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2021

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The Relationship Of Leptin And Thyroid Hormones With Milk Yield And Some Fertilityparameters In Simmental Dairy Cows During Transition Period, Özkan Duru, Alparslan Kadi̇r Devri̇m, Hasan Ceyhun Macun, Si̇bel Yasa Duru, Ali̇ Şenol Jan 2021

The Relationship Of Leptin And Thyroid Hormones With Milk Yield And Some Fertilityparameters In Simmental Dairy Cows During Transition Period, Özkan Duru, Alparslan Kadi̇r Devri̇m, Hasan Ceyhun Macun, Si̇bel Yasa Duru, Ali̇ Şenol

Turkish Journal of Veterinary & Animal Sciences

In this study, transition period cows were used to test the hypothesis that serum levels of leptin and thyroid hormones would correlate the production efficiency such as milk yield, body condition score, and fertility in dairy cows raised under the same controlled conditions. The study comprised 37 Simmental cows, which were 3 years old and between 257-265 days of gestation. Serum levels of leptin, T3, T4, FT3, and FT4 hormones were measured in blood samples obtained from the animals, which were in the period of 3 weeks before and 3 weeks after delivery. Prepartum serum leptin levels were significantly (p < 0.05) lower in cows having increased milk production compared to the first lactation peak value. Also, postpartum serum FT3 levels were significantly (p < 0.05) lower in cows having milk yield of ≥ 30 kg. Leptin levels were found to be inversely related with milk production and fertility. FT3 levels exhibited a negative correlation with milk production and similarly T3 levels showed an inverse correlation with body condition score. The present study proposed that routine monitoring of leptin and thyroid hormones would be useful for the reproductive management of cows with breeding problems.

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History Repeats Itself: Horse Originated Hyperimmune Sera Production Against Sars Cov-2, Ahu Pakdemi̇rli̇, Elvi̇n Çalişkan, Sabri̇ Hacioğlu, Erdem Danyer, Özlem Kardoğan, Züleyha Ergün Kurt, Özcan Yildirim, Hakan Taşkaya, Bora Ündar, Yasemi̇n Sezgi̇n, Gencay Ergi̇n, Hi̇mmet Eki̇ci̇, Ufuk Ülker, Erkan Taçbaş, Şahi̇n Çakir Jan 2021

History Repeats Itself: Horse Originated Hyperimmune Sera Production Against Sars Cov-2, Ahu Pakdemi̇rli̇, Elvi̇n Çalişkan, Sabri̇ Hacioğlu, Erdem Danyer, Özlem Kardoğan, Züleyha Ergün Kurt, Özcan Yildirim, Hakan Taşkaya, Bora Ündar, Yasemi̇n Sezgi̇n, Gencay Ergi̇n, Hi̇mmet Eki̇ci̇, Ufuk Ülker, Erkan Taçbaş, Şahi̇n Çakir

Turkish Journal of Medical Sciences

Background/aim: SARS-CoV-2 disease was announced as a pandemic by The World Health Organization in early 2020. It is still threatening the world population. Here, we aimed to produce hyperimmune sera that contain immunoglobulin G and F(ab')2 fragments sourced from horse antibodies as an urgent response to the pandemic. Materials and methods: SARS-CoV-2 was produced and inactivated with three different methods [formaldehyde (FA), formaldehyde, and binary ethylene amine (FA + BEI), and heat treatment]. After in vitro inactivation control, immunogens were mixed with Freund's adjuvant, thereafter horses (n: 2 for FA, 4 for FA + BEI, 2 for heat inactivation) and …

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What Plays A Role In The Severity Of Atopic Dermatitis In Children?, Murat Cansever, Çi̇ğdem Oruç Jan 2021

What Plays A Role In The Severity Of Atopic Dermatitis In Children?, Murat Cansever, Çi̇ğdem Oruç

Turkish Journal of Medical Sciences

Background/aim: Determining the characteristics and risk factors of severe disease is extremely important to combat atopic dermatitis (AD), which has recently shown increasing prevalence. In this study, we aimed to investigate the clinical characteristics of pediatric patients with AD and identifying the factors associated with the severity of the disease. Materials and methods: A total of 304 pediatric patients diagnosed with atopic dermatitis were included in the study. The patients' age at admission, age at onset of symptoms, the presence of atopy history in their family, eosinophil levels obtained from blood counts were recorded, together with the data of cigarette …

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Allergic Bronchopulmonary Aspergillosis In Children, Özge Atay, Suna Asi̇lsoy, Gi̇zem Atakul, Serdar Al, Özge Kangalli Boyacioğlu, Nevi̇n Uzuner, Özkan Karaman Jan 2021

Allergic Bronchopulmonary Aspergillosis In Children, Özge Atay, Suna Asi̇lsoy, Gi̇zem Atakul, Serdar Al, Özge Kangalli Boyacioğlu, Nevi̇n Uzuner, Özkan Karaman

Turkish Journal of Medical Sciences

Background/aim: Allergic bronchopulmonary aspergillus (ABPA) is a lung disease caused by hypersensitivity from Aspergillus fumigatus. Diagnostic criteria, staging systems and treatment methods for ABPA disease have been reported in studies evaluating populations, the majority of which are adult patients. Our study aimed to discuss the use of ABPA diagnostic criteria in children, the success of other alternative regimens to oral corticosteroids in the treatment of ABPA, and the changes that occur during treatment, in the light of the literature. Materials and methods: Between January 2017 and 2020, patients diagnosed with ABPA at the Dokuz Eylül University Child Allergy and Immunology …

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Nondamaging Retinal Laser Therapy In Recurrent Diabetic Macular Edema After Antivegf Injections, Mehmet Çitirik Jan 2021

Nondamaging Retinal Laser Therapy In Recurrent Diabetic Macular Edema After Antivegf Injections, Mehmet Çitirik

Turkish Journal of Medical Sciences

Background/aim: Subthreshold yellow nondamaging retinal laser therapy (NRT) could provide a greater safety profile when compared to conventional laser methods. NRT may also improve diabetic macular edema (DME). This study aims to assess whether the severity of DME affects the efficacy of subthreshold yellow NRT. Materials and methods: The study included 70 eyes that had previously been treated with ranibizumab for DME and then developed recurrent macular edema, which was treated with NRT once. The central foveal thickness (CFT) and best-corrected visual acuity (BCVA) were evaluated retrospectively 2 months following the NRT. The eyes in the study were divided into …

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Incidence, Risk Factors, And Adverse Outcomes Of Acute Kidney Injury In Very Prematureneonates: A Single Center Experience, Nuran Üstün Jan 2021

Incidence, Risk Factors, And Adverse Outcomes Of Acute Kidney Injury In Very Prematureneonates: A Single Center Experience, Nuran Üstün

Turkish Journal of Medical Sciences

Background/aim: Acute kidney injury (AKI) is a serious morbidity in premature neonates. The aim of this study was to determine the incidence of AKI and to evaluate its impact on morbidity and mortality in very premature infants. Materials and methods: This retrospective cohort study was conducted in the neonatal intensive care unit (NICU). A total of 410 preterm infants who were born before 32 gestational weeks were screened and 318 were included in this analysis. AKI was defined according to the modified neonatal Kidney Disease: Improving Global Outcomes criteria. Results: The incidence of AKI was 32.1% (102/318). Regression analyses revealed …

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The Role Of Circadian Rhythm In The Regulation Of Cellular Protein Profiles In The Brain, Mustafa Caglar Beker, Ertuğrul Kiliç Jan 2021

The Role Of Circadian Rhythm In The Regulation Of Cellular Protein Profiles In The Brain, Mustafa Caglar Beker, Ertuğrul Kiliç

Turkish Journal of Medical Sciences

Background/aim: Circadian rhythm plays a significant role in the regulation of almost all kinds of physiological processes. In addition, it may also have a direct or indirect effect on the neurodegenerative processes, including Alzheimer's disease, Parkinson's disease, and ischemic stroke. Therefore, the identification of circadian rhythm-related proteins is crucial to be able to understand the molecular mechanism of the circadian rhythm and to define new therapeutic target for the treatment of degenerative disorders. Materials and methods: To identify the light and dark regulated proteins, 8-12 weeks, male Balb/C mice were used at two different time points (morning (Zeitgeber time-0 (ZT0)) …

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The Protective Effect Of Boric Acid On Cholestatic Rat Liver Ischemia Reperfusion Injury, Serkan Güler, Ari̇f Aslaner, Hami̇t Yaşar Elli̇dağ, Şenay Yildirim, Tuğrul Çakir Jan 2021

The Protective Effect Of Boric Acid On Cholestatic Rat Liver Ischemia Reperfusion Injury, Serkan Güler, Ari̇f Aslaner, Hami̇t Yaşar Elli̇dağ, Şenay Yildirim, Tuğrul Çakir

Turkish Journal of Medical Sciences

Background/aim: To evaluate the potential protective effects of boric acid (BA) in experimental cholestatic liver ischemia reperfusion (IR) injury model. Materials and methods: The study included 24 female rats which were divided into 3 groups each containing 8 rats. The control group (Group 1) only received laparotomy. In the IR group (Group 2) biliary tract ligation was applied and 1 week later 45 min ischemia and 1 h reperfusion with relaparotomy without any treatment was implemented. In the treatment BA+IR group (Group 3). 1 week after the biliary ligation intraperitoneal administration of 200 mg/kg BA was given 10 min before …

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What Is The Restorative Effect Of Vegf Inhibitor Bevacuzimab Against Subarachnoidhemorrhage In An Experimental Model?, Adnan Yalçin Demi̇rci̇, Yahya Güvenç, Ersi̇n Özeren, Çeti̇n Akyol, Pinar Bayram, Deni̇z Bi̇llur, Sevi̇m Aydin, Hakan Seçki̇n, Kazim Yi̇ği̇tkanli Jan 2021

What Is The Restorative Effect Of Vegf Inhibitor Bevacuzimab Against Subarachnoidhemorrhage In An Experimental Model?, Adnan Yalçin Demi̇rci̇, Yahya Güvenç, Ersi̇n Özeren, Çeti̇n Akyol, Pinar Bayram, Deni̇z Bi̇llur, Sevi̇m Aydin, Hakan Seçki̇n, Kazim Yi̇ği̇tkanli

Turkish Journal of Medical Sciences

Background/aim: This study investigated the effect of vascular endothelial growth factor (VEGF) inhibitor bevacuzimab (BVZ) on the rabbit basilar artery using an experimental subarachnoid hemorrhage (SAH) model. Materials and methods: Eighteen adult male New-Zealand white rabbits were randomly divided into three groups: a control group (n = 6), SAH group (n = 6), and SAH+BVZ group (n = 6). Experimental SAH was created by injecting autologous arterial blood into the cisterna magna. In the treatment group, the subjects were administered a daily dose of 10 mg/kg, intravenous BVZ for 2 days after the SAH. Basilar artery diameters were measured with …

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Antiinflammatory Effects Of Adalimumab, Tocilizumab, And Steroid Onlipopolysaccharide-Induced Lung Injury, Nurhan Sarioğlu, Fatma Bahar Sunay, Arzu Hanim Yay, Oğuzhan Korkut, Fuat Erel, Adnan Adi̇l Hi̇şmi̇oğullari, Mehmet Köse, Betül Yalçin Jan 2021

Antiinflammatory Effects Of Adalimumab, Tocilizumab, And Steroid Onlipopolysaccharide-Induced Lung Injury, Nurhan Sarioğlu, Fatma Bahar Sunay, Arzu Hanim Yay, Oğuzhan Korkut, Fuat Erel, Adnan Adi̇l Hi̇şmi̇oğullari, Mehmet Köse, Betül Yalçin

Turkish Journal of Medical Sciences

Background/aim: Acute lung injury (ALI) is a major cause of death in the intensive care unit. Lipopolysaccharide (LPS) induced lung injury is the most widely used experimental ALI model and provides opportunities for new targeting therapy. In this study, we investigated the effects of tocilizumab, adalimumab, and methylprednisolone in LPS-induced acute lung injury. Materials and methods: Lung injury was established by intratracheal instillation of LPS. The rats were randomly divided into six groups: LPS, control, and treatment groups (adalimumab, tocilizumab, methylprednisolone, adalimumab + tocilizumab). Bronchoalveolar lavage (BAL) and lung tissues were collected at 48 h and 96 h following LPS …

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An Immunohistochemical Examination Of Cinnamon Extract Administration Ondistribution Of Ngf (Nerve Growth Factor) And Trk-A (Tyrosine Kinase-A) Receptor Fordiabetic Rats With Pancreatic Tissue, Şükran Yedi̇el Aras, Ebru Karadağ Sari Jan 2021

An Immunohistochemical Examination Of Cinnamon Extract Administration Ondistribution Of Ngf (Nerve Growth Factor) And Trk-A (Tyrosine Kinase-A) Receptor Fordiabetic Rats With Pancreatic Tissue, Şükran Yedi̇el Aras, Ebru Karadağ Sari

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to investigate the administration of cinnamon extract that is known to be effective in decreasing the high blood glucose and the distribution of NGF and Trk-A receptor in pancreas with immunohistochemistry way. Materials and methods: The experimental groups were defined as control, sham, cinnamon, diabetes, and diabetes-cinnamon. At the end of the experiment, the pancreatic tissue samples were obtained for the rats. The hematoxylin-eosin and triple staining were used to examine histology. The immunohistochemical methods were performed on the sections of pancreatic tissue. In all groups, the body weight and fasting blood glucose …

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The Protective Effects Of Anakinra In A Neonatal Rat Model Of Necrotizing Enterocolitis, Hati̇ce Güneş, Sevcan İpek, Sadik Yurttutan, Tuncay Kuloğlu, Fatma İnanç Tolun, Ülkü Kazanci, Adem Doğaner Jan 2021

The Protective Effects Of Anakinra In A Neonatal Rat Model Of Necrotizing Enterocolitis, Hati̇ce Güneş, Sevcan İpek, Sadik Yurttutan, Tuncay Kuloğlu, Fatma İnanç Tolun, Ülkü Kazanci, Adem Doğaner

Turkish Journal of Medical Sciences

Background/aim: Necrotizing enterocolitis (NEC) is a commonly seen life-threatening condition in newborns characterized by ischemic necrosis. This study aimed to investigate anakinra's effects, an interleukin-1 receptor antagonist, on oxidative stress, inflammation, and tissue necrosis in an NEC rat model. Materials and methods: Forty Wistar albino pups were divided into four groups randomly as follows; group 1, control group; group 2, anakinra-treated control group; group 3, NEC group; and group 4, NEC and anakinra treatment group. The rats were given hyperosmolar formula feeding, and they were exposed to hypoxia after cold stress at +4 °C and oxygen in order to create …

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Effects Of Bevacizumab Administration On The Hypoxia - Induced Pulmonaryhypertension Rat Model, Canan Demi̇r, Meral Karaman, Eyüp Sabri̇ Uçan, Ali̇ Necati̇ Gökmen, Duygu Gürel, Şadi̇ye Canan Çoker, Yasemen Adali, Osman Yilmaz Jan 2021

Effects Of Bevacizumab Administration On The Hypoxia - Induced Pulmonaryhypertension Rat Model, Canan Demi̇r, Meral Karaman, Eyüp Sabri̇ Uçan, Ali̇ Necati̇ Gökmen, Duygu Gürel, Şadi̇ye Canan Çoker, Yasemen Adali, Osman Yilmaz

Turkish Journal of Medical Sciences

Background/aim: Bevacizumab is a chemotherapeutic drug, which selectively binds to vascular endothelial growth factor (VEGF) and mainly inhibits angiogenesis and neovascularization. We aimed to study the possible effects of bevacizumab on right ventricular pressure (RVP), right ventricular hypertrophy, and VEGF, in hypoxia - induced pulmonary hypertension (PH) rat model. Materials and methods: 24 adult Wistar Albino rats were randomly divided into four groups: control group - saline; Bevacizumab Group; PH Group; PH + Bevacizumab Group. In hypoxia - induced model, 10% oxygen and 90% nitrogen were applied in a plexiglas box for eight days to PH Group and PH + …

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The Effects Of Iloprost And Beta3 Receptor Agonist On Trpa1 And Trpc1 Immunreactivityin An Experimental Lower Extremty Ischemia-Reperfusion Injury Model, Lati̇f Üstünel, İbrahi̇m Murat Özgüler Jan 2021

The Effects Of Iloprost And Beta3 Receptor Agonist On Trpa1 And Trpc1 Immunreactivityin An Experimental Lower Extremty Ischemia-Reperfusion Injury Model, Lati̇f Üstünel, İbrahi̇m Murat Özgüler

Turkish Journal of Medical Sciences

Background/aim: In this study, we aimed to investigate the effects of antioxidant iloprost (ILO) and ß3 adrenergic receptor agonist (BRL) on transient receptor potential ankyrin 1 (TRPA1) and transient receptor potential canonical 1 (TRPC1) ion channels on an experimental ischemia and reperfusion injury model in 30 male Wistar albino rats aged 8-10 weeks. Materials and methods: Wistar Albino rats aged were divided into 5 equal groups. Group I Sham operation, Group II IR (ischemiareperfusion) procedure, Group III IR + intravenous ILO administration, Group IV IR + intraperitoneal BRL administration, and Group V IR + intravenous ILO + intraperitoneal BRL administration …

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Prevalence Of Comorbidities And Associated Factors In Acromegaly Patients In The Turkishpopulation, Mustafa Can, Muhammet Kocabaş, İlker Çordan, Hati̇ce Çalişkan Burgucu, Meli̇a Karaköse, Mustafa Kulaksizoğlu, Feridun Karakurt Jan 2021

Prevalence Of Comorbidities And Associated Factors In Acromegaly Patients In The Turkishpopulation, Mustafa Can, Muhammet Kocabaş, İlker Çordan, Hati̇ce Çalişkan Burgucu, Meli̇a Karaköse, Mustafa Kulaksizoğlu, Feridun Karakurt

Turkish Journal of Medical Sciences

Background/aim: The presence of comorbidities in patients with acromegaly causes an increase in morbidity and/or mortality and a decrease in quality of life. In this study, we aimed to investigate the demographic, clinical and laboratory features, prevalence of acromegaly-related comorbidities, and factors associated with these comorbidities in patients with acromegaly. Materials and methods: In the study, 96 patients who were followed up with the diagnosis of acromegaly were included. Clinical, laboratory and imaging features, and accompanying comorbidities of the patients were recorded from the patient files. Results: Of the patients included in the study, 63 (65.6%) were female and 33 …

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Cadaver Versus Simulator Based Arthroscopic Training In Shoulder Surgery, Gazi̇ Huri̇, Mert Ruşen Gülşen, Ece Belen Karmiş, Doğaç Karagüven Jan 2021

Cadaver Versus Simulator Based Arthroscopic Training In Shoulder Surgery, Gazi̇ Huri̇, Mert Ruşen Gülşen, Ece Belen Karmiş, Doğaç Karagüven

Turkish Journal of Medical Sciences

Introduction: There are few studies that compare the cadaver dissections with the medical simulators in means of talent improvement. Therefore, the aim of this study is to find out if using cadaver dissections is still the golden standard for surgical training or using the medical simulators in surgery could replace cadaver dissections. Materials and methods: The study is conducted during the European Orthopaedics & Traumatology Education Platform accredited Shoulder Club International Cadaver Course including a number of 34 orthopedics trainees. The participants were randomly divided into two groups to be trained with the simulator (Group 1) and on cadavers (Group …

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Impact Of Fetal Brain Tissue Derived Mesenchymal Stem Cell And Fibrin Glue On Facial Nervecrash Injury, Ömer Bayir, Tuğba Karagöz, Ferda Alpaslan Pinarli, Güli̇stan Sanem Saribaş, Candan Özoğul, Kemal Keseroğlu, Güleser Saylam, Emel Çadalli Tatar, Sevi̇lay Karahan, Bülent Öcal, Mehmet Hakan Korkmaz Jan 2021

Impact Of Fetal Brain Tissue Derived Mesenchymal Stem Cell And Fibrin Glue On Facial Nervecrash Injury, Ömer Bayir, Tuğba Karagöz, Ferda Alpaslan Pinarli, Güli̇stan Sanem Saribaş, Candan Özoğul, Kemal Keseroğlu, Güleser Saylam, Emel Çadalli Tatar, Sevi̇lay Karahan, Bülent Öcal, Mehmet Hakan Korkmaz

Turkish Journal of Medical Sciences

Background/aim: To evaluate the clinical and histopathological effects of fetal brain tissue derived mesenchymal stem cells (FBTMSC) and fibrin glue (FG) on the facial nerve (FN) regeneration in rats with traumatic FN injury. Materials and methods: Twenty-eight Sprague Dawley rats were included in the study and divided into 4 groups. Traumatic FN injury (FP) was created by a surgical clamp compression to the main trunk of left FN in all groups. In the control group (group 1) no treatment was applied, in group 2 (FBTMSC group) 2 × 106 FBTMSC was injected, in group 3 (FG group) only FG was …

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The Effect Of Testosterone Replacement Therapy On Bladder Functions, Histology, Apoptosis,And Rho-Kinase Expression In Bladder Outlet Obstruction And Hypogonadism Rat Model, Bariş Saylam, Ozan Efesoy, Rabi̇a Bozdoğan Arpaci, Ruki̇ye Nalan Ti̇fti̇k, Mesut Tek, Kansu Büyükafşar, Murat Bozlu, Selahi̇tti̇n Çayan Jan 2021

The Effect Of Testosterone Replacement Therapy On Bladder Functions, Histology, Apoptosis,And Rho-Kinase Expression In Bladder Outlet Obstruction And Hypogonadism Rat Model, Bariş Saylam, Ozan Efesoy, Rabi̇a Bozdoğan Arpaci, Ruki̇ye Nalan Ti̇fti̇k, Mesut Tek, Kansu Büyükafşar, Murat Bozlu, Selahi̇tti̇n Çayan

Turkish Journal of Medical Sciences

Background/aim: The effect of testosterone replacement therapy was investigated on bladder functions, histology, apoptosis as well as Rho-kinase expression in the rat bladder outlet obstruction (BOO) and hypogonadism models. Materials and methods: 30 mature male rats divided into 4 groups: sham group (n = 8), BOO group (n = 8), BOO + orchiectomy group (n = 7), BOO + orchiectomy + testosterone (T) treatment group (n = 7). Cystometric findings, apoptosis index, Rho-kinase (ROCK-2) expression, and smooth muscle/collagen ratio were compared. Results: BOO did not change ROCK-2 expression level, compared to sham group (P > 0.05). However, when compared to BOO …

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Investigation Of The Effect Of Hyperthyroidism On Endoplasmic Reticulum Stress And Transient Receptor Potential Canonical 1 Channel In The Kidney, Nuri̇ye Ezgi̇ Bektur, Erhan Şahi̇n, Sedat Kaçar, Ridvan Bağci, Şeri̇fe Karakaya, Di̇lek Burukoğlu Dönmez, Varol Şahi̇ntürk Jan 2021

Investigation Of The Effect Of Hyperthyroidism On Endoplasmic Reticulum Stress And Transient Receptor Potential Canonical 1 Channel In The Kidney, Nuri̇ye Ezgi̇ Bektur, Erhan Şahi̇n, Sedat Kaçar, Ridvan Bağci, Şeri̇fe Karakaya, Di̇lek Burukoğlu Dönmez, Varol Şahi̇ntürk

Turkish Journal of Medical Sciences

Background/aim: Hyperthyroidism is associated with results in increased glomerular filtration rate as well as increased renin-angiotensin-aldosterone activation. The disturbance of Ca2+ homeostasis in the endoplasmic reticulum (ER) is associated with many diseases, including diabetic nephropathy and hyperthyroidism. Transient receptor potential canonical 1 (TRPC1) channel is the first cloned TRPC family protein. Although it is expressed in many places in the kidney, its function is uncertain. TRPC1 is involved in regulating Ca2+ homeostasis, and its upregulation increases ER Ca2+ level, activates the unfolded protein response, which leads to cellular damage in the kidney. This study investigated the role of TRPC1 in …

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Contribution Of Amniotic Membrane To The Healing Of Iatrogenic Vas Deferens Injury, Sabri̇ Demi̇r, Ahmet Ertürk, Mehmet Zengi̇n, Di̇nçer Yildiz, Si̇yami̇ Karahan, Emrah Şenel Jan 2021

Contribution Of Amniotic Membrane To The Healing Of Iatrogenic Vas Deferens Injury, Sabri̇ Demi̇r, Ahmet Ertürk, Mehmet Zengi̇n, Di̇nçer Yildiz, Si̇yami̇ Karahan, Emrah Şenel

Turkish Journal of Medical Sciences

Background/aim: Iatrogenic vas deferens injury is one of the most serious complications of operations in the inguinal region. Vasovasostomy is performed as treatment. However, stenosis is common after vasovasostomy. Oligospermia or azoospermia may develop and result in infertility. This study aimed to investigate the effect of amniotic membrane on healing in vas deferens injuries. Materials and methods: Four groups consisting of 10 rats each were formed. No procedure was performed in Group-I. In GroupII, the left vas deferens was transected and left to spontaneous healing. In Group-III, the left vas deferens was transected, and endto-end anastomosis was performed. In Group-IV, …

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Protective And Therapeutic Effect Of Hydrogen Sulfide On Hemorrhagic Cystitis And Testisdysfunction Induced With Cyclophosphamide, Fi̇kri̇ye Yasemi̇n Özati̇k, Orhan Özati̇k, Yasemi̇n Tekşen, Semra Yi̇ği̇taslan, Nezi̇ha Senem Ari Jan 2021

Protective And Therapeutic Effect Of Hydrogen Sulfide On Hemorrhagic Cystitis And Testisdysfunction Induced With Cyclophosphamide, Fi̇kri̇ye Yasemi̇n Özati̇k, Orhan Özati̇k, Yasemi̇n Tekşen, Semra Yi̇ği̇taslan, Nezi̇ha Senem Ari

Turkish Journal of Medical Sciences

Backround/aim: Cyclophosphamide (CP) is a drug used for treatment of many malignant diseases. However, it can cause serious side effects such as hemorrhagic cystitis and male infertility. Hydrogen sulfide (H2 S) is a gaseous mediator and is suggested to have antioxidant, antiinflammatory, and antiapoptotic effects. In this study, dose-dependent effects of H2 S donor sodium hydrosulfide (NaHS) on cyclophosphamide-induced hemorrhagic cystitis and testicular dysfunction were investigated in rats. Material and methods: Rats were divided into 5 groups (n = 8): control, CP, NaHS25 μmol/kg, NaHS50 μmol/kg, and NaHS100 μmol/ kg. After treatment for 7 days intraperitoneally (ip), a single ip …

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Sodium Valproate Improves Sensorimotor Gating Deficit Induced By Sleep Deprivation Atlow Doses, Muhammet Teki̇n, Fatma Duygu Kaya Yertutanol, Burcu Çevreli̇, Asi̇l Ali̇ Özdoğru, Hamza Kulaksiz, İsmai̇l Tayfun Uzbay Jan 2021

Sodium Valproate Improves Sensorimotor Gating Deficit Induced By Sleep Deprivation Atlow Doses, Muhammet Teki̇n, Fatma Duygu Kaya Yertutanol, Burcu Çevreli̇, Asi̇l Ali̇ Özdoğru, Hamza Kulaksiz, İsmai̇l Tayfun Uzbay

Turkish Journal of Medical Sciences

Background/aim: Sleep deprivation disrupts prepulse inhibition of acoustic startle reflex and can be used to mimic psychosis in experimental animals. On the other hand, it is also a model for other disorders of sensory processing, including migraine. This study aims to assess the effects of sodium valproate, a drug that is used in a variety of neuropsychiatric disorders, on normal and disrupted sensorimotor gating in rats. Materials and methods: Sixty-two Wistar albino rats were randomly distributed into 8 groups. Subchronic and intraperitoneal sodium valproate were administrated to the sleep-deprived and nonsleep-deprived rats by either 50-100 or 200 mg/kg/day. Prepulse inhibition …

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Potential Antidiabetic Activity Of Benzimidazole Derivative Albendazole And Lansoprazoledrugs In Different Doses In Experimental Type 2 Diabetic Rats, Burak Di̇k, Devran Coşkun, Emre Bahçi̇van, Kami̇l Üney Jan 2021

Potential Antidiabetic Activity Of Benzimidazole Derivative Albendazole And Lansoprazoledrugs In Different Doses In Experimental Type 2 Diabetic Rats, Burak Di̇k, Devran Coşkun, Emre Bahçi̇van, Kami̇l Üney

Turkish Journal of Medical Sciences

Aim: The aim of this study is to determine the effects of different concentrations of albendazole and lansoprazole, which were benzimidazole derivatives, on endocrinologic and biochemical parameters in experimental type 2 diabetic (T2D) rats. Materials and methods: In this study, 46 male Wistar Albino rats were used. Animals were divided as healthy control (0.1 mL/rat/day saline, s.c, n = 6), diabetes control (0.1 mL/rat/day saline, s.c, n = 8), diabetes+low-dose albendazole (5 mg/kg, oral, n = 8), diabetes+highdose albendazole (10 mg/kg, oral n = 8), diabetes+low-dose lansoprazole (15 mg/kg, subcutaneous, n = 8), and diabetes+high-dose lansoprazole (30 mg/kg, subcutaneous, n …

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The Effect Of 1,25-Dihydroxyvitamin D3 On Liver Damage, Oxidative Stress, And Advanced Glycation End Products In Experimental Nonalcoholicand Alcoholic- Fatty Liver Disease, İlknur Bi̇ngül, Abdurrahman Fati̇h Aydin, Canan Küçükgergi̇n, Asi̇ye Işin Doğan Eki̇ci̇, Semra Abbasoğlu, Mehmet Müjdat Uysal Jan 2021

The Effect Of 1,25-Dihydroxyvitamin D3 On Liver Damage, Oxidative Stress, And Advanced Glycation End Products In Experimental Nonalcoholicand Alcoholic- Fatty Liver Disease, İlknur Bi̇ngül, Abdurrahman Fati̇h Aydin, Canan Küçükgergi̇n, Asi̇ye Işin Doğan Eki̇ci̇, Semra Abbasoğlu, Mehmet Müjdat Uysal

Turkish Journal of Medical Sciences

Background/aim: Oxidative stress and advanced glycation end products (AGEs) formation are proposed as effective mechanisms in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD). 1,25(OH)2 D3 was proposed to have antioxidant, antiinflammatory and antiglycation properties. In this study, the effect of 1,25(OH)2 D3 treatment on oxidative stress parameters and AGEs levels together with hepatic histopathology was investigated in high fructose (HFr) or ethanol (EtOH)-treated rats. Materials and methods: Rats were treated with fructose (30%) or ethanol (5-20%) in drinking water with and without 1,25(OH)2 D3 treatment (5 µg/kg two times a week) for 8 weeks. …

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The Histopathological Effects Of Reabsorbable Polyethylene Glycol Hydrogel (Coseal) Onepidural Fibrosis In An Experimental Postlaminectomy Model In Rats, Emrah Keski̇n, Hasan Ali̇ Aydin, Murat Kalayci, Emre Işik, Utku Özgen, Kenan Şi̇mşek, Deni̇z Baklaci, Mertol Gökçe Jan 2021

The Histopathological Effects Of Reabsorbable Polyethylene Glycol Hydrogel (Coseal) Onepidural Fibrosis In An Experimental Postlaminectomy Model In Rats, Emrah Keski̇n, Hasan Ali̇ Aydin, Murat Kalayci, Emre Işik, Utku Özgen, Kenan Şi̇mşek, Deni̇z Baklaci, Mertol Gökçe

Turkish Journal of Medical Sciences

Background/aim: To investigate the histopathological effects of reabsorbable polyethylene glycol hydrogel (RPGH, Coseal) on epidural fibrosis (EF) following laminectomy in rats. Materials and methods: A total of 24 rats were equally divided into three groups. In the first group, no treatment was applied after laminectomy (control group, Group 1). In the second group, hemostasis was achieved after laminectomy, and 2 mm absorbable gelatin sponge soaked in saline was placed over the epidural space and the wound was closed (Group 2). In the third group, hemostasis was achieved following laminectomy, and 0.5 mL RPGH (Coseal, Group 3) was squeezed over the …

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Hyperbaric Oxygen Therapy Affects Insulin Sensitivity/Resistance By Increasingadiponectin, Resistin, And Plasminogen Activator Inhibitor-I In Rats, Cemi̇l Kahraman, Hüseyi̇n Yaman Jan 2021

Hyperbaric Oxygen Therapy Affects Insulin Sensitivity/Resistance By Increasingadiponectin, Resistin, And Plasminogen Activator Inhibitor-I In Rats, Cemi̇l Kahraman, Hüseyi̇n Yaman

Turkish Journal of Medical Sciences

Background/aim: Hyperbaric oxygen therapy (HBOT) causes insulin sensitivity, but the reason for this is not known yet. The aim of the present study was to investigate the effect of HBOT on insulin sensitivity via resistin, plasminogen activator inhibitor-I (PAI-I), and adiponectin. Materials and methods: The study was designed using HBOT and control groups, with eight rats in each group. After 20 days of HBOT under 2.5 atmospheres for 90 min, the fasting insulin (FI), resistin, PAI-I, homeostatic model assessment of insulin resistance scores (HOMA-IR), quantitative insulin sensitivity check index (QUICKI), fasting plasma glucose (FPG), triglyceride, and high-density lipoprotein cholesterol (HDL-C) …

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Cover And Contents Jan 2021

Cover And Contents

Turkish Journal of Medical Sciences

No abstract provided.

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Evaluation Of Seroprevalence And Clinical And Laboratory Findings Of Patients Admitted Tohealth Institutions In Gümüşhane With Suspicion Of Crimean-Congo Hemorrhagic Fever, Esra Gürbüz, Abdurrahman Eki̇ci̇, Ahmet Hakan Ünlü, Hasan Yilmaz Jan 2021

Evaluation Of Seroprevalence And Clinical And Laboratory Findings Of Patients Admitted Tohealth Institutions In Gümüşhane With Suspicion Of Crimean-Congo Hemorrhagic Fever, Esra Gürbüz, Abdurrahman Eki̇ci̇, Ahmet Hakan Ünlü, Hasan Yilmaz

Turkish Journal of Medical Sciences

Background/aim: To determine the seroprevalence and evaluate clinical findings and laboratory results of patients prediagnosed with Crimean-Congo hemorrhagic fever (CCHF) in Gümüşhane. Materials and methods: Included in the cross-sectional study were 362 patients (162 female, 200 male) between 0 and 94 years of age, who were followed up after receiving a preliminary diagnosis of CCHF between January 2011 and December 2019. Anamnesis, age, sex, clinical findings, laboratory results, epidemiological and clinical evaluations, severity criteria, risk factor reviews, and a comparison of the suspected negative cases with positive cases were analyzed retrospectively. Patients included in the study were evaluated as RNApositive …

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Investigation Of The Relationship Between Immune Checkpoints And Mismatch Repairdeficiency In Recurrent And Nonrecurrent Glioblastoma, Emel Çakir, İsmai̇l Sayğin, Mustafa Emre Erci̇n Jan 2021

Investigation Of The Relationship Between Immune Checkpoints And Mismatch Repairdeficiency In Recurrent And Nonrecurrent Glioblastoma, Emel Çakir, İsmai̇l Sayğin, Mustafa Emre Erci̇n

Turkish Journal of Medical Sciences

Background/aim: Microsatellite instability tests and programmed cell death-1 (PD-1)/programmed cell death ligand-1 (PD-L1) in the immune checkpoint pathway are the tests that determine who will benefit from immune checkpoint inhibitor therapy. We aimed to show the expression of DNA mismatch repair proteins and PD-1/PD-L1 molecules that inhibit immune checkpoints, to explain the relationship between them, and to demonstrate their predictive role in recurrent and nonrecurrent glioblastoma. Materials and methods: We analyzed 27 recurrent and 47 nonrecurrent cases at our archive. We performed immunohistochemical analysis to determine expressions of PD-1, PD-L1, and mismatch repair proteins in glioblastoma. We evaluated the relationship …

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Investigation Of Oxidative Stress Status In Cumulus Cells In Patıents With In Vitrofertilization, Rabi̇a Tural, Cengi̇z Karakaya, Mehmet Erdem, Zeynep Aykol, Recep Onur Karabacak, Mustafa Kavutçu Jan 2021

Investigation Of Oxidative Stress Status In Cumulus Cells In Patıents With In Vitrofertilization, Rabi̇a Tural, Cengi̇z Karakaya, Mehmet Erdem, Zeynep Aykol, Recep Onur Karabacak, Mustafa Kavutçu

Turkish Journal of Medical Sciences

Background/aim: The negative impact of oxidative stress on oocytes obtained from in vitro fertilization (IVF) patients is a challenge for the optimization of live birth rates. In this study, it is aimed to investigate whether oxidant/antioxidant parameters have a predictive value in terms of determining the count and quality of oocytes. Materials and methods: Catalase (CAT), glutathione-S-transferase (GST), arylesterase (ARE) enzyme activities, and malondialdehyde (MDA) levels were analysed in cumulus cells of poor responder (n = 28, oocyte count ≤ 4), normo responder (n = 48, 5 ≤ oocyte count ≤ 14), and high responder (n = 26, oocyte count …

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