Digital Commons Network^™

Enable The People To Say, "Amazing: We Did It, All By Ourselves!", Yeomin Yoon

KAUPA Letters

No abstract provided.

Revisiting An Igg Fc Loss-Of-Function Experiment: The Role Of Complement In Hiv Broadly Neutralizing Antibody B12 Activity, Benjamin S. Goldberg, Chengzi I. Kaku, Jérémy Dufloo, Timothée Bruel, Olivier Schwartz, David A. Spencer, Ann J. Hessell, Margaret E. Ackerman

Dartmouth Scholarship

The role of the complement system in HIV-1 immunity and pathogenesis is multifaceted, and an improved understanding of complement activities mediated by HIV-1-specific antibodies has the potential to inform and advance clinical development efforts. A seminal nonhuman primate challenge experiment suggested that complement was dispensable for the protective effect of the early broadly neutralizing antibody (bnAb) b12, but recent experiments have raised questions about the breadth of circumstances under which this conclusion may hold. Here, we reassess the original observation using Fc variants of IgG1 b12 that enhance complement activity and report that complement fixation on recombinant antigen, virions, and …

Variations, Validations, Degradations, And Noninvasive Determination Of Pregnancy Using Fecal Steroid Metabolites In Free-Ranging Pronghorn, Cole A. Bleke, Eric M. Gese, Susannah S. French

United States Department of Agriculture Wildlife Services: Staff Publications

Pregnancy status is a key parameter used to assess reproductive performance of a species as it represents a starting point for measuring vital rates. Vital rates allow managers to determine trends in populations such as neonate survival and recruitment; two important factors in ungulate population growth rates. Techniques to determine pregnancy have generally involved capture and restraint of the animal to obtain blood samples for determining serum hormone levels. Non-invasive pregnancy assessment, via feces, eliminates any hazards between handler and animal, as well as removes handling-induced physiological biases. Using noninvasive fecal sampling, we conducted hormone validations, investigated pregnancy rates, and …

Medieval Saints And Modern Screens: Divine Visions As Cinematic Experience, Stephen Okey

Journal of Religion & Film

This is a book review of Alicia Spencer-Hall, Medieval Saints and Modern Screens: Divine Visions as Cinematic Experience (Amsterdam University Press, 2018).

Sensory Evaluation Of Camel Milk, Reem Amer Al Kaabi

Theses

Camel milk is one of the most important sources of nutrients for humans in numerous arid and semiarid environments. Consumer acceptability and sensory analysis are decisive for the commercialization of camel milk. It is essential to understand the sensory qualities of camel milk because of its unfamiliarity and its typical sensory profile, which is different from that of bovine milk. This study aimed to evaluate a trained panel qualitative description of sensory characteristics as well as consumer acceptability and attitude towards pasteurized non-flavoured, flavoured, and camel milk powders. In the consumer acceptability test, samples were evaluated based on acceptability with …

Mems 411: Safely Capturing Giant African Pouch Rats, Anthony Brown, John Christensen, Jared Harrison

Mechanical Engineering Design Project Class

We were tasked with designing a trap to safely capture Giant African Pouch Rats. The traps are used in both urban and rural environments that include city streets, basements, farms, river beds, and bushes among other locations. Pouch rats are much larger than most rats and are a very ferocious species; they will harm themselves if there are any non-smooth surfaces when captured. It is very important that we designed a trap with this safety top of mind.

Mems 411: Giant Pouched Rat Trap, Ronald Fields, Mariano Gonzalez, Edward Li, Jordan Hu

Mechanical Engineering Design Project Class

Dr. Braude from the Biology department at Washington University in St. Louis is currently working on a project training giant Gambian pouched rats to find mines and other bombs in former conflict zones. In order to trap Gambian pouched rats, Professor Braude asked a few MEMS 411 Senior Design groups to design and build a trap that can safely capture the rats. The trap had to be about 2-3 feet long, 6 inches in diameter, completely mechanical, simple, and it had to cost less than 30 USD to build.

Mems 411: Giant Pouched Rat Trap, Shannon Wang, Isha Shah, Vaishali Shah, Elizabeh Saliba

Mechanical Engineering Design Project Class

Our goal is to design a giant pouched rat trap that meets the customer needs from professor Stan Braude. The giant pouched rats are to be breed and trained to find land mines. Therefore, the rats must be captured in good condition. However, giant pouched rats are not passive once caught and tries to escape every way possible. In the past, with traditional trap wires, they tend to get caught in the wire and hurt themselves. Our solution offers a completely smooth inner wall of the trap to prevent damage to the rats, while improving on the functionality of the …

Mems 411: African Pouched Rat Trap, Kelechi Achilefu, Paul Joseph, David Allen, Chase Green

Mechanical Engineering Design Project Class

What is often thought of as a rat trap is often in reality a mouse trap, or a trap designed to catch small rodents. Rats can be quite large and catching them without harming them can be quite difficult. Current market solutions generally either kill or harm the rodent which is not acceptable for our client's needs. While there are some solutions on the market, they fall short of the needs of our client which is more specialized due to the size of rodent they will be capturing, the circumstances surrounding the capture, the number of rodents our client needs …

Mems 411: Q.T. B-Bar, Gambian Pouched Rat Trap, Benjamin W. Horine Jr., Ileane Ho, Sarangi Pathirana

Mechanical Engineering Design Project Class

To design and build an improved rat trap that will effectively capture a Gambian Pouched Rat of larger size ensuring the rodents' safety, easy deployment in natural environments, simple mechanical release mechanisms, and cost-effectiveness.

Law School Announcements 2021-2022, Law School Announcements Editors

Announcements

• Officers and Faculty
• The Law School – History
• Programs of Instruction
• Curriculum
• Student Activities and Organizations
• Funds and Endowments

Using The 4-H Essential Elements To Evaluate Teen Programming, Joy Lile, Elizabeth Weybright, Pam Watson

Journal of Youth Development

National and state trends indicate participation in 4-H programming declines throughout adolescence. Past research suggests factors that may influence recruitment and retention of teens into youth development programming. Washington State University undertook an evaluation to understand the needs and desires of teens in the 4-H program and make recommendations for improvements to recruitment and retention of teens in 4-H. The study sample was made up of 93 young people aged 12 to 19 years who participated in the online survey. Results included youth demographics, participation styles, communication preferences, youth outcomes, and feedback about program benefits and opportunities for growth. The …

Enhancing The International Study Of Positive Youth Development: Process, Specificity, And The Sample Case Of Character Virtues, Richard Lerner, Pamela Jervis, Marc Bornstein

Journal of Youth Development

This article focuses on the interplay of research and practice (researchpractice integration) in advancing international efforts to understand and enhance positive youth development (PYD). We discuss 3 facets of PYD research and application that have cross-cutting relevance to theory, to the use of theory for designing principles of PYD programs, and to evaluating whether specific instances of youth development programs have features that promote PYD. Using dynamic, relational developmental-systems-based concepts, we discuss the process of development involved in PYD, the use of the specificity principle to frame research and practice and, as a sample case illustrating how PYD research and …

Positive Youth Development In Senegal: A Case Study Of 4-H Senegal, Thomas Archibald, Bineta Guisse, Amadou Ndiaye, Fatimata Kane

Journal of Youth Development

African youth face great challenges and great opportunities. Positive youth development (PYD) programs have the potential to support youth in Africa to reach their full potential. Yet PYD approaches must be tailored if they are to be contextually and culturally responsive and relevant. The purpose of this paper is to provide an evidence-informed description of one such program, the 4-H Senegal PYD program. We first provide a conceptual background for the program, informed especially by the literature on global and cross-cultural PYD. We then share empirical results of a qualitative case study focused on the establishment, scale-up, and institutionalization of …

Dancing With The Devil Revisited, Marlene Galván

Writing and Language Studies Faculty Publications

No abstract provided.

Mask, The Drosophila Ankyrin Repeat And Kh Domain-Containing Protein, Affects Microtubule Stability, Daniel Martinez, Mingwei Zhu, Jessie J. Guidry, Niles Majeste, Hui Mao, Sarah T. Yanofsky, Xiaolin Tian, Chunlai Wu

School of Medicine Faculty Publications

Proper regulation of microtubule (MT) stability and dynamics is vital for essential cellular processes, including axonal transportation and synaptic growth and remodeling in neurons. In the present study, we demonstrate that the Drosophila ankyrin repeat and KH domain-containing protein Mask negatively affects MT stability in both larval muscles and motor neurons. In larval muscles, loss-of-function of mask increases MT polymer length, and in motor neurons, loss of mask function results in overexpansion of the presynaptic terminal at the larval neuromuscular junctions (NMJs). mask genetically interacts with stathmin (stai), a neuronal modulator of MT stability, in the regulation of axon transportation …

With Due Respect For Humanity: Engaging Affectivity Through Simulation In Catholic Seminary Formation, Marie Diane Pitt-Payne

Dissertations (1934 -)

Since 1992, Catholic seminaries have approached the education of future priests through a lens of four areas of formation: intellectual, human, pastoral, and spiritual. Although human formation is considered foundational in the formation process, it has not been effectively integrated into seminary curriculum. The language of integral personalism was introduced into the formation landscape by Pope John Paul II, but this anthropology has not sufficiently informed seminary pedagogy. There is a still a subordination of the affective sphere in seminaries, particularly in intellectual formation. Medical schools have developed a pedagogical method that inserts real emotion into the educational process. This …

The Empathetic Autistic: A Phenomenological Look At The Feminine Experience, Dana Fritz

Dissertations (1934 -)

Western philosophy has asserted that in order to be a person, one must be rational. This idea was not challenged until the nineteenth century. One school to challenge this notion was phenomenology, which asserted that what made one a person was their ability to empathize. While the founder of the school, Edmund Husserl, did not assert that the ability to decipher nonverbal cues was necessary in order to empathize, several of his followers did. This emphasis on deciphering nonverbal cues proved problematic for some populations, especially the Autistic. Autism is a neurological condition which makes it difficult to decipher nonverbal …

Motor Performance And Motor Unit Behavior In Response To Ischemic Conditioning Post Stroke, Saad Alqahtani

Dissertations (1934 -)

The purpose of this dissertation was to quantify changes in motor performance and motor unit behavior in response to ischemic conditioning (IC) post stroke. People with stroke often have long term functional deficits following therapeutic interventions characterized by underlying muscle weakness and fatigability. IC is an emerging therapy which involves transient bouts of ischemia to a limb with some evidence that IC may help improve motor function post stroke. Although the mechanisms of IC are likely multifactorial, the premise for this dissertation is that IC increases sympathetic drive and the excitability of the nervous system resulting in enhanced activation of …

Arbitration At The Supreme Court: The Faa From Rbg To Acb, Brian Farkas

Cardozo Law Review

Justice Ruth Bader Ginsburg left a profound mark on countless areas of law: gender equality, discrimination law, and voting rights, to name just a few. These weighty subjects have rightfully occupied the many scholars and journalists who have analyzed her legacy. These same subjects have animated vigorous conversations around former President Donald Trump’s selection of Justice Amy Coney Barrett—previously of the U.S. Court of Appeals for the Seventh Circuit—to replace her.

Multi-Omics Analysis Reveals The Mechanism Underlying The Edaphic Adaptation In Wild Barley At Evolution Slope (Tabigha), Shengguan Cai, Qiufang Shen, Yuqing Huang, Zhigang Han, Dezhi Wu, Zhong-Hua Chen, Eviatar Nevo, Guoping Zhang

Publications

At the microsite "Evolution Slope", Tabigha, Israel, wild barley (Hordeum spontaneum) populations adapted to dry Terra Rossa soil, and its derivative abutting wild barley population adapted to moist and fungi-rich Basalt soil. However, the mechanisms underlying the edaphic adaptation remain elusive. Accordingly, whole genome bisulfite sequencing, RNA-sequencing, and metabolome analysis are performed on ten wild barley accessions inhabiting Terra Rossa and Basalt soil. A total of 121 433 differentially methylated regions (DMRs) and 10 478 DMR-genes are identified between the two wild barley populations. DMR-genes in CG context (CG-DMR-genes) are enriched in the pathways related with the fundamental processes, and …

The Anchor: Fall 2021, Issue Iii, Hope College

The Anchor: 2021

The Anchor began in 1887 and was first issued weekly in 1914. Covering national and campus news alike, Hope College’s student-run newspaper has grown over the years to encompass over two-dozen editors, reporters, and staff. For much of The Anchor's history, the latest issue was distributed across campus each Wednesday throughout the academic school year (with few exceptions). In recent years The Anchor moved to monthly print issues and a more frequently updated website. The Anchor is now published in print twice per academic semester. Occasionally, the volume and/or issue numbering is irregular.

Full Issue

Journal of Adventist Mission Studies

No abstract provided.

Dualistic Worldviews: Implications For Discipleship, Temesgen B. Besha

Journal of Adventist Mission Studies

No abstract provided.

Manufacturing Sovereign State Mootness, Daniel Bruce

William & Mary Law Review

The idea that public defendants should receive any special treatment in the mootness context has been subject to intense criticism among commentators. Most notably, in the lead-up to the New York Rifle decision, Joseph Davis and Nicholas Reaves—two prominent First Amendment litigators from the Becket Fund for Religious Liberty—urged the Supreme Court to take the opportunity to correct the lower courts’ practice of blessing government abuse of the voluntary cessation doctrine. Indeed, the Supreme Court has never adopted a presumption in favor of government defendants such as the one applied by the Seventh Circuit in Killeen, and it failed to …

Design Modifications Affect Bat Box Temperatures And Suitability As Maternity Habitat, Francis E. Tillman, George S. Bakken, Joy M. O'Keefe

KIP Articles

Artificial roosting structures (e.g. bat boxes) are widely used as conservation tools for many animals, including bats. Although it is relatively easy to monitor bat box temperatures, we know little about the effect of design on temperatures within a box. Box microclimate affects energy budgets and physiological processes and, thus, suitability as a roost. Optimal temperature varies during the period when reproductive females aggregate to rear pups; warm roosts enhance pup development during gestation and lactation, while cool roosts facilitate energy savings by torpor, which is often important during post‐lactation. To better understand the relation of design to internal temperature, …

2021 (Fall) Ensi Informer Magazine, Morehead State University. Engineering Sciences Department

ENSI Informer Magazine Archive

The ENSI Informer Magazine published in the fall of 2019.

Assessment Of Mitochondrial Dysfunction In Lungs From Rats Exposed To Hyperoxia And The Efficacy Of Duroquinone, Swetha Ganesh

Master's Theses (2009 -)

Dissipation of mitochondrial membrane potential (ΔΨm) is a hallmark of mitochondrial dysfunction. The objective of this thesis was to use a previously developed experimental-computational approach to estimate tissue ΔΨm in intact lungs of rats exposed to hyperoxia, and to evaluate the ability of duroquinone (DQ) to reverse any hyperoxia-induced depolarization of lung Ψm. Rats were exposed to hyperoxia (>95% O2) or normoxia (room air) for 48 hrs, after which lungs were excised and connected to a ventilation-perfusion system. The experimental protocol consisted of measuring the concentration of the fluorescent dye rhodamine 6G (R6G) during three single-pass phases: loading, washing, …

Neuron-Specific Mitochondrial Oxidative Stress Results In Epilepsy, Glucose Dysregulation And A Striking Astrocyte Response, Ruth E Fulton, Jennifer N Pearson-Smith, Christopher Q Huynh, Timothy Fabisiak, Li-Ping Liang, Stefanos Aivazidis, Brigit A High, Georgia Buscaglia, Timothy Corrigan, Robert Valdez, Takahiko Shimizu, Manisha N Patel

Faculty, Staff and Students Publications

Mitochondrial superoxide (O2.−) production is implicated in aging, neurodegenerative disease, and most recently epilepsy. Yet the specific contribution of neuronal O2.− to these phenomena is unclear. Here, we selectively deleted superoxide dismutase-2 (SOD2) in neuronal basic helix-loop-helix transcription factor (NEX)-expressing cells restricting deletion to a subset of excitatory principle neurons primarily in the forebrain (cortex and hippocampus). This resulted in nSOD2 KO mice that lived into adulthood (2-3 months) with epilepsy, selective loss of neurons, metabolic rewiring and a marked mitohormetic gene response. Surprisingly, expression of an astrocytic gene, glial fibrillary acidic protein (GFAP) was significantly increased relative …

Chairs Of Excellence Annual Report 2021, Tennessee. Higher Education Commission.

Academic Programs and Workforce Reports

No abstract provided.