Digital Commons Network^™

Man V.S. Wild: An Analysis Of Language Used Regarding Human-Wildlife Conflict In The Kibale National Park Community, Western Region, Uganda, Sophie Perfetto

Independent Study Project (ISP) Collection

If humans are to live sustainably and in harmony with wildlife in the vicinity of Protected Areas, policy makers, and government authorities need to make informed decisions with consideration to the needs of local communities. For this to happen, policy makers must understand the perceptions of local communities and take local perspectives into account. As language is at the root of perception, language was studied in the context of its role in shaping local perceptions of human-wildlife conflict and consequential conflict mitigation strategies. Six communities around the Northern region of Kibale National Park, Uganda, were studied, with sites located in …

Discontinuity Between Religion, Law, And Society Through Animal Treatment In Morocco, Michael Altman

Independent Study Project (ISP) Collection

Animal treatment is a topic which is covered by many facets of what helps create the guiding principles for humans, yet all in different ways; there is some overlap, and there is some distinction. From my three months of study in Rabat, Morocco, seeing how each person approaches the homeless animal differently, I write on how three important overarching areas: religious, legal, and societal, discuss how animals should be treated.

In this paper, I will be analyzing religious texts, legal writings both in place and in draft, and will rely on external works written animal markets and on the school …

Islam And Equality Through Symbolism, Nellie Bowers

Independent Study Project (ISP) Collection

As a Muslim Majority Country governed by laws born out of religious doctrine, Morocco deals with issues of equality and justice that are forcefully related to and intertwined with religion. This paper looks at the intersection of religion and equality, especially in the interpretive context of society and governance. It also considers the difference in religious interpretation affecting religious use and image. Additionally, the religious notion of Tawhid is analyzed in a symbolic context to further understand how God’s nature influences the actions of humans, especially with actions pertaining to social justice and equality. Through ethnographic interview, the perspective on …

An Eventful Past Predicting A Bizarre Future: Assessing The Influence Of Ocean Circulation On Key Fish Species In Icelandic Waters. An Analysis Of Past Circulation Records In Order To Predict The State Of Demersal Fish Stocks In Future Climate Scenarios, Matthew Engfer

Independent Study Project (ISP) Collection

Feedback-driven changes in North Atlantic Ocean circulation are affecting marine ecosystems off the coast of Iceland and are predicted to have differing outcomes by 2100. In this study, data reflecting Icelandic fish stock distributions was compiled on a map with oceanographic temperature and depth in order to observe patterns of population changes with changes in ocean currents. After evaluating past temperature effects on demersal fish stocks, future habitat predictions were estimated in weaker ocean circulation scenarios. A number of assumptions were made in order to pinpoint a correlation between ocean temperature and fish habitat. Iceland’s unique location and climate offers …

A Phenological Analysis Of Páramo Vegetation Along An Altitudinal Gradient: The Influence Of Camelids On Andean Flora In The Páramo Of Chimborazo, Ecuador, Tessa Seifried

Independent Study Project (ISP) Collection

This study hopes to reveal the mechanisms behind camelid-plant interactions in the Chimborazo province of Ecuador, which is known for having a large population of domesticated alpacas (Vicugna pacos), along with wild vicuñas (Vicugna vicugna) that were reintroduced into the area 30 years ago. These camelid species, especially vicuñas, are understudied within Ecuador in regards to their effects on plant composition, diversity, and spatial phenology. To gain a better insight into this topic, three sites were chosen: a site inhabited by only vicuña, a site inhabited by only alpaca, and a site inhabited by both species. The vicuña site sat …

Retrato De Una Economía En Movimiento: Retos De La Economía Sustentable En San Francisco De Borja, Quijos, Napo, Meghan Mary Edwards

Independent Study Project (ISP) Collection

Esta monografía presenta la situación económica actual en el Valle Quijos, en la parte occidental de la provincia de Napo, Ecuador. La mayoría de los residentes son gente campesina, que se dedica a la ganadería y la lechería. Se encuentran en la zona de amortiguamiento de dos parques nacionales, y mientras la población está creciendo, la gente tiene cada vez menos espacio entre las áreas protegidas, que ha generado conflictos sociales y conflictos ambientales, que incluyen la deforestación, la caza ilegal, y la erosión de las áreas pendientes. La monografía investiga el turismo y la ganadería tecnificada como algunos posibles …

Black Sound Matter(S): The Sonic Soundscape Of Black Auditory Liberation, Todd Craig

Publications and Research

In an attempt to embody the practices of DJ rhetoric as it relates to sound studies as well as sonic composing, Todd Craig will not speak with his own voice. Instead, this entire SonicText will serve as documentation of a live composition that engages with the theme of "Black Sound Matter(s)." Deploying the concept of sonic lineage (Craig, forthcoming; Polson, 2019), this piece aims to radically transform this intellectual space through sonic and DJ rhetorical practices. Thus, Todd Craig's voice is inconsequential; instead, what is most critical is his collaborators: historical scholars and organic intellectual-musicologists starring as Black Musician-Griots. The …

Have We No Shame? A Moral Exemplar Account Of Atonement, Meghan D. Page, Allison Krile Thornton

Faith and Philosophy: Journal of the Society of Christian Philosophers

No abstract provided.

Volume Cxxxx, Number 2, October 1, 2021, Lawrence University

The Lawrentian

No abstract provided.

Beach Suitability For Nesting Olive Ridley Sea Turtles (Lepidochelys Olivacea), Playa Malena, Azuero Peninsula, Panama, Soleil Foy

Independent Study Project (ISP) Collection

Sea turtle species all over the world are facing continuous declines in their populations partly due to diminished viable nesting habitat. Understanding sea turtle nesting preferences and the suitability of beaches for reproductive success is necessary in order to sustain their populations and ensure their conservation. Olive ridley sea turtles (Lepidochelys olivacea) are one of the species experiencing this trend, especially in the Eastern Pacific. This study examined the beach suitability of a site known as Playa Malena in the Azuero Peninsula in Panama for Olive ridley nesting. This site was compared to the suitability of 7 other …

Implementing An Application Programming Interface For Promis Measures At Three Medical Centers, Michael Bass, Christian Oncken, Allison W. Mcintyre, Chris Dasilva, Joshua Spuhl, Nan E. Rothrock

2020-Current year OA Pubs

BACKGROUND: There is an increasing body of literature advocating for the collection of patient-reported outcomes (PROs) in clinical care. Unfortunately, there are many barriers to integrating PRO measures, particularly computer adaptive tests (CATs), within electronic health records (EHRs), thereby limiting access to advances in PRO measures in clinical care settings.

OBJECTIVE: To address this obstacle, we created and evaluated a software integration of an Application Programming Interface (API) service for administering and scoring Patient-Reported Outcomes Measurement Information System (PROMIS) measures with the EHR system.

METHODS: We created a RESTful API and evaluated the technical feasibility and impact on clinical workflow …

Bigger, Better, Wider, And Always More: What Has Wealth To Do With Mission?, Gerald A. Klingbeil

Faculty Publications

No abstract provided.

Integrative Narrative Therapy In Counseling: Experiencing Strengthened Spiritual Resiliency: A Phenomenological Study, Marcy Lynn Hill

Doctoral Dissertations and Projects

The following DMIN action research project is a phenomenological study that evaluates the correlation between integrative Narrative Therapy approaches in non-clinical counseling and the cultivation of spiritual resilience among suffering Christians. Phenomenological data were generated from three case study subjects, who volitionally participated in interviews, questionnaires, and three, one-hour integrative Narrative Therapy intervention counseling sessions facilitated by the researcher. Each intervention session introduced the participants to specific Narrative Therapy exercises to which they had not been exposed before. All case study participants have experienced previous counseling that did not include Narrative Therapy approaches and were evaluated as ineffective by the …

Structure Of Venezuelan Equine Encephalitis Virus In Complex With The Ldlrad3 Receptor, Katherine Basore, Hongming Ma, Natasha M Kafai, Samantha Mackin, Arthur S Kim, Christopher A Nelson, Michael S Diamond, Daved H Fremont

Open Access Publications

LDLRAD3 is a recently defined attachment and entry receptor for Venezuelan equine encephalitis virus (VEEV)

Dicer1 Tumor Predisposition Syndrome: An Evolving Story Initiated With The Pleuropulmonary Blastoma, Iván A González, Douglas R Stewart, Kris Ann P Schultz, Amanda P Field, D Ashley Hill, Louis P Dehner

Open Access Publications

DICER1 syndrome (OMIM 606241, 601200) is a rare autosomal dominant familial tumor predisposition disorder with a heterozygous DICER1 germline mutation. The most common tumor seen clinically is the pleuropulmonary blastoma (PPB), a lung neoplasm of early childhood which is classified on its morphologic features into four types (IR, I, II and III) with tumor progression over time within the first 4-5 years of life from the prognostically favorable cystic type I to the unfavorable solid type III. Following the initial report of PPB, its association with other cystic neoplasms was demonstrated in family studies. The detection of the germline mutation …

A Transcriptomic And Epigenomic Cell Atlas Of The Mouse Primary Motor Cortex, Zizhen Yao, Hanqing Liu, Fangming Xie, Stephan Fischer, Xinxin Wang, Et Al

Open Access Publications

Single-cell transcriptomics can provide quantitative molecular signatures for large, unbiased samples of the diverse cell types in the brain

Cellular Regeneration As A Potential Strategy To Treat Cardiac Conduction Disorders, Satadru K Lahiri, Mohit M Hulsurkar, Xander Ht Wehrens

Faculty, Staff and Students Publications

Loss of atrioventricular conduction system (AVCS) cells due to either inherited or acquired deficits leads to conduction diseases, which can deteriorate into fatal cardiac arrhythmias and sudden death. In this issue of the JCI, Wang et al. constructed a mouse model of atrioventricular block (AVB) by inducing AVCS cell-specific injury using the Cx30.2 enhancer to drive expression of diphtheria toxin fragment A. AVCS cell ablation in adult mice led to irreversible AVB. jkjkIn contrast, AVCS cell injury in neonatal mice was followed by spontaneous recovery in a subset of mice, revealing a limited postnatal time window during which the regeneration …

The Timing Of Intermittent Hypoxia Differentially Affects Macronutrient Intake And Energy Substrate Utilization In Mice, Sarah N. Framnes-Deboer, Aaron A. Jones, Michelle Y. Kang, Kat Propsom, Lauren R. Nelson, Deanna M. Arble

Biological Sciences Faculty Research and Publications

Sleep apnea is a common sleep disorder characterized by periodic breathing cessation and intermittent hypoxia (IH). Although previous studies have demonstrated that IH alone can influence metabolic outcomes such as body weight, it remains unclear how the timing of IH can specifically affect these outcomes. Here, we examine how pairing 10-h periods of IH to either the animals’ resting phase (e.g., IH during the day) or active phase (e.g., IH during the night) differentially affects body weight, macronutrient selection, energy expenditure, respiratory exchange rate, and glucose tolerance. We find that in contrast to mice exposed to IH during the night, …

Special Matters: Filtering Privileged Materials In Federal Prosecutions, Christina Frohock

Articles

This Article reviews the U.S. Department of Justice's toolbox for handling potentially privileged materials, with close attention to the evolution from filter teams to the Special Matters Unit in fraud prosecutions. Significant case opinions from the U.S. Courts of Appeals for the Fourth, Sixth, and Eleventh Circuits reveal the judiciary's diverse views on filter teams. The recent case of United States v. Esformes in the U.S. District Court for the Southern District of Florida, now on appeal to the Eleventh Circuit, illustrates how a filter team can fall short and draw unflattering attention to the Department of Justice. In the …

Bioactive Nanotherapeutic Trends To Combat Triple Negative Breast Cancer, Pallabita Chowdhury, Upasana Ghosh, Kamalika Samanta, Meena Jaggi, Subhash C. Chauhan, Murali M. Yallapu

School of Medicine Publications

The management of aggressive breast cancer, particularly, triple negative breast cancer (TNBC) remains a formidable challenge, despite treatment advancement. Although newer therapies such as atezolizumab, olaparib, and sacituzumab can tackle the breast cancer prognosis and/or progression, but achieved limited survival benefit(s). The current research efforts are aimed to develop and implement strategies for improved bioavailability, targetability, reduce systemic toxicity, and enhance therapeutic outcome of FDA-approved treatment regimen. This review presents various nanoparticle technology mediated delivery of chemotherapeutic agent(s) for breast cancer treatment. This article also documents novel strategies to employ cellular and cell membrane cloaked (biomimetic) nanoparticles for effective clinical …

Pharmaceutical Potential Of Laboratory Grown Cultures Of Blue-Green Algae: A Comprehensive Review And Future Possibilities, Ritu Chauhan, Abhishek Chauhan, Ashutosh Tripathi, Anuj Ranjan, Subhash C. Chauhan, Tanu Jindal

School of Medicine Publications

COVID-19 pandemic has taught the world researchers the urgent need for new sources and novel pharmaceuticals not only for existing diseases but also for both seasonal epidemics and future pandemics. Pharmaceutical drug discoveries for the past fifty years depended deeply on the procedure of empirical transmission of a huge number of pure bioactive compounds to provide new leads. The screening of extracts or isolating compounds is a common way to discover novel biologically active molecules. Most of the valuable Blue-Green algal metabolites are concentrated in their biomass. For existence in nature, Blue-Green algae (BGA) secrete and contain various organic substances …

Victory Temple House Of Refuge: A Missional Focused Revitalization Strategy, David Lee Nalls

Doctoral Dissertations and Projects

The purpose for this DMIN action research thesis is to develop a revitalization strategy for Victory Temple House of Refuge located in Fayette, Alabama, that will connect the hearts and minds of its leaders to biblical principles for restoring church vibrancy and growth. The purpose rises to confront a problem of church membership decline and community contraction, frequently associated with a lusterless existence. The purpose statement also introduces a study on church revitalization’s incipit principles of returning to missional activities and discipleship fundamentals as a means of restoring congregational vitality. Researching the problem is inextricable to a Christian community’s mandate …

Developing An Innovative Pandemic Treaty To Advance Global Health Security, Lawrence O. Gostin, Benjamin Mason Meier, Barbara Stocking

Georgetown Law Faculty Publications and Other Works

Recognizing marked limitations of global health law in the COVID-19 pandemic, a rising number of states are supporting the development of a new pandemic treaty. This prospective treaty has the potential to clarify state obligations for pandemic preparedness and response and strengthen World Health Organization authorities to promote global health security. Examining the essential scope and content of a pandemic treaty, this column analyzes the policymaking processes and substantive authorities necessary to meet this historic moment.

Clinical Trial And Postmarketing Safety Of Onasemnogene Abeparvovec Therapy, John W Day, Jerry R Mendell, Eugenio Mercuri, Richard S Finkel, Kevin A Strauss, Aaron Kleyn, Sitra Tauscher-Wisniewski, Francis Fonyuy Tukov, Sandra P Reyna, Deepa H Chand

2020-Current year OA Pubs

INTRODUCTION: This is the first description of safety data for intravenous onasemnogene abeparvovec, the only approved systemically administered gene-replacement therapy for spinal muscular atrophy.

OBJECTIVE: We comprehensively assessed the safety of intravenous onasemnogene abeparvovec from preclinical studies, clinical studies, and postmarketing data.

METHODS: Single-dose toxicity studies were performed in neonatal mice and juvenile or neonatal cynomolgus nonhuman primates (NHPs). Data presented are from a composite of preclinical studies, seven clinical trials, and postmarketing sources (clinical trials, n = 102 patients; postmarketing surveillance, n = 665 reported adverse event [AE] cases). In clinical trials, safety was assessed through AE monitoring, vital-sign …

A Human Ipsc-Derived Inducible Neuronal Model Of Niemann-Pick Disease, Type C1, Anika V Prabhu, Insung Kang, Raffaella De Pace, Christopher A Wassif, Hideji Fujiwara, Pamela Kell, Xuntian Jiang, Daniel S Ory, Juan S Bonifacino, Michael E Ward, Forbes D Porter

2020-Current year OA Pubs

BACKGROUND: Niemann-Pick disease, type C (NPC) is a childhood-onset, lethal, neurodegenerative disorder caused by autosomal recessive mutations in the genes NPC1 or NPC2 and characterized by impaired cholesterol homeostasis, a lipid essential for cellular function. Cellular cholesterol levels are tightly regulated, and mutations in either NPC1 or NPC2 lead to deficient transport and accumulation of unesterified cholesterol in the late endosome/lysosome compartment, and progressive neurodegeneration in affected individuals. Previous cell-based studies to understand the NPC cellular pathophysiology and screen for therapeutic agents have mainly used patient fibroblasts. However, these do not allow modeling the neurodegenerative aspect of NPC disease, highlighting …

The Article Iii Publication Power And The Foreign Intelligence Surveillance Court, John Langford

Cardozo Law Review

The Framers vested “the judicial Power of the United States” in independent courts so that they may protect individual liberty and serve as a check on the legislative and executive branches. The judicial power, however, is narrow and not self-executing. As Chief Justice Marshall put it, it is merely the power “to say what the law is.” Federal courts cannot raise armies or pay money to enforce their decrees. Having neither force nor will, courts must instead rely on cultivating public support to secure the authoritative legitimacy necessary to effectuate their judgments.

But what happens when the executive branch asserts …

Employers’ Secret Weapon: How The After-Acquired Evidence Doctrine Allows Employers To Get Away With Disability Discrimination, Emma Schwab

Cardozo Law Review

No abstract provided.

“Los Programadores Debieron Pensarse Como Dos Veces”: Exploring The Intersections Of Language, Power And Technology With Bi/Multilingual Students, Sara Vogel

Publications and Research

Critical computing approaches to K-12 Computer Science (CS) education aim to promote justice in computing and the wider world. Despite being intertwined with inequitable power dynamics in computing, issues of linguistic (in)justice have received less attention in critical computing. In this article, I draw on theoretical ideas from sociolinguistics and critical computing to analyze qualitative data collected in computing and technology-integrated language and humanities classes serving emergent bi/multilingual middle school students. Conversations about language, technology, and power were close at hand in focal classrooms, and surfaced in moments when students acted as users and critics of, and tinkerers with digital …

Alveolar Socket Healing In 5-Lipoxygenase Knockout Aged Female Mice Treated Or Not With High Dose Of Zoledronic Acid, Ramez H. Mahmoud, Cláudia Cristina Biguetti, Gustavo B. Simionato, Isabela C. Custódio, Raquel B. P. Silva, Marco A. H. Duarte, Leonardo P. Faverani, Edilson Ervolino, Walid D. Fakhouri, Mariza A. Matsumoto

School of Podiatric Medicine Publications

This study investigated the role 5-lypoxigenase (5-LO) on alveolar socket healing in aged female mice treated with zoledronic acid (ZL). Forty 129/Sv female mice (64-68 weeks old), 20 wild type (WT) and 20 5-LO knockout (5LOKO) were equally distributed according to ZL treatment: WT Control, WT ZL, 5LOKO Control, and 5LOKO ZL. ZL groups were treated with an intraperitoneal injection of 250 µg/Kg of ZL, while controls were treated with saline. Treatments were administered once a week, starting four weeks before surgery for tooth extraction and until 7 and 21 days post-surgery. Mice were euthanized for a comprehensive microscopic analysis …

Electronic Journal Of Information System In Developing Countries (2014-2021): A Bibliometric Study, Azeem Akbar, Ayesha Gulzar, Nadeem Siddique, Muhammad Ajmal Khan

Library Philosophy and Practice (e-journal)

Electronic Journal of Information System in Developing Countries (EJISDC) has already published a bibliometric study from 2000-2013, and this study is a further continuation of the pervious study from 2014-2021. The data retrieved from the Scopus database was analyzed through VOS viewer, biblioshiny, Microsoft Excel, and MS Access. This bibliometric study found the different aspects of the EJISDC, i.e., document types, publishing trends, authorship patterns, most productive countries, prolific authors, organizations, frequently used keywords, and country collaboration during 2014-21. The result found that total 346 publications having 1513 citation and most of the documents type was published research articles. The …