Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2021

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 2671 - 2700 of 24316

Full-Text Articles in Entire DC Network

2021-11-03 Sga Meeting Minutes, Morehead State University. Student Government Association. Nov 2021

2021-11-03 Sga Meeting Minutes, Morehead State University. Student Government Association.

Student Government Association Records

Meeting minutes of the Student Government Association from November 3, 2021.


November 3, 2021 Faculty Senate Minutes, University Of South Carolina Nov 2021

November 3, 2021 Faculty Senate Minutes, University Of South Carolina

Faculty Senate

No abstract provided.


The Lumberjack, November 03, 2021 Nov 2021

The Lumberjack, November 03, 2021

Cal Poly Humboldt's Student Newspaper

The student newspaper of Humboldt State University.


Human Immunodeficiency Virus Type-1 (Hiv-1) Transcriptional Regulation, Latency And Therapy In The Central Nervous System, Joseph Hokello, Adhikarimayum Lakhikumar Sharma, Priya Tyagi, Alok Bhushan, Mudit Tyagi Nov 2021

Human Immunodeficiency Virus Type-1 (Hiv-1) Transcriptional Regulation, Latency And Therapy In The Central Nervous System, Joseph Hokello, Adhikarimayum Lakhikumar Sharma, Priya Tyagi, Alok Bhushan, Mudit Tyagi

College of Pharmacy Faculty Papers

The central nervous system (CNS) is highly compartmentalized and serves as a specific site of human immunodeficiency virus (HIV) infection. Therefore, an understanding of the cellular populations that are infected by HIV or that harbor latent HIV proviruses is imperative in the attempts to address cure strategies, taking into account that HIV infection and latency in the CNS may differ considerably from those in the periphery. HIV replication in the CNS is reported to persist despite prolonged combination antiretroviral therapy due to the inability of the current antiretroviral drugs to penetrate and cross the blood–brain barrier. Consequently, as a result …


3 Cases Of Superior Vena Cava Syndrome Following Percutaneous Right Ventricular Assist Device Placement, John R Vaile, J. Eduardo Rame, René J Alvarez, H. Todd Massey, Vakhtang Tchantchaleishvili, Alec Vishnevsky, Indranee Rajapreyar, Yevgeniy Brailovsky, Mahek Shah Nov 2021

3 Cases Of Superior Vena Cava Syndrome Following Percutaneous Right Ventricular Assist Device Placement, John R Vaile, J. Eduardo Rame, René J Alvarez, H. Todd Massey, Vakhtang Tchantchaleishvili, Alec Vishnevsky, Indranee Rajapreyar, Yevgeniy Brailovsky, Mahek Shah

Division of Cardiology Faculty Papers

We present 3 cases of superior vena cava (SVC) syndrome following percutaneous right ventricular assist device (RVAD) placement. Each case underscores the importance of early recognition of SVC syndrome in patients with percutaneous RVAD insertion via the internal jugular vein and calls for heightened awareness of device-associated complications. (Level of Difficulty: Advanced.).


The Bg News November 03, 2021, Bowling Green State University Nov 2021

The Bg News November 03, 2021, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. November 03, 2021. Volume 101-Issue 11.


The Student Movement Volume 106 Issue 6: Cold Weather, Hot Dogs: Students Feast At Fall Festival, Grace No, Irina Gagiu, Taylor Uphus, Adoniah Simon, Kaela Mcfadden, Solana Campbell, Andrew Pak, Abigail Lee, Nathan Mathieu, Brendan Syto, Nathan Cheng, Qualyn Robinson, Angelina Nesmith, Gloria Oh, Wambui Karanja, Karenna Lee, Alyssa Henriquez Nov 2021

The Student Movement Volume 106 Issue 6: Cold Weather, Hot Dogs: Students Feast At Fall Festival, Grace No, Irina Gagiu, Taylor Uphus, Adoniah Simon, Kaela Mcfadden, Solana Campbell, Andrew Pak, Abigail Lee, Nathan Mathieu, Brendan Syto, Nathan Cheng, Qualyn Robinson, Angelina Nesmith, Gloria Oh, Wambui Karanja, Karenna Lee, Alyssa Henriquez

The Student Movement v. 106 (2021-2022)

HUMANS

New Director of Innovation and Entrepreneurship: Interview with Matias Soto, Interviewed by: Grace No

Our AUSA President: An Interview with Dongchan Kim, Interviewed by: Irina Gagiu

The People Who Inspire Us, Taylor Uphus

ARTS & ENTERTAINMENT

Creative Spotlight: Matthew Jackson (aka Mateo Banks), Interviewed by: Adoniah Simon

Current Favorites: November 2021, Kaela McFadden

"Dune": Ushering in an Era of Sci-Fi Majesty, Solana Campbell

NEWS

For "Sure On This Shining Night": It Was a Concert to Remember, Andrew Pak

Fall Festival 2021: Autumnal Celebrations at Andrews University, Abigail Lee

How to Call to (Flu) Shots at Andrews University, Nathan Mathieu …


Competitive Binding Of E3 Ligases Trim26 And Wwp2 Controls Sox2 In Glioblastoma, Tatenda Mahlokozera, Bhuvic Patel, Hao Chen, Patrick Desouza, Xuan Qu, Diane D Mao, Daniel Hafez, Wei Yang, Rukayat Taiwo, Mounica Paturu, Afshin Salehi, Amit D Gujar, Gavin P Dunn, Nima Mosammaparast, Allegra A Petti, Hiroko Yano, Albert H Kim Nov 2021

Competitive Binding Of E3 Ligases Trim26 And Wwp2 Controls Sox2 In Glioblastoma, Tatenda Mahlokozera, Bhuvic Patel, Hao Chen, Patrick Desouza, Xuan Qu, Diane D Mao, Daniel Hafez, Wei Yang, Rukayat Taiwo, Mounica Paturu, Afshin Salehi, Amit D Gujar, Gavin P Dunn, Nima Mosammaparast, Allegra A Petti, Hiroko Yano, Albert H Kim

2020-Current year OA Pubs

The pluripotency transcription factor SOX2 is essential for the maintenance of glioblastoma stem cells (GSC), which are thought to underlie tumor growth, treatment resistance, and recurrence. To understand how SOX2 is regulated in GSCs, we utilized a proteomic approach and identified the E3 ubiquitin ligase TRIM26 as a direct SOX2-interacting protein. Unexpectedly, we found TRIM26 depletion decreased SOX2 protein levels and increased SOX2 polyubiquitination in patient-derived GSCs, suggesting TRIM26 promotes SOX2 protein stability. Accordingly, TRIM26 knockdown disrupted the SOX2 gene network and inhibited both self-renewal capacity as well as in vivo tumorigenicity in multiple GSC lines. Mechanistically, we found TRIM26, …


The Ethically Conscious Flower Consumer: Understanding Fair Trade Cut Flower Purchase Behavior In Germany, Meike Rombach, David L. Dean, Nicole Olynk Widmar, Vera Bitsch Nov 2021

The Ethically Conscious Flower Consumer: Understanding Fair Trade Cut Flower Purchase Behavior In Germany, Meike Rombach, David L. Dean, Nicole Olynk Widmar, Vera Bitsch

Department of Agricultural Economics Faculty Publications

Fair trade flowers are an important niche product relevant to ethically conscious consumers. The study proposes a model that investigates key factors affecting the behavior of these cut flower consumers in Germany. The study serves to complement the existing studies dedicated to preferences for flower attributes and products, as well as consumers’ willingness to pay. It builds on an online survey with a representative sample of 772 German cut-flower consumers. Partial least squares structural equation modelling shows that concern for the treatment of workers from countries with poor environmental and labor reputations, the breadth of fair trade cut flower information …


Evolutionary Mechanisms For Host Resistance To Tumor Growth And Subsequent Cancer Cell Counter-Adaptations, Arig Ibrahim Hashim Nov 2021

Evolutionary Mechanisms For Host Resistance To Tumor Growth And Subsequent Cancer Cell Counter-Adaptations, Arig Ibrahim Hashim

USF Tampa Graduate Theses and Dissertations

Cancer is well-recognized as an evolutionary system, as first proposed by Cairns and Nowell more than 60 years ago. In an evolutionary context, cancers growing in vivo typically consist of heterogeneous subpopulations of cells that interact with each other and with host cells through selection forces operating at many temporal and spatial scales. Moreover, the tumor environment comprises more than just cancer cells; it includes a rich cancer stroma and cancer-driving molecules such as cytokines and metabolites. The tumor’s environment comprises intratumoral heterogeneity that often leads to therapy resistance attributed to the essential roles of many genetic and nongenetic mechanisms. …


Artist Note On Evolvements And Interpretations Of Wang Gongxin's Works, Gong-Xin Wang 王功新 Nov 2021

Artist Note On Evolvements And Interpretations Of Wang Gongxin's Works, Gong-Xin Wang 王功新

Zhou Documents

This artist's note on his works -- paralleled together with peer's comments -- is scripted in English. (Jerry Wu'23).


Meaningful Music-Making In A Casual Social Environment: An Ethnographic Study Of An Amateur University Taiko Ensemble, Palmer Haffner Nov 2021

Meaningful Music-Making In A Casual Social Environment: An Ethnographic Study Of An Amateur University Taiko Ensemble, Palmer Haffner

Visions of Research in Music Education

Although taiko drumming in America has been investigated by various researchers, from many different lenses, research is absent in this field that studies taiko ensembles at an amateur level. This ethnography aims to discover the meaning and values within the music-making of people who participate in Tora Taiko, a group of amateurs that specialize in Japanese taiko drumming, on the Princeton University campus. This study analyzed the actions and words of this amateur taiko ensemble as a lens for music education, through participant observations, interviews, and artifact collection. Themes of group identity and environment building emerged that showed the strength …


Elephant In The Music Room: A Content Analysis Of Ten Years Of Publications Related To Urban Music Education, Carol Frierson-Campbell, Constance L. Mckoy, Nicole R. Robinson Nov 2021

Elephant In The Music Room: A Content Analysis Of Ten Years Of Publications Related To Urban Music Education, Carol Frierson-Campbell, Constance L. Mckoy, Nicole R. Robinson

Visions of Research in Music Education

As suggested by the metaphor of the elephant in the (music) room, our field cannot challenge a problem that we do not acknowledge. The 10th anniversary of Teaching Music in the Urban Classroom provided a milestone for appraising the written conversation about music education in urban schools in the United States. To this end, three authors initiated a content analysis of publications from 2006-2015 that addressed urban contexts. Using Milner’s urban school typology and Farmer’s critical analysis of urban music education publications, we examined peer-reviewed trade and scholarly periodicals as well as master’s theses and doctoral dissertations. Our findings suggest …


Chris Thile, Kendrick Lamar, And The Problem Of The White Rap Cover, Ethan Hein Nov 2021

Chris Thile, Kendrick Lamar, And The Problem Of The White Rap Cover, Ethan Hein

Visions of Research in Music Education

In this paper, I examine a performance that the bluegrass musician Chris Thile gave of “Alright” by Kendrick Lamar, a song with strong themes of policy brutality that is associated with the Black Lives Matter movement. While Thile approached the song with respectful intentions, the performance nevertheless received strongly negative reactions. In this paper, I examine the performance and its reception. I ask whether Thile should be accused of cultural appropriation, and whether or how any white person could perform such a song without facing a similar accusation. Finally, I explore this debate’s ramifications for music educators who wish to …


Culturally Responsive Research Projects In A Title I Elementary Center For Fine Arts, Donald Devito, Tamyra Telles, Brandon Hidalgo Smith Nov 2021

Culturally Responsive Research Projects In A Title I Elementary Center For Fine Arts, Donald Devito, Tamyra Telles, Brandon Hidalgo Smith

Visions of Research in Music Education

This paper is a research project report for the purpose of developing methods to document cultural responsiveness and student identification of cultural identity in the community, school and in online global cultural exchanges at a 98% minority Title I Elementary Center for Fine Arts. This school was ranked as one of the 300 lowest performing schools in Florida with a county graduation rate for minorities among the lowest in the state. Three phases constituted the Rawlings approach for observing and assessing student cultural responsiveness in arts education: Phase one involved defining cultural responsiveness and culturally relevancy from students in the …


Reimagining Pedagogical Possibilities In The Schulwerk: Intersections Of Critical Pedagogy For Music Education And Orff, Ian Cicco Nov 2021

Reimagining Pedagogical Possibilities In The Schulwerk: Intersections Of Critical Pedagogy For Music Education And Orff, Ian Cicco

Visions of Research in Music Education

Critical pedagogy for music education (Abrahams, 2005), as influenced by Freire’s (1970) conception of critical pedagogy, emphasizes the importance of deconstructing power imbalances between students and teachers, in addition to placing students’ musical cultures at the forefront of learning. Though the Orff Schulwerk teaching approach is similar to CPME in terms of its emphasis on student creation, collaboration, and improvisation, Benedict (2009) posited that Orff pedagogy might be a systematized, rigid method that neither fully engages students to critically interact with music nor considers their varying musical interests. The purpose of this paper is to examine how tenets of CPME …


Music Composition As Immersive Learning In K–5 General Music Education: Results Of A 4-Year Study, Elissa Johnson-Green Nov 2021

Music Composition As Immersive Learning In K–5 General Music Education: Results Of A 4-Year Study, Elissa Johnson-Green

Visions of Research in Music Education

This paper focuses on immersive learning in a composition-centered curriculum in K–5 general music education. It is one aspect of a 4-year longitudinal study of children’s musical development through composition. I collected data over 4 years on the work of students (N=300) who attended music classes as part of their general education. Data comprised video and audio recordings of student performances of and interviews about their compositional processes; photographs of student written work and of classroom activity; students’ written and drawn scores, notated scores, and other drawings; researcher written work, lesson plans, and observational notes of classroom activity. I transcribed …


Examining Elementary General Music Teachers’ Ratings Of Musical Vignettes, H. Ellie Falter Nov 2021

Examining Elementary General Music Teachers’ Ratings Of Musical Vignettes, H. Ellie Falter

Visions of Research in Music Education

The degree to which a teacher perceives a behavior as musical may impact their ability to support young children's musicking and musical development actively. The purpose of this study was to examine elementary general music teachers’ perception of young children’s music making. Elementary general music teachers (n = 125) completed a questionnaire, rating the extent to which they agreed children and teachers described in six vignettes were engaged in making music. Vignettes were given with different conditions (1, 2, or 5 kindergartners; 0 or 1 teachers). 2x3 factorial ANOVAs showed agreement ratings were statistically different for two vignettes, one each …


Live Long And Prosper: A Systematic Review Of Equipment-Based Training Programs For Older Adults., Charisma Byrd, Patric Lee, Katie Lopez, Sarah Pearce, Landen Wong, Alexandra Auslander, Zakkoyya Lewis, Lara Killick Nov 2021

Live Long And Prosper: A Systematic Review Of Equipment-Based Training Programs For Older Adults., Charisma Byrd, Patric Lee, Katie Lopez, Sarah Pearce, Landen Wong, Alexandra Auslander, Zakkoyya Lewis, Lara Killick

International Journal of Exercise Science: Conference Proceedings

PURPOSE: Within the US, people are experiencing longer life expectancy, yet these extended lifespans have not necessarily translated into years living in good health. Degenerative diseases such as osteoporosis and sarcopenia are particularly prevalent amongst older adults. Research shows that regular resistance exercise carries distinct preventive health benefits to combat these conditions. Therefore, the purpose of this study was to conduct a systematic review into the effectiveness of equipment-based resistance training programs for older adults (65+ years) on physical function. METHODS: Five databases were searched (PubMed, Web of Science, Science Direct, Medline, and Sports Medicine & Education Index) …


Thinking Critically About Rural Music Education, Vincent C. Bates Nov 2021

Thinking Critically About Rural Music Education, Vincent C. Bates

Visions of Research in Music Education

Thousands of music teachers in North America still teach in a diverse array of rural settings. Many find lifelong fulfillment in these positions, but there are also many who move on to metropolitan places as soon as possible. In this paper, I explore how urbanormativity— ideologies that privilege metropolitan places and values—can frame rural music teaching from a deficit perspective, rather than acknowledging the many assets of teaching music in rural settings. I discuss five suggestions for rural music teachers, administrators, policy-makers, and teacher educators. First, embrace the benefits of smallness. Second, honor local musical preferences and traditions. Third, shape …


Estrogen Receptor Alpha Controls Mitochondrial Function And Metabolic Homeostasis, And Is Critical For Exercise-Induced Improvements In Metabolism, Alexia M. Joseph Nov 2021

Estrogen Receptor Alpha Controls Mitochondrial Function And Metabolic Homeostasis, And Is Critical For Exercise-Induced Improvements In Metabolism, Alexia M. Joseph

International Journal of Exercise Science: Conference Proceedings

Skeletal muscle is an important tissue responsible for locomotion, oxidative metabolism, and insulin-stimulated glucose disposal. Because exercise is the most effective means to combat metabolic dysfunction and prevent the progression of type 2 diabetes, our laboratory is interested in understanding the molecular transducers underlying the health benefits of exercise. Previous work by our group has shown that muscle ESR1/ERα expression is correlated with indices of metabolic health, and Esr1 expression in muscle is induced following exercise training.

PURPOSE: Determine whether genetic overexpression of Esr1 to mimic transcript induction by physical activity is sufficient to produce favorable metabolic changes …


Genetic Drivers Of Cardiac Remodeling In Health And Disease In Female Mice, Alexander R. Strumwasser Nov 2021

Genetic Drivers Of Cardiac Remodeling In Health And Disease In Female Mice, Alexander R. Strumwasser

International Journal of Exercise Science: Conference Proceedings

SWACSM Abstract

Genetic drivers of cardiac remodeling in health and disease in female mice

Alexander R. Strumwasser1, Timothy M. Moore1, Zhenqi Zhou1, Lorraine P. Turcotte2, Aldons J. Lusis1, Andrea L. Hevener1

1Department of Medicine, University of California, Los Angeles 2Department of Biological Sciences, University of Southern California

Hevener Laboratory; Department of Medicine; University of California Los Angeles Laboratory

Category: Masters

Advisor / Mentor: Hevener, Andrea L. [email protected]

ABSTRACT

PURPOSE: Sex differences in cardiac metabolism and cardiometabolic disease susceptibility are well documented. However, the mechanisms underlying sexual dimorphism and …


A Comparison Of Heat Treatment-Induced Skeletal Muscle Adaptations Relative To Exercise Training, Jamie P. Kaluhiokalani, Jack Mehling, Brandon Pfeifer, Mohadeseh Ahmadi Nov 2021

A Comparison Of Heat Treatment-Induced Skeletal Muscle Adaptations Relative To Exercise Training, Jamie P. Kaluhiokalani, Jack Mehling, Brandon Pfeifer, Mohadeseh Ahmadi

International Journal of Exercise Science: Conference Proceedings

ABSTRACT

In vitro and animal studies indicate that the response to heat stress is associated with beneficial adaptations that promote cell health and survival. Few studies to date have examined this finding in human subjects, and it is unclear how the adaptation compares in magnitude to exercise training. PURPOSE: To investigate the skeletal muscle adaptations (namely mitochondrial biogenesis and capillarization) of 6 weeks of deep-muscle heat treatment relative to exercise training. We hypothesized that heat treatment (HT), applied through pulsed shortwave diathermy (2 hr, 3 days/week) over a 6-week intervention period would lead to increased mitochondrial content and capillarity …


Effects Of Selection On Morphological Characteristics In Setaria Sphacelata (Schumach.) Moss, Liana Jank, Kenneth H. Quesenberry, P. Mislevy Nov 2021

Effects Of Selection On Morphological Characteristics In Setaria Sphacelata (Schumach.) Moss, Liana Jank, Kenneth H. Quesenberry, P. Mislevy

IGC Proceedings (1977-2023)

Cattle production in Florida is limited by the lack of available warm-season forages adapted to the cool winters of the region. Setaria (S. sphacelata) has demonstrated green growth during cool conditions in subtropical climates around the world, and has the potential to fill this niche in cattle production in Florida. Four populations were selected in Gainesville and Ona, Florida: two cycles of selection for increased head number, one cycle for increased leaf width and one cycle for grazing tolerance. The objectives of this research were to compare these populations morphologically to determine changes due to selection. Selection for …


Correlated Evolution Of Distinct Signals Associated With Increased Social Selection In Female White-Shouldered Fairywrens, John Anthony Jones, Karan J. Odom, Ian R. Hoppe, Doka Nason, Serena Ketaloya, Jordan Karubian Nov 2021

Correlated Evolution Of Distinct Signals Associated With Increased Social Selection In Female White-Shouldered Fairywrens, John Anthony Jones, Karan J. Odom, Ian R. Hoppe, Doka Nason, Serena Ketaloya, Jordan Karubian

School of Natural Resources: Faculty Publications

Conspicuous female signals have recently received substantial scientific attention, but it remains unclear if their evolution is the result of selection acting on females independently of males or if mutual selection facilitates female change. Species that express female, but not male, phenotypic variation among populations represents a useful opportunity to address this knowledge gap. White-shouldered fairywrens (Malurus alboscapulatus) are tropical songbirds with a well-resolved phylogeny where female, but not male, coloration varies allopatrically across subspecies. We explored how four distinct signaling modalities, each putatively associated with increased social selection, are expressed in two populations that vary in competitive pressure on …


11-02-2021 Swosu Participating In Halloween Candy Collection For The Troops, Southwestern Oklahoma State University Nov 2021

11-02-2021 Swosu Participating In Halloween Candy Collection For The Troops, Southwestern Oklahoma State University

THE BARK ARCHIVE 2021

No abstract provided.


Triumph Of The Commons: Sustainable Community Practices On Rapa Nui (Easter Island), Robert J. Dinapoli, Carl P. Lipo, Terry L. Hunt Nov 2021

Triumph Of The Commons: Sustainable Community Practices On Rapa Nui (Easter Island), Robert J. Dinapoli, Carl P. Lipo, Terry L. Hunt

Anthropology Faculty Scholarship

The history of Rapa Nui (Easter Island) has long been framed as a parable for how societies can fail catastrophically due to the selfish actions of individuals and a failure to wisely manage common-pool resources. While originating in the interpretations made by 18th-century visitors to the island, 20th-century scholars recast this narrative as a “tragedy of the commons,” assuming that past populations were unsustainable and selfishly overexploited the limited resources on the island. This narrative, however, is now at odds with a range of archaeological, ethnohistoric, and environmental evidence. Here, we argue that while Rapa Nui did experience large-scale deforestation …


Ethanol And Opioids Do Not Act Synergistically To Depress Excitation In Carotid Body Type I Cells, Ryan J. Rakoczy, Kajal Kamra, Yoon-Jae Yi, Christopher N. Wyatt Nov 2021

Ethanol And Opioids Do Not Act Synergistically To Depress Excitation In Carotid Body Type I Cells, Ryan J. Rakoczy, Kajal Kamra, Yoon-Jae Yi, Christopher N. Wyatt

Neuroscience, Cell Biology & Physiology Faculty Publications

The combination of opioids and ethanol can synergistically depress breathing and the acute ventilatory response to hypoxia. Multiple studies have shown that the underlying mechanisms for this may involve calcium channel inhibition in central neurons. But we have previously identified opioid receptors in the carotid bodies and shown that their activation inhibits calcium influx into the chemosensitive cells. Given that the carotid bodies contribute to the drive to breathe and underpin the acute hypoxic ventilatory response, we hypothesized that ethanol and opioids may act synergistically in these peripheral sensory organs to further inhibit calcium influx and therefore inhibit ventilation.

Methods …


The Indiana Statesman, November 2, 2021, Indiana State University Nov 2021

The Indiana Statesman, November 2, 2021, Indiana State University

Student Newspaper

How have students handled in-person classes again?; Biden urges action at UN climate summit; Judge rules on Chicago vaccine mandate; YouTube taps new boss to grow content across the Americas


Changes In Histone H3 Acetylation On Lysine 9 Accompany Aβ 1-40 Overexpression In An Alzheimer’S Disease Yeast Model, Muna M. Hugais, Samantha N. Cobos, Seth A. Bennett, Jailene Paredes, Genevieve Foran, Mariana P. Torrente Nov 2021

Changes In Histone H3 Acetylation On Lysine 9 Accompany Aβ 1-40 Overexpression In An Alzheimer’S Disease Yeast Model, Muna M. Hugais, Samantha N. Cobos, Seth A. Bennett, Jailene Paredes, Genevieve Foran, Mariana P. Torrente

Publications and Research

Alzheimer’s Disease (AD), the most common type of dementia, is a neurodegenerative disease characterized by plaques of amyloid-beta (Aβ) peptides found in the cerebral cortex of the brain. The pathological mechanism by which Aβ aggregation leads to neurodegeneration remains unknown. Interestingly, genetic mutations do not explain most AD cases suggesting that other mechanisms are at play. Epigenetic mechanisms, such as histone post-translational modifications (PTMs), may provide insight into the development of AD. Here, we exploit a yeast Aβ overexpression model to map out the histone PTM landscape associated with AD. We find a modest decrease in the acetylation levels on …