Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Physical Sciences and Mathematics (13)
- Chemistry (11)
- Medicine and Health Sciences (5)
- Biochemistry, Biophysics, and Structural Biology (4)
- Education (4)
-
- Life Sciences (4)
- Medical Sciences (4)
- Medical Specialties (4)
- Biology (3)
- Oncology (3)
- Diseases (2)
- Engineering (2)
- Environmental Chemistry (2)
- Environmental Sciences (2)
- Hematology (2)
- Hemic and Lymphatic Diseases (2)
- Oceanography and Atmospheric Sciences and Meteorology (2)
- Physical Chemistry (2)
- Science and Mathematics Education (2)
- Atmospheric Sciences (1)
- Biochemical Phenomena, Metabolism, and Nutrition (1)
- Biological Phenomena, Cell Phenomena, and Immunity (1)
- Civil and Environmental Engineering (1)
- Curriculum and Instruction (1)
- Dermatology (1)
- Earth Sciences (1)
- Environmental Engineering (1)
- Environmental Health and Protection (1)
- Environmental Monitoring (1)
- Environmental Public Health (1)
- Institution
-
- The Texas Medical Center Library (5)
- Portland State University (3)
- Binghamton University (1)
- Bucknell University (1)
- City University of New York (CUNY) (1)
-
- Duquesne University (1)
- Eastern Kentucky University (1)
- Georgia Southern University (1)
- Hope College (1)
- Kansas City University (1)
- Karbala International Journal of Modern Science (1)
- Kean University (1)
- Lynn University (1)
- Michigan Technological University (1)
- Minnesota State University Moorhead (1)
- New Jersey Institute of Technology (1)
- South Dakota State University (1)
- The University of San Francisco (1)
- Universitas Negeri Malang (1)
- University of Mississippi (1)
- University of Northern Iowa (1)
- University of South Florida (1)
- Utah State University (1)
- Virginia Commonwealth University (1)
- Washington University in St. Louis (1)
- Keyword
-
- Animals (3)
- Humans (3)
- Leukemia (3)
- Mice (3)
- Acute (2)
-
- Antiviral Agents (2)
- Cell Line (2)
- Chemistry (2)
- Chemistry -- Curriculum -- Assessment (2)
- Chemistry -- Study and teaching (Higher) -- Research (2)
- Fusion (2)
- Molecular Structure (2)
- Myeloid (2)
- Oncogene Proteins (2)
- Oncogene Proteins, Fusion (2)
- Serine Endopeptidases (2)
- Structure-Activity Relationship (2)
- Tumor (2)
- Viral Nonstructural Proteins (2)
- Zika Virus (2)
- 300-level (1)
- 40Ar/39Ar (1)
- AIM (1)
- AML (1)
- Accident Tolerant Fuel (1)
- Action research in education -- United States (1)
- Active learning (1)
- Activity-based (1)
- Adenosine Triphosphate (1)
- Administrative program review (1)
- Publication
-
- Faculty, Staff and Students Publications (5)
- Chemistry Faculty Publications and Presentations (3)
- Arts & Sciences Graduate Student Theses and Dissertations (1)
- Chemistry and Biochemistry Faculty Publications (1)
- Chemistry, Environmental and Forensic Science Syllabi (1)
-
- College of Graduate Studies: Theses & Dissertations (1)
- Dissertations, Master's Theses and Master's Reports (1)
- Dissertations, Theses, and Capstone Projects (1)
- Dissertations, Theses, and Projects (1)
- EKU Faculty and Staff Scholarship (1)
- Electronic Theses and Dissertations (1)
- Evidence Inventory (1)
- Faculty Journal Articles (1)
- Faculty and Staff Publications (1)
- Faculty and Staff Publications & Presentations (1)
- Graduate Research Papers (1)
- Jurnal Pendidikan Sains (1)
- KIP Articles (1)
- Karbala International Journal of Modern Science (1)
- Master's Theses (1)
- Newspaper Indexes (1)
- Theses and Dissertations (1)
- Undergraduate Honors Theses (1)
- Undergraduate Research and Scholarship Symposium (1)
- University of Mississippi News (1)
- Publication Type
Articles 31 - 31 of 31
Full-Text Articles in Entire DC Network
Small-Molecule Inhibitor Of Af9/Enl-Dot1l/Af4/Aff4 Interactions Suppresses Malignant Gene Expression And Tumor Grow, Fangrui Wu, Shenyou Nie, Yuan Yao, Tong Huo, Xin Li, Xiaowei Wu, Jidong Zhao, Yi-Lun Lin, Yinjie Zhang, Qianxing Mo, Yongcheng Song
Small-Molecule Inhibitor Of Af9/Enl-Dot1l/Af4/Aff4 Interactions Suppresses Malignant Gene Expression And Tumor Grow, Fangrui Wu, Shenyou Nie, Yuan Yao, Tong Huo, Xin Li, Xiaowei Wu, Jidong Zhao, Yi-Lun Lin, Yinjie Zhang, Qianxing Mo, Yongcheng Song
Faculty, Staff and Students Publications
Chromosome translocations involving mixed lineage leukemia (MLL) gene cause acute leukemia with a poor prognosis. MLL is frequently fused with transcription cofactors AF4 (~35%), AF9 (25%) or its paralog ENL (10%). The AHD domain of AF9/ENL binds to AF4, its paralog AFF4, or histone-H3 lysine-79 (H3K79) methyltransferase DOT1L. Formation of AF9/ENL/AF4/AFF4-containing super elongation complexes (SEC) and the catalytic activity of DOT1L are essential for MLL-rearranged leukemia. Protein-protein interactions (PPI) between AF9/ENL and DOT1L/AF4/AFF4 are therefore a potential drug target.
Methods: Compound screening followed by medicinal chemistry was used to find inhibitors of such PPIs, which were examined for their biological …