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Molecular Mechanisms Of Aberrant Protein Glycosylation In Pancreatic Cancer Stemness And Metastasis, Frank Leon

Theses & Dissertations

A myriad of genetic and other abnormal changes underlies the aggressiveness and dissemination properties observed in pancreatic cancer (PC). Aberrant protein glycosylation is a commonly observed feature in PC. The modification of protein O-glycosylation is mediated by glycosyltransferases, which attach and sequentially elongate monosaccharides on Serine/Threonine (Ser/Thr) motifs. Aberrant glycosylation is recognized as an emerging hallmark of cancer where a disruption in normal glycosylation results in irregular O-glycans.

This dissertation research has investigated the consequences of aberrant protein glycosylation on stemness and enhancement of metastatic properties in pancreatic ductal adenocarcinoma (PDAC). Several publications have reported aberrant O-glycosylation increases in oncogenic …

Design And Development Of A Mobile Health (Mhealth) Platform For Dementia Prevention In The Prevention Of Dementia By Mobile Phone Applications (Prodemos) Project, Melanie Hafdi, Esmé Eggink, Marieke P. Hoevenaar-Blom, M. Patrick Witvliet, Sandrine Andrieu, Linda Barnes, Carol Brayne, Rachael Brooks, Nicola Coley, Jean Georges, Abraham Van Der Groep, Harm Van Marwijk, Mark Van Der Meijden, Libin Song, Manshu Song, Youxin Wang, Wenzhi Wang, Wei Wang, Anders Wimo, Xiaoyan Ye, Eric P. Moll Van Charante, Edo Richard, Prodemos Consortium

Research outputs 2014 to 2021

Background:

Mobile health (mHealth) has the potential to bring preventive healthcare within reach of populations with limited access to preventive services, by delivering personalized support at low cost. Although numerous mHealth interventions are available, very few have been developed following an evidence-based rationale or have been tested for efficacy. This article describes the systematic development of a coach-supported mHealth application to improve healthy lifestyles for the prevention of dementia and cardiovascular disease in the United Kingdom (UK) and China.

Methods:

Development of the Prevention of Dementia by Mobile Phone applications (PRODEMOS) platform built upon the experiences with the Healthy Aging …

Paleoindian Response To Climate Change In The Northern Jornada Del Muerto, Christopher Wayne Merriman

Anthropology ETDs

Human-environment interaction is a long-standing and productive line of inquiry that includes the study of cultural responses to climate change. However, demonstrating a causal relationship between climate change and the consequent culture change is rarely straightforward for numerous reasons. In this dissertation I develop an optimality model to predict how Paleoindians should have responded to changes in precipitation across the Late Pleistocene-Early Holocene. The water supply model (WSM) ranks water supplies much like the diet breadth model ranks food resources. To adjust the WSM for climate change, paleoclimate records from playas in the northern Jornada del Muerto were used in …

Correlating Sentiment In Reddit’S Wallstreetbets With The Stock Market Using Machine Learning Techniques, Sultan Ali Alzaabi

Theses

The issue that this study addresses is to observe whether there exists a statistical relation between the stock market and Reddit’s wallstreetbets. Previous research mainly focused on the relation between the stock market and Twitter. To gather data for the study, comments were scrapped from the subreddit wallstreetbets for a period of four months, Jan 1, 2021, till April 30, 2021. Different sentiment classifiers were, then, applied on a sample of the data to observe the most accurate classifier for the study. The study concluded that the most accurate sentiment classifier was an SVM classifier trained on 80% of Reddit …

A New Criterion For Fluoroquinolone-Associated Disability Diagnosis: Functional Gastrointestinal Disorders, Deanna N. Cannizzaro, Lydia F. Naughton, Maya Z. Freeman, Linda Martin, Charles L. Bennett M.D., Ph.D., Cecilia Bove

Faculty Publications

Background and Objectives: Fluoroquinolones (FQs) are a broad-spectrum class of antibiotics routinely prescribed for common bacterial infections despite recent recommendations to use them only for life-threatening cases. In addition to their antimicrobial properties, FQs act in the central nervous system as GABAA receptor inhibitors, which could potentially affect functionality of the vagus nerve at the forefront of gastrointestinal (GI) tract function. Alterations in neural control of digestion have been shown to be linked to Functional Gastrointestinal Disorders (FGIDs), which are usually diagnosed based on self-reported symptoms. The aim of this study was to assess the incidence of FGIDs following FQ …

Stimming Expresses Empathy, Not To Be Masked Or Persecuted: A Scoping Review And Case Study Of The “Double-Empathy Problem” Solved By Recognizing The Autism Language, Kathryn Haas

Student Capstone Papers

This article critically examines autism and autistic stimming through the lenses of neurotypicals and autistics, evaluates confines currently imposed upon autistics by neurotypical society, and synthesizes what autistic leaders have expressed about their experiences striving for inclusion (Gernsbacher, 2017; Milton, 2012). Autistic-led studies are now at the forefront of the neurodiversity movement and are growing in fervor. The following themes were identified: (a) prevalence of autism, (b) the interpretation and measurement of empathy, (c) discovery of genetic factors transformed autistics’ identity, (d) publication of non-genetic factors such as vaccines undermined the legitimacy of the autism language, (e) the problem with …

Phage Commander, An Application For Rapid Gene Identification In Bacteriophage Genomes Using Multiple Programs, Matt Lazeriff, Geordie Ryder, Sarah L. Harris, Philippos K. Tsourkas

Computer Science Faculty Research

The number of sequenced bacteriophage genomes is growing at an exponential rate. The majority of sequenced bacteriophage genomes are annotated by one or more of several freely available gene identification programs (Glimmer, GeneMark, RAST, Prodigal, etc.). No program has been shown to consistently outperform the others; thus, the choice of which program to use is not obvious. We present the Phage Commander application for rapid identification of bacteriophage genes using multiple gene identification programs. Phage Commander runs a bacteriophage genome sequence through nine gene identification programs (and an additional program for identification of tRNAs) and integrates the results within a …

Female Puma (Puma Concolor) Highway Crossings In The Yucatan Peninsula, Carlos A. López González, Fernanda Cruz Torres, Mircea G. Hidalgo Mihart

Western North American Naturalist

Human infrastructure, particularly highway infrastructure, has proven to be a hazard for the resilience of large felid populations throughout the world. The Yucatan Peninsula is no exception and is presently confronted with the establishment of the “Tren Maya,” a continental railway that will reshape the road network of the peninsula. We describe 12 successful crossings of a 4-lane highway on the peninsula by a female puma (Puma concolor) fitted with a GPS radio-transmitter. The median time between sequential locations was 24 h (range 8–56 h), and the average number of days between crossings was 4.33 (SD = 2.50). …

Robotic Olfactory-Based Navigation With Mobile Robots, Lingxiao Wang

Doctoral Dissertations and Master's Theses

Robotic odor source localization (OSL) is a technology that enables mobile robots or autonomous vehicles to find an odor source in unknown environments. It has been viewed as challenging due to the turbulent nature of airflows and the resulting odor plume characteristics. The key to correctly finding an odor source is designing an effective olfactory-based navigation algorithm, which guides the robot to detect emitted odor plumes as cues in finding the source. This dissertation proposes three kinds of olfactory-based navigation methods to improve search efficiency while maintaining a low computational cost, incorporating different machine learning and artificial intelligence methods.

A. …

Climate Mitigation Through Biological Conservation: Extensive And Valuable Blue Carbon Natural Capital In Tristan Da Cunha’S Giant Marine Protected Zone, David K.A. Barnes, James B. Bell, Amelia E. Bridges, Louise Ireland, Kerry L. Howell, Stephanie M. Martin, Chester J. Sands, Soto A Mora, Terri Souster, Gareth Flint, Simon A. Morley

School of Biological and Marine Sciences

Carbon-rich habitats can provide powerful climate mitigation if meaningful protection is put in place. We attempted to quantify this around the Tristan da Cunha archipelago Marine Protected Area. Its shallows (<1000 m depth) are varied and productive. The 5.4 km2 of kelp stores ~60 tonnes of carbon (tC) and may export ~240 tC into surrounding depths. In deep-waters we analysed seabed data collected from three research cruises, including seabed mapping, camera imagery, seabed oceanography and benthic samples from mini-Agassiz trawl. Rich biological assemblages on seamounts significantly differed to the islands and carbon storage had complex drivers. We estimate ~2.3 million tC are stored in benthic biodiversity of waters <1000 m, which includes >0.22 million tC that can be sequestered (the proportion of the carbon captured that is expected to become buried in sediment or locked away in skeletal tissue for at least 100 years). Much of this carbon is captured by cold-water coral reefs as a mixture of inorganic (largely calcium carbonate) and organic compounds. As part of its 2020 Marine Protection Strategy, these deep-water reef systems are now protected by …

Family Planning And Its Limits, Dov Fox

The Journal of Contemporary Legal Issues

A doctor botches a vasectomy. Or says it’d be dangerous to keep a healthy pregnancy. Or misses a risk of passing along disease. Our laws do little to deter such reproductive negligence or compensate its victims. Some of this misconduct leaves people without the baby they desperately want. Other times, it foists on parents a child they’d set out to avoid. Or one with meaningfully different traits than what they were led to believe.

I call these three harms procreation deprived, procreation imposed, and procreation confounded.

Thousands of fertility patients were deprived of biological parenthood when their …

Pollinators On Green Roofs: Diversity And Trait Analysis Of Wild Bees (Hymenoptera: Anthophila) And Hoverflies (Diptera: Syrphidae) In An Urban Area (Geneva, Switzerland), Aurelia Passaseo, Sophie Rochefort, Gaël Pétremand, Emmanuel Castella

Cities and the Environment (CATE)

Green roofs can provide food resources to several insect groups. For pollinators found in cities, as are wild bees and hoverflies, the existence of a wide variety of green infrastructures is crucial to ensure their development and survival. In order to investigate if wild bees and hoverflies use green roofs and how local and landscape factors influence their abundance and diversity, sampling of these insects was done in 2017 using cornet traps on extensive green roofs of two types: 1) urban green roofs (30% of green spaces in a 200m radius). There were 62 wild bee species and 10 hoverfly …

Management Of Meadow Fescue Pasture For High-Producing Dairy Cows In Northern Japan, K. Sudo, K. Ochiai, T. Ikeda

IGC Proceedings (1977-2023)

The objective of this study was to establish an intensive grazing system of meadow fescue (Festuca elatior L.) pasture for high-producing dairy cows in some areas of Japan where soil freezes in winter. Plant succession of meadow fescue pastures that had been grazed at different plant heights and milk production from cows grazed on meadow fescue pasture compared to that from cows grazed on perennial ryegrass pasture were surveyed over a five year period. Succession of meadow fescue pasture depended on the management of plant height before grazing use. Milk production from cows grazed on meadow fescue pasture was …

Leaf Blade Selection By Sheep In Kleingrass (Panicum Coloratum L.) Pastures With Different Deferment Periods, P. Sierra, M. S. Cid, M. A. Brizuela, C. M. Ferri

IGC Proceedings (1977-2023)

The winter use of standing dead biomass produced by warm season grasses during the previous growing season may be an alternative to grazing systems in the semi-arid Pampean Region of Argentina. This study evaluated: 1) the effect of different deferment periods on the leaf blade percentage and quality of ‘kleingrass’ (Panicum coloratum L.), a warm season specie recently introduced to that region, and 2) whether rams grazing the vegetation accumulated during these different periods are able to select leaf blades to maintain the quality of their diets. It was generated three treatments by deferment of the forage produced after …

Microhistological Estimation Of Leaf Blade Percentage In Diets From Monoespecific Pastures, P. Sierra, M. S. Cid, M. A. Brizuela, C. M. Ferri

IGC Proceedings (1977-2023)

Although a decrease in the leaf-stem ratio affects the nutritive value of pastures, herbivores can reinforce selection for leaf blades to maintain the quality of their diets. This study evaluated whether the percentage of fragments with furrows in blades could be used to estimate the relative intake of this part of the leaves by herbivores grazing monoespecific pastures. It was worked with vegetation of kleingrass (Panicum coloratum L.) from paddocks with three deferment periods. Blade samples, and different plant part mixtures hand compounded were in vitro digested. The digestion residues were microhistological analyzed determining the number of fragment with …

Evaluation Of Kentucky Bluegrass (Poa Pratensis L.) For Creating Sustainable Grazing Swards In Hokkaido, T. Saigusa, S. Tejima, Y. Ogawa, S. Takahashi

IGC Proceedings (1977-2023)

Kentucky bluegrass (Poa pratensis L.) is generally considered to be a weed in the meadows of Hokkaido. However, a revaluation of this species should be undertaken in terms of its useful characteristics for labor-saving management on farms in marginal areas. The performance of steers (Holstein-Friesian) and botanical composition of Kentucky bluegrass swards were investigated under the stocking methods of set and rotational grazing and compared with timothy (Phleum pratense L.) swards. Kentucky bluegrass was stable over the grazing season under both methods, although timothy decreased rapidly. The average daily gain of steers raised on Kentucky bluegrass swards was …

Accuracy Of Routine 2d Echocardiography To Estimate Pda Type And Dimension And Predict Device Selection For Successful Pda Occlusion, Mohammed Omar Galal, Zaheer Ahmed, Arif Hussain, Masroor Sharfi, Yahia El Mahdi, Fayzah El Khattab, Amjad Alkouatli, Riad Abou Zahr

Journal of the Saudi Heart Association

Background: Assessment of the shape and dimensions of PDA is usually done angiographically and in the majority of cases need arterial access. Our aim was to evaluate the value of routine 2 D echocardiography (ECHO) in predicting type, dimensions of PDA and to anticipate device size to be used during the intervention. Material and Methods: The charts of all patients who underwent transcatheter closure of PDA between January 2015 and December 2020 were reviewed. Their pre-procedure ECHO and catheterization details at the time of device closure were analyzed. Results: Total of 139 patients were reviewed and 8 were excluded because …

More Than Just Cataloging, In Three Acts: Reflections, Adrian Applin, Regina Carra, Sarah Nguyen

Urban Library Journal

This article contains proceedings from a performance-presentation at the 2021 LACUNY Institute called “More Than Just Cataloging, In Three Acts.” It features three performing artist-librarians, showcasing dance, music, and theatre while reflecting on connections between the performing arts and the information professions. Accompanying performance footage shared at the Institute is referenced in this article.

Take That Covid! Positive Documents Emerging From The Museum Sector, Kiersten F. Latham, Katherine F. Jaede

Proceedings from the Document Academy

Although the field of museology has discussed many concepts found in other positive disciplines, such as flow in positive psychology, the field itself has not yet developed a purposeful framework for positive museology. A long history of research in museum studies and on museal endeavors reveals aspects of a positive approach already exist but have yet to be woven together into a synthetic whole. In 2020-2021, during the COVID-19 pandemic, museums themselves showed their positive strengths and virtues through documents such as social media and field-wide communication, revealing their capacity for a positive approach. This paper uses a developing framework …

A Nation In Crisis... In Three Acts, William D. Senn

Proceedings from the Document Academy

A dramatic, spoken-word performance based on a detailed examination of the text of more than 1.7 million tweets concerning coronavirus and covid that were sent during the hours surrounding the president's declaration of emergency on March 13, 2020 including the transcript of the remarks made at the Rose Garden press conference. The researcher used the Twitter JSON API to retrieve all of the tweets containing the search terms "covid" and "corona" occurring during the timeframe. A text analysis was performed to identify the most frequently occurring n-grams present in the corpus of tweets. Thematic analysis and sentiment analysis were used …

Modeling Deception: A Case Study Of Email Phishing, Abdullah Almoqbil, Brian C. O'Connor, Richard Anderson, Jibril Shittu, Patrick Mcleod

Proceedings from the Document Academy

Information manipulation for deception continues to evolve at a remarkable rate. Artificial intelligence has greatly reduced the burden of combing through documents for evidence of manipulation; but it has also enabled the development of clever modes of deception.

In this study, we modeled deception attacks by examining phishing emails that successfully evaded detection by the Microsoft 365 filtering system. The sample population selected for this study was the University of North Texas students, faculty, staff, alumni and retirees who maintain their university email accounts. The model explains why certain individuals and organizations are selected as targets, and identifies potential counter …

Emergence: Documents In Crisis, Wayne De Fremery

Proceedings from the Document Academy

This essay suggests the etymologies of emergence, emergency, and crisis create a useful framework for theorizing documents. Indeed, the overlapping semantic associations of the words allow for the idea that documents emerge in crisis. The semantic overlap also allows a means for theorizing how documents descend into crisis. Theorizing documents in crisis, the essay argues, usefully complements documentalist theories of documentary representation suggested by thinkers like Paul Otlet and Suzanne Briet, as well newer conceptualizations of documentality as conceived by Michael Buckland and Maurizio Ferraris and documentarity as described by Ronald Day.

Bringing Political Upheaval And Cultural Trauma Into Order: A Document-Theoretical Approach To The Social Significance Of Bibliographic Classification Systems, Joacim Hansson

Proceedings from the Document Academy

This paper explores the ability to define bibliographic classification systems as socially significant documents in a way that goes beyond their immediate function in the information retrieval process. It does so in dialog with theory on documents and documentality, and knowledge organization theory. Two examples show how development of new classification systems address social and cultural structures in periods of rapid social and cultural change and crisis. The first example discusses the design of a classification system for Swedish public libraries in the late 1910s, and the second addresses the re-formulation of the Holocaust experience in American Jewish library classification …

Cultural Warrant And Hospitality In Animation Film Abstracting, Admeire Sundström

Proceedings from the Document Academy

In the Brazilian context, we lack a methodology for abstracting audiovisual documents. To address this, several authors have proposed different approaches. As an additional contribution, this research proposes cultural warrant and hospitality as a principle that could be considered during the abstracting of animation. Domain analysis was used as a method, and from the analyzed animation institutions we identified the discursive community and the institutional proposals. From the literature reviewed, the existing approach for abstracting was identified and named here as the document dimension. As a result, we concluded that the principle of cultural warrant and hospitality needs more theoretical …

Tailoring Explosive Ordnance Risk Education: How Mag Addresses Gender/Cultural Sensitivities And Local Risk-Taking Behavior, Sebastian Kasack

The Journal of Conventional Weapons Destruction

The relevance of risk education is widely acknowledged as reflected in the Oslo Action Plan (OAP) with its distinct chapter on ‘Mine risk education and reduction’ and five explicit actions. Good risk education must be tailored. MAG’s experience delivering explosive ordnance risk education (EORE) in four-teen countries confirms the relevance of tailoring EORE to the local reality: to people’s risk taking behaviors, to the actual explosive ordnance (EO) threat, to seasonality, availability of people for risk education sessions, and approaches that re-spect gender and diversity and take conflict sensitivity into account.

Hidden Crisis In Borno State, Sean Sutton

The Journal of Conventional Weapons Destruction

At the end of 2019, Nigeria reported a significant increase of landmine, explosive remnants of war (ERW), and improvised explosive device (IED) contamination in its states. In 2019 alone, a total of 239 known mine casualties were recorded in Nigeria. Although the exact amount of contamination in Nigeria today is unknown, the Landmine & Cluster Munition Monitor asserts that Borno is the most heavily affected state in the country. Due to mounting mine contamination and increasing pressure from non-state armed groups (NSAG), internally displaced persons (IDPs) and communities are unable to safely return to the region. Extensive landmine use by …

Bullying In The C-Suite: A Nurse Leader Perspective, Kimberly Ann Colonnelli

Doctor of Nursing Practice (DNP) Projects

An estimated 35% of American workers have experienced bullying, and in 80% of those situations, the perpetrator was a supervisor or boss. 1 However, the reality is that bullying can come from anyone in the workplace, including subordinates. Victims are generally well liked and good performers, making them feel like threats to a bully’s power base. Bullying, unlike harassment, is not a legally defined behavior, so no laws currently exist to punish it. Victims are, therefore, at the mercy of their bosses, supervisors, co-workers, and human resource departments for protection or relief. Bullying is not a singular event, but rather …

Flavonoids Reduce Lipid Peroxides And Increase Glutathione Levels In Pooled Human Liver Microsomes (Hlms), William Yaw Boadi, Camille Stevenson, Dontrez Johnson, Mohamed Adel Mohamed

Chemistry Faculty Research

The effects of each of the flavonoids; genistein (G), quercetin (Q) and kaempferol (K) at several doses on lipid peroxides (LP) and reduced glutathione (GSH) in pooled human liver microsomes (HLMs) were investigated following the oxidative damage for 4, 6, 18 and 24 hr. HLMs (1 mg/ml) were exposed to each of the above flavonoids at 0, 5, 10, 15, 20 or 25 μM and incubated for the respective times as previously stated. Our hypothesis was that HLMs exposed to the flavonoids for the respective exposure times can decrease LP and increase GSH in HLMs to better cope with the …

December 15, 2021 Agenda, A-State Staff Senate

Staff Senate Minutes

No abstract provided.

Moderate Prenatal Ethanol Exposure, Sex, And Housing Modify Spatial Navigation Behavior And Hippocampal Cell Firing In Adult Rodents, Christy Magcalas

Psychology ETDs

Prenatal alcohol exposure (PAE) is associated with structural and physiological changes that impact the central nervous system and can result in persistent negative consequences in a broad spectrum of cognitive and behavioral domains including deficits in spatial learning and memory and behavioral flexibility. The current study focuses on examining the behavioral and mechanistic consequences of PAE, sex and housing. Rats were tested in the Morris Water Task where they were trained to navigate to a goal location and tested in a pool shift manipulation. There were no significant differences between PAE treatment, sex, or housing groups during training, but there …