Digital Commons Network^™

Socio-Ecological Predictors Of Social Connection Among Older Adults, Georganna Amateau

Theses and Dissertations

Decades of research has established an unequivocal link between states of social connection and health status. Lack of social connection, whether construed as social isolation or loneliness, negatively influences health and is highly associated with cardiovascular disease, high blood pressure, fall risk, and premature death. Despite extensive research on social isolation and loneliness, evidence relative to the broader construct of social connection suffers. Few studies inform practice standards for community-based organizations. This study aimed to develop a multidimensional, continuous composite variable of social connection and use the composite variable to examine predictors with a socio-ecological lens.

A secondary data analysis …

Systematic Structure-Activity Relationship Studies Of Nalfurafine, Mengchu Li

Theses and Dissertations

Today’s opioid crisis is one of the most challenging public health emergency. Two million Americans suffer opioid addiction. Over 20 million adults are affected by daily pain without non-addictive analgesics.

Kappa opioid receptor (KOR) is one of the most studied new pain targets void of abuse liability. KOR agonists have shown potent analgesia and also potential in alleviating opioid addiction. The only approved KOR agonist in clinic is nalfurafine (NFU). Though not leading to addiction, the analgesic effects of NFU are accompanied by sedative side effects. Therefore, we designed a systematical structure-activity relationship study of NFU for developing non-addictive analgesics. …

Treatment Outcome Of Perforation Repair With Bio-Ceramic Based Materials: A Retrospective Study, Lolwa Alyahya

Theses and Dissertations

INTRODUCTION:

The aim of this retrospective cohort study was to assess the treatment outcome of orthograde perforation repair using bio-ceramic based materials.

METHODs:

Data from the VCU graduate endodontic practice were analyzed retrospectively. Treatment had been conducted by VCU endodontic residents under the supervision of qualified endodontists during the period from August 2014-December 2020. All cases in which a bio-ceramic based material had been used as a perforation repair material were included. Bio-ceramic based materials included MTA, EndoSequence Root Repair Material Putty and Paste (ERRM), and iRoot BP Plus Root Repair Material (BP-RRM). Perforation repair was performed using a dental …

Detrimental Role Of Irf1 In Myeloid Cells During Influenza Infection, Bianca L. Baum

Theses and Dissertations

The influenza virus is constantly evolving new ways to overcome both innate and vaccine-induced host defenses, making the innate immune response a critical therapeutic target for minimizing morbidity and mortality caused by infection. Here we examined the role that interferon regulatory factor 1 (IRF1) plays in regulating host innate immune responses in myeloid cells. We found that knocking out IRF1 from myeloid cells in mice (IRF1^DMy) led to a partial protection during IAV infection. Interestingly, recruitment of bone marrow derived myeloid cells as well as NLRP3 inflammasome expression were decreased in the lungs of IRF1^DMy mice, whereas …

Il-36g Cytokine Induction In Oral Epithelial Cells Triggered By Treponema Denticola And Their Role In Chronic Periodontitis, Christopher Blake

Theses and Dissertations

Periodontal disease is a polymicrobial disease affecting 10-15% of the population. Periodontal disease affects the quality of life by reducing mastication and potentially causing tooth loss. Periodontal disease is also linked to more severe, systemic diseases such as cardiovascular disease and rheumatoid arthritis. Development of the diseased state occurs when the plaque biofilm shifts from healthy to dysbiotic. The shift to a dysbiotic biome brings with it a shift in bacterial presence, specifically an increase in gram-negative bacteria, such as T. denticola. T. denticola is a gram-negative, anaerobic spirochete whose relationship with oral epithelial cells is poorly understood. Preliminary data …

Hamburger Helper Recipes, John Alex Goss

Theses and Dissertations

Hamburger Helper Recipes is a collection of essays and public addresses that aim to recuperate castoff and misfit material surrounding industries and tools which produce science-fiction fantasies, specifically videogames and television shows. The following essays confront the normative violence of capitalism, whiteness, and hetero-patriarchy that socially and technologically haunt these imaginary worlds and build hegemonic idealogy into their audiences. This collection takes industrial materials and software from their intended commercial purposes of production and “success” into places of abjection and quiet breakdown. The author’s own proximity to masculine and often toxic "work cultures'' within industrial spaces of coding and manufacturing …

Virtual Reality Tool For Visualizing The Oral Microbiome, Alexus M. Harris

Theses and Dissertations

There are limited teaching tools for helping both students and patients understand the oral microbiome. It is important to understand the oral microbiome as it heavily influences the health of your oral cavity and the dysbiosis of disease. The oral microbiome influences other aspects of health and serves as an indicator for health. With a greater understanding of the oral microbiome, patients can make healthier lifestyle changes and dentists can better educate their patients. For that reason, the goal of this project was to create a virtual reality tool for visualizing the oral microbiome. The assets for the VR tool …

Molecular Basis Of Cross-Sensitization In Colonic Inflammation-Induced Somatic Hypersensitivity, Parshva K. Mehta

Theses and Dissertations

A major portion of pain experienced by patients with an Irritable Bowel Disease (IBD) or Irritable Bowel Syndrome (IBS) can be attributed to visceral hypersensitivity. Visceral stimuli transmitted through primary afferent neurons in the dorsal root ganglia (DRG) induce a nociceptive response. Notably, a subset of patients has also experienced the development of somatic pain, such as leg pain, after diagnosis of a bowel disorder. The aim of this investigation is to ascertain which biochemical mediators are involved in the development of such viscerosomatic cross-sensitization. Initially, the Von Frey Test was used to find behavioral evidence of somatic referred pain; …

Modulation In Nmda Receptor Function Alleviates Safety Learning Deficit In Females Who Experienced Chronic Stress During Adolescence, Zuby C. Okafor

Theses and Dissertations

Anxiety disorders disproportionately impact women and are more prevalent in people with a history of chronic stress. Post-traumatic stress disorder (PTSD) is a type of stress and trauma-related disorder that is largely characterized by hyperarousal to fear-based cues. The inability to dissociate the fear-response from a non-threatening cue is known as impaired safety learning. Given that N-methyl-D-aspartate (NMDA) receptors are key mediators of learning behaviors, we examined the role of NMDAr function in deficient safety learning. Previous studies have shown that female rats with a history of stress have altered NMDAr gene expression and altered glutamatergic signaling; therefore, we hypothesized …

The Effect Of Local Anesthesia When Used In Dental Restorative Cases Under General Anesthesia On Control Of Intraoperative Physiologic Parameters And Post-Operative Comfort, Kathryn S. Skarda

Theses and Dissertations

Purpose:

To determine the effect of local anesthesia on post-operative pain and physiologic parameters intraoperatively in patients undergoing dental care under general anesthesia.

Methods:

This study was modeled as a double-blinded randomized control trial. Patients included healthy children under the age of six scheduled for restorative dental treatment under general anesthesia. Patient behavior was evaluated pre and post-operatively using the FLACC score and post-operatively using the Parental Pain Score Measure. Intraoperatively, all participants followed a standardized general anesthesia protocol and were given either local anesthetic infiltration by the dental surgeon performing the surgery or no anesthesia was utilized. Intraoperatively physiologic …

Pushing The Limits: Increasing The Speed And Specificity Of Sars-Cov-2 Testing, Grayson Way

Theses and Dissertations

The prevalence and spread of the current COVID-19 pandemic have highlighted the importance of continual improvements upon current microbiological testing methods. Rapid and accurate testing can help mitigate spread by improving on the time to quarantine and quarantine duration required. As of the writing of this thesis, COVID-19 has been responsible for more than 500,000 deaths in the United States of America, and greater than 2 million deaths globally. The work done in this thesis has shown improvements in the current SARS-CoV-2 testing methodology by reducing the time it takes for patient testing while maintaining accuracy and the sensitivity required …

The Role Of Glt-1 Signaling In Oligodendrocytes During Development And Myelin Repair, Elizabeth Thomason

Theses and Dissertations

The differentiation of oligodendrocyte progenitor cells (OPCs) into myelinating oligodendrocytes (OLGs) requires an increase in the complexity of process morphology, alterations in membrane trafficking, and the production of myelin proteins. Branching and process extension have already been shown to follow glutamate signaling through OLG-expressed excitatory amino acid transporters (EAATs), mostly via GLT-1. It is of note that glutamate homeostasis often goes awry in multiple sclerosis (MS), the main demyelinating disease in humans. Thus, we have sought to gain an understanding of the role that GLT-1 plays under the myelination and remyelination conditions that arise during natural development of OLGs and …

Climate Disruption In Canadian Constitutional Law: References Re Greenhouse Gas Pollution Pricing Act, Jocelyn Stacey

All Faculty Publications

This analysis considers the Supreme Court of Canada’s decision in References re Greenhouse Gas Pollution Pricing Act, 2021 SCC 11, in which a majority of the Court upheld as constitutional national carbon pricing legislation. The decision presents an excellent illustration of the legally disruptive nature of climate change. Illustrating that nothing is static in a climate disrupted world—including constitutional law—this article identifies three shifts the Court makes in relation to climate disruption. First, the decision represents a shift away from climate denialism toward a judicial willingness to confront the environmental, social and legal implications of climate change for Canada. Second, …

Testosterone Amplifies The Negative Valence Of An Agonistic Gestural Display By Exploiting Receiver Perceptual Bias, Nigel K. Anderson, Martina Grabner, Lisa A. Mangiamele, Doris Preininger, Matthew J. Fuxjager

Biological Sciences: Faculty Publications

Many animals communicate by performing elaborate displays that are incredibly extravagant and wildly bizarre. So, how do these displays evolve? One idea is that innate sensory biases arbitrarily favour the emergence of certain display traits over others, leading to the design of an unusual display. Here, we study how physiological factors associated with signal production influence this process, a topic that has received almost no attention. We focus on a tropical frog, whose males compete for access to females by performing an elaborate waving display. Our results show that sex hormones like testosterone regulate specific display gestures that exploit a …

Effects Of Nutrition On Honey Bee Microbiology, Disease Occurrence, And Hive Growth, Shelby P. Fettig

EWU Masters Thesis Collection

Honey bees (Apis mellifera) are major pollinators of many food crops, but unfortunately, population declines are threatening global food security and ecosystem health. Honey bees are under multiple stressors, such as poor nutrition, parasitic mites, and pathogens. Similar to human health, the gut microbiome of the honey bee is hypothesized to affect bee’s overall health by supporting host metabolism and immune system. However, it’s not clear how stressors impact gut microbiome, and thus health, of bees. Nutritional supplementation could mitigate negative effects of stressors, particularly for bees that don’t have access to diverse floral resources. In this study, I conducted …

Evaluating An Interprofessional Ergonomic Intervention For Dental Hygiene Students, Lashonna M. Knight

EWU Masters Thesis Collection

Purpose: Ergonomics plays an important role in identifying and reducing biomechanical stress and preventing musculoskeletal (MSK) injuries by creating a better fit between physical requirements and work environments. This study examined the benefits of implementing an interprofessional education (IPE) module in a dental hygiene curriculum with a dental hygienist (DH) and occupational therapist (OT) teaching and assessing students’ ergonomics.

Methods: Students participated in an IPE intervention to incorporate preventive techniques into their daily routine, to model these protective strategies for use as practicing DHs throughout their careers. Prior to the module and at the end of the six-week study, students …

Bryozoan Taxa Of The Toroweap Formation Of Clark County, Nevada, Amy Joy Hess

EWU Masters Thesis Collection

No abstract provided.

Anthology Of An Empath, Meriel Melendrez Mees

Cal Poly Humboldt theses and projects

How can we live here together? How can we, human beings (especially those of us not considered as such, historically, presently, or in the future) and more-than-human beings live here together and care for each other? I set out to learn how a pair of permaculture farmers in Southern Humboldt lived and worked with these questions: I attempted a qualitative and quantitative analysis of twenty years of natural history journals that one of them recorded. I was particularly interested in the aesthetics of land tending, affective relationships with more-than-human beings, and disrupting settler colonialism through epistemic reparations to the Sinkyone …

Why Do People Donate? Motivation Of Major Donors In Higher Education, Karin Hsuan Chao-Bushoven

Cal Poly Humboldt theses and projects

Higher education has relied on private philanthropy since the establishment of the first universities in the U.S. This reliance has increased over the decades as a result of rising costs and decreased government investment. As such, it has become more critical to better understand what factors motivate philanthropists to increase their support of higher education; including direct support for teaching and research and increasing financial support for those students otherwise not able to pursue secondary education. However, much of the existing data focuses only on point-of-philanthropic-act, and neglects to examine motivational factors of long-term donors that have progressively increased their …

Write Yourself Awake: The Double Pursuit Of Mindfulness Meditation And Writing, Alysia M. Hegg

Cal Poly Humboldt theses and projects

Contemplative pedagogy involves teaching methods designed to cultivate deepened awareness, concentration, and insight. Contemplative practices work to undo the Cartesian mind–body dualism that says that mental phenomena are non-physical, or that the mind and body are distinct and separable. This project focuses on an understanding that our internal world includes communication with one’s self, acts of imagination and visualization, and recall and memory. These internal experiences foster many things, such as compassion and kindness, as well as resilience and sustainability through connection.

“McMindfulness” is a term that refers to when mindfulness is used for self-serving and ego-enhancing purposes. Symptoms of …

A Comparison Of The Removal Of Estrogen Between Different Wastewater Treatment Processes, Danielle J. Jones

Cal Poly Humboldt theses and projects

Pharmaceuticals are found in water systems and are classified as contaminants due to their adverse effects on numerous types of aquatic organisms. Estradiol, a natural occurring estrogen and ethinylestradiol, a common synthetic estrogen found in birth control, are a class of pharmaceuticals called endocrine-disruptive contaminants (EDC). These contaminants have been shown to cause developmental delays in fish as well as feminizing male fish in concentrations as low as 1 ng/L for both estradiol and ethinylestradiol, and bioaccumulating in mollusks and oysters. There are many natural and human-assisted methods for removing pharmaceuticals in water, and they are dependent on both the …

Laboratory To Landscape: Mycorestoration, Riley Sanae Allen

Cal Poly Humboldt theses and projects

Mycorestoration is the use of saprophytic fungi to remediate pollutants from land and water. To address contaminant presence in non-point source pollution primarily from agricultural runoff, we worked towards identifying the community-scale implementation process of mycofiltration, a type of mycorestoration that filters contaminants from water, in Arcata, California. This place-based study used Participatory Action Research (PAR) to collaboratively conduct Transdisciplinary Research (TR) to collect baseline qualitative and quantitative data that did not exist for Arcata’s context. These data have been compiled into a written implementation plan which is intended to exist as a living document that is referenced and transformed …

Use Of Redwood Basal Hollows By Bats: A Focus On The Townsend's Big-Eared Bat On The North Coast Of California, Amon Jotesh Armstrong

Cal Poly Humboldt theses and projects

Loss of roosting resources, either through disturbance or removal, negatively affects bats. For sensitive species, such as the Townsend’s big-eared bat (Corynorhinus townsendii), determining roost requirements is a critical component in conserving their habitat. Such cavity roosting bats on the North Coast of California may use hollows in large redwood trees. In this study, I examined the factors determining the use of basal tree hollows by different bat species at eight redwood forest sites in Del Norte, Humboldt, and Mendocino Counties, California. Bat guano was collected from 179 basal hollow roosts from 2017 to 2018, and guano mass …

Comparison Of Standard And Environmental Dna Methods For Estimating Chinook Salmon Smolt Abundance In The Klamath River, California, Doyle Joseph Coyne

Cal Poly Humboldt theses and projects

Evaluating abundance of juvenile salmonids is critical to conservation and management. Current abundance estimation involves use of rotary screw traps and mark-recapture studies. Use of environmental DNA (eDNA) in water samples offers a noninvasive and less expensive approach that may potentially improve or eventually replace traditional monitoring. Here I evaluate the utility of eDNA to predict weekly abundance estimates of outmigrating Chinook salmon (Oncorhynchus tshawytscha) smolts in the Klamath River, California. A total of 15 water samples were collected per week over the 17-week smolt outmigration in both 2019 and 2020. Chinook salmon eDNA concentration in each water …

Identifying Neuron Clusters Controlling Movement Vigor, Jay A. Strabinick

Cal Poly Humboldt theses and projects

Parkinson’s disease (PD) is a neurodegenerative disease that progressively decreases dopaminergic function. Lower amounts of dopamine may cause an innate motivational shift that decreases movement vigor when performing difficult tasks. In PD patients, bradykinesia, the slowing of movement, is characteristic of this decrease in vigor. The movement vigor hypothesis proposes that dopamine neurons modulate performance aspects of movement, like speed and persistence. This paper proposes a series experiments utilizing neuron recording techniques in zebrafish that would test the movement vigor hypothesis by determining whether in fact there is a distinct group of dopamine neurons that modulate movement vigor. Core elements …

On The Acceptance Of Urban Beavers In Martinez, California, Zane A. Eddy

Cal Poly Humboldt theses and projects

As ecosystem engineers, beavers construct complex riparian and wetland habitats that benefit many other species, including endangered salmonids. Through their landscape alterations, beavers also promote increased groundwater recharge and provide refugia during wildfires and high flow events by impounding water and allowing it to spread across the landscape. Prior to the North American colonial fur trapping campaigns, there were between 60 and 400 million beavers in North America. By the beginning of the 20th century, beavers were extirpated from many parts of the continent, however through human efforts, their population has since rebounded to between 10 and 15 million. The …

Beaver Moderated Fire Resistance In The North Cascades And Potential For Climate Change Adaptation, Joseph John Weirich Iii

EWU Masters Thesis Collection

Climate change and fire suppression have altered historic fire regimes, creating conditions for larger, more intense fires. Intense burns can alter watershed hydrology, increasing the potential for harmful channel incision, which impairs riparian ecosystem function by lowering the water table, disconnecting floodplains from aquatic environments. However, wetlands and functioning riparian zones can reduce burn intensity. Beaver, with their unique ability to build dams, can restore incised and degraded streams, store water, and expand wetland environments, potentially decreasing wildfire intensity, fire spread and create fire breaks across the landscape. My objective was to test the hypothesis that beaver impoundments increase landscape …

Queering Bostock, Jeremiah A. Ho

All Faculty Scholarship

Although the Supreme Court’s 2020 Title VII decision, Bostock v. Clayton County, Georgia, is a victory for LGBTQ individuals, its doctrinal limitations unavoidably preserve a discriminatory status quo. This Article critically examines how and why Bostock fails to highlight the indignities experienced by queer minorities under decades of employment discrimination. In Bostock, Justice Gorsuch presents a sweeping textualist interpretation of Title VII that protects against sexual orientation and gender identity discrimination. Yet, the decision sparsely recognizes queer lived experiences, compared to prior pro-LGBTQ cases where such recognition contributed to developing an anti-stereotyping framework that confronted some of the heteronormative biases …

A Pilot Study: Periodontal Risk Factor Screening Tool For Certified Diabetes Care Education Specialists, Holly Brawner

EWU Masters Thesis Collection

Purpose: There is a bidirectional link between uncontrolled diabetes and untreated periodontal disease. Controlling periodontal infection plays an essential role in the overall management of diabetes. This study explored an interprofessional (IP) collaboration between Certified Diabetes Care and Education Specialists (CDCES) and Dental Hygienists and the utility of a point of care Periodontal Screening Tool (PST) for CDCES to build confidence in informing their clients on periodontal disease risk factors and providing resources to seek dental care.

Methods: This pilot study used a pre-test post-test design where a survey was administered prior to CDCES participating in an Education and Training …

Cover And Contents

Turkish Journal of Veterinary & Animal Sciences

No abstract provided.