Digital Commons Network^™

When And Why Did Human Brains Decrease In Size? A New Change-Point Analysis And Insights From Brain Evolution In Ants, Jeremy M. Desilva, James F.A. Traniello, Alexander G. Claxton, Luke D. Fannin

Dartmouth Scholarship

Human brain size nearly quadrupled in the six million years since Homo last shared a common ancestor with chimpanzees, but human brains are thought to have decreased in volume since the end of the last Ice Age. The timing and reason for this decrease is enigmatic. Here we use change-point analysis to estimate the timing of changes in the rate of hominin brain evolution. We find that hominin brains experienced positive rate changes at 2.1 and 1.5 million years ago, coincident with the early evolution of Homo and technological innovations evident in the archeological record. But we also find that …

Super-Resolution Microscopy Reveals Photoreceptor-Specific Subciliary Location And Function Of Ciliopathy-Associated Protein Cep290, Valencia L Potter, Abigail R Moye, Michael A Robichaux, Theodore G Wensel

Faculty, Staff and Students Publications

Mutations in the cilium-associated protein CEP290 cause retinal degeneration as part of multiorgan ciliopathies or as retina-specific diseases. The precise location and the functional roles of CEP290 within cilia and, specifically, the connecting cilia (CC) of photoreceptors, remain unclear. We used super-resolution fluorescence microscopy and electron microscopy to localize CEP290 in the CC and in the primary cilia of cultured cells with subdiffraction resolution and to determine effects of CEP290 deficiency in 3 mutant models. Radially, CEP290 localizes in close proximity to the microtubule doublets in the region between the doublets and the ciliary membrane. Longitudinally, it is distributed throughout …

Legumes As A Strategy For Reducing Greenhouse Gas Emissions Of Forage-Livestock Systems, N. Dilorenzo, José C. B. Dubeux Jr., L. Garcia, R. D. Guevara, S. Lagrange, J. Macadam, J. J. Villalba

IGC Proceedings (1977-2023)

Incorporation of legumes into forage systems has been a widely adopted strategy to increase pasture productivity and forage nutritive value, while reducing N inputs. Considering the population growth, and the diminishing land resources for food production, the need to increase the food supply will have to be balanced with the environmental impact of these systems, particularly their carbon footprint. Enteric methane production represents the largest source of greenhouse gas emissions from livestock. Certain forage legumes have evolved plant secondary compounds, such as tannins and other polyphenols, which have been associated with reductions in enteric methane emissions. Studies were conducted at …

Forage Legumes In Tropical Regions: Recent Advances And Future Challenges, D. R. Casagrande, B. G. C. Homem, R. M. Boddey

IGC Proceedings (1977-2023)

Nitrogen input in tropical pastures increases forage and animal productivity. Forage legumes can fix atmospheric nitrogen and are the most economical way to add this nutrient to the soil. Our objective was to report the benefits of forage legumes in tropical pastures and possible strategies to implement different forage legumes. In tropical conditions, such as in Brazil, the use of forage legumes is still scarce. Even with low legume adoption on tropical pastures, forage legumes can provide ecosystem services. Increased animal productivity is the first ecosystem service provided by these legumes, mainly due to the addition of nitrogen that is …

“An Object Lesson To The Country”—The 1915 Atlantic Fleet Summer Exercise And The U.S. Navy On The Eve Of World War I, Ryan Peeks

Naval War College Review

This unrealistic summer exercise scenario was designed to embarrass the Secretary of the Navy and force the Wilson administration to expand the Navy, illuminating three aspects of the service on the cusp of America’s entry into war: a rupture in civil-military relations, the use to which the Navy put its German counterpart, and Navy leaders’ assessment of the service after two decades of naval buildup.

Using Digital Libraries To Engage The Whole Student: Culturally Sustaining Pedagogies, Trauma-Informed Classrooms, And Project-Based Learning, Alejandra Torres

Journal of Critical Digital Librarianship

Engaging students with an online library does not have to be limited to research purposes only. This essay includes lesson plan ideas that use the Louisiana Digital Library to engage middle and high school students in ways that help amplify their curiosity and explore their identities. To ensure the lesson plans engage the whole student, I ground them in three components (culturally sustaining pedagogies, trauma-informed classrooms, and project-based learning) and seven core values. These lessons could be used alone as writing workshops or can be used to introduce or make connections to other concepts. The activities are adaptable to fit …

Interventions For Mitigating Drought-Related Livestock Mortality In Africa’S Pastoral Areas: A Review Of Their Relevance And Effectiveness With Special Reference To Kenya, Hallo Dabasso Bulle

IGC Proceedings (1977-2023)

One of the key challenges facing pastoral livestock production in Africa’s drylands is the recurring drought which triggers shortage of grazing resources and massive losses of livestock. Though the pastoralists have traditional drought coping mechanisms, the changing land use, insecure land-tenure arrangements, and the declining natural resource base, have undermined the effectiveness of the mechanisms and worsen the drought impacts. Several interventions have hence been implemented over the years to mitigate the increasing drought impacts and to create more resilient pastoralist societies. Focusing on Kenyan pastoral areas, this study reviewed the relevance and effectiveness of various interventions in reducing the …

Importance Of Grazing Management In Improving Water Use Efficiency Of Tropical Forage Grasses, Juan A. Cardoso, J. D. L. C. Jiménez, Mauricio Sotelo, Idupulapati M. Rao, Michael Peters

IGC Proceedings (1977-2023)

The growing number of extreme weather events has created the need to identify tropical forage grasses with greater water use efficiency (WUE) to cope with water-limited conditions. WUE can be defined as the ratio of forage biomass produced per unit of water used. However, WUE is a dynamic ratio that changes according to environmental gradients (e.g., water or nutrient availability) or ontogenetic drift (e.g., changes in root to shoot biomass allocation across phenological stages). Furthermore, genetic improvement leading to greater WUE is likely to result in smaller plants that produce less than the required forage biomass to sustain good animal …

Risk Of Climate-Related Impacts On Global Rangelands – A Review And Modelling Study, C. M. Godde, R. B. Boone, A. Ash, K. Waha, L. Sloat, P. Thornton, D. Mason-D’Croz, D. Mayberry, M. Herrero

IGC Proceedings (1977-2023)

Climate change threatens the ability of global rangelands to provide food, support livelihoods and deliver important ecosystems services. The extent and magnitude of potential impacts are however poorly understood. In this study, we review the risk of climate impacts along the rangeland systems food supply chain. We also present results from biophysical modelling simulations and spatial data analyses to identify where and to what extent rangelands may be at climatic risk. Although a quantification of the net impacts of climate change on rangeland production systems is beyond the reach of our current understanding, there is strong evidence that there will …

Quantifying Greenhouse Gas Emissions Attributable To Smallholder Livestock Systems In Western Kenya: Cradle To Farm Gate Life Cycle Assessment, P. W. Ndung’U, T. Takahashi, C. J. L. Du Toit, M. Robertson-Dean, K. Butterbach-Bahl, G. Mcauliffe, L. Merbold, J. P. Goopy

IGC Proceedings (1977-2023)

Ruminants are central to the economic and nutritional life of much of sub-Saharan Africa, but cattle are now blamed for having disproportionately large negative environmental impact through (amongst other things) emissions of greenhouse gases. However, the exact mechanism behind these emissions is not well-understood and indeed accurate estimates themselves are lacking due to a paucity of reliable data. Employing individual animal records obtained at regular farm visits, this study quantified emissions intensities (EIs) of smallholder farms in three counties of Western Kenya through life cycle assessment (LCA). Crude protein (CP) was chosen as the functional unit to capture outputs of …

Long-Term N Addition, Not Warming, Increases Net Ecosystem Co2 Exchange In A Desert Steppe In Northern China, Guodong Han, Qian Wu

IGC Proceedings (1977-2023)

Grasslands cover a major part of the global terrestrial area and provide important ecosystem functions such as sequestration of carbon (C). Desert steppes are unique ecosystems with properties in between desert and grasslands. They are considered to be vulnerable ecosystems that are at risk of desertification due to global change. To provide a robust prediction of the effect of climate warming and increased nitrogen (N) deposition on desert steppe, long-term studies that capture the annual variation in precipitation are needed. We conducted a 12-year field experiment in a desert steppe which showed that warming did not change ecosystem C exchange …

Synergistic Anticancer Response Of Curcumin And Piperine Loaded Lignin-G-P (Nipam-Co-Dmaema) Gold Nanogels Against Glioblastoma Multiforme, Xinyi Zhao, Bilal Javad, Daxing Cui, James Curtin, Furong Tian

Articles

Glioblastoma multiforme (GBM) is the most aggressive and commonly diag- 11 nosed brain cancer and presents a strong resistance to routine chemotherapeutic drugs. 12 The present study involves the synthesis of Lignin-g- p (NIPAM-co-DMAEMA) gold 13 nanogel, loaded with curcumin and piperine to treat GBM. The application has three 14 functions: (1) overcome the limitations of biodistribution, (2) enhance the toxicity of an- 15 ticancer drugs against GBM, (3) identify the uptake pathway. Atom transfer radical 16 polymerization was used to synthesize the Lignin-g-PNIPAM network, crosslinked with 17 the gold nanoparticles (GNPs) to self-assemble into nanogels. The size distribution and …

Better Tired Than Lost: Turtle Ant Trail Networks Favor Coherence Over Short Edges, Arjun Chandrasekhar, James A. R. Marshall, Cortnea Austin, Saket Navlakha, Deborah M. Gordon

Student Published Works

Creating a routing backbone is a fundamental problem in both biology and engineering. The routing backbone of the trail networks of arboreal turtle ants (Cephalotes goniodontus) connects many nests and food sources using trail pheromone deposited by ants as they walk. Unlike species that forage on the ground, the trail networks of arboreal ants are constrained by the vegetation. We examined what objectives the trail networks meet by comparing the observed ant trail networks with networks of random, hypothetical trail networks in the same surrounding vegetation and with trails optimized for four objectives: minimizing path length, minimizing average …

Interview With Rebecca Kieffer Connolly, Rebecca Kieffer Connolly, Mirsa Trevino, Andrea Avendano

Community Historical Archaeology Project with Schools (CHAPS) Oral Histories

The interviewee was Mrs. Rebecca Connolly. She is a family member of the Kieffer’s Family. Mrs. Connolly left the Rio Grande Valley when she got married. She lived in the farm with her siblings throughout her childhood. Base on her accounts she was able to provide us information regarding how her life was growing up in the farm.

Ontogeny Of Carbon Monoxide-Related Gene Expression In A Deep-Diving Marine Mammal, Elizabeth R. Piotrowski, Michael S. Tift, Daniel E. Crocker, Anna B. Pearson, José P. Vázquez-Medina, Anna D. Keith, Jane I. Khudyakov

Pacific Faculty Work

Marine mammals such as northern elephant seals (NES) routinely experience hypoxemia and ischemia-reperfusion events to many tissues during deep dives with no apparent adverse effects. Adaptations to diving include increased antioxidants and elevated oxygen storage capacity associated with high hemoprotein content in blood and muscle. The natural turnover of heme by heme oxygenase enzymes (encoded by HMOX1 and HMOX2) produces endogenous carbon monoxide (CO), which is present at high levels in NES blood and has been shown to have cytoprotective effects in laboratory systems exposed to hypoxia. To understand how pathways associated with endogenous CO production and signaling change across …

2021.10.21 - Academic/Student Affairs, Enrollment, And Technology Committee Meeting Minutes, Northeastern Illinois University Board Of Trustees

Board of Trustees - 2021

Meeting materials for the NEIU Academic/Student Affairs, Enrollment, and Technology Committee

Montana Kaimin, October 21, 2021, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

Micrornas As Biomarkers For Early Diagnosis, Prognosis, And Therapeutic Targeting Of Ovarian Cancer, Yegane Mirahmadi, Reza Nabavi, Fourough Taheri, Mohammad Mahdi Samadian, Zari Naderi Ghale-Noie, Mahsa Farjami, Abbas Samadi-Khouzani, Meysam Yousefi, Sara Azhdari, Arash Salmaninejad, Amirhossein Sahebkar

Department of Animal Science: Faculty Publications

Ovarian cancer is the major cause of gynecologic cancer-related mortality. Regardless of outstanding advances, which have been made for improving the prognosis, diagnosis, and treatment of ovarian cancer, the majority of the patients will die of the disease. Late-stage diagnosis and the occurrence of recurrent cancer after treatment are the most important causes of the high mortality rate observed in ovarian cancer patients. Unraveling the molecular mechanisms involved in the pathogenesis of ovarian cancer may help find new biomarkers and therapeutic targets for ovarian cancer. MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression, mostly at the posttranscriptional stage, …

Conquer And Prevail Issue 85 October 21 2021, Wofford College. Office Of Marketing And Communications

Conquer and Prevail Newsletter

No abstract provided.

Perches As Cooling Devices For Reducing Heat Stress In Caged Laying Hens: A Review, Jiaying Hu, Yijie Xiong

Department of Animal Science: Faculty Publications

Heat stress is one of the most detrimental environmental challenges affecting the biological process and the related production performance of farm animals, especially in poultry. Commercial laying hens have been bred (selected) for high egg production, resulting in increased sensitivity to heat stress due to breeding-linked metabolic heat production. In addition, laying hens are prone to heat stress due to their inadequate species-specific cooling mechanisms resulting in low heat tolerance. In addition, hens have no sweat glands and feathering covers almost their entire body to minimize body heat loss. The poultry industry and scientists are developing cooling methods to prevent …

Inheritance Of A Mutation Causing Neuropathy With Splayed Forelimbs In Jersey Cattle, A. Al-Khudhair, D. J. Null, J. B. Cole, C. W. Wolfe, David J. Steffen, P. M. Vanraden

School of Veterinary and Biomedical Sciences: Faculty Publications

A new undesirable genetic factor, neuropathy with splayed forelimbs (JNS), has been identified recently in the Jersey breed. Calves affected with JNS are unable to stand on splayed forelimbs that exhibit significant extensor rigidity and excessive lateral abduction at birth. Affected calves generally are alert at birth but exhibit neurologic symptoms, including spasticity of head and neck and convulsive behavior. Other symptoms reported include dislocated shoulders, congenital craniofacial anomalies, and degenerative myelopathy. Inheritance of an undesirable genetic factor was determined from a study of 16 affected calves reported by Jersey breeders across the United States. All of their pedigrees traced …

Dixie Flyer, Memphis, 4:5, 1982

Documents

Vol. 4, No. 5 of "The Dixie Flyer", edited by Sara Van Horn, published in Memphis, Tennessee, in February 1982.

The Montclarion, October 21, 2021, The Montclarion

The Montclarion

Student Newspaper of Montclair State University

Therapeutic Resistance In Pancreatic Ductal Adenocarcinoma: Current Challenges And Future Opportunities, Aditi Jain, Phd, Vikas Bhardwaj

Kimmel Cancer Center Faculty Papers

Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancerrelated deaths in the United States. Although chemotherapeutic regimens such as gemcitabine+ nab-paclitaxel and FOLFIRINOX (FOLinic acid, 5-Fluroruracil, IRINotecan, and Oxaliplatin) significantly improve patient survival, the prevalence of therapy resistance remains a major roadblock in the success of these agents. This review discusses the molecular mechanisms that play a crucial role in PDAC therapy resistance and how a better understanding of these mechanisms has shaped clinical trials for pancreatic cancer chemotherapy. Specifically, we have discussed the metabolic alterations and DNA repair mechanisms observed in PDAC and current approaches in targeting …

Domarchive: A Century Of Published Dominance Data, Eli D. Strauss, Alex R. Decasien, Gabriela Galindo, Elizabeth A. Hobson, Daizaburo Shizuka, James P. Curley

School of Biological Sciences: Faculty Publications

Dominance behaviours have been collected for many groups of animals since 1922 and serve as a foundation for research on social behaviour and social structure. Despite a wealth of data from the last century of research on dominance hierarchies, these data are only rarely used for comparative insight. Here, we aim to facilitate comparative studies of the structure and function of dominance hierarchies by compiling published dominance interaction datasets from the last 100 years of work. This compiled archive includes 436 datasets from 190 studies of 367 unique groups (mean group size 13.8, s.d. = 13.4) of 135 different species, …

Crime Scene Investigation: Simulated Post-Mortem Lc-Ms/Ms Analysis Of Cocaine And Cocaine Metabolites In Synthetic Human Serum, Matt J. Vergne

Faculty Works

This laboratory experiment introduces upper-division undergraduate analytical chemistry students to liquid chromatography-tandem mass spectrometry (LC-MS/MS) in a forensic application: the analysis of cocaine and metabolites of cocaine in simulated serum ostensibly from drug overdose victims. For this investigation, students developed the analytical methods. First, the students determined the multiple reaction monitoring (MRM) transitions and optimized collision energy. The MS methods developed were then added to an LC method for LC-MS/MS quantitation with a 2.5 min run time. Students successfully quantified the drugs and metabolites, and they were able to identify which samples indicated cocaine use and overdose

Updating The Distribution Of American Black Bears (Ursus Americanus) In Texas Using Community Science, State Agencies, And Natural History Collections, Jessica E. Light, Alaya S. Keane, Jonah W. Evans

Western North American Naturalist

The American black bear (Ursus americanus) is one of largest terrestrial mammals found in Texas. Despite the black bear’s large size and charismatic nature, its distribution across the state has been difficult to determine due to outdated distribution maps. Although recent sighting reports indicate that the current distribution of black bears in Texas may be expanding in some areas, researching changes in black bear populations can be difficult and cost prohibitive. Data from community science initiatives and natural history collections can be useful to better understand species distributions and ecology. We used records from Texas Parks and Wildlife …

The George-Anne, Georgia Southern University

The George-Anne

• Reflector
• Campus Life
• Liquor sale in town, Early voting opens
• How can students get an emotional support animal?
• SEND SILENCE PACKING
• GS Museum Reopens after 3 Years of Renovations
• Missing former GS football star found safe
• Women's March
• The Suave Life in Statesboro
• Style Maximalism for Less
• Homecoming 2021 Calendar

Meta-Analysis Reveals Transcription Factor Upregulation In Cells Of Injured Mouse Sciatic Nerve, Mingchao Li, Matthew C. Banton, Qing Min, David B. Parkinson, Xinpeng Dun

School of Biomedical Sciences

Following peripheral nerve injury, transcription factors upregulated in the distal nerve play essential roles in Schwann cell reprogramming, fibroblast activation and immune cell function to create a permissive distal nerve environment for axonal regrowth. In this report, we first analysed four microarray data sets to identify transcription factors that have at least twofold upregulation in the mouse distal nerve stump at day 3 and day 7 post-injury. Next, we compared their relative mRNA levels through the analysis of an available bulk mRNA sequencing data set at day 5 post-injury. We then investigated the expression of identified TFs in analysed single-cell …

Kenyon Collegian - October 21, 2021

The Kenyon Collegian

No abstract provided.