Digital Commons Network^™

Antibiotic-Driven Intestinal Dysbiosis In Pediatric Short Bowel Syndrome Is Associated With Persistently Altered Microbiome Functions And Gut-Derived Bloodstream Infections, Robert Thänert, Anna Thänert, Jocelyn Ou, Adam Bajinting, Carey-Ann D Burnham, Holly J Engelstad, Maria E Tecos, I Malick Ndao, Carla Hall-Moore, Colleen Rouggly-Nickless, Mike A Carl, Deborah C Rubin, Nicholas O Davidson, Phillip I Tarr, Barbara B Warner, Gautam Dantas, Brad W Warner

Open Access Publications

Surgical removal of the intestine, lifesaving in catastrophic gastrointestinal disorders of infancy, can result in a form of intestinal failure known as short bowel syndrome (SBS). Bloodstream infections (BSIs) are a major challenge in pediatric SBS management. BSIs require frequent antibiotic therapy, with ill-defined consequences for the gut microbiome and childhood health. Here, we combine serial stool collection, shotgun metagenomic sequencing, multivariate statistics and genome-resolved strain-tracking in a cohort of 19 patients with surgically-induced SBS to show that antibiotic-driven intestinal dysbiosis in SBS enriches for persistent intestinal colonization with BSI causative pathogens in SBS. Comparing the gut microbiome composition of …

Paeonol Ameliorates Chronic Itch And Spinal Astrocytic Activation Via Cxcr3 In An Experimental Dry Skin Model In Mice, Wen Wang, Qiaoyun Li, Zhongqiu Zhao, Yutong Liu, Yi Wang, Hui Xiong, Zhinan Mei

Open Access Publications

Paeonol is a bioactive phenol presents mainly in

Perceptions Of Clinical Dental Students Toward Online Education During The Covid-19 Crisis: An Egyptian Multicenter Cross-Sectional Survey, Reham Hassan, Ayman R Khalifa, Tarek Elsewify, Mohamed G Hassan

Open Access Publications

No abstract provided.

Superior Verbal Memory Outcome After Stereotactic Laser Amygdalohippocampotomy, Daniel L Drane, Jon T Willie, Et Al

Open Access Publications

No abstract provided.

Care Gaps And Recommendations In Vestibular Migraine: An Expert Panel Summit, Monica P Mallampalli, Joel A Goebel, Et Al

Open Access Publications

Vestibular migraine (VM) is an increasingly recognized pathology yet remains as an underdiagnosed cause of vestibular disorders. While current diagnostic criteria are codified in the 2012 Barany Society document and included in the third edition of the international classification of headache disorders, the pathophysiology of this disorder is still elusive. The Association for Migraine Disorders hosted a multidisciplinary, international expert workshop in October 2020 and identified seven current care gaps that the scientific community needs to resolve, including a better understanding of the range of symptoms and phenotypes of VM, the lack of a diagnostic marker, a better understanding of …

Encephalitic Arboviruses Of Africa: Emergence, Clinical Presentation And Neuropathogenesis, Robyn S Klein

Open Access Publications

Many mosquito-borne viruses (arboviruses) are endemic in Africa, contributing to systemic and neurological infections in various geographical locations on the continent. While most arboviral infections do not lead to neuroinvasive diseases of the central nervous system, neurologic diseases caused by arboviruses include flaccid paralysis, meningitis, encephalitis, myelitis, encephalomyelitis, neuritis, and post-infectious autoimmune or memory disorders. Here we review endemic members of the

Hyperexcitability Of Sensory Neurons In Fragile X Mouse Model, Pan-Yue Deng, Oshri Avraham, Valeria Cavalli, Vitaly A Klyachko

Open Access Publications

Sensory hypersensitivity and somatosensory deficits represent the core symptoms of Fragile X syndrome (FXS). These alterations are believed to arise from changes in cortical sensory processing, while potential deficits in the function of peripheral sensory neurons residing in dorsal root ganglia remain unexplored. We found that peripheral sensory neurons exhibit pronounced hyperexcitability in

Rubella Virus Infected Macrophages And Neutrophils Define Patterns Of Granulomatous Inflammation In Inborn And Acquired Errors Of Immunity, Ludmila Perelygina, Amy Musiek, Et Al

Open Access Publications

Rubella virus (RuV) has recently been found in association with granulomatous inflammation of the skin and several internal organs in patients with inborn errors of immunity (IEI). The cellular tropism and molecular mechanisms of RuV persistence and pathogenesis in select immunocompromised hosts are not clear. We provide clinical, immunological, virological, and histological data on a cohort of 28 patients with a broad spectrum of IEI and RuV-associated granulomas in skin and nine extracutaneous tissues to further delineate this relationship. Combined immunodeficiency was the most frequent diagnosis (67.8%) among patients. Patients with previously undocumented conditions, i.e., humoral immunodeficiencies, a secondary immunodeficiency, …

A Real-World Observation Of Antipsychotic Effects On Brain Volumes And Intrinsic Brain Activity In Schizophrenia, Yifan Chen, Fay Y Womer, Ruiqi Feng, Xizhe Zhang, Yanbo Zhang, Jia Duan, Miao Chang, Zhiyang Yin, Xiaowei Jiang, Shengnan Wei, Yange Wei, Yanqing Tang, Fei Wang

Open Access Publications

Background: The confounding effects of antipsychotics that led to the inconsistencies of neuroimaging findings have long been the barriers to understanding the pathophysiology of schizophrenia (SZ). Although it is widely accepted that antipsychotics can alleviate psychotic symptoms during the early most acute phase, the longer-term effects of antipsychotics on the brain have been unclear. This study aims to look at the susceptibility of different imaging measures to longer-term medicated status through real-world observation.

Methods: We compared gray matter volume (GMV) with amplitude of low-frequency fluctuations (ALFFs) in 89 medicated-schizophrenia (med-SZ), 81 unmedicated-schizophrenia (unmed-SZ), and 235 healthy controls (HC), and the …

Development And Testing Of A Spray-Dried Tuberculosis Vaccine Candidate In A Mouse Model, Mellissa Gomez, Mushtaq Ahmed, Shibali Das, Leah Mellett, Rosemary Swanson, Ananya Gupta, Shabaana A Khader, Et Al

Open Access Publications

Converting a vaccine into a thermostable dry powder is advantageous as it reduces the resource burden linked with the cold chain and provides flexibility in dosage and administration through different routes. Such a dry powder presentation may be especially useful in the development of a vaccine towards the respiratory infectious disease tuberculosis (TB). This study assesses the immunogenicity and protective efficacy of spray-dried ID93+GLA-SE, a promising TB vaccine candidate, against

The T-Type Calcium Channel Isoform Ca V 3.1 Is A Target For The Hypnotic Effect Of The Anaesthetic Neurosteroid (3Β,5Β,17Β)-3-Hydroxyandrostane-17-Carbonitrile, Tamara Timic Stamenic, Simon Feseha, Francesca M Manzella, Damon Wallace, Davis Wilkey, Timothy Corrigan, Hanna Fiedler, Patricia Doerr, Kathiresan Krishnan, Yogendra H Raol, Douglas F Covey, Vesna Jevtovic-Todorovic, Slobodan M Todorovic

Open Access Publications

BACKGROUND: The mechanisms underlying the role of T-type calcium channels (T-channels) in thalamocortical excitability and oscillations in vivo during neurosteroid-induced hypnosis are largely unknown.

METHODS: We used patch-clamp electrophysiological recordings from acute brain slices ex vivo, recordings of local field potentials (LFPs) from the central medial thalamic nucleus in vivo, and wild-type (WT) and Ca

RESULTS: Patch-clamp recordings showed that 3β-OH inhibited isolated T-currents but had no effect on phasic or tonic γ-aminobutyric acid A currents. Also in acute brain slices, 3β-OH inhibited the spike firing mode more profoundly in WT than in Ca

CONCLUSIONS: The Ca

Kentucky And The Thoroughbred Industries: Prospects And Challenges As Gambling Stagnates, Thomas E. Lambert

Faculty and Staff Scholarship

Over the last 15 to 20 years or so horse racing has seen declines in wagering and fan attendance throughout the US. Because of this, the number of races, horses per race, the number of thoroughbred farms, and new thoroughbreds bred and born each year for about the last 10 to 12 years have also declined. The decline in wagering has occurred despite simulcasting of races, online betting, and gambling machines which employ films of past races (historical horse racing machines). Those racetracks doing well are usually part of larger casino and entertainment complexes (racinos). Kentucky, which has one of …

The Benefits Of Being A Suicidal Curmudgeon: Emil Cioran On Killing Yourself, Glenn M. Trujillo Jr

Faculty and Staff Scholarship

Emil Cioran offers novel arguments against suicide. He assumes a meaningless world. But in such a world, he argues, suicide and death would be equally as meaningless as life or anything else. Suicide and death are as cumbersome and useless as meaning and life. Yet Cioran also argues that we should contemplate suicide to live better lives. By contemplating suicide, we confront the deep suffering inherent in existence. This humbles us enough to allow us to change even the deepest aspects of ourselves. Yet it also reminds us that our peculiar human ability—being able to contemplate suicide—sets us above anything …

Malondialdehyde Acetaldehyde Adducts (Maa-Adducts) Direct Distinctive Pro-Inflammatory Responses In Endothelial And Macrophage Cell Lines, Patrick J. Opperman, Michael J. Duryee, Ted R. Mikuls, Geoffrey M. Thiele, Dahn L. Clemens, Daniel R. Anderson

EMET Projects

Chronic inflammation plays a critical role in the pathogenesis of atherosclerosis. At present, the mechanism(s) by which inflammation contributes to this disease isnot entirely understood. Inflammation is known to induce oxidative stress, of which one consequence is lipid peroxidation. This process leads to the production of malondialdehyde (MDA), which can subsequently break down to form acetaldehyde (AA). These two aldehyde by-products can covalently interact with the ε-amino group of lysineswithin proteins and lipoproteins leading to the formation of highly immunogenic malondialdehyde-acetaldehyde adducts (MAA-adducts). The aim of this study was to determine the in-vitro cytokine response of endothelial cells and macrophages …

The Induction Of Autoimmune Arthritis And Sex Differences In Mice Impact The Lung Inflammatory Response To Repetitive Inhalant Organic Dust Extract Exposures, Kathryn Rentfro, Geoffrey M. Thiele, Katherine Janike, Amy J. Nelson, Michael J. Duryee, Bryant R. England, Debra J. Romberger, Joseph Carrington, Dong Wang, Benjamin J. Swanson, Lynell W. Klassen, Ted R. Mikuls, Jill A. Poole

EMET Projects

Asthma, chronic bronchitis and COPD are common adverse respiratory health effects among persons exposed to agriculture organic dust work environments.

• Occupational inhalant exposures have been increasingly associated with the risk of rheumatoid arthritis (RA) disease development, particularly among males. Agriculture workers have increased risk of RA and generalized bone disease.
• Chronic lung disease is associated with production of characteristic autoantibodies associated with RA (e.g.anti-citrullinated antibodies), even in absence of RA disease.
• The mechanistic link between pulmonary inflammation and arthritis (and vice versa) remains poorly understood. Animal models are lacking.

Social Emotional Competence In School Leaders, Melanie Sanders

UNF Graduate Theses and Dissertations

School principals are responsible for the recruitment and retention of effective teachers, leading the instructional program, maintaining the climate and culture of the building, ensuring school safety, and improving student achievement, among other things. Social emotional learning (SEL) has become an important part of K-12 education and has been found to improve climate and culture, student achievement, long term student outcomes, and many other benefits. Research has been conducted on many of the student outcomes associated with SEL but there is limited literature in the area of the social emotional competence (SEC) of adults who work in schools, particularly school …

Watching The Watchdogs: Online News Commenters' Critiques Of Journalistic Performance During Terrorist Attacks, Ioana A. Coman

Iowa Journal of Communication

This international comparative analysis explores what categories the public uses to evaluate the media performances of American and French journalists and media covering terrorist attacks. Specifically, the study looked at the Boston Marathon bombing (2013), and the Paris (Bataclan) terrorist attacks (2015), and the related online news stories comment sections of The New York Times and Le Figaro. The online comments of each news story were examined through a qualitative content analysis. The study shows that in a time of crisis commenters both appreciate and criticize journalistic performance and make direct demands to the journalists and editors. When applying journalistic …

Three-Dimensional Mapping Reveals Scale-Dependent Dynamics In Biogenic Reef Habitat Structure, Tim Jackson-Bué, Gareth J. Williams, Guy Walker-Springett, Steven J. Rowlands, Andrew J. Davies

Biological Sciences Faculty Publications

Habitat structure influences a broad range of ecological interactions and ecosystem functions across biomes. To understand and effectively manage dynamic ecosystems, we need detailed information about habitat properties and how they vary across spatial and temporal scales. Measuring and monitoring variation in three-dimensional (3D) habitat structure has traditionally been challenging, despite recognition of its importance to ecological processes. Modern 3D mapping technologies present opportunities to characterize spatial and temporal variation in habitat structure at a range of ecologically relevant scales. Biogenic reefs are structurally complex and dynamic habitats, in which structure has a pivotal influence on ecosystem biodiversity, function and …

A Counter-History Of Rhetorical Ecologies, Madison Jones

Professional and Public Writing Faculty Publications

In this essay, I argue that the ecological turn in rhetorical studies has produced spatiotemporal problems and that these problems are directly tied to the material disciplinary history of ecosystems ecology and its connections to the Anthropocene violence of nuclear colonialism. These spatiotemporal concerns result from rhetoric’s “ecological moment”—a kairotic framework that emphasizes flux but elides material histories. Building from rhetorical scholarship in decolonial historiography and place-based methods, I offer a counterhistory of ecology to demonstrate how our field can better engage with the dynamic narrative pasts that shape contemporary rhetorical ecological inquiry. Through this counterhistory, I provide a method …

Deep Mapping For Environmental Communication Design, Shannon Butts, Madison Jones

Professional and Public Writing Faculty Publications

This article shares lessons from designing EcoTour, a multimedia environmental advocacy project in a state park, and it describes theoretical, practical, and pedagogical connections between locative media and community-engaged design. While maps can help share information about places, people, and change, they also limit how we visualize complex stories. Using deep mapping, and blending augmented reality with digital maps, EcoTour helps people understand big problems like climate change within the context of their local community. This article demonstrates the rhetorical potential of community-engaged design strategies to affect users, prompt action, and create more democratic discourse in environmental communication.

Is It Scientific? Viewer Perceptions Of Storm Surge Visualizations, Peter J. Stempel, Austin Becker

Marine Affairs Faculty Publications

Scientists and coastal risk managers use semi-realistic visualizations of storm surge connected to hydrodynamic models to make projected impacts engaging and accessible. Such visualizations do not fit within established frameworks for visualizing risk because they add representational detail and may imply more certainty than exists regarding outcomes. This study explores how audiences regard these visualizations in relation to perceived representational norms for scientific graphics and visualizations. Online survey respondents (735 experts and members of the general public, primarily in Rhode Island and the northeastern United States) were asked about characteristics that make a representation “scientific.” Results demonstrate differences in norms …

Indigenizing Ecosystem Management In Rhode Island, Jackson Cox

Open Access Master's Theses

This project interviewed members of the Narragansett Tribe on the concerns the Tribe has with climate change. Following the guidelines of decolonizing methodologies and the concept of Indigenizing futures, this project aimed to be as respectful and useful to the Narragansett Tribe as possible. The project delves into current and future Narragansett concerns the Narragansett regarding climate change, and it identifies some of the cultural, historical, and societal factors that inform their viewpoints on climate change and climate change adaptation. Some of the concerns for the Tribe included: air quality, the health of forest resources, and energy production and consumption. …

The Effects Of Message Framing On Response To Plastic Reduction Policies, Courtney Milley

Open Access Master's Theses

Academic literature to date has effectively proven the scale of plastic pollution’s harm to the environment. Some scholars have even argued that it should be discussed broadly in society as a crisis (Mæland & Staupe‐Delgado 2019). To reduce plastic pollution, potential policies need widespread support. Existing literature shows framing manipulations can influence opinion and care for plastic pollution but have not been tied to policy support. This study looked to assess the difference in policy support between groups framed with plastic pollution contributing to climate change causing emissions, plastic pollution endangering charismatic animals, or a control framing with simple information …

Advances In The Arms Race Between Silkworm And Baculovirus, Liang Jiang, Marian R. Goldsmith, Qingyou Xia

Biological Sciences Faculty Publications

Insects are the largest group of animals. Nearly all organisms, including insects, have viral pathogens. An important domesticated economic insect is the silkworm moth Bombyx mori. B. mori nucleopolyhedrovirus (BmNPV) is a typical baculovirus and a primary silkworm pathogen. It causes major economic losses in sericulture. Baculoviruses are used in biological pest control and as a bioreactor. Silkworm and baculovirus comprise a well-established model of insect–virus interactions. Several recent studies have focused on this model and provided novel insights into viral infections and host defense. Here, we focus on baculovirus invasion, silkworm immune response, baculovirus evasion of host immunity, …

Draft Genome Sequence Of Salegentibacter Sp. Strain Bdj18, A Plankton-Associated Bacterium In The Northeast Atlantic Ocean, Elizabeth J. Mcdermith, Alexa R. Sterling, Matthew J. Bertin, Bethany D. Jenkins

Cell and Molecular Biology Faculty Publications

Salegentibacter sp. strain BDJ18 was isolated from a plankton-associated seawater sample from the northeast Atlantic Ocean. We report its draft genome assembly, which includes genes potentially important for microbial interactions in the marine environment.

Beyond Plea Bargaining: A Theory Of Criminal Settlement, Richard Lorren Jolly, J.J. Prescott

Articles

Settlement is a term rarely used in criminal law. Instead, people speak almost exclusively of plea bargaining—i.e., enforceable agreements in which a defendant promises to plead guilty in exchange for a prosecutor’s promise to seek leniency in charging or at sentencing. But a traditional plea agreement is just the most visible instance of a much broader class of possible criminal settlement agreements. In terms of their fundamentals, criminal settlements are indistinguishable from their civil counterparts: through either an atomized or comprehensive bargain, parties exchange what they have for what they want, advancing their respective interests in cost minimization, risk mitigation, …

Reproductive Biology Of The Spinner Shark Carcharhinus Brevipinna, Off The Southeast U.S. Coast, Kristin K. Palmrose

UNF Graduate Theses and Dissertations

The spinner shark, Carcharhinus brevipinna, is a large coastal shark species that is common on the U.S. southeast coast and caught in both commercial and recreational fisheries. Little research has been conducted on the life history of C. brevipinna in the Northwestern Atlantic, presenting challenges for fishery management. This is especially true for reproductive biology, warranting a need to determine how rapidly individuals are reproducing and contributing to the population. This study aimed to characterize reproduction in C. brevipinna by determining size-at-maturity, reproductive seasonality, periodicity, and fecundity. This was accomplished by analyzing changes in reproductive tract morphology and histology, …

Distribution, Bars, And Arcade Stars: Joe Anthony’S Entrepreneurial Expansion In Houston’S Gay Media Industries, Finley Freibert

Faculty and Staff Scholarship

This article develops the concept of "gay useful media" to explore a case study of gay entrepreneurship in Houston, Texas, of the 1970s. A father and son developed a gay media empire in the city, which spanned bars, bookstores, distribution, and vending. One of the pair's key establishments was Houston's legendary gay bar Mary's at 1022 Westheimer (also known as Mary's Lounge, Mary's, Naturally, and Mary's…Naturally).

“With Facebook, You Have A Voice:” Neoliberalism And Activism In Mark Zuckerberg’S Georgetown Address, Calvin Coker, Ryan Corso-Gonzales

Faculty and Staff Scholarship

In October of 2019, Facebook CEO Mark Zuckerberg streamed a speech from Georgetown University defending the company’s practice of not regulating or rejecting blatantly false political advertisements placed on their site. The speech, part of his “transparency tour” to allay concerns about the growing social power and stunning irresponsibility of Facebook, presents a troubling articulation of “voice” along neoliberal lines that atomizes the individual, separates activism from communities, and conflates activity on Facebook with free expression. In this essay, we use rhetorical scholarship on voice to illuminate how Zuckerberg’s speech both relies on and retrenches neoliberal rationality to flatten difference …

Rework The Network: Implementing Virtual Outreach Methods In The Covid Era, Alexandra Howard

Faculty and Staff Scholarship

The COVID-19 pandemic forced academic libraries to be innovative and efficient in shifting to support online learning. While there has been much discussion of online teaching resources and tools among librarians and educators, there has been less of a focus on online outreach and virtual networking. This article presents a case study describing how a new liaison librarian used virtual outreach to build relationships in her liaison subject area, leading to opportunities for research assistance and instruction despite the challenges of starting as a new librarian in the midst of a global pandemic.