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2021

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Using Formulation To Unlock Vaccine Adjuvant Efficacy For Toll-Like And C-Type Lectin Receptor Agonsts, Kristopher Kenneth Short Jan 2021

Using Formulation To Unlock Vaccine Adjuvant Efficacy For Toll-Like And C-Type Lectin Receptor Agonsts, Kristopher Kenneth Short

Graduate Student Theses, Dissertations, & Professional Papers

Ligands for pattern recognition receptors (PRRs) have been isolated or synthesized for use as adjuvants in order to improve the magnitude and quality of the immune response of vaccines. In particular, basic research of toll-like receptor (TLR) and C-type lectin receptor (CLR) families has culminated in the production of novel ligands with agonist activity. To use these PRR agonists as vaccine adjuvants, it is necessary to properly formulate them in delivery systems to unlock their agonist activity. The objective of this work was to develop liposomal and oil-in-water (O/W) emulsion formulations for TLR4 and TLR7/8 agonists and to develop O/W …

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Tennessee Williams: The Characters Are The Playwright, Peter A. Philips Jan 2021

Tennessee Williams: The Characters Are The Playwright, Peter A. Philips

Graduate Student Theses, Dissertations, & Professional Papers

Tennessee Williams was first and foremost a personage of the South, having been born, raised, and nurtured in the Mississippi Delta country. His early influences formed the concept of his “American Theatre.” He was a keen observer of people and places and wrote about the individuals he studied. He espoused the idea that as a homosexual he had the innate capability to write and appreciate various genders and sexualities, expressing himself as the character being developed in the moment of creation. Williams’s works, though containing moments of great humor, often trend toward darkness, becoming ever more pessimistic of human survival …

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"It Kind Of Polishes All Your Flaws Away": Long-Term Experiences With Psilocybin Mushrooms And The Influence Of Set And Setting, Danielle Nicole Daniel Jan 2021

"It Kind Of Polishes All Your Flaws Away": Long-Term Experiences With Psilocybin Mushrooms And The Influence Of Set And Setting, Danielle Nicole Daniel

Cal Poly Humboldt theses and projects

This study explores the experiences and motivations of people who take psilocybin mushrooms long-term. Little scholarly attention has been given to the psilocybin experience outside of a clinical setting. Likewise, there is a dearth of research examining the factors that lead to first-time and ongoing experiences with mushrooms. I conducted in-depth semi-structured interviews with 18 informants who have taken psilocybin mushrooms at least 10 times and for over three years. I encouraged open dialog and storytelling to gain a deeper understanding of their mushroom experiences and motivations to take long-term. Using a grounded theory approach, I identified the following patterns …

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Do Beaver Dam Analogues Act As Passage Barriers To Juvenile Coho Salmon And Juvenile Steelhead Trout?, Christopher G. O'Keefe Jan 2021

Do Beaver Dam Analogues Act As Passage Barriers To Juvenile Coho Salmon And Juvenile Steelhead Trout?, Christopher G. O'Keefe

Cal Poly Humboldt theses and projects

In the Pacific Northwest, the human-caused reduction of quality and quantity of freshwater rearing habitat is a limiting factor for Pacific Salmon populations. Beaver dam analogues (BDAs) increase suitable rearing habitat for juvenile salmonids and promote the restoration of critical stream processes. Installing BDAs is an increasingly popular alternative to more intensive restoration techniques, due to the relatively low cost and effort required to install BDA structures. However, widespread installation of BDAs has been slowed by regulatory agencies’ concerns that BDAs may impede fish passage. Few studies have empirically assessed the extent to which BDAs impede fish passage, and no …

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Hózhó, “To Walk In Beauty And Balance”: Indigenous Writers Decolonize Theories Of Myth, Aaron Laughlin Jan 2021

Hózhó, “To Walk In Beauty And Balance”: Indigenous Writers Decolonize Theories Of Myth, Aaron Laughlin

Cal Poly Humboldt theses and projects

In this project, I argue for an Indigenous theory of myth in order to reconsider popular and academic paradigms about myth and its function. My goal is to articulate how Indigenous understandings might revise these paradigms by emphasizing myth as a means to foster ethical relationships of health and balance within ourselves and in the world. Inspired by the Indigenous writers Leslie Marmon Silko, Thomas King, and Gerald Vizenor, I outline how these authors think, write, and talk about the concept of myth. I explain prevailing academic paradigms, including the term’s long history of associations with old-fashioned, “primitive,” superstitious stories …

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Oral Versus Gastrointestinal Mucosal Immune Niches In Homeostasis And Allostasis, Lina J Suárez, Silie Arboleda, Nikola Angelov, Roger M Arce Jan 2021

Oral Versus Gastrointestinal Mucosal Immune Niches In Homeostasis And Allostasis, Lina J Suárez, Silie Arboleda, Nikola Angelov, Roger M Arce

Faculty, Staff and Student Publications

Different body systems (epidermis, respiratory tract, cornea, oral cavity, and gastrointestinal tract) are in continuous direct contact with innocuous and/or potentially harmful external agents, exhibiting dynamic and highly selective interaction throughout the epithelia, which function as both a physical and chemical protective barrier. Resident immune cells in the epithelia are constantly challenged and must distinguish among antigens that must be either tolerated or those to which a response must be mounted for. When such a decision begins to take place in lymphoid foci and/or mucosa-associated lymphoid tissues, the epithelia network of immune surveillance actively dominates both oral and gastrointestinal compartments, …

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Full Issue, Socio-Legal Review Jan 2021

Full Issue, Socio-Legal Review

Socio-Legal Review

No abstract provided.

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Web Content And Performance Evaluation Of Animal Sciences University Library Websites In India : An Analysis, Manoj Kumar Verma Dr., Sur Chandra Singha Jan 2021

Web Content And Performance Evaluation Of Animal Sciences University Library Websites In India : An Analysis, Manoj Kumar Verma Dr., Sur Chandra Singha

Library Philosophy and Practice (e-journal)

Library Website is considered as one of the most substantial tools to publish and disseminate the information of several activities such as mission vision, library notice, rules and regulations, new arrival, library facilities, e-resources, and services, etc. The present study is based on the information available on the Animal Sciences University Library Websites/Webpage of India. A checklist method was used for content assessment based on an earlier study conducted by several professionals on this particular topic. The findings result of the present study presented that Lala Lajpat Rai University of Veterinary & Animal Sciences, Hisar website has to have highest …

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Juvenile Justice Workers’ Perceptions Of Teen Court And Traditional Court, Kesla M. Holder Jan 2021

Juvenile Justice Workers’ Perceptions Of Teen Court And Traditional Court, Kesla M. Holder

Walden Dissertations and Doctoral Studies

The impact of alternative programs for juveniles within the juvenile justice court system was not well understood. Studies such as research from the Annie E. Casey Foundation identified juvenile diversion approaches as an effective method of reducing recidivism in juvenile courts. The purpose of this qualitative case study was to seek understanding of the nontraditional juvenile court process from the perceptions of juvenile justice workers in a local teen court program. Deterrence theory provided the theoretical framework to guide the study. Open-ended survey questions were used to collect data from 11 juvenile justice officers from the local Department of Juvenile …

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Nonprofit Leaders’ Digital Marketing Strategies To Secure And Sustain Donors, Valayia Jones-Smith Jan 2021

Nonprofit Leaders’ Digital Marketing Strategies To Secure And Sustain Donors, Valayia Jones-Smith

Walden Dissertations and Doctoral Studies

Without systematic strategies to increase their donor base, some leaders of nonprofit organizations might be unable to develop and sustain a solid financial foundation to support programs and services related to organizational missions, values, and goals. Grounded in the relationship management theory, the purpose of this qualitative single case study was to explore strategies three executive leaders of a nonprofit organization in the northeastern United States used to increase and sustain their donor base using digital marketing. Data were collected from semistructured interviews, the organization’s website, organizational documents, publicly available data, and organizational social media channels. Data were analyzed using …

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Examining Terrorism Attacks And Regional Preparedness In The United States, Trebor Curtis Yocum Jan 2021

Examining Terrorism Attacks And Regional Preparedness In The United States, Trebor Curtis Yocum

Walden Dissertations and Doctoral Studies

After the 9/11 terrorist attacks, the U.S. government renewed efforts to prepare for future attacks. Despite research on federal and state government preparedness, there was a lack of scholarship on trends in terrorist attacks at the local level. The purpose of this quantitative descriptive study was to examine trends in terrorism attacks in the United States between 2001 and 2018 and determine whether significance exists between characteristics of the terrorism incidents (weapon used, target type) and region. The conceptual framework included Grundmann’s risk management and Tomuzia et al.’s risk assessment scenario models. Answering the research questions entailed examining trends in …

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Social Support, Substance Use, And Mental Health Services Utilization Among African Americans, Thomas Symche Bendu Jan 2021

Social Support, Substance Use, And Mental Health Services Utilization Among African Americans, Thomas Symche Bendu

Walden Dissertations and Doctoral Studies

Mental illness is more prevalent among African Americans than their Non-Hispanic White counterparts; however, this population is less inclined to receive behavioral treatment. The purpose of this study was to examine the association between perceived social support, substance use, and gender with mental health care services utilization among African Americans. The social ecological model and social support theory grounded this study. The research design was a quantitative cross-sectional analysis of the 2016 Behavioral Risk Factor Surveillance Survey. The sample consisted of 486,3030 African American adults that represented the U.S. population using weighted estimates. The overall logistic regression models for the …

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Foster Parents’ Experience Of Placement Disruptions For Youths In Foster Care, Deyettea Kim Alexander Jan 2021

Foster Parents’ Experience Of Placement Disruptions For Youths In Foster Care, Deyettea Kim Alexander

Walden Dissertations and Doctoral Studies

Placement disruptions for youths placed in foster care have been the focus of multiple studies due to the negative and long-lasting impacts on these vulnerable youths. The purpose of this interpretative phenomenological study was to explore the lived experience of placement disruptions from the foster parent’s perspective to gain further understanding of potential causes of placement disruptions and what may be helpful to prevent them. The study was based on the lens of attachment theory. Data were collected from interviews with six participants recruited on social media who were licensed in the State of Washington for at least 1 year …

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Demographic And Socioeconomic Determinants Of Lassa Fever In Edo State, Nigeria, Faith Ogagaroghene Ireye Jan 2021

Demographic And Socioeconomic Determinants Of Lassa Fever In Edo State, Nigeria, Faith Ogagaroghene Ireye

Walden Dissertations and Doctoral Studies

Lassa fever is a viral hemorrhagic fever caused by the Lassa virus and associated with significant morbidity and mortality. Yearly outbreaks of the disease occur in Edo State, Nigeria. The purpose of this study was to examine the demographic and socioeconomic factors that can influence transmission of the disease. The Commission on Social Determinants of Health conceptual framework was used in this research study. This framework describes the relationship between structural and intermediary factors and how they determine health outcomes. To answer the research question of how demographic and socioeconomic factors influence Lassa fever transmission in Edo State, a cross-sectional …

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Developing A Lifestyle Modification Tool To Prevent And Manage Elevated Blood Pressure Among African Americans, Magdalene Oziwo Jan 2021

Developing A Lifestyle Modification Tool To Prevent And Manage Elevated Blood Pressure Among African Americans, Magdalene Oziwo

Walden Dissertations and Doctoral Studies

Hypertension is a national medical problem that has been predominantly seen amongst African Americans. Within this community, hypertension has been associated with obesity, a sedentary lifestyle, and poor nutrition. It is for this reason that lifestyle modifications can be used as applied tools in the field of nursing in the prevention and management of hypertension among African American patients. This doctoral project was conducted to address the gap in nursing practice that currently exists for the African American population with regards to hypertension. The project focused on a nursing staff education program with 10 participants to promote the implementation of …

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The Role Of The Public During The Decision-Making Process In Preparation For And In Response To A Pandemic, Ludmila M. Flores Jan 2021

The Role Of The Public During The Decision-Making Process In Preparation For And In Response To A Pandemic, Ludmila M. Flores

Walden Dissertations and Doctoral Studies

AbstractMany advances have been made in technology and medicine; however, humanity remains vulnerable to existing, emerging, and re-emerging infectious diseases that have a profound negative impact on our society. This study investigated how individuals balance socioeconomics, demographics, and religious views with their actual behavior in response to public health guidelines during an epidemic/pandemic. The participants' perceptions and experiences of a practical problem, how the public was asked to respond, and how the public ultimately responded to public health guidelines were explored. The theoretical model for the study, the polarity of democracy model, has been explored as a possible decision-making tool …

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The Effects Of Personality On Obtaining Microloans For Small Business Owners In The United States, Luis Moncayo Jan 2021

The Effects Of Personality On Obtaining Microloans For Small Business Owners In The United States, Luis Moncayo

Walden Dissertations and Doctoral Studies

This study addressed the perceived negative individual characteristics that may precipitate failure of small business owners in securing microloans. The purpose of this quantitative, nonexperimental, correlational study was to examine how the personality traits of small business owners related to their ability to secure microloans for their business needs. Goldberg’s big five theory provided a framework for the study and aided in forming the research questions focused on the relationship between personality traits of the big five theory and the ability of small business owners to secure microloans for their business needs. A sample of 196 small business owners in …

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Contaminated Raw Produce As A Major Source Of Foodborne Salmonellosis, Barisua C. Ikpe Jan 2021

Contaminated Raw Produce As A Major Source Of Foodborne Salmonellosis, Barisua C. Ikpe

Walden Dissertations and Doctoral Studies

Foodborne pathogens continue to threaten the food supply chain. Salmonellosis is a persistent foodborne pathogen responsible for gastroenteritis, leading to severe illness in children below 5 years of age, adults 65 and older, and people with weakened immune systems. Maryland has rising cases of salmonellosis linked to outbreaks due to consumption of raw or fresh fruits and produce. The purpose of this quantitative study was to determine the association between the development of salmonellosis and the consumption of raw (fresh) produce, demographic and geographic characteristics, type of produce, and seasonal variation in Maryland. The study is based on the theory …

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Microfinance For Smallholder Farmers: The Lived Experience Of Borrowers In Akaki, Ethiopia, Amsalu Alemayehu Gutema Jan 2021

Microfinance For Smallholder Farmers: The Lived Experience Of Borrowers In Akaki, Ethiopia, Amsalu Alemayehu Gutema

Walden Dissertations and Doctoral Studies

Microfinance was intended to help smallholder farmers (SHFs), but the results have been disastrous for some individuals who have been unable to repay loans, often displacing them from their land. A lack of understanding of the lived experiences of borrowers complicates a full analysis of microfinance as a tool for poverty alleviation. The purpose of this qualitative descriptive phenomenological study was to explore the lived experiences of SHF borrowers in Akaki District, Ethiopia, related to microfinance loan repayment decisions. Habermas's critical social theory, which divides the social world into lifeworld and system, was the conceptual framework for the study. The …

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Implementation Strategies For Modeling And Simulation In Military Organizations, Cody Lynn Taylor Jan 2021

Implementation Strategies For Modeling And Simulation In Military Organizations, Cody Lynn Taylor

Walden Dissertations and Doctoral Studies

Some IT project managers working for U.S. military organizations are struggling to implement modern modeling and simulation (M&S) technology. Implementation strategies are needed to help IT practitioners deliver meaningful simulations and models that ultimately help senior leaders make logical and science-based decisions. Grounded in the extended technology acceptance model, the purpose of this qualitative multiple-case study was to explore strategies some IT project managers supporting U.S. military organizations use to implement modern M&S technology. The participants included 10 civil servants who successfully implemented modeling and simulation technology for military organizations located in the United States eastern region. Data was collected …

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Integrating Tf-Cbt And Play Therapy: Promoting Resilience In Child Sexual Assault Survivors, Shayla Polk Jan 2021

Integrating Tf-Cbt And Play Therapy: Promoting Resilience In Child Sexual Assault Survivors, Shayla Polk

Walden Dissertations and Doctoral Studies

Licensed social workers and counselors provide services to children who experience child sexual assault (CSA), which disrupt their normal childhood developmental processes. Trauma outcomes include symptoms related to somatization, inability to cope, feelings of helplessness, decreased self-esteem, difficulty expressing proper emotions, anxiety, depression, and posttraumatic stress disorder. Trauma-focused cognitive-behavioral therapy (TF-CBT) combined with play therapy can be helpful for CSA survivors. Still, it is not yet fully understood how therapists perceive the combined approach or how it fosters resiliency in children who experience sexual assault. The purpose of this action research study was (a) to explore the experiences and perspectives …

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Conflict In Human Relationships And Seeking Out Pets As A Safe Haven, Jennifer Rachael Bakal Jan 2021

Conflict In Human Relationships And Seeking Out Pets As A Safe Haven, Jennifer Rachael Bakal

Walden Dissertations and Doctoral Studies

Research has revealed the positive physical and the psychological aspects of pet ownership, suggesting that an individual’s attachment style can impact the kind of relationship they have with their pet. Two theories guided this qualitative study; the first was Bowlby’s attachment theory, which suggests that if a child feels that the attachment figure is attentive and accessible, the child will feel loved and secure. Another theory was Ainsworth’s attachment theory in which attachment figures are described as possessing four features: proximity maintenance, separation distress, secure base, and safe haven. This study consisted of 212 participants at least 18 years old …

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Impact Of Conservation Agreements On Livelihoods And Forest Protection In Rural Liberia, Peter Gayflor Mulbah Jan 2021

Impact Of Conservation Agreements On Livelihoods And Forest Protection In Rural Liberia, Peter Gayflor Mulbah

Walden Dissertations and Doctoral Studies

People living near forests in Liberia are facing pressure to protect the forests for conservation while they are struggling for alternative incomes for livelihoods. The purpose of this quantitative correlational study was to assess whether conservation agreements improve rural livelihoods and promote forest conservation by examining the relationship between direct payment of conservation benefits to forest communities and forest protection, and the relationship between direct payment of conservation benefits to forest communities and livelihood improvement in rural Liberia. A total of 150 participants aged 18 and above were surveyed from three regions in Liberia using a precoded questionnaire. The frequency …

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Association Between Bisphenols, Acrylamide, Glycidamide, Fast Food, And Obesity: An Obesogenic Perspective, Morgan Murphy Jan 2021

Association Between Bisphenols, Acrylamide, Glycidamide, Fast Food, And Obesity: An Obesogenic Perspective, Morgan Murphy

Walden Dissertations and Doctoral Studies

Endocrine disrupting chemicals (EDCs) are exogenous man-made substances that have the ability to interfere with hormone action and are believed to be a contributing factor to chronic illnesses, including but not limited to obesity. Recent studies have suggested that environmental agents (environmental obesogens), such as food additives, plasticizers, and personal care products are contributors that aid in the altering of hormone receptors and hormone mimicry. Such environmental obesogens have the potential to promote adipogenesis and fat accumulation. In this study, the social-ecological model was used to determine the factors that can influence the increased exposure to obesogenic chemicals at the …

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Leadership Influence On Dispatcher Access Of Trauma Recovery Resources, Ariel R. Place Jan 2021

Leadership Influence On Dispatcher Access Of Trauma Recovery Resources, Ariel R. Place

Walden Dissertations and Doctoral Studies

Emergency dispatchers experience duty-related trauma exposure that can lead to reduced work engagement, compromised employee health, and increased organizational costs. Leadership is crucial in providing guidance and support to first responders following traumatic events. This study’s purpose was to understand how one public service organization’s (PSO) leaders influence emergency dispatchers’ access to trauma-recovery resources. The Baldrige Excellence Framework provided the framework for this qualitative case study. Semi-structured interviews with the public service organization partner site (PSOPS) leaders were conducted and archival data and documents were reviewed and analyzed to gain a clearer picture of PSOPS leaders’ personal perspectives of and …

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Social Influences On Citizens' Attitudes Toward The Police In A Public Assistance Role, Raymond Griego Jan 2021

Social Influences On Citizens' Attitudes Toward The Police In A Public Assistance Role, Raymond Griego

Walden Dissertations and Doctoral Studies

Much research is based on the experience of participants in crime-related situations where they have contact with police. It is significant, however, that researchers have documented that 70 to 80% of calls requesting police service are not related to criminal activity. Despite this little is known about how police interaction with citizens in noncriminal and nonemergency situations impacts public perception of law enforcement. The aim of this phenomenological study was to explore the thoughts and perceptions of individuals who experienced a noncriminal police-citizen interaction as a result of receiving nonemergency assistance from the police. The conceptual framework for this study …

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Reducing Infection Rates Through Handwashing Education, Maureen N. Osegbe Jan 2021

Reducing Infection Rates Through Handwashing Education, Maureen N. Osegbe

Walden Dissertations and Doctoral Studies

AbstractHealth care-associated infections (HCAIs) affect millions of people worldwide, causing morbidity and mortality among hospitalized patients. Hand hygiene is the single most effective way to prevent HCAIs. This project addressed a gap in practice regarding nurses’ knowledge on the effective use of hand hygiene in a medical/surgical unit in a hospital located in northeastern Maryland. This project addressed the question of whether an educational program on handwashing for nurses reduced HCAI rates. A literature review was conducted to support the development of the educational program; relevant sources included peer-reviewed journal articles, systematic reviews, and guidelines that supported the practice-focused question, …

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Assessing Risk Factors Pre-Disposing Individuals To Noise Induced Hearing Loss, Martin David Slade Jan 2021

Assessing Risk Factors Pre-Disposing Individuals To Noise Induced Hearing Loss, Martin David Slade

Walden Dissertations and Doctoral Studies

Noise induced hearing loss (NIHL) has the highest prevalence of all occupational diseases in the manufacturing sector accounting for one out of every nine recordable illnesses. Currently, after accounting for known risk factors, a large amount of unexplained variance remains in statistical models of NIHL. The purpose of this study was to determine the underlying factors pre-disposing people to NIHL as well as the association between early and future occupational hearing loss. The ecological model of health behavior provided the theoretical framework for this study. The key research questions were: which demographic factors (age, gender, and race) are associated with …

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Improving Staff Retention In Adolescent Psychiatric Residential Treatment Facilities, Tasha C. Moses Jan 2021

Improving Staff Retention In Adolescent Psychiatric Residential Treatment Facilities, Tasha C. Moses

Walden Dissertations and Doctoral Studies

AbstractHigh direct care staff (DCS) turnover in psychiatric residential treatment facilities presents significant organizational challenges. Insufficient DCS levels and high turnover rates can undermine an organization’s ability to provide quality care to residents who have acute psychiatric symptoms, maintain a safe environment, and achieve strategic goals. This case study was grounded in the Baldrige Excellence Framework and focused on the DCS retention challenges experienced by a psychiatric residential treatment facility in the southeastern United States. Sources of data included semi structured interviews with seven organizational leaders, a review of organizational archival records, and an academic literature review. Thematic content analysis …

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Antibiotic Stewardship: Decreasing Antibiotic Use For Viral Upper Respiratory Infections, Merkessie Taresa Redix Jan 2021

Antibiotic Stewardship: Decreasing Antibiotic Use For Viral Upper Respiratory Infections, Merkessie Taresa Redix

Walden Dissertations and Doctoral Studies

AbstractOverprescribing antibiotics for viral upper respiratory infections is a common practice in the United States. This overprescribing of antibiotics can cause several health issues and increase health care costs. Despite the current guidelines recommended by the Centers for Disease Control and Prevention (CDC) the overprescribing of antibiotics by providers remains an issue. The purpose of this project was to educate providers on antibiotic stewardship for viral upper respiratory infections. The practice question was used to explore whether an educational program using concepts from Lewin’s change theory and Kolb’s learning theory would increase provider’s knowledge about the current evidence- based prescriptive …

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