Digital Commons Network^™

Enabling Technologies For Medicinal Chemistry And Synthesis: I. Cannabinoids; Ii. Illudalic Acid; Iii. Microwave Chemistry, Harvey Fulo

Graduate Theses, Dissertations, and Problem Reports (ETD)

Innovations in synthetic organic chemistry such as methodology improvements, new chemical transformations and technology development significantly impact medicinal chemistry and continue to drive the drug discovery process. Here, new cyclization strategies to the pharmaceutically underexplored 3,3-dimethylcyclopentane-fused aromatic rings are described. One approach highlighted oxidative cycloisomerization, intermolecular [2+2+2] cyclotrimerization and 5-exo-dig cyclization providing indanoylindole cannabinoids that possess high affinity for human CB₂ receptors at nanomolar concentration and good selectivity index. Another featured a [4+2]-type benzannulation reaction which enabled the 5-step synthesis of illudalic acid — compared to the current available sequences (≥16 steps) — and its equipotent and LAR-selective analogs. …

Gendered Use Of Language In Facebook Status Updates Among Jordanian And American Youths: A Sociopragmatic Study, Ashraf Wenas Al Sad

Graduate Theses, Dissertations, and Problem Reports (ETD)

The study examines the types of speech acts of Facebook status updates that are posted by Jordanian and American youth. The participants were from Yarmouk University which is located in northern Jordan and from West Virginia University which is located in the US. The data was elicited from 50 American males, 50 American females, 50 Jordanian males, and 50 Jordanian females. Searle’s taxonomy was used to do the content analysis of the data. Searle’s taxonomy and additional speech acts were found: directive, expressive, assertive, God’s invocation, humor, and quotation. The findings of the study indicate that the religious and cultural …

Examining Changes In Learning And Engagement Of Higher Education Students In A Fully Online Flipped Learning Distance Education Classroom, James David Riel

Graduate Theses, Dissertations, and Problem Reports (ETD)

The challenge of implementing effective online distance education courses for academics and institutions is a centuries-old task. We can look across early developments in the 18^th century with the creation and delivery of correspondence courses; into the 20^th century with teaching and learning across analog methods such as audio and video; and now in the current era of digitized mechanisms that enable the online classroom. This includes advances in internet technologies and computing abilities that are the empowering the backbone processes, bridging connectivity between the student and the instructor. As society has trended toward massive increases in online …

Analysis Of Cell Signaling Perturbations In Response To Chronic Localized Infections, Amber Nicole Prince

Graduate Theses, Dissertations, and Problem Reports (ETD)

The tissue-level response to pathogens involves an intricate series of signal transduction events, influenced by immune and healing mediators that alert the host to danger and eliminate the infection. Disruptions to normal signaling events can compromise the host’s ability to respond and lead to the development of chronic infections that cannot be resolved without clinical intervention. Prolonged inflammation due to chronic infection can damage tissues and compromise healing processes, thus, the interactions of immune and healing mediators in signaling cascades are intimately linked to tissue health outcomes. Studying signaling networks relevant to these responses provided a more thorough understanding of …

An Examination Of The Start Now Dialectical Behavior Therapy-Based Intervention Plus A Behavioral Level System On Male Inmate Misbehavior, Aggressive Behavior, And Mental Health, Victoria Disciullo

Graduate Theses, Dissertations, and Problem Reports (ETD)

The purpose of this study was to evaluate the impact of the START NOW program + behavioral level system (BLS) in a self-contained therapeutic community (SCTC) on inmate misbehavior at a correctional facility in a southern state. The SCTC includes the START NOW manualized mental health treatment, recreation groups, process groups as needed, and additional positive reinforcement to target inmate prosocial behavior (i.e., level system to obtain privileges). Inmate data was evaluated at 3-months pre-START NOW intervention and 3-months post-START NOW intervention to determine if there were differences in the number of referrals to mental health services for misbehavior, write-ups …

Population Genetics Of A Reintroduced Fisher (Pekania Pennanti) Population In West Virginia, Caroline E. Harms

Graduate Theses, Dissertations, and Problem Reports (ETD)

Fishers (Pekania pennanti) were reintroduced in West Virginia in 1969 with no population wide genetic analysis ever having been conducted. Genetic analysis of reintroduced populations is vital to assess genetic diversity as an indicative of population viability. My objective was to collect fisher samples throughout West Virginia, nearby states where fisher may be migrating (PA and NY), and the New Hampshire source population to provide a full genetic interpretation of the reintroduced West Virginia population. Genetic analysis was used to measure genetic diversity, admixture or delineation of subpopulations, and effective population size. Sample location and genetic data were …

Behind The Lens: How Women Photojournalists’ Experiences Are Impacted By Gendered Double Standards And Emotion Management On The Sidelines Of The National Football League, Caylie M. Silveira

Graduate Theses, Dissertations, and Problem Reports (ETD)

Women photojournalists working on the sidelines for the National Football League (NFL) are scarce, despite many advancements made by women in sports media. In the workplace, women face double standards and are expected to manage their emotions differently than their male colleagues. This study aimed to analyze the expectations of women by looking at the different stereotypes and biases that they face as well as the gendered wage gaps. Feminist standpoint theory assisted in the qualitative research approach of this study because it states that women are the only ones that can speak about their experiences since they are the …

Perceptions And Instructional Practices Used By West Virginian Secondary Agricultural Teachers In Meat Science Education, Kindra D. Carr

Graduate Theses, Dissertations, and Problem Reports (ETD)

A focus on classroom integration of science, technology, engineering, and math (STEM) concepts has resulted in secondary teachers broadening the scope and delivery of STEM principles in their classes. Because agriculture classes allow students to convert abstract ideas into concrete ideas, they provide a useful setting to teach STEM concepts. Using secondary agricultural classes to teach science is effective and has contributed to higher standardized science test scores, as opposed to a science class alone. West Virginia is known for meat processing facilities and meat technology learning activities in its public schools. However, little is known about how the content …

Sustainability Key Performance Indicators For Mass Customization, Md Fahid Hasan Pulak

Graduate Theses, Dissertations, and Problem Reports (ETD)

Today’s manufacturers are striving towards a more sustainable and customized product offering in their value chain to satisfy customer demand and compete on the marketplace. By adopting sustainability practices, companies are not only complying with environmental regulations but are strategically addressing the triple bottom line (TBL) of sustainability (environmental, social, and economic). Similarly, mass customization allows a company to better satisfy their customers by creating individualized products economically. Moving forward, it is important to better understand the relationship of these two competitive strategies. In order to assess the sustainability performance of mass customization, it is important to understand the appropriate …

Level Of Adoption Of West Virginia Agriculture Teachers' Usage Of Internet-Based Educational Technology In The Classroom, Travis Daniel Veach

Graduate Theses, Dissertations, and Problem Reports (ETD)

The purpose of this study was to determine the level of adoption of West Virginia agricultural educators’ usage of internet-based educational technology for instruction. The population for this study included 103 educators during the 2020-2021 school year. The study yielded thirty-two responses from the population. Respondents indicated they use internet-based educational technology for their classroom instruction. Respondents indicated they use internet-based educational technology in a variety of different ways for instruction. Respondents adopted internet-based educational technology at varying degrees depending on the technology, some respondents being early adopters, and others later adopters.

Enacting Sustainability In Footwear Product Development, Mary Samantha Hale

Graduate Theses, Dissertations, and Problem Reports (ETD)

The apparel and footwear industry's negative environmental impacts have companies facing scrutiny as consumer environmental consciousness increases (Brewer, 2019). Apparel and footwear companies are scrambling to develop sustainable initiatives with more consumers demanding they be held accountable for their actions. The industry has focused on recycling, raw materials sourcing, and reducing production waste during product development for more sustainable outcomes. This qualitative case study explores how sustainability as an abstract corporate initiative affects footwear companies and product development processes. The best way to explore how companies engage and execute sustainable practices in their product development process is by examining it …

Evaluating Social Media As A Medium Of Private Communication Through Steganographic Images, Kendall Weldon Coles

Graduate Theses, Dissertations, and Problem Reports (ETD)

Social media is a vastly used communication tool with billions of users worldwide. These social networks provide users the ability to share their ideas and thoughts through the messages, videos, and images that they post. The images that are shared can possibly be embedded with private messages through the use of a steganographic tool. The messages are embedded in a fashion that doesn’t change the visual appearance of an image. This allows for these types of images to hide in plain sight, which creates the possibility of someone communicating privately in a public social media setting. This project proved how …

Iot Malicious Traffic Classification Using Machine Learning, Michael Austin

Graduate Theses, Dissertations, and Problem Reports (ETD)

Although desktops and laptops have historically composed the bulk of botnet nodes, Internet of Things (IoT) devices have become more recent targets. Lightbulbs, outdoor cameras, watches, and many other small items are connected to WiFi and each other; and few have well-developed security or hardening. Research on botnets typically leverages honeypots, PCAPs, and network traffic analysis tools to develop detection models. The research questions addressed in this Problem Report are: (1) What machine learning algorithm performs the best in a binary classification task for a representative dataset of malicious and benign IoT traffic; and (2) What features have the most …

Development Of Collision Resilient Drone For Flying In Cluttered Environment, Al Mahmud

Graduate Theses, Dissertations, and Problem Reports (ETD)

The use of multi-rotor aerial vehicles, also known as drones, has increased significantly in the last decade due to their ease of use and applicability to an extended range of functions. Therefore, the importance of making these vehicles safe, for both themselves and the people around them, has also increased. A clear solution to this problem is the development of algorithms that generate collision-free paths using different sensors. However, even with such onboard computation, avoiding a collision is not always possible. Thus, the use of a protective structure (cage) around the aerial vehicle is a solution to keep it safe …

Deep Models For Improving The Performance And Reliability Of Person Recognition, Sobhan Soleymani

Graduate Theses, Dissertations, and Problem Reports (ETD)

Deep models have provided high accuracy for different applications such as person recognition, image segmentation, image captioning, scene description, and action recognition. In this dissertation, we study the deep learning models and their application in improving the performance and reliability of person recognition. This dissertation focuses on five aspects of person recognition: (1) multimodal person recognition, (2) quality-aware multi-sample person recognition, (3) text-independent speaker verification, (4) adversarial iris examples, and (5) morphed face images. First, we discuss the application of multimodal networks consisting of face, iris, fingerprint, and speech modalities in person recognition. We propose multi-stream convolutional neural network architectures …

Climatic Drivers Of Growth In Mixed Conifer Forests Of The Sierra Nevada For Different Tree Sizes And Thinning Treatments, Andrew M. Hirsch

Graduate Theses, Dissertations, and Problem Reports (ETD)

The Mediterranean region of northern California is projected to get increasingly warmer under all Intergovernmental Panel on Climate Change (IPCC) emission scenarios, with future precipitation projections not showing much of a trend. This poses a problem to the already dry summers that are experienced in the Mediterranean region of California. If precipitation does not increase alongside temperatures, the dry seasons will likely only get drier. The use of dendroclimatology to assess how mixed conifer species in the Sierra Nevada responded to past climate is a key resource that can be used to infer how trees may respond to a future …

Adolescents' Production Of Clausal Structures In Written Narrative, Expository, And Persuasive Genres, Lauren Elizabeth Myers

Graduate Theses, Dissertations, and Problem Reports (ETD)

The aim of this study was to analyze written language samples across different genres and age groups to provide information about the production of complex syntax emergence as time progresses across tasks. Complex syntax is both a socially and academically relevant language skill that is observed to advance well into later life. In order to analyze language samples as a way to identify language abilities, we must first understand syntactic emergence across genres with adolescents who are identified as having typical language development. In this study, written narrative, expository, and persuasive language samples were elicited from sixty typical adolescents in …

Application Of 3d Seismic Signal And Geomechanical Attributes For Subsurface Fracture Characterization: A Case Study In Clearfield County, Central Pennsylvania, Iman F. Zulkapeli

Graduate Theses, Dissertations, and Problem Reports (ETD)

Hydrocarbon exploration in unconventional reservoirs is highly risky due to the nature of the reservoirs and the variability in fractures and reservoir geomechanical properties in the subsurface. The reservoir needs to be fully characterized to avoid any complication such as frac hit, wellbore failure, blowout, or even a dry hole. The Clearfield reservoir produces an exceptionally low amount of gas, compared to the neighboring region in the proximity, which has been poorly understood. This raises the question as to what causes the reservoir to have low productivity.

This study focuses on the natural fracture characterization using high-quality 3D seismic signal …

Standby Lovers: A Typology And Theoretical Investigation Of Back Burner Relational Maintenance, Dana Borzea

Graduate Theses, Dissertations, and Problem Reports (ETD)

The purpose of this dissertation was to investigate the connections between relational maintenance behaviors, theoretical factors, and relational characteristics in back burner relationships. A back burner relationship involves at least one individual who is romantically or sexually interested in a target, but they are not currently involved with the target. Given that back burners maintain communication with each other with the possibility of becoming romantically or sexually involved in the future, Study 1 was concerned with inductively identifying the relational maintenance behaviors used in back burner relationships. Following prior typology methods, participants (N = 86) in Study 1 were …

When Face-To-Face Communication Fails: A Case Study Of Wvu Extension Agents Utilizing Innovative Social Media Practices, Madison Brooke Quinn

Graduate Theses, Dissertations, and Problem Reports (ETD)

An important aspect that contributes to the success of county Extension programs is relationships and collaborations with community members. This became a challenge when face-to-face communication was no longer possible as a response to the national pandemic that occurred due to COVID-19. In recent years, society has been increasing their reliability on social networking for communication (Diem et al., 2011). Social media played a central role in the diffusion of information in a variety of organizations and businesses during COVID-19 (Geol et al., 2020). The purpose of this study was to describe how WVU Extension Service is utilizing innovative social …

The Joyful Path Of Lifelong Mastery Of The Piano, John Alan Rose

Graduate Theses, Dissertations, and Problem Reports (ETD)

Designed to function as a handbook for pianists, this research project is written in a friendly manner. Organized by theme, it contains a multiplicity of approaches that pianists at all levels can apply to their daily piano practice to help deepen the meaning and efficacy of their work. No matter what role the piano plays in your life, there is much in this document that will help you find joy as you discover new things about yourself through practicing the piano. From methods of practice to philosophies by established performers, this project has enough material to be kept within arm’s …

Increasing The Reliability Of Software Systems On Small Satellites Using Software-Based Simulation Of The Embedded System, Matthew D. Grubb

Graduate Theses, Dissertations, and Problem Reports (ETD)

The utility of Small Satellites (SmallSats) for technology demonstrations and scientific research has been proven over the past few decades by governments, universities, and private companies. While the research and technology demonstration objectives that can be provided by these SmallSats are becoming similar to larger spacecraft, their reliability still falls behind. This is in part due to the reduced cost of SmallSat missions in comparison to large spacecraft, which requires cheaper components, rapid development schedules, and accepted risk. In these missions, the importance of the flight software is often overlooked, and the software is rushed through development and not fully …

Describing A Putative Corollary Discharge Circuit In Drosophila, Kaitlyn Nicole Boone

Graduate Theses, Dissertations, and Problem Reports (ETD)

Corollary discharge (CD) circuits provide critical information about movement and behavior to provide context to sensory processing. However, to date, there has not been a comprehensive study of CD circuits at a single-cell level. In this thesis, I aimed to resolve the connectivity of ascending histaminergic neurons, consisting of two pairs, the mesothoracic pair (MsAHNs) and metathoracic pair (MtAHNs) at a single-cell level and characterize contexts of activation. Using transgenic techniques, connectomics and transcriptomics, we identify neural populations receiving input from the AHNs and neural populations with significant output to the AHNs. We explored where the AHNs predominantly receive synaptic …

Erosion And Sediment Controls On Reclaimed Mine Refuse Impoundments, Sara Dalen

Graduate Theses, Dissertations, and Problem Reports (ETD)

To ensure the sustainable use of one of West Virginia’s precious resources, conscientious long-term management of residual waste is of immense importance. This thesis examined two main topics: i) the dewatering process of acid mine drainage (AMD) sludge, and ii) an investigation of soil loss predictions of a reclaimed coal refuse impoundment.

The first aspect of this thesis addresses clarification and remediation of AMD prior to disposal is a prominent component to preventing runoff and seepage of environmentally detrimental byproducts. To examine the effects of flocculation and dewatering more closely by means of geotextiles, an AMD sludge was analyzed. The …

#Canceled: Positionality And Authenticity In Country Music’S Cancel Culture, Gabriella Saporito

Graduate Theses, Dissertations, and Problem Reports (ETD)

From its beginning in film and television and its early adoption by Black Twitter, cancel culture has become a phenomenon in the era of social media. Marked by the popular hashtags #cancel, #canceled, #[InsertNameHere]isOverParty, and #Surviving[InsertNameHere], cancel culture is a practice which involves publicly denouncing and/or shaming a person or company when they do something that is considered offensive or objectionable. It saw a resurgence in the era of #MeToo that has not slowed down in an age dominated by social media presidents and global pandemics. Cancel culture has also seen a recent re-adoption by the political right, which begs …

Technical Direction Process For King Lear, Ashley Noel Hungerford

Graduate Theses, Dissertations, and Problem Reports (ETD)

This thesis is my account as the Technical Director of King Lear filmed at West Virginia University, College of Creative Arts, School of Theatre & Dance in collaboration with West Virginia Public Broadcasting. This production took place during the COVID-19 pandemic from September 2020 – March 2021. This document will take you through budgeting, drafting, build, load in, filming, and strike processes, including how COVID-19 affected these processes. This thesis is supported by images, schedules, drafting, and paperwork.

Causal Determinants Of College Success, Benjamin Blemings

Graduate Theses, Dissertations, and Problem Reports (ETD)

The first essay focuses on alcohol access in college, which is an impediment to many students' success. Alcohol sales to general seating at college football games has been broadly adopted despite results suggesting greater alcohol availability increases crime and college alcohol abuse. Using differences-in-differences, this paper estimates how allowing alcohol sales in college football general seating sections affects crime. Reductions in crime are found after sales are allowed. After sales begin, those under the age of 21 are still not legally permitted to purchase in-stadium alcohol, but are still affected by changes in other stadium policies or law enforcement strategies. …

Reframing: A Grounded Theory Study Of Postmenopausal Women Following Osteoporotic Fracture, Ashley D. Barber

Graduate Theses, Dissertations, and Problem Reports (ETD)

BACKGROUND: Osteoporosis is a chronic disease resulting in low bone mass and increased bone fragility. Most often seen in women age 65 and older, osteoporosis is usually diagnosed following osteoporotic fracture. Despite numerous treatment options many women continue to remain untreated for osteoporosis and are at increased risk for subsequent fractures and complications. PURPOSE: The initial purpose of this classic grounded theory study was to explore the decision-making process women aged 65 and older experience when considering osteoporosis treatment following osteoporotic fracture. Following the tenth participant interview the researcher discovered a new main concern that emerged from participant interviews. Participants …

Understanding The Variable Drivers Of Toxicity For The Broad Class Of Carbon Nanotubes And Nanofibers From U.S. Facilities, Kelly E. Fraser

Graduate Theses, Dissertations, and Problem Reports (ETD)

Pulmonary exposure to carbon nanotubes or nanofibers (CNT/F) is known to induce inflammation, toxicity, or tumorigenesis, and is a concern in the occupational setting. U. S. facility employees are at risk of inhalation exposure of multi-walled carbon nanotubes and carbon nanofibers during primary and secondary manufacturing. To date, only one MWCNT, Mitsui-7 has been classified as possibly carcinogenic to humans (Group 2B), while all other materials were subsequently categorized as unclassifiable (Group 3). This class of material has recently been listed as a high priority to the International Agency for Research on Cancer due to this significant knowledge gap. Furthermore, …

Three Essays On The Impact Of Cuteness On Consumer Behavior, Alexis Taeeun Yim

Graduate Theses, Dissertations, and Problem Reports (ETD)

Over the last decade, the world has seen a rise in the popularity of cute stimuli. Adorable baby pictures, fluffy puppy videos, and whimsical emojis seem ever-present in social media news feeds and friends’ posts. In addition, products marketed toward adults that feature cute characters drive sales worth billions of dollars. The growing presence of cute stimuli in our daily lives is accompanied by emerging research on their social and behavioral impacts. Correspondingly, the current dissertation consists of three essays that contribute to the literature on cuteness by empirically testing the impacts of cuteness in the marketplace. To extend the …