatgi, Christian Siebold

Open Access Publications

Hedgehog (HH) morphogen signalling, crucial for cell growth and tissue patterning in animals, is initiated by the binding of dually lipidated HH ligands to cell surface receptors. Hedgehog-Interacting Protein (HHIP), the only reported secreted inhibitor of Sonic Hedgehog (SHH) signalling, binds directly to SHH with high nanomolar affinity, sequestering SHH. Here, we report the structure of the HHIP N-terminal domain (HHIP-N) in complex with a glycosaminoglycan (GAG). HHIP-N displays a unique bipartite fold with a GAG-binding domain alongside a Cysteine Rich Domain (CRD). We show that HHIP-N is required to convey full HHIP inhibitory function, likely by interacting with the …

Lyl-1 Regulates Primitive Macrophages And Microglia Development, Shoutang Wang, Deshan Ren, Brahim Arkoun, Anna-Lila Kaushik, Gabriel Matherat, Yann Lécluse, Dominik Filipp, William Vainchenker, Hana Raslova, Isabelle Plo, Isabelle Godin

Open Access Publications

During ontogeny, macrophage populations emerge in the Yolk Sac (YS) via two distinct progenitor waves, prior to hematopoietic stem cell development. Macrophage progenitors from the primitive/"early EMP" and transient-definitive/"late EMP" waves both contribute to various resident primitive macrophage populations in the developing embryonic organs. Identifying factors that modulates early stages of macrophage progenitor development may lead to a better understanding of defective function of specific resident macrophage subsets. Here we show that YS primitive macrophage progenitors express Lyl-1, a bHLH transcription factor related to SCL/Tal-1. Transcriptomic analysis of YS macrophage progenitors indicate that primitive macrophage progenitors present at embryonic day …

Hospital Survey On Culture Of Transitions In Patient Care At A Community Hospital, Gwen Burley, Victoria Y. Mccue, Dawn Kressly, Ronye Kreiner

Nursing & Health Sciences Research Journal

Background: Delays in patient transitions of care are complex and, therefore, a reductionist model of improvement is not likely to produce sustainable results. Exploration of the culture-performance link in the organization has the potential to guide improvement methods aimed at complex, non-linear processes.

Methods: An exploratory, descriptive correlational study was conducted employing the administration of the Hospital Culture of Transitions in Patient Care survey to a cross sectional convenience sample.

Results: Sixty-three participants responded to the survey. In assigning a grade to transitions in the organization, 35% of participants selected a grade of “A” with 33.3% “B”, …

Montana Kaimin, December 9, 2021, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

The Grizzly, December 9, 2021, Layla Halterman, Morgan Mason, Cici Chagnon, Brooke Hurley, Mike Johnston, Katie Cressman, Kathy Logan, Alessandra Armour

Ursinus College Grizzly Newspaper, 1978 to Present

Bears Walk for Project Healing Hive • Basement Fire in BWC • Phi Psi Fundraiser Gets Messy • Senior Spotlight: Zenya Yanoff • Meet Connor Donovan • Opinions: First Year Check In; Chem Night Exams • Leaving a Player, Returning a Coach • Men and Women's BB Recap

The Rusty Butler Archive: Revelations Of Cultural Repression During The Brazilian Military Dictatorship, Calla J. C. Knapp

Theses and Dissertations

The twenty-one years of military dictatorship in Brazil were marked by severe repression as government censors controlled every aspect of the media and artistic production. During these tense years from 1964 to 1985, many journalists, academics, writers, and artists struggled to voice their opposition to oppressive military control. In this same period, many playwrights turned to protest theater as a way to speak out against the dictatorship's abuses. Unsurprisingly, some of the plays produced at this time were heavily censored or shut down. In the late 1960s and early 1970s, a young Brazilianist scholar, Ross "Rusty" Butler, befriended, interviewed, and …

Artifact, Durotimi A. Akinkugbe

Theses

Artifact is a 3D animated short film following the journey of a mysterious metal, altered by time and human interaction across several millennia. The titular artifact first arrives on a barren prehistoric Earth as the remains of a meteorite impact, a rock glistening with metallic ore. The epoch passes as the natural world comes to life, vegetation growing at the site of the crater. The ore-rock, having remained untouched all these years, is finally found by an early human. It is attached to a stick, forming a primitive hammer. After some use, the hammer breaks, and the ore is smelted, …

School Of Culinary Arts & Food Technology – Winter Newsletter 2021, James Murphy

Other resources

The School of Culinary Arts and Food Technology, TU Dublin, Winter Newsletter captured the many events, research, awards, significant contributions, special civic, community and sustainability activities which the students and staff members of the school have successfully completed up to the Winter period of 2021. The successful completion of these activities would not be possible without the active and on-going support of the 'INSPIRED' friends of Culinary Arts (school supporters) and our school's industry association supporters. We thank you all, consider getting involved in our New Campus (Central Quad, Grangegorman, Dublin 7). Take care and stay safe !!

University Of Northern Iowa Graduate Council Minutes, December 9, 2021, University Of Northern Iowa. Graduate Council.

Documents - Graduate Council

Meeting minutes from the Graduate Council of the University of Northern Iowa.

Regenerative Responses Of Rabbit Corneal Endothelial Cells To Stimulation By Fibroblast Growth Factor 1 (Fgf1) Derivatives, Tthx1001 And Tthx1114, Jessica Weant, David D Eveleth, Amuthakannan Subramaniam, Jennifer Jenkins-Eveleth, Michael Blaber, Ling Li, David M Ornitz, Asaf Alimardanov, Trevor Broadt, Hui Dong, Vinay Vyas, Xiaoyi Yang, Ralph A Bradshaw

Open Access Publications

Utilising rabbit corneal endothelial cells (CEC) in three different paradigms, two human FGF1 derivatives (TTHX1001 and TTHX1114), engineered to exhibit greater stability, were tested as proliferative agents. Primary CECs and mouse NIH 3T3 cells treated with the two FGF1 derivatives showed equivalent EC

“Condemned To Be Free:” The Dilemmas Of Canadian Civilians In Japanese-Occupied Hong Kong, Brian Edgar

Canadian Military History

Enemy occupation after military defeat is generally seen as a situation in which the defeated are deprived of choices. This is obviously correct, but it is also true that they are sometimes faced with dilemmas harsher and more significant than those of peacetime. The study of the experience of Canadian civilians during the Japanese occupation of Hong Kong casts light on some of these dilemmas. This article begins with an account of the Hong Kong Canadians on the eve of war, showing them to consist of two distinct but linked communities—the Chinese and the European. It goes on to describe …

Early Childhood Family Education: Language And Pre-Academic Skills For Latinx Dual Language Learners, Katherine B. Green, Robert A. Griffin, Chelsea T. Morris, Mary Alice Varga

Journal of English Learner Education

This study describes the effectiveness of an early childhood family education (ECFE) program built on a two-generation and strengths-based model to support dual language learners (DLLs) and their families. The researchers investigated the extent to which participation in the ECFE program influenced adult caregivers (n = 15) and the preschool-aged Latinx DLLs (n = 32) who participated, specifically regarding change related to the children’s language and literacy skills and pre-academic skills, families’ perceptions of their home literacy environments, caregivers’ perceptions of their own literacy skills, and caregivers’ actions regarding early literacy at home. Findings were robust and revealed …

Planning For Instruction Using A Language-Based Approach To Content Instruction For Multilingual Learners, Luciana C. De Oliveira, Destini Braxton, Jia Gui

Journal of English Learner Education

This article briefly describes a language-based approach to content instruction (LACI), an approach to content instruction for multilingual learners in general education classrooms that incorporates six Cs of support for scaffolding. The authors provide examples of classroom instruction by a fifth-grade teacher who used several elements of LACI in her instruction. A planning guide to assist implementation of these elements is proposed and concrete examples of how to plan for classroom instruction for multilingual learners are included.

Voices From The Sunshine State: Program And Policy Advocates, Ryan W. Pontier, Rosa Castro Feinberg, Arlene Costello

Journal of English Learner Education

As educators, we are engrossed in a world that pushes us to critically examine what is. Particularly in language education, we explore the various theories and practices involved in learning new language(s)—or expanding our linguistic repertoire, depending on your paradigmatic stance. No matter our position—whether it refers to our jobs or to an ideological stance—we are advocates. We are thus challenged to understand our diverse roles as advocates, which, as Foley and Valenzuela (2004) demonstrate, come in many forms.

We expand Staehr Fenner’s (2014) definition of advocacy—working for students’ equitable and excellent education by taking appropriate actions on their …

Unf Mascot Articles, University Of North Florida

Athletics Printed Materials

Compiled flyers and articles regarding the selection of a mascot for the University of North Florida.

A Halifax: The Story Of Mz 899, David J. Bercuson

Canadian Military History

We know a great deal about the Royal Air Force’s (RAF)’s bomber offensive. There is also an extensive library of autobiographies, memoirs and other primary sources telling the personal stories of a great many aircrew, some famous—such as Guy Gibson who led the Dam Busters Raid of 1943—and others not so famous—such as Howard Hewer’s In For a Penny, In for a Pound, the story of a young man who flew in Nos. 148 and 218 Squadrons of the RAF. But few of those works have focused on the aircrew of individual aircraft because of the dearth of primary source …

The Victors, Not The Vanquished: A Conversation With Hong Kong Veteran George Macdonell, Brad St.Croix

Canadian Military History

This article centres around a conversation the author had with Battle of Hong Kong veteran George MacDonell. Several questions were asked to gain insights about events related to the battle as MacDonell saw it and the years the Canadian prisoners of war spent in brutal Japanese captivity. MacDonell was also asked about his opinions on a variety of subjects. Ultimately, one of his greatest concerns is that the exploits of him and his comrades would be forgotten. This article is designed to bring attention to such a worry so that work can be done to ensure this does not happen.

Fun Behind The Wire?: Francis “Huck” O’Neill And The Canadian Pow Experience In Hong Kong, 1941-1945, Michael B. Pass

Canadian Military History

Many prior studies of Canadian POWs during the Pacific War have focused on the sadism and mistreatment of their Japanese jailors, helping to make this a dominant image of the conflict. This article moderates this view by discrediting the notion that Japanese soldiers were motivated by an omnipresent belief in “bushido,” as well as by studying newly discovered documents produced in captivity by Canadian Auxiliary Services Officer Francis O’Neill. It argues that Japanese conduct towards POWs was more variable than previously recognised and highlights moments of levity and fun as O’Neill and his fellow prisoners organised sporting events, games and …

Reappraising The Battle Of Hong Kong: Preliminary Observations From A Spatial History Project, Chi Man Kwong

Canadian Military History

This article summarises the author’s recent experience of revisiting the Battle of Hong Kong in 1941 through a spatial history project based on a critical reading of primary sources from Hong Kong, the United Kingdom, Canada and Japan. The spatial history approach allows the author to propose new observations about the operational and tactical dimensions of the battle, the experience of the Canadian forces, the performance of the Japanese forces and the reasons for the battle’s outcome, which was seemingly a foregone conclusion. This article also discusses some possible future research directions on the topic and outlines how these new …

Kalea, Brian Nicholson

Diamond Line Undergraduate Literary Magazine

Brian Nicholson is currently a Sophomore here at the University of Arkansas. He has a deep love for writing, fantasy, and storytelling in all its colors, which has largely been fed by my huge passion for Dungeons and Dragons. He is from Houston, Texas, and is a Political Science and English Major with a minor in Pre-Law, but I’m likely going to drop the Poli Sci and Pre Law and add on Literature and Creative Writing next semester!

Diamond Line - Fall 2021, Diamond Line Editors

Diamond Line Undergraduate Literary Magazine

No abstract provided.

Case Report Silver-Russell Syndrome: A Case Report Of Three Years Old Yemeni Boy, Mazin Ahmed Jawass, Hanan Saeed Bin Gouth

Hadhramout University Journal of Natural & Applied Sciences

Silver Russell Syndrome (SRS) is a rare condition. For diagnosis of SRS at least four of the following criteria should be present which are intrauterine growth retardation , postnatal growth retardation , preservation of occipitofrontal head circumference, classic facial phenotype (broad prominent forehead with small triangular face, small narrow chin and low set ears) and body asymmetry. There is no data about cases of SRS reported in Yemen. We present a three years old Yemeni boy with SRS. He is the first child of Yemeni consanguineous parent‟s average length. He is born following normal pregnancy. The boy fulfilled the criteria …

Changes In Intraocular Pressure After Hemodialysis At Hemodialysis Center Al Gamhoria Teaching Hospital, Aden, Sawsan Fuad Mohamed, Abeer Ahmed Ba Abbad, Seena Abdulla Yousuf

Hadhramout University Journal of Natural & Applied Sciences

The relationship between intraocular pressure (IOP) changes and haemodialysis (HD) has been evaluated for more than 50 years, the reported findings are variable.The aim of the study is to evaluate the changes in IOP after HD.Ninety patients (180 eyes) undergoing HD with chronic renal failure were enrolled. Measurement of IOP was taken before and approximately 5 minutes after ending HD . Demographic data, causes of the chronic renal failure, duration of HD, and medical history of eye state were recorded. The mean age of the patients was 40.8 ± 14.1 years. The mean pre-dialysis IOP was 14.538 ± 3.66 mm …

Case Report Intramedullary Epidermoid Cyst: A Rare Intraspinal Tumor, Abdulkhaleq Ayedh Bin Nuhaid, Wadea Saeed Bin Ghouth

Hadhramout University Journal of Natural & Applied Sciences

We adduce this case of a very rare intraspinal tumor, an intramedullary epidermoid cyst in a male child of a 3 yearold, which is also a rare age presentation. This tumor was diagnosed through spine magnetic resonance imaging(MRI) examination. The child presented with spastic paraparesis of about three months’ duration. The child was set for spine computed tomographic(CT) scan examination (prior to the MRI study) that failed to detect the lesion well, leading to delay of correct management. MRI should be carried out directly as the investigation of first choice whenever spinal lesion questionable in non-informative CT scan study. In …

Color Doppler Ultrasonographic Evaluation Of Varicocele: Best Position And Site For Improving Maximal Vein Diameter Measurement, Jamal Omer Bahabara, Wadea Saeed Bin Ghouth

Hadhramout University Journal of Natural & Applied Sciences

The purpose of this study is to identify the best position and site for color Doppler ultrasonography evaluation of testicular vein to obtain optimal diameter measurement. Over the first six months of the year 2017, eighty nine patients aged 22-48 years who proved to have varicocele were included in the study. Color Doppler sonography was performed using a 7.5 MHz linear-array transducer, and the diameter of the largest testicular vein at three different sites was measured in both supine and standing positions with and without Valsalva maneuver. Patients' varicoceles were graded according to the supine-rest maximum vein diameter into: Grade …

Evaluation Of Blood Transfusion Practice At University Of Science & Technology Hospital, Yemen, Noor Abdull-Aziz Bin Kroom

Hadhramout University Journal of Natural & Applied Sciences

Blood transfusion is a vital part of the health care system. The accrediting and regulatory agencies make essential policies and guidelines for its transfusion process. The study aimed to evaluate blood transfusion practice specifically its indications at the University of Science and Technology (UST) Hospital in Sana‟a, Yemen to improve this service. This was a retrospective descriptive study. A total of 200 files (100 donors, 100 recipients) were reviewed during the study period from January to December 2013. The sample was selected using simple random technique and the size was determined as a rule of thumb. Data was collected in …

Ultrasonographic Evaluation Of Acute Pelvic Pain In Female Patients, Jamal Omer Bahabara, Wadea Saeed Bin Ghouth, Abdulkhaleq Ayedh Bin Nuhaid

Hadhramout University Journal of Natural & Applied Sciences

Acute pelvic pain is a common emergency presentation among female patients. This study was done to identify its' common causes and sonographic patterns in our local community. From June 2011 to December 2016, 94 female patients from Hadramout, Shabwa and Almahra governorates, aged between 13 and 45 years, who referred to Bahabara radiology center in Mukalla complaining of acute pelvic pain, were examined and evaluated using sonography with a deep frequency transducer (3.5-5 MHz). Their age groups and resulting sonographic findings were recorded and classified accordingly. The results showed that eighteen patients (19.15%) had negative or normal ultrasound results, while …

Benign Skin And Conjunctivalnevus Versus Malignant Melanoma: Clinicpathological Study Of 83 Cases In Aden, Saleh Salman Ba-Saleh, Mazen Abood Bin Thabit

Hadhramout University Journal of Natural & Applied Sciences

The study aimed to provide basic information of skin &conjunctival nevi and melanoma in Aden. The study was a retrospective review of patients’ records and the data were analyzed through descriptive statistics. Of the 83 patients studied 32 (38.6%) were males and 51 (61.4%) were females.Patients ranged in age from 3 years to 70 years. The most frequent age range was 20 to 39 years 30 (36.2%) patients. The benign nevi lesions were 68 (81.9%) while malignant consists of 15(18.1%) patients.The site of lesions were predominant on skin with 65 (78.3%) followed by conjunctiva 18 (21.7%). Nevi lesions on face …

The Role Of African Proverbs In Advancing Information Systems Research, Tiko Iyamu

The African Journal of Information Systems

Despite the richness of African proverbs, they have been muted in information systems (IS) research. This explicitly contributes to the lag in developing information systems and technology solutions for African people by African researchers in African terms. It is on this basis that two related objectives were formulated: (1) to examine the role which African proverbs can play in further advancing IS research, and (2) to understand how the concept can be employed to indigenize IS research. Qualitative data were collected from different sources, and the dimension of social change from structuration theory was employed to examine the role African …

We Are ... Marshall, December 8, 2021, Office Of Marshall University Communicatiions

We Are ... Marshall: the Newsletter for Marshall University 1999-2023

No abstract provided.