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Resolving Variability In Size Structure In An Individual-Based Model For The North Pacific Krill, Euphausia Pacifica, Roxanne Robertson

Cal Poly Humboldt theses and projects

Individual-based models (IBMs) have emerged as a powerful tool for ecological research and are particularly well suited to studies of plankton ecology. In this thesis, I develop an IBM for the North Pacific krill, Euphausia pacifica, with the goal of replicating observed variability in size-structure in the northern California Current Ecosystem. Krill, and E. pacifica in particular, are central to the structure and function of the California Current Ecosystem. Their response to environmental forcing translates climate variability to higher trophic levels and underpins broader ecosystem responses. Recent observations indicate environmental and climate-related shifts in E. pacifica size distributions, which …

Bypassing The Blood-Brain Barrier: A Physical And Pharmacological Approach For The Treatment Of Metastatic Brain Tumors, Samuel A. Sprowls

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation (a) provided an in depth literature review of methods to disrupt the BBB/BTB and improve therapeutic distribution to brain tumors, (b) evaluated the use of azacitidine as a single agent therapy for the treatment of brain metastasis of breast cancer and a potential molecular mechanism by which brain tropic cells are sensitized to hypomethylating agents, (c) determined the impact cannabidiol has on P-glycoprotein mediated efflux at the blood-brain barrier and its potential for use as a single agent treatment for metastatic brain tumors, (d) developed a preclinical radiation therapy protocol for use in small animals and in vitro …

Evaluation Of Population Structure, Age, Growth, And Mortality Of Blue Catfish And Flathead Catfish Within The Robert C. Byrd Pool Of The Ohio And Kanawha Rivers, Joseph Vincent Siegel

Graduate Theses, Dissertations, and Problem Reports (ETD)

The Ohio River is continuing to recover from a long history of anthropogenic impacts. Blue Catfish were considered locally extirpated from the West Virginia sections and have been reintroduced through fingerling stockings beginning in 2002. Flathead Catfish are naturally sustaining in the pool and combined with Blue Catfish provide two popular recreational fisheries. The Blue Catfish and Flathead Catfish studies shared similar objectives: (1) evaluating size structure, (2) estimating growth rates, and (3) estimating annual mortality. From 2017 to 2020, we collected catfish annually through low frequency electrofishing and trotline surveys at 10 fixed locations. Electrofishing catch rates for Blue …

The Receptor Basis Of Serotonergic Modulation In An Olfactory Network, Tyler Ryan Sizemore

Graduate Theses, Dissertations, and Problem Reports (ETD)

Neuromodulation is a nearly ubiquitous process that endows the nervous system with the capacity to alter neural function at every level (synaptic, circuit, network, etc.) without necessarily adding new neurons. Through the actions of neuromodulators, the existing neural circuitry can be adaptively tuned to achieve flexible network output and similarly dynamic behavioral output. However, despite their near ubiquity in all sensory modalities, the mechanisms underlying neuromodulation of sensory processing remain poorly understood. In this dissertation, I address three main questions regarding the mechanisms of one modulator (serotonin) within one sensory modality (olfaction). I begin by establishing a "functional atlas" of …

Effect Of Fecal Egg Count Estimated Breeding Value On Antibody Production In Katahdin Lambs, Kelsey L. Bentley

Graduate Theses, Dissertations, and Problem Reports (ETD)

With current pressures to seek out genetic solutions to combat antimicrobial resistance, genetic resistance to the gastrointestinal nematode Haemonchus contortus may reduce need for prophylactic antibiotic use. The Katahdin breed has effectively utilized post-weaning fecal egg count estimated breeding value (PFEC EBV) to reduce parasitism within their flocks, but there still remains significant opportunity for selection within breed. In a previous study, Katahdin sheep sired by low PFEC sires had greater survivability to weaning than lambs sired by high PFEC rams and preweaning was caused by other diseases than parasitism. Those data lead to the hypothesis that selection for PFEC …

Tree Species Influence On Microbial Functional Gene Abundance And N Cycling In Riparian Soil, Elizabeth Matejczyk

Graduate Theses, Dissertations, and Problem Reports (ETD)

Little is known about how above-ground vegetation may differentially influence the below-ground microbial community structure, abundance, and function. Abundance of soil microbial N cycling genes responsible for nitrification (amoA), denitrification (nirK and nirS), and nitrous oxide reduction (nosZ) may vary with tree species and increasing N availability, and these variables may be used to predict production of NO₃^- and N₂O from soil. Variability of nitrification and denitrification rates have also been linked to tree mycorrhizal associations, with soil beneath tree species associated with arbuscular mycorrhizal (AM) exhibiting greater denitrification rates …

Women, Water, And Well-Being: Gendered Experiences Of Household Water Contamination In Parkersburg, West Virginia, Emily Brooke Tingler

Graduate Theses, Dissertations, and Problem Reports (ETD)

DuPont Washington Works chemical plant knowingly pumped hundreds of thousands of pounds of toxic C8 waste into local waterways, water tables, and landfills for over 40 years, contaminating the drinking water for more than 100,000 residents in and around Parkersburg, West Virginia. Drawing on feminist political ecology and the political ecology of water with literature on perceptions of risk in contaminated communities, environmental reproductive justice, modern water, and hydrosocial waterscapes, I examine, through a qualitative case study, the lived experiences of women who have an intimate understanding of C8 water contamination from the DuPont Washington Works chemical plant. Specifically, I …

The Effects Of Genetic Differences In An Innate Immune Receptor On Immune Responses To Haemonchus Contortus In Sheep, Denzel Deshawn Middleton

Graduate Theses, Dissertations, and Problem Reports (ETD)

Little is known about differences observed in early immunological signaling events that result in cellular infiltration and Th2 cytokine production that mediate parasite expulsion. Parasite resistant St. Croix (STC) sheep have been used as model for full host protective immunity as they present the ability to respond to larval stages of H. contortus. RNA sequencing analysis of peripheral blood mononuclear cells (PBMC) stimulated with H. contortus larval antigen (HcLA) revealed significant upregulation in NLRP3 and its pathway component TLR4. Predicted protein structural software identified distinct differences in NLRP3 protein structure in STC and parasite susceptible Suffolk (SUF) sheep. NLRP3 …

Timber Bridge Pile Splicing With Fiber Reinforced Polymer Wraps, Drew L. Damich

Graduate Theses, Dissertations, and Problem Reports (ETD)

Timber pile repair using splicing is widely used but little research has been done to determine their strength capacity after repair using this method. Current timber pile splicing mechanisms utilize various steel or wooden components. Fiber Reinforced Polymer (FRP) wraps can be utilized as replacement to conventional materials in splicing of timber piles. This study evaluated the strength capacities of traditional splicing mechanisms in relation to FRP wrap splice mechanisms. Traditional splicing mechanisms consisted of flat steel plate, C-channel steel plate, and wooden plate splices. The FRP wrap splice consisted of unidirectional glass/epoxy composite with three layers of fabric as …

Examining West Virginia's Economic Development: Natural Resources, Development Agencies, And Labor Force Development, Gaillynn Marie Bowman

Graduate Theses, Dissertations, and Problem Reports (ETD)

Examining West Virginia's Economic Development: Natural Resources, Development Agencies, and Labor Force Development Gaillynn Bowman Economic development is well-recognized as being fundamental to facilitating an overall improved quality of life for communities and their residents. Throughout West Virginia’s history, the state has experienced economic hardships caused by boom and bust cycles associated with resource extraction. This dissertation consists of three essays that explore the impacts of economic development activities, including conservation programs, economic development agency initiatives, and workforce development agencies. The first essay explores the relationship nonresident landowners have with the conservation programs within West Virginia, specifically the Natural Resources …

Novel Mechanisms Of Neuronal And Hormonal Regulation Of Large Intestinal Electrolyte Transport, Andrew John Nickerson

Graduate Theses, Dissertations, and Problem Reports (ETD)

The mammalian colon plays a vital role in maintaining overall electrolyte and fluid homeostasis in the body, and it possesses the ability to either secrete or absorb water depending upon the needs of the organism. Secretion or absorption of electrolyte ions, such as Na⁺, Cl^- and K⁺, drives the movement of water across the colonic epithelium – the inner gut lining where all transport takes place. Aberrant absorptive and/or secretory activity within the colonic epithelium is central to the pathogenesis of many gastrointestinal diseases, such as irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), constipation …

Pandemic Pedagogy: A Zoom Teaching Experiment Using Cognitive Theory Of Multimedia Learning Principles Of Multimedia Design, Kevin C. Knoster

Graduate Theses, Dissertations, and Problem Reports (ETD)

The purpose of this dissertation was to conduct an experimental study exploring the applicability of multimedia principles of effective instructional design to Zoom teaching. In the wake of the COVID-19 pandemic, educators across higher education were forced to rapidly transition from traditional face-to-face instruction to online teaching. One of the most common ways in which colleges and universities navigated this transition in the United States was via mass adoption of the video conferencing platform Zoom. However, best practices have not yet been identified to assist instructors inexperienced with online teaching in adapting to remote instruction via Zoom. This dissertation argued …

Targeting The Cerebrovasculature In Sepsis: A Focus On The Brain Microvascular Endothelium, Divine C. Nwafor

Graduate Theses, Dissertations, and Problem Reports (ETD)

The blood-brain barrier (BBB) is a critical interface between the systemic circulation and the brain. It is a specialized multicellular unit composed of brain microvascular endothelial cells (BMECs), pericytes, a basement membrane, and astrocytic end foot processes. BMECs are a principal component of the BBB that provide the structural framework needed for the stringent transport of molecules into the brain. BMEC dysfunction permits the trafficking of neurotoxins from systemic circulation into the brain, which ultimately exacerbates BBB dysfunction and neuroinflammation. Studies have shown that BBB dysfunction is a key determinant of cognitive decline in sepsis. However, there are critical knowledge …

The Key To Simplified Management Of An Undescended Parathyroid Adenoma [La Clave Para El Manejo Simplificado De Un Adenoma Paratiroideo No Descendido], Humberto Ruiz-Hernández, Joyce Meza-Venegas, Samuel K. Snyder

School of Medicine Publications

Undescended parathyroid adenoma is a rare cause of primary hyperparathyroidism that happens < 1% of cases. If not suspected, it can lead to a negative bilateral parathyroid exploration and extensive iatrogenic trauma. We propose that with proper imaging the correct diagnosis can be established to simplify surgical management. We describe two cases of patients who underwent a targeted neck exploration due to an undescended parathyroid adenoma diagnosed with an appropriate preoperative imaging protocol. With an appropriate imaging protocol for primary hyperparathyroidism and parathyroid hormone aspirates, an undescended parathyroid adenoma can be primarily diagnosed to guide a focused parathyroidectomy

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El adenoma paratiroideo no descendido ocasiona hiperparatiroidismo primario en <1% de los casos. Si no se sospecha, puede llevar a exploraciones negativas y trauma iatrogénico extenso. Proponemos que, con un protocolo imagenológico adecuado, se puede realizar un diagnóstico correcto, simplificando el abordaje quirúrgico. Describimos dos casos en que se realizó una exploración de cuello dirigida debido a un adenoma paratiroideo no descendido diagnosticado con un protocolo de imagen preoperatorio apropiado. Un protocolo de imagen apropiado para hiperparatiroidismo primario y aspirados de PTH pueden diagnosticar de manera inicial un adenoma paratiroideo no descendido para guiar una paratiroidectomía dirigida.

Malware Classification With Gmm-Hmm Models, Jing Zhao, Samanvitha Basole, Mark Stamp

Faculty Research, Scholarly, and Creative Activity

Discrete hidden Markov models (HMM) are often applied to malware detection and classification problems. However, the continuous analog of discrete HMMs, that is, Gaussian mixture model-HMMs (GMM-HMM), are rarely considered in the field of cybersecurity. In this paper, we use GMM-HMMs for malware classification and we compare our results to those obtained using discrete HMMs. As features, we consider opcode sequences and entropy-based sequences. For our opcode features, GMM-HMMs produce results that are comparable to those obtained using discrete HMMs, whereas for our entropy-based features, GMM-HMMs generally improve significantly on the classification results that we have achieved with discrete HMMs.

Trauma-Informed Career Counselling To Address Work Traumas Resulting From The Covid-19 Pandemic, Jennifer J. Linnekaste

Counseling & Human Services Faculty Publications

Background: Sudden work traumas as a result of the coronavirus disease 2019 (COVID-19) pandemic have left thousands displaced from their current jobs and occupations. Traditional career counselling approaches that overlook the role of emotion are not adequate to address the numerous emotional difficulties that arise after a sudden unexpected job loss.

Objectives: The objective of this research is to examine to what extent career counselling theories and interventions incorporate a trauma-informed career counselling approach and are prepared to address the emotional, psychological, and career counselling concerns that arise from work traumas as a result of the COVID-19 pandemic.

Methods: A …

Restoring The Balance Of Copyright: Antitrust, Misuse, And Other Possible Paths To Challenge Inequitable Licensing Practices, Michelle M. Wu

Georgetown Law Faculty Publications and Other Works

Libraries’ purposes of ensuring access to and preservation of information have been compromised as licensing increasingly replaces ownership. This article outlines various novel legal strategies that libraries could use to restore copyright’s intended balance, including antitrust, preemption, misuse, and unconscionability.

The Corruption Of Copyright And Returning It To Its Original Purposes, Michelle M. Wu

Georgetown Law Faculty Publications and Other Works

Since its inception, Copyright has had two purposes: the private interest of the author in being paid for her work and the public interest served by the dissemination of these works. Within the last two decades, though, some industries have systematically undermined both of those interests, redirecting the benefits of copyright towards themselves instead of the intended beneficiaries. This paper looks at the book, music, and entertainment industries, examines how copyright has been used to suppress the uses it was intended to foster, and explores ongoing and proposed avenues for course correction.

Hippocampal Functional Connectivity And Memory Performance After Exercise Intervention In Older Adults With Mild Cognitive Impairment, Junyeon Won, Daniel D. Callow, Gabriel S. Pena, Leslie S. Jordan, Naomi A. Arnold-Nedimala, Kristy A. Nielson, J. Carson Smith

Psychology Faculty Research and Publications

Background:

Exercise training (ET) has neuroprotective effects in the hippocampus, a key brain region for memory that is vulnerable to age-related dysfunction.

Objective:

We investigated the effects of ET on functional connectivity (FC) of the hippocampus in older adults with mild cognitive impairment (MCI) and a cognitively normal (CN) control group. We also assessed whether the ET-induced changes in hippocampal FC (Δhippocampal-FC) are associated with changes in memory task performance (Δmemory performance).

Methods:

32 older adults (77.0±7.6 years; 16 MCI and 16 CN) participated in the present study. Cardiorespiratory fitness tests, memory tasks (Rey Auditory Verbal Learning Test (RAVLT) and …

The Role Of Alexithymia In Memory And Executive Functioning Across The Lifespan, Anthony N. Correro, Elizabeth Rose Paitel, Steven J. Byers, Kristy A. Nielson

Psychology Faculty Research and Publications

Alexithymia is a personality trait characterised by difficulties identifying feelings (DIF), describing feelings (DDF), and externally oriented thinking (EOT). Alexithymia has been associated with poorer memory, at least for emotive materials, and recently, with executive and neural dysfunction. Aging is also accompanied by poorer memory and executive functioning (EF), neural dysfunction, and increasing alexithymia. Thus, the hypothesis of a general cognitive impairment in alexithymia, particularly in elders, needs investigation. Three large, independent, cross-sectional experiments (n = 296, 139 and 121, respectively) investigated memory and EF in healthy adults, ranging from young to old adulthood, with age, sex, and the …

Wildlife Forage Recovery Following Boreal Wildfire, Alexis Jorgensen, Jennifer Baltzer

Theses and Dissertations (Comprehensive)

Climate change is altering the boreal wildfire regime through increases in the extent and severity of burning and reductions in fire return intervals. These changes can alter the regeneration trajectory of canopy species and ground vegetation, with implications for wildlife habitat. There is some uncertainty about the timelines of when different animal species will use burned areas as their preferred forage taxa recover following fire, and how such recovery is mediated by environmental factors. Here, we aim to address these knowledge gaps through the following questions: 1) What are the main forage types consumed by boreal wildlife and how much …

Containment & Covid-19 In The Settler State: Indigenous Incarceration And Immigration Detention In Canada And Australia, Kate Motluk

Theses and Dissertations (Comprehensive)

Canada and Australia each have long histories of containing Indigenous peoples and migrants. The overincarceration of Indigenous peoples continues to worsen in both countries, despite targeted reforms. Migrant detention is on the rise worldwide, with Canada and Australia’s systems understood as among the harshest. This thesis explores why Canada and Australia contain these populations by examining these practices through the lens of contemporary settler colonialism. Like most everything, containment by states has undergone rapid changes as a result of the COVID-19 pandemic. This study aims to understand how COVID-19 impacted those within carceral institutions, and contextualize that treatment within the …

Anticipating And Adapting To The Future Impacts Of Climate Change On The Health, Security And Welfare Of Low Elevation Coastal Zone (Lecz) Communities In Southeastern Usa, Thomas Allen, Joshua Behr, Anamaria Bukvic, Ryan S.D. Calder, Kiki Caruson, Charles Connor, Christopher D'Elia, David Dismukes, Robin Ersing, Rima Franklin, Jesse Goldstein, Jonathon Goodall, Scott Hemmerling, Jennifer Irish, Steven Lazarus, Derek Loftis, Mark Luther, Leigh Mccallister, Karen Mcglathery, Molly Mitchell, William Moore, Charles Reid Nichols, Karinna Nunez, Matthew Reidenbach, Julie Shortridge, Robert Weisberg, Robert Weiss, Lynn Donelson Wright, Meng Xia, Kehui Xu, Donald Young, Gary Zarillo, Julie C. Zinnert

Political Science & Geography Faculty Publications

Low elevation coastal zones (LECZ) are extensive throughout the southeastern United States. LECZ communities are threatened by inundation from sea level rise, storm surge, wetland degradation, land subsidence, and hydrological flooding. Communication among scientists, stakeholders, policy makers and minority and poor residents must improve. We must predict processes spanning the ecological, physical, social, and health sciences. Communities need to address linkages of (1) human and socioeconomic vulnerabilities; (2) public health and safety; (3) economic concerns; (4) land loss; (5) wetland threats; and (6) coastal inundation. Essential capabilities must include a network to assemble and distribute data and model code to …

A Group-Protocol: Returning To Life Post Breast Cancer Treatment, Janice Finley, Ashley Timm

Occupational Therapy Capstones

The purpose of this project was to design a group protocol to assist breast cancer survivors living in the community to address unmet physical, cognitive, and psychosocial needs. There are more than 3.5 million breast cancer survivors within the United States today (American Cancer Society, n.d.). A cancer survivor's performance in meaningful occupations and roles need to be addressed as they learn to live with the long-term physical and psychosocial effects of treatments such as self-confidence and pain management (Burg et al., 2015; Kim, Kim, & Han, 2020). There is a lack of occupational therapy services for individuals diagnosed with …

A Practitioner's Guide: Using The Cognitive Performance Test To Increase Independent Living Skills For Individuals With Intellectual Disabilities, Alycia Peacock, Grace Spanos

Occupational Therapy Capstones

Problem: Individuals with intellectual disabilities (ID) have the desire to live as independently as possible (Gragoudas, 2014). There are a number of barriers that impact living independently including the ability to complete self-care tasks, money management, home management, and health management (Bond & Hurst, 2010). Other barriers reported for individuals with ID include relationships with caregivers, living alone, and vulnerability (Bond & Hurst, 2010). Research identifies that it is difficult to determine the amount of support needed to promote independence in individuals with ID (Francis & Reed, 2019). Occupational therapists (OTs) possess a unique skillset to assist clients with ID …

Empowering Grand-Families Through Occupation: An Occupational Therapy Intervention Program For Grandchildren And Custodial Grandparents, Macie Romsdal, Gabrielle Wavra

Occupational Therapy Capstones

The purpose of this scholarly project was to create a program for occupational therapists to use with custodial grandparents and their grandchildren. The number of grandparents becoming primary caregivers to grandchildren continues to increase, and more than 5.7 million grandchildren in the United States were living with and being provided for by grandparents in 2014 (U.S. Census Bureau, 2014). Although there are benefits to being placed in grandparent care, there are also challenges. Some of the challenges custodial grandparents face are health concerns, financial resources, and changes in social supports and occupational roles (Marken & Howard, 2014). Grandchildren may have …

Il-15/Il-15rα Heterodimeric Complex As Cancer Immunotherapy In Murine Breast Cancer Models, Siqi Guo, Ronald B. Smeltz, Anthony Nanajian, Richard Heller

Bioelectrics Publications

Interleukin 15 (IL-15) has been evaluated as a potential treatment for solid tumors in clinical trials, but the effectiveness of systemic IL-15 administration as a monotherapy has not been realized. IL-15 receptor alpha (IL-15Rα) can stabilize IL-15 and enhance its bioactivity. The goal of this study was to examine the activity of IL-15/IL-15Rα complex (IL-15cx) to CD8(+) T cells and evaluate its potential efficacy in murine breast cancer models. The antitumor efficacy was studied in mouse mammary carcinoma models (Her2/neu transgenic and 4T1-luc mammary cancers) treated with systemic recombinant protein with/without the depletion of myeloid-derived suppressor cells or intra-tumoral gene …

Connexin Hemichannel Activation By S-Nitrosoglutathione Synergizes Strongly With Photodynamic Therapy Potentiating Anti-Tumor Bystander Killing, Chiara Nardin, Chiara Peres, Sabrina Putti, Tiziana Orsini, Claudia Colussi, Flavia Mazzarda, Marcello Raspa, Ferdinando Scavizzi, Anna Maria Salvatore, Francesco Chiani, Abraham Tettey-Matey, Yuanyuan Kuang, Guang Yang, Mauricio A. Retamal, Fabio Mammano

Bioelectrics Publications

In this study, we used B16-F10 cells grown in the dorsal skinfold chamber (DSC) preparation that allowed us to gain optical access to the processes triggered by photodynamic therapy (PDT). Partial irradiation of a photosensitized melanoma triggered cell death in non-irradiated tumor cells. Multiphoton intravital microscopy with genetically encoded fluorescence indicators revealed that bystander cell death was mediated by paracrine signaling due to adenosine triphosphate (ATP) release from connexin (Cx) hemichannels (HCs). Intercellular calcium (Ca²⁺) waves propagated from irradiated to bystander cells promoting intracellular Ca²⁺ transfer from the endoplasmic reticulum (ER) to mitochondria and rapid activation of …

Design Matters: Development And Validation Of The Online Course Design Elements (Ocde) Instrument, Florence Martin, Doris U. Bolliger, Claudia Flowers

STEMPS Faculty Publications

Course design is critical to online student engagement and retention. This study focused on the development and validation of an online course design elements (OCDE) instrument with 38 Likert-type scale items in five subscales: (a) overview, (b) content presentation, (c) interaction and communication, (d) assessment and evaluation, and (e) learner support. The validation process included implementation with 222 online instructors and instructional designers in higher education. Three models were evaluated which included a one-factor model, five-factor model, and higher-order model. The five-factor and higher-order models aligned with the development of the OCDE. The frequency of use of OCDE items was …

Food Allergy Bullying As Disability Harassment: Holding Schools Accountable, D'Andra Millsap Shu

University of Colorado Law Review

Millions of American schoolchildren of all ages suffer from food allergies, and increasingly, bullies target these children because of their allergies. If a bully exposes a victim to an allergen, food allergy bullying can sicken or kill within minutes. Food allergy bullying is already responsible for many hospitalizations and at least one death. Most food allergy bullying happens at school, and schools play a crucial part in addressing and preventing bullying. All too often, though, schools fail to take appropriate action. Sovereign immunity and other obstacles insulate public schools from liability in many instances, but federal disability law may provide …