Digital Commons Network^™

Tongluo Yishen Decoction Ameliorates Renal Fibrosis Via Regulating Mitochondrial Dysfunction Induced By Oxidative Stress In Unilateral Ureteral Obstruction Rats, Qi Jia, Lin Han, Xiaoyu Zhang, Wenning Yang, Yushan Gao, Yifan Shen, Bing Li, Shuyan Wang, Mingzhen Qin, Scott Lowe, Jianguo Qin, Gaimei Hao

Student Publications

Tongluo Yishen (TLYS) decoction is an herb that is extensively applied for the treatment of chronic kidney disease (CKD) in traditional Chinese medicine. In this study, 37 different dominant chemical constituents of TLYS were identified. Rats with unilateral ureteral obstruction (UUO) were used as animal models, and TLYS decoction was administered orally for 14 days. TLYS decoction reduced the levels of renal function indicators, serum creatinine levels and blood urea nitrogen levels and alleviated renal pathological changes. Gene Ontology (GO) and KEGG pathway analyses of RNA sequencing data showed that TLYS decoction had significant effects on biological processes, cellular components …

Biophysical Evaluation Of Rhesus Macaque Fc Gamma Receptors Reveals Similar Igg Fc Glycoform Preferences To Human Receptors, Andrew R. Crowley, Nana Yaw Osei-Owusu, Gillian Dekkers, Wenda Gao, Manfred Wuhrer, Diogo M. Magnani, Keith A. Reimann, Seth H. Pincus, Gestur Vidarsson, Margaret E. Ackerman

Dartmouth Scholarship

Rhesus macaques are a common non-human primate model used in the evaluation of human monoclonal antibodies, molecules whose effector functions depend on a conserved N-linked glycan in the Fc region. This carbohydrate is a target of glycoengineering efforts aimed at altering antibody effector function by modulating the affinity of Fcγ receptors. For example, a reduction in the overall core fucose content is one such strategy that can increase antibody-mediated cellular cytotoxicity by increasing Fc-FcγRIIIa affinity. While the position of the Fc glycan is conserved in macaques, differences in the frequency of glycoforms and the use of an alternate monosaccharide in …

Luminescence Complementation Technology For The Identification Of Myc:Trrap Inhibitors, Edmond J. Feris, John W. Hinds, Michael D. Cole

Dartmouth Scholarship

Mechanism-based targeted therapies have exhibited remarkable success in treating otherwise untreatable or unresectable cancers. Novel targeted therapies that correct dysregulated transcriptional programs in cancer are an unmet medical need. The transcription factor MYC is the most frequently amplified gene in human cancer and is overexpressed because of mutations in an array of oncogenic signaling pathways. The fact that many cancer cells cannot survive without MYC - a phenomenon termed "MYC addiction" - provides a compelling case for the development of MYC-specific targeted therapies. We propose a new strategy to inhibit MYC function by disrupting its essential interaction with TRRAP using …

Evaluating Alternative Feed Sources During Drought, Matthew D. Garcia, Ruger P. Carter, Ryan Larsen, Eric Thacker, Jacob Hadfield, Reganne K. Briggs, Justen Smith

All Current Publications

During years of drought, it is important to critically evaluate alternative feed sources available for cattle. The traditional method for sustaining a herd through a drought is feeding extra stored forage to compensate for decreased forage production or decreased forage quality available on rangelands and pastures due to drought conditions. However, hay prices rise substantially, and availability decreases due to irrigation water limitations and increased demand from livestock producers. This fact sheet will evaluate why hay prices rise and what alternatives are available to compensate for forage reductions during drought.

Collagen-Based Biomaterials With Possible Therapeutic Effects, Ramona Mihaela Nedelcuţă, Gigi Călin, Mihai Cristian Nedelcuţă, Vlad Dumitru Baleanu, Dragos Virgil Davitoiu, Bogdan Socea, Bogdan-Petre Stănoiu

Journal of Mind and Medical Sciences

Epidermolysis bullosa (EB) is a rare, serious genetic disease, incurable through the current means. Apart from this initial definition, there was later some ease in the definition of the disease, including the manifestations of toxic epidermal necrolysis and Stevens Johnson syndrome in this entity. In medical practice, there are cases that do not overlap with the description in the literature, thus the treatment must be adapted and personalized to the particularities. We present the case of a female new-born, with "de novo" mutation for the early-onset antenatal epidermolysis and our personalized therapeutic management, based on collagen from bovine corneas by …

Analysis Of Potentially Toxic Contaminants In Milk Powder, Magdalena Mititelu, Lucian Hîncu, Emma Adriana Ozon, Daniela Luiza Baconi, Ioana Paunica, Oana Denisa Bălălău

Journal of Mind and Medical Sciences

The aim of this study was to identify potentially toxic contaminants in milk powder. Powdered milk contains a range of toxic and non-toxic substances that are present in a wide variety, also having very different origins. A number of seven milk powder samples from different producers sold on the Romanian market were analyzed, the samples that were collected from the original packaging: P1, P 2, P3, P4, P5, P6 and P7. The concentration of the following elements was analyzed using the X-ray (XRF) fluorescence method: potassium (K), chlorine (Cl), calcium (Ca), phosphorus (P) and aluminum (Al). The vast majority of …

Intestinal Dysbiosis – A New Treatment Target In The Prevention Of Colorectal Cancer, Florinela-Andrada Dumitru, Sergiu Ioan Micu, Roxana Emanuela Popoiag, Marilena Musat, Andreea Daniela Caloian, Valentin Calu, Vlad Denis Constantin, Daniela Gabriela Balan, Cornelia Nitipir, Florin Enache

Journal of Mind and Medical Sciences

The gastrointestinal microbiome contains at least 100 trillion microorganisms (bacteria, viruses, fungi), whose distribution varies from the mouth to the rectum spatially and temporally throughout one's lifetime. The microbiome benefits from advancing research due to its major role in human health. Studies indicate that its functions are immunity, metabolic processes and mucosal barrier. The disturbances of these functions, dysbiosis, influence physiology, lead to diabetes, inflammatory bowel disease, obesity and colon tumorigenesis. The third most common form of cancer, colorectal cancer, is the result of many factors and genes, and although the link between dysbiosis and this type of cancer is …

Neuropsychological Symptoms Related To The Covid-19 Pandemic Experienced By The General Population And Particularly By The Healthcare Personnel, Alina Zorina Stroe, Alexandru Floris Stuparu, Silviu Docu Axelerad, Daniel Docu Axelerad, Aurelia Moraru

Journal of Mind and Medical Sciences

Undoubtedly, the outbreak of COVID-19 still represents an overanxious event for both society and population. The fear of getting infected is ubiquitous in the time of the pandemic. The population presented worrying thoughts related to the fact that the health care system was not able to provide enough services during the COVID-19 pandemic. The number of the hospital beds and ventilators was insufficient in order to ensure enough care, considering the increased number of COVID-19 cases that were admitted to the hospitals. Furthermore, people were fearful about the possibility of the global economy becoming decimated. The fright and also the …

Therapeutic Efficacy Of Mesenchymal Stem Cells For Cardiovascular Diseases, Dragana Radoje Miloradovic, Dragica Radoje Pavlovic, Miodrag Bozidar Stojkovic, Sanja Bratislav Bojic, Vladislav Bogdan Volarevic, Marina Milosav Gazdic Jankovic, Biljana Tomislav Ljujic

Journal of Mind and Medical Sciences

Despite the improvements in pharmacological and surgical treatments, cardiovascular diseases (CVDs) are the number one cause of death worldwide. During the last two decades, the search for new therapies has been revolutionized with the growing knowledge of stem cell biology. Due to their huge differentiation capacity and paracrine effects, mesenchymal stem cells (MSCs) are a promising tool for the treatment of CVDs. The encouraging outcomes of preclinical studies using MSCs as a treatment for diseased myocardium have set the scene for worldwide clinical trials. In this review, we overview either complete or ongoing clinical trials using MSCs for the therapy …

The Molecular Mechanisms Linking Metabolic Syndrome To Endometrial And Breast Cancers, Andrada-Luciana Lazar, Romana Vulturar, Adriana Fodor, Olga Hilda Orasan, Camil-Horia Eusebiu Crișan, Cezar Login, Ioana Para, Vasile Negrean, Brandusa Tiperciuc, Angela Cozma

Journal of Mind and Medical Sciences

The metabolic syndrome represents a plethora of cardio-metabolic risk factors including obesity, arterial hypertension, atherogenic dyslipidemia, hyperglycemia, accompanied by pro-inflammatory and pro-thrombotic state. The metabolic syndrome is one of the key risk factors for certain types of cancer. Among these malignancies, breast cancer and endometrial neoplasms require special attention. Incriminated major causes for the development of breast and endometrial cancer in metabolic syndrome patients are: the pro-inflammatory status and related cytokines, adipokine imbalances, hyperestrogenism, growth factors, disturbances in cancer microenvironment, insulin resistance and hyperinsulinemia. The metabolic syndrome consists of molecular dysregulations that create a pro-oncogenic status. Our review aims at …

Looking Back, Or Re-Visioning: Contemporary American Jewish Poets On “Lot’S Wife”, Anat Koplowitz-Breier

CLCWeb: Comparative Literature and Culture

Although mentioned only twice in Genesis (19:17, 26), Lot’s wife has been a topic of much discussion amongst both traditional and modern commentators and exegetes. The traditional midrashim seek to explain why she chose to disregard the instructions she was given and the nature of her punishment. In doing so, they follow two principal directions, representing her a) negatively as a wicked sinner, a Sodomite who acted as such even before disobeying the divine decree not to look backwards—thus linking her disobedience with her intrinsic character (e.g., curious, greedy, inhospitable, faithless); or b) positively as a loving mother and daughter. …

Where Are The Women?: An Ecofeminist Reading Of William Golding’S Lord Of The Flies, Hawk Chang

CLCWeb: Comparative Literature and Culture

The absence of female characters and their voices in William Golding’s Lord of the Flies (1954) has been previously examined. On the surface, this fiction focuses on the struggle and survival of a group of boys who are left alone on a Pacific island against the background of nuclear warfare. The only presence of women in the story seems to be the aunt via a boy’s narration. However, when approaching the fiction through the lens of ecofeminism, we can find a range of feminized entities which are metaphorically embodied in the natural surroundings of the secluded island. The boys’ interactions …

Vulgarity As Springboard For High Art—A Comparative Study Of Vladimir Nabokov And Qian Zhongshu’S Notions Of Vulgarity, Derong Cao

CLCWeb: Comparative Literature and Culture

The discussion of vulgarity features prominently in both Nabokov and Qian’s creative writing. In this essay, their notions of vulgarity will be compared and contrasted. Nabokov and Qian have surprisingly similar understandings of vulgarity. To be more specific, both identify pretense/ affectation and triteness/ mediocrity as its fundamental characteristics. Moreover, both authors believe that the quintessential feature of vulgarity lies in its downplay of individual consciousness. The two authors’ understandings of vulgarity also differ in major ways. Qian’s Fortress Besieged, though showing deep social and moral concerns, did not seem to suspect a direct causal link between vulgarity and …

Graphic Nonsense And Historical Trauma In Fred Chao’S Johnny Hiro, Jin Lee

CLCWeb: Comparative Literature and Culture

This article introduces the concept of “graphic nonsense” to explain nonsense in Fred Chao’s graphic narrative, Johnny Hiro, which features figures of monster (Godzilla and King Kong) as well as real U.S. political figures (Michael Bloomberg and John P. O’Brien). Focusing on transpacific trauma, this article articulates a counter-history using Fredric Jameson’s terms to expose the process of silencing the other and “retextualizing” history. Although puzzling at first, if not silly at best, the nonsensical elements in the graphic narrative can prompt the reader to find out historical allusions in Godzilla and King Kong to make sense out of …

Searching For Molecular Markers For Salt Tolerance In Rhodes Grass (Chloris Gayana Kunth), E. Taleisnik, M. Salgado, M. D. Bonafede, L. E. Manghers, H. Pérez, L. García Seffino, A. Castagnaro, D. G. Díaz

IGC Proceedings (1977-2023)

Rhodes grass (Chloris gayana Kunth), a C4 forage grass, is regarded as salttolerant and exhibits intra- and inter-cultivar variability for this trait. Plants of cv Boma were selected for salt tolerance at the seedling and adult stages, cloned and characterized by RAPD and AFLP amplification patterns. Both techniques were equally efficient for fingerprinting these clones. More bands were obtained by AFLP but the ratio of polymorphic bands and the proportion present only in tolerant clones were the same by both methods. These bands, along with those exclusive for sensitive clones could be useful as markers for assisted selection.

Human 5’-Tailed Mirtrons Are Processed By Rnasep, Mohammad Farid Zia

Dissertations

Approximately a thousand microRNAs (miRNAs) are documented from human cells. A third appear to transit non-canonical pathways that typically bypass processing by Drosha, the dedicated nuclear miRNA producing enzyme. The largest class of non-canonical miRNAs are mirtrons which eschew Drosha to mature through spliceosome activity. While mirtrons are found in several configurations, the vast majority of human mirtron species are 5’-tailed. For these mirtrons, a 3’ splice site defines the 3’ end of their hairpin precursor while a “tail” of variable length separates the 5’ base of the hairpin from the nearest splice site. How this tail is removed is …

Localization Of Kisspeptin, Nkb, And Nk3r In The Hypothalamus Of Gilts Treated With The Progestin Altrenogest, Ashley N. Lindo, Jennifer F. Thorson, Michelle N. Bedenbaugh, Richard B. Mccosh, Justin A. Lopez, Samantha A. Young, Lanny J. Meadows, Elizabeth C. Bowdridge, Chrysanthi Fergani, Bradley A. Freking, Michael N. Lehman, Stanley M. Hileman, Clay A. Lents

Roman L. Hruska U.S. Meat Animal Research Center: Reports

Mechanisms in the brain controlling secretion of gonadotropin hormones in pigs, particularly luteinizing hormone (LH), are poorly understood. Kisspeptin is a potent LH stimulant that is essential for fertility in many species, including pigs. Neurokinin B (NKB) acting through neurokinin 3 receptor (NK3R) is involved in kisspeptin-stimulated LH release, but organization of NKB and NK3R within the porcine hypothalamus is unknown. Hypothalamic tissue from ovariectomized (OVX) gilts was used to determine the distribution of immunoreactive kisspeptin, NKB, and NK3R cells in the arcuate nucleus (ARC). Almost all kisspeptin neurons coexpressed NKB in the porcine ARC. Immunostaining for NK3R was distributed …

Interview With Kimberly Kieffer Orr, Kimberly Kieffer Orr, Julio Cuestas, Reyna Garcia, Keila Barajas

Community Historical Archaeology Project with Schools (CHAPS) Oral Histories

The interviewee is Ms. Kimberly Kieffer. She is the eldest sister of the previous generation Kieffer children. She used to live in Edinburg, Texas, but then moved to Texas A&M University for her completion of her degree. She is currently residing in Burleson, Texas, and provided us with her story as a family member of the Kieffer family.

Multi-Organs-On-Chips For Testing Small-Molecule Drugs: Challenges And Perspectives., Berivan Cecen, Christina Karavasili, Mubashir Nazir, Anant Bhusal, Elvan Dogan, Fatemeh Shahriyari, Sedef Tamburaci, Melda Buyukoz, Leyla Didem Kozaci, Amir K Miri

Henry M. Rowan College of Engineering Departmental Research

Organ-on-a-chip technology has been used in testing small-molecule drugs for screening potential therapeutics and regulatory protocols. The technology is expected to boost the development of novel therapies and accelerate the discovery of drug combinations in the coming years. This has led to the development of multi-organ-on-a-chip (MOC) for recapitulating various organs involved in the drug-body interactions. In this review, we discuss the current MOCs used in screening small-molecule drugs and then focus on the dynamic process of drug absorption, distribution, metabolism, and excretion. We also address appropriate materials used for MOCs at low cost and scale-up capacity suitable for high-performance …

A Systematic Review Of Diet Quality Index And Obesity Among Chinese Adults, Isma'il Kadam, Sudeep Neupane, Jingkai Wei, Lee Ann Fullington, Tricia Li, Ruopeng An, Li Zhao, Amy Ellithorpe, Xinyin Jiang, Liang Wang

Publications and Research

Diet quality scores are designed mainly based on Western-style dietary patterns. They were demonstrated to be good indicators of obesity in developed but not developing countries. Several diet quality scores were developed based on the Chinese dietary guidelines, yet no systematic review exists regarding how they were related to obesity. We searched research articles published between 2000 and 2021 in PubMed, CINAHL, and Scopus databases. Both cross-sectional and prospective studies that examined the relationship between a diet quality score and weight, body mass index, obesity, or waist circumference conducted in a Chinese population were selected. From the 602 articles searched, …

Week Of October 11, 2021 - October 15, 2021, Benjamin N. Cardozo School Of Law

Today at Cardozo 2021

Events occurring this week have been sponsored by:

• Asian Pacific American Law Students Association (APALSA)
• Black Law Students Association (BLSA)
• Cardozo Art Law Society
• Cardozo Criminal Law Society (CCLS)
• Cardozo Family Law Society
• Cardozo Fashion Law Society
• Cardozo Federalist Society
• Cardozo For Immigrants' Rights and Equality (FIRE)
• Cardozo International & Comparative Law Review
• Cardozo International Law Society
• Cardozo Law Institute in Holocaust and Human Rights (CLIHHR)
• Cardozo National Lawyers Guild (NLG)
• Cardozo Office of Student Life
• Cardozo Office of Student Services & Advising
• Cardozo Public Service Scholars Program
• Cardozo Student Animal Legal Defense Fund (SALDF)
• Cardozo Students for Human Rights …

Combatting The Effects Of Greenhouse Gas Emissions By Cattle To Decrease Global Warming, Grace Stockmal

D.U.Quark

Greenhouse gases (GHG), specifically methane, carbon dioxide, and nitrous oxide, contribute to eutrophication and global warming. Large amounts of these gases are released by beef and dairy farms. The misconception is how and why greenhouse gases are emitted from cows. It is hypothesized that greenhouse gas emissions from cattle can be reduced through mitigation strategies in beef and dairy production along with farmers’ contributions to their livestock’s emissions. The reduction of emissions and increase in milk production comes from increased activity and care of the cows, including medicating lesions and diseases. It is also concluded that waste management and records …

Uncovering Disease Mechanisms In A Novel Mouse Model Expressing Humanized Apoeε4 And Trem2*R47h., Kevin P Kotredes, Adrian Oblak, Ravi S Pandey, Peter Bor-Chian Lin, Dylan Garceau, Harriet M. Jackson, Asli Uyar, Rita O'Rourke, Sarah O'Rourke, Cynthia Ingraham, Daria Bednarycek, Melisa Belanger, Zackary Cope, Kate E Foley, Benjamin A Logsdon, Lara M Mangravite, Stacey J Sukoff Rizzo, Paul R Territo, Gregory W. Carter, Michael Sasner, Bruce T Lamb, Gareth R Howell

Faculty Research 2021

Late-onset Alzheimer's disease (AD; LOAD) is the most common human neurodegenerative disease, however, the availability and efficacy of disease-modifying interventions is severely lacking. Despite exceptional efforts to understand disease progression via legacy amyloidogenic transgene mouse models, focus on disease translation with innovative mouse strains that better model the complexity of human AD is required to accelerate the development of future treatment modalities. LOAD within the human population is a polygenic and environmentally influenced disease with many risk factors acting in concert to produce disease processes parallel to those often muted by the early and aggressive aggregate formation in popular mouse …

Impact Of Feeding Syngenta Enogen® Feed Corn Compared To Control Corn In Different Diet Scenarios To Finishing Beef Cattle, Stacia M. Volk, Hannah H. Wilson, Kathryn J. Hanford, James C. Macdonald, Galen E. Erickson

Department of Animal Science: Faculty Publications

The objective of this pooled statistical analysis was to evaluate Syngenta Enogen® Feed Corn (EFC) versus conventional corn (CON) when fed as either dry-rolled corn (DRC) or highmoisture corn (HMC) for effects on finishing beef cattle performance and carcass characteristics. Corns were evaluated in diets with byproduct inclusion rates of 0, 15, 18, 20, and 30% distiller grains or 25 and 35% Sweet Bran® (a commercial corn gluten feed product). Seven trials (n = 1856) consisting of 200 pen means comparing 26 diet treatments were analyzed using regression in a pooled analysis. When EFC was processed as DRC, the gain …

Fairy Led, Savannah Hsu

Individual Item Submissions

A story about fairies who trap you in the woods until you turn your clothes inside out.

Parpura's Pioneering Work On Misunderstood Brain Cells Honored In Journal Special Issue, Matt Windsor

Browse All News

No abstract provided.

Crow's Nest, October 11, 2021, Crow's Nest Staff

Crow's Nest

The October 11, 2021, issue of the Crow's Nest.

The Guardian, Week Of October 11, 2021, Wright State Student Body

The Guardian Student Newspaper

News articles from The Guardian for the week of October 11, 2021. The Guardian is the official student-run newspaper for Wright State University. It has been published regularly since March of 1965.

Review Of Dry Milk, Alvina Lock

Perspectives in the Arts and Humanities Asia

No abstract provided.

Dragon, Josh Stenberg

Perspectives in the Arts and Humanities Asia

No abstract provided.