Digital Commons Network^™

Spatially Distributed Infection Increases Viral Load In A Computational Model Of Sars-Cov-2 Lung Infection, Melanie E. Moses, Steven Hofmeyr, Judy L. Cannon, Akil Andrews, Rebekah Gridley, Monica Hinga, Kirtus Leyba, Abigail Pribisova, Vanessa Surjadidjaja, Humayra Tasnim, Stephanie Forrest

Pathology Research and Scholarship

A key question in SARS-CoV-2 infection is why viral loads and patient outcomes vary dramatically across individuals. Because spatial-temporal dynamics of viral spread and immune response are challenging to study in vivo, we developed Spatial Immune Model of Coronavirus (SIMCoV), a scalable computational model that simulates hundreds of millions of lung cells, including respiratory epithelial cells and T cells. SIMCoV replicates viral growth dynamics observed in patients and shows how spatially dispersed infections can lead to increased viral loads. The model also shows how the timing and strength of the T cell response can affect viral persistence, oscillations, and control. …

Influence Of Prolonged Serotonin And Ergovaline Pre-Exposure On Vasoconstriction Ex Vivo, Eriton E. L. Valente, David L. Harmon, James L. Klotz

Animal and Food Sciences Faculty Publications

Ergot alkaloid mycotoxins interfere in many functions associated with serotonergic neurotransmitters. Therefore, the objective was to evaluate whether the association of serotonin (5-hydroxytryptamine, 5-HT) and ergot alkaloids during a 24 h pre-incubation could affect the vascular contractile response to ergot alkaloids. To evaluate the effects of 24 h exposure to 5-HT and ergot alkaloids (ergovaline, ERV), two assays were conducted. The first assay determined the half-maximal inhibitory concentration (IC₅₀)following the 24 h pre-exposure period, while the second assay evaluated the effect of IC₅₀ concentrations of 5-HT and ERV either individually or in combination. There was an interaction …

Trial Of Spesolimab For Generalized Pustular Psoriasis, Hervé Bachelez, Milan J Anadkat, Et Al

Open Access Publications

BACKGROUND: Generalized pustular psoriasis (GPP) is a rare, life-threatening, inflammatory skin disease characterized by widespread eruption of sterile pustules. Interleukin-36 signaling is involved in the pathogenesis of this disorder. Spesolimab, a humanized anti-interleukin-36 receptor monoclonal antibody, is being studied for the treatment of GPP flares.

METHODS: In a phase 2 trial, we randomly assigned patients with a GPP flare in a 2:1 ratio to receive a single 900-mg intravenous dose of spesolimab or placebo. Patients in both groups could receive an open-label dose of spesolimab on day 8, an open-label dose of spesolimab as a rescue medication after day 8, …

Paving The Way For Mind-Reading: Reinterpreting "Coercion" In Article 17 Of The Third Geneva Convention, John Zarrilli

Duke Journal of Constitutional Law & Public Policy Sidebar

Mind-reading is no longer a concept confined to the world of science-fiction: "Brain reading technologies are rapidly being developed in a number of neuroscience fields." One obvious application is to the field of criminal justice: Mind-reading technology can potentially aid investigators in assessing critical legal questions such as guilt, legal insanity, and the risk of recidivism. Two current techniques have received the most scholarly attention for their potential in aiding interrogators in determining guilt: brain-based lie detection and brain-based memory detection. The growing ability to peer inside someone's mind raises significant legal issues. A number of American scholars, especially in …

Ferpa And State Open Records Laws: What The North Carolina Supreme Court Got Wrong In Dth Media Corp. V. Folt, And How Courts & Congress Can Take Measures To Reconcile Privacy And Access Interests, Danielle Siegel

Duke Journal of Constitutional Law & Public Policy Sidebar

Over the past few years, courts across the country have confronted a common scenario. Members of the public and media request records from a public university pertaining to its investigations of sexual assault and misconduct on campus. Then, media outlets contend they have a right to access these records under state open records laws. But the university claims that it cannot, or will not, disclose the records under the Family Educational Rights and Privacy Act of 1974 ("FERPA").

The media outlet then files suit to compel disclosure. This Note explores the competing privacy and access interests at stake in this …

See You In The Funny Pages: Forms And Aesthetics Of Newspaper Comic Strips In Bill Watterson's Calvin And Hobbes, Jack Mallard

LSU Doctoral Dissertations

This project looks at how Bill Watterson’s aesthetics and his employment of the comics apparatus, as well as his advocacy for learning the history of the formal development (and decline) of the newspaper comic strip, influence Calvin and Hobbes’ approach to art, family, education, and other cultural topics. By adapting Thierry Groensteen’s theory of spatio-topia, a term describing comics’ ability to provoke meaning from how graphic, verbal, and structural elements inhabit space and relate to one another within space, I demonstrate how Bill Watterson’s quality as a comics artist comes as much from his ability to activate spatio-topic potentials …

Nutritional And Physiological Constraints Contributing To Limitations In Small Intestinal Starch Digestion And Glucose Absorption In Ruminants, Ronald J. Trotta, David L. Harmon, James C. Matthews, Kendall C. Swanson

Animal and Food Sciences Faculty Publications

Increased efficiency of nutrient utilization can potentially be gained with increased starch digestion in the small intestine in ruminants. However, ruminants have quantitative limits in the extent of starch disappearance in the small intestine. The objective is to explore the nutritional and physiological constraints that contribute to limitations of carbohydrate assimilation in the ruminant small intestine. Altered digesta composition and passage rate in the small intestine, insufficient pancreatic α-amylase and/or small intestinal carbohydrase activity, and reduced glucose absorption could all be potentially limiting factors of intestinal starch assimilation. The absence of intestinal sucrase activity in ruminants may be related to …

Levels Of Angiotensin-Converting Enzyme And Apolipoproteins Are Associated With Alzheimer’S Disease And Cardiovascular Diseases, Chun Xu, Debra Garcia, Yongke Lu, Kaysie Ozuna, Donald A. Adjeroh, Kesheng Wang

Health & Biomedical Sciences Faculty Publications

Angiotensin-converting enzyme-1 (ACE1) and apolipoproteins (APOs) may play important roles in the development of Alzheimer’s disease (AD) and cardiovascular diseases (CVDs). This study aimed to examine the associations of AD, CVD, and endocrine-metabolic diseases (EMDs) with the levels of ACE1 and 9 APO proteins (ApoAI, ApoAII, ApoAIV, ApoB, ApoCI, ApoCIII, ApoD, ApoE, and ApoH). Non-Hispanic white individuals including 109 patients with AD, 356 mild cognitive impairment (MCI), 373 CVD, 198 EMD and controls were selected from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) dataset. Multivariable general linear model (GLM) was used to examine the associations. ApoE ε4 allele was associated with …

This Is The House That Law Built: A Systems Story Of Racism, Palma Joy Strand

San Diego Law Review

In this essay, I explore the system-ness of racism. A systems understanding of racism enables us to more fully comprehend the magnitude and depth of racism, its reach and rootedness. This systems understanding provides the foundation for some initial and overarching observations about law and systemic racism.

Think Nationally, Act Locally: Cities And The Struggle For Social Justice, Harold Mcdougall

San Diego Law Review

Liberals and progressives typically look to the national government to make policy aimed at achieving social justice. Historically, that is not without reason. As Professor Kathleen Morris of Golden Gate University School of Law put it in a recent email exchange, "social elites reached for the federal level in large part because the states and localities proved themselves to be genuinely terrifying to marginalized folks between 1860 and 1980.”

Few things remain constant in the struggle for social justice, however. The liberal and progressive national focus backfired as conservative and right-wing forces built power in state legislatures, enabling them to …

Machine Learning Applications With Qupath In Histopathology, Bianca Lang

Mechanical Engineering and Materials Science Independent Study

My primary objective for this semester was to help develop machine learning techniques that help further our understanding of the cellular mechanism and the healing response.

The Carrying Capacity Of Pure And Oversown Giant Star Grass (Cynodon Nlemfuensis Vanderyst) Under Different Stocking Rate In South-Western Islands Of Japan, Yasuhiro Kawamoto, T. Namihira, Y. Imura, M. Nagano

IGC Proceedings (1977-2023)

The objective of this study was firstly to know the potential carrying capacity, pasture production, pasture utilization of giant star grass under different stocking rates in intensive rotational grazing system, and to evaluate a carrying capacity of giant star grass (Cynodon nlemfuensis Vanderyst) pasture oversown with annual hybrid ryegrass (Lolium multiflorum X Lolium perenne) on short low productive winter pasture in South-western Islands of Japan. High herbage availability and good quality forage to bring about effective animal productions were produced by using relatively heavy stocking rates of 6 - 8 heads/ha, and achieved optimum pasture utilization of …

Residual Forage And Animal Performance From A Kikuyo Pasture Under Mixed Grazing And Supplementation, F. C. Gómez-Merino, Pedro A. Martínez-Hernández, J. Pérez-Pérez, Alfonso Hernández-Garay

IGC Proceedings (1977-2023)

Five grazing strategies were compared: grazing by ewes only and mixed grazing (ewes + heifers), in mixed grazing heifers received no supplement or one of three supplements. Ruminal undegradable protein (RUP) varied among supplement: 4.25, 9.11 and 9.13%, the supplement with the highest RUP included protected methionine. All supplements were 21% crude protein and 3.0 Mcal/kg of metabolizable energy. Grazing was on kikuyu, ratio was 30 kg of ewe per 100 kg of heifer in the mixed grazing treatments. Experimental grazing lasted 84 days. Variables measured were residual forage, proline content in residual forage and liveweight gains per animal and …

Stubble Height Effects On Limpograss Pasture Characteristics And Performance Of Beef Heifers, Y. C. Newman, Lynn E. Sollenberger, W. E. Kunkle, D. B. Bates, C. G. Chambliss, A. M. Fox

IGC Proceedings (1977-2023)

Limpograss (Hemarthria altissima [Poir.] Stapf. & C.E. Hubb.) is a C₄ species used in Florida beef production systems because of its cool-season growth, persistence on poorly drained soils, and high yield and digestibility. Animal performance on limpograss pastures, however, has been limited by low herbage crude protein (CP). This study evaluated the effect of canopy height of limpograss pastures and N supplementation of grazing cattle on sward characteristics and weight gain and blood urea N (BUN) concentration of yearling beef heifers. Under continuous stocking, six treatments were imposed that included all combinations of three stubble heights (20, 40, …

The Duration Of Regrowth Period And The Structural Traits In A Rotationally Grazed Panicum Maximum Sward, Carlos A. M. Gomide, J. A. Gomide

IGC Proceedings (1977-2023)

Panicum maximum 'cv'. Mombaça was rotationally grazed by steers. Three regrowth periods based on the number of expanded leaves per tiller: 2.5; 3.5 and 4.5, were compared. Three groups of seven tester steers, one for each treatment, grazed the replications of each experimental paddocks, the animals being removed from a paddock after 4 to 5 day grazing period when its sward leaf area index (LAI) was 1.5, on the average. Sward height and available biomass increased while tiller population density and leaf-stem ratio decreased with regrowth period. Overall averages observed for LAI and photosyntheticly active radiation interception by the end …

Effect Of Different Strategies Of Management Of Elephantgrass On Pasture Availability And Milk Yield Of Crossbred Holstein X Zebu Cows, Fermino Deresz

IGC Proceedings (1977-2023)

The trial was done to study different strategies of pasture management on milk production of cows grazing Elephantgrass (Pennisetum purpureum, Schum.). The treatments were: Elephantgrass with 30 days of resting and fertilized monthly (30MF), fertilized every two months (30BF). Elephantgrass with 45 days of resting and a stubble height of 90-100 cm (45HS) or a stubble height of 40-50 cm (45LS). The stubble height for treatments 30MF and 30BF was 90-100 cm. The study was done using six crossbred Holstein x Zebu cows/treatment, with 100 days of lactation, on average. The experimental design was a completely randomized block …

Visions: Re-Historicizing Genre: Teaching Haywood’S The Adventures Of Eovaai In A Fantasy-Themed Survey Course, Megan E. Cole

ABO: Interactive Journal for Women in the Arts, 1640–1830

Eliza Haywood is an increasingly popular author to assign in eighteenth-century literature courses. But Haywood is also a prime figure to represent the eighteenth century in courses with a broader scope. This essay proposes teaching The Adventures of Eovaai in a fantasy-focused, introductory-level survey of British Literature. Identifying Eovaai as part of the fantasy tradition leverages students’ prior knowledge and facilitates teaching this complex novel to first-year students. Eovaai provides a wealth of topics for class discussions and activities, including the development of the novel as a genre, identity and othering in fantasy literature, and the use of fantasy conventions …

Visions: “If You See Her Face You Die”: Orientalist Gothic And Colonialism In Bithia Croker’S Indian Ghost Stories., Preeshita Biswas

ABO: Interactive Journal for Women in the Arts, 1640–1830

This paper analyzes Bithia Mary Croker’s ghost stories of the British Raj to argue that Croker in her texts reframes the eighteenth-century Orientalist Gothic writing tradition to critique British imperial presence in India. I specifically discuss two of Croker’s short stories, namely “To Let” (1893) and “If You See Her Face” (1893) published in her anthology of Indian ghost fiction To Let (1893). The paper traces how Croker uses two distinct characteristics of eighteenth-century colonial Indian society–-the tradition of nautch performances and the architectural space of the dak bungalows–-which continued into early-nineteenth century British India under the vigilance of …

Status And Relative Abundance Of Alabama Shad, Alosa Alabamae, In Alabama, Steven J. Rider, Travis R. Powell, Jason E. Dattilo, Gregory T. Miles

Southeastern Fishes Council Proceedings

Alabama Shad, Alosa alabamae, an anadromous fish found historically from the Mississippi River basin eastward to the Suwanee River, has experienced population declines and even extirpation in some States. In Alabama, A. alabamae have been found in rivers of the Mobile River basin and Conecuh, Yellow, and Choctawhatchee rivers in the coastal Gulf Plain. We report on our directed and targeted efforts to assess the current status and relative abundance of A. alabamae in Alabama and compare our results to past A. alabamae surveys in Alabama. We completed 52 sampling trips and expended 129.5 hours of boat-electrofishing effort targeting …

Evaluation Of Salmonella Biofilm Cell Transfer From Common Food Contact Surfaces To Beef Products, Rong Wong, David A. King, Norasak Kalchayanand

Roman L. Hruska U.S. Meat Animal Research Center: Reports

Meat contamination by Salmonella enterica is a serious public health concern. Available data have suggested that biofilm formation at processing plants and contaminated contact surfaces might contribute to meat contamination. Because transfer from contact surfaces to food products via direct contact has been deemed the most common bacteria transmission route that can lead to contamination, we evaluated the effect of Salmonella biofilm forming ability, contact surface material, and beef surface tissue type on Salmonella biofilm transfer from hard surfaces to beef products. Salmonella biofilms developed on the common contact surfaces stainless steel (SS) and polyvinylchloride (PVC) were transferred consecutively via …

Systemic Racism And Minority Disparities In Health Care, Constance Fain

The Bridge: Interdisciplinary Perspectives on Legal & Social Policy

Historically, racial discrimination in society has had an adverse effect on the health of African Americans. This type of inequality has also affected other persons of color, and it has been reported that racism has insidious effects on many White individuals, especially on their health as well. Four critical issues will be addressed in this paper: First, the impact of discrimination on the health care of African Americans and others. From slavery to lynching to incarceration, generations of African American families have endured trauma. Psychologist and other social scientists have said that these continuing experiences with racism may lie at …

Evaluating Apoptosis, Autophagy, And Hormonal Effects On Oocyte Regulation And Cyst Breakdown, Jessica M. O'Connell

Theses - ALL

Infertility in women is caused by a depletion of eggs below the threshold for functional ovulation. Unlike men where sperm production is maintained throughout their reproductive lifespan, a women's proliferation of eggs ceases prior to birth. Interestingly during development, a fetus has up to 7 million eggs and two-thirds of these eggs die via apoptosis before they are born, further signifying the importance of the quantity control of eggs to maintain fertility. The remaining eggs break apart from each other and become enclosed individually by pre-granulosa cells together forming primordial follicles. Over time, the number of oocytes will continue to …

The Exploration Into The Influence Of Social Unconscious On The Individual Through Cyberpunk, Jiarong Lin

Theses - ALL

The main purpose of this thesis is to explore the influence of the social unconscious on human beings in a future context. In Fromm's view, the social unconscious refers to Individuals who are afraid of being separated from the society they live in, they often adapt and distort their human needs to meet the requirements of our social system. However, with the strengthening of personality and self-awareness in the present society, how will the relationship between the social subconscious and people's selfawareness change in the future? This is the key issue of this thesis. In the first part, by studying …

The Role Of Rab11 Or Rab8-Associated Membranes During Kupffer's Vesicle (Kv) Lumen Formation In Vivo, Eric Ingram

Theses - ALL

In early embryonic development, cells undergo a series of shape changes called tissue morphogenesis by which tissues develop into an organ. One mechanism that is potentially vital to tissue morphogenesis is abscission, the cleavage of the cytokinetic bridge. Our lab has proposed that abscission is required for tissue morphogenesis in vivo, specifically in the zebrafish left-right organizer, Kupffer's vesicle (KV). The Hehnly Lab's testable model for KV morphogenesis is that a population of cells, some in cytokinesis, group together in a pre-rosette structure and then self-assemble to form a rosette-structure where cells orient their cytokinetic bridges toward the rosette center. …

Aeiva Has You Covered For Art Entertainment In Early 2022, Staff

Browse All News

No abstract provided.

Predicting Drug-Induced Liver Injury With Artificial Intelligence, Ting Li

Theses and Dissertations

Drug-induced liver injury (DILI) is an undesirable side effect to the liver caused by the common use of drugs, which is of great concern to the patients, physicians, the pharmaceutical industry, and government regulators. The current animal testing models do not present reliable results on the human DILI risk prediction during the preclinical phase. Therefore, there is an urgent need to find alternative methods to improve the human DILI risk prediction during the early stage of development. Utilizing the accumulated high-throughput transcriptomics profiles from L1000, we constructed an 8-layer deep neural network for human DILI prediction based on the largest …

The Poverty Of Simplicity: Austerity, Alienation, And Tiny Houses, Brian Richard Hennigan

Dissertations - ALL

Tiny houses – stand-alone, fully functional dwellings generally between 100 and 400 square-feet – are increasingly popular in the United States. The degradation of working class life wrought through neoliberal policy and then punctuated by the Great Recession propels this popularity. Next to traditional houses, tiny houses are significantly cheaper. Those among the middle stratum of the working class have sought out tiny houses as a means to ease their financial anxiety. Rather than merely a newer form of cheaper housing, an entire lifestyle movement has emerged around tiny houses. Anti-consumerism is the keystone to this lifestyle movement. For enthusiasts, …

Policy And Polity: Space, Boundaries, And Governance In Early Modern London, 1580-1640, Michael Britton

Dissertations - ALL

The kingdom's principal city for law, governance, trade, and consumption, early modern London experienced a period of rapid growth and sprawl from the mid-sixteenth century. This nurtured more dense and frequent mobility and produced a dynamic, kinetic city. For civic authorities, however, boundaries took on greater urgence. Drawing on theories and principles of border studies, this dissertation treats the city's boundaries as processes forged and transformed by engagement, by the interplay between popular activity, political programs, and perceptions of space and authority. Policy and Polity, Space, Boundaries, and Governance in Early Modern London, 1580-1640 examines bordering at London Bridge, the …

The Dark Realism Of Miyazawa Kenji: Social Activism In The Science-Fiction Children's Story, The Life Of Gusukō Budori, And Its Precursor Work, Elsiemae Ann Ito

Dissertations and Theses

Miyazawa Kenji (1896-1933) is widely known in Japan as a children's story writer and poet, but he was also grounded in real life as a teacher, soil scientist, and farmer. Recognizing the harsh realities for farmers in his native Iwate, he nonetheless dreamed of an ideal world, as seen in his stories. To better understand the dark realities of life in Iwate, Japan, Miyazawa changed his occupation from teacher to farmer, focusing more on social activism that would better the lives of the people in his community. His late children's story, The Life of Gusukō Budori (Gusukō Budori no …

Developing An Air Pollutant Emissions Database For Global Economic Analysis, Maksym Chepeliev

Department of Agricultural Economics Faculty Publications

According to the Global Burden of Disease study (Cohen et al., 2017), in 2015 ambient air pollutant emissions caused 4.2 million deaths and a loss of 103.1 million disability-adjusted life-years, making it the fifth-ranked global risk factor. In terms of the welfare costs of mortality and illnesses associated with outdoor air pollutant emissions, global estimates for 2015 range between $2.7-3.2 trillion (Coady et al., 2015; OECD, 2016). Still, while greenhouse gas emissions are usually well represented in many global economic databases and models, air pollutant emission accounts in most cases are not included. In particular, this is the case for …