Digital Commons Network^™

Art Museum Docent Coordinators’ Perceptions: A Difficult Kind Of Balancing Act, Jennifer E. Schero

Theses and Dissertations

With visitors numbering in the millions, museums provide numerous entry points for attendees to engage with the objects in their care, including offering tours of their collections. Looking specifically at art museums, many institutions utilize volunteers to facilitate these guided looking experiences. Considerable research within the field of museum education focuses on the qualities of effective touring and methods and theories to support these endeavors. However, there is a lack of research focusing on the docent coordinators who oversee these volunteer guides. This study utilizes interpretive phenomenological analysis to explore perceptions of encyclopedic art museum docent coordinators concerning their preparation …

The Default: The Paradox Of Play And Productivity, Yeon Geong Hwang

Theses and Dissertations

Society takes a dim view of idleness, regarding downtime as wasted time, but what if society’s view is wrong? This thesis champions daydreaming; it advocates for quirky, playful experiences that improve quality-of-life by avoiding burnout and mitigating tedium. Borrowing language from the Theatre of the Absurd, The Default challenges society’s attitudes toward productivity, striking a new relationship between a cubicle worker and a set of seemingly-familiar but surprising objects. Reflecting on the absurdity of contemporary work-life imbalance, the objects and narratives depicted in The Default invite playful interactions, when objects that appear to be normal behave unexpectedly. The Default is …

Floating Home: An Imagined Community, Carrie Collier

Theses and Dissertations

Climate experts around the world agree that anthropogenic climate change threatens the long-term survival of the human species. Human activity has already contributed to an exponential spike in the rate of extinction among other Earthly species, beginning at the time of the industrial revolution.

The American home is a site of concentrated resource consumption, waste production, and greenhouse gas emission. It is also a site where gender-based expectations continue to burden women with a majority share of uncompensated, under-valued domestic labor. Collective or communal housing arrangements could reduce per capita carbon output while facilitating the equitable re-distribution of work that …

≥I++ Wayward Self, Space, And Language, Mystie Do, Thu Tm Do

Theses and Dissertations

Having crossed different geographical and cultural borders, I can’t seem to position myself beyond society’s forced binaries of race, sexuality, and materiality. My personal diasporic experience drives me to bring together various presences, putting them next to one another, engaging them in dialogues. My works often share multiple space–time possibilities: a digital space, a physical site, a virtual alternity. Occupying these parallel worlds are varied ratios of mixtures of natural ecosystems, my own system of abstraction, and existing technological systems that allow us a level of individual engagement not previously available. I want to invite people to fluctuate between these …

Tya And Educational Outreach In Higher Education: An Asset To Undergraduates And Their Community, Emily J. Mattison

Theses and Dissertations

Undergraduate students pursuing a career in theatre are at the beginning of their life-long training and understanding and appreciation for the art. Performing in a Theatre for Young Audiences (TYA) touring production alongside the responsibility of crafting educational outreach opportunities provides the students with a unique chance to comprehend the art they have chosen to devote their lives to. This paper details the value of offering a course I crafted entitled “TYA Educational Outreach”, for both the undergraduates enrolled and the community they would be reaching. While undergraduates develop an understanding of the impact theatre can have on an individual …

Anywhere I Stand, Hanaa Safwat

Theses and Dissertations

In this paper I will trace the effects of colonialism and the nationalism, conceptions of deserts as empty spaces form a sense of place and create a subjecthood and orientation that is unable to freely move through the landscape. I relate these structures to the thesis installation titled Anywhere I Stand I Block the Flow of the Wind that was installed at theVCU Anderson Gallery on April 9 2021.

Pase Perdido Missing Pass, Larissa M. Garcia

Theses and Dissertations

This paper contains the following terms: colonialism, ghost populations, natural occurrences, global positioning, poetic relation, confrontation/vengeance, mapping, graphs, models, warfare, bio warfare, magic, mystery, migration, memory, mutation, ghosts, and esoteric systems

Reward-Related Effects Of Amphetamines Administered By Electronic Cigarette, Lucas Wohler

Theses and Dissertations

While e-cigarette vaporizers are primarily used for the delivery of nicotine, they can also be used to administer a wide range of other substances of abuse including stimulants such as d-amphetamine and methamphetamine. Methamphetamine and prescription amphetamines are widely abused throughout the United States and across the world leading us to believe there may be abuse potential with vaping methamphetamine as vaping becomes increasingly popular. In the present study, methamphetamine and amphetamine vapor were assessed using vapor capture methods. The vapor samples were then analyzed using liquid chromatography mass spectroscopy (LC-MS). Three experiments were carried out to examine the abuse …

Effects Of Abiotic And Biotic Factors On Hornworm Distributions, Emelia O. Kusi

Theses and Dissertations

Determining the drivers of species occurrences is a central topic in ecology. Both abiotic and biotic factors are important predictors of species distributions, yet most species distribution models consider abiotic variables only. In this study, the influence of abiotic and biotic factors on current distributions of herbivores, Manduca sexta, and Manduca quinquemaculata, their major cultivated and wild host plants, and a parasitoid, Cotesia congregata, was quantified using an ensemble of three models (generalized linear model, maximum entropy, and random forest). The predictive ability of abiotic-only, biotic-only, and abiotic-biotic models was evaluated. Winter temperatures and precipitation (i.e., precipitation of …

A Novel Immunostimulatory Platform For Amplifying The Abscopal Response Rates Of Radiation Therapy, Patrick A. Paez

Theses and Dissertations

Radiation therapy (RT) is one of the primary treatment modalities for head and neck squamous cell carcinoma (HNSCC). At the time of diagnosis two-thirds of HNSCC patients have local-advanced disease and 50-60% of these patients will experience a local-regional or metastatic relapse within three years. Improving the immunogenic response of RT may help address this clinical problem. However, current RT regimens have failed to reliably generate robust antitumor immunity as evidenced by the rarity of clinical abscopal responses. Recently we engineered a chimeric fusion molecule called Flagrp170, a novel immunostimulatory agent highly capable of promoting antigen presentation and T-cell activation. …

Glucocorticoid Receptor Dysregulation Underlies 5-Ht2a Receptor-Dependent Synaptic And Behavioral Deficits In A Mouse Neurodevelopmental Disorder Model, Justin M. Saunders

Theses and Dissertations

Schizophrenia is a severe neuropsychiatric disorder that presents with diverse symptoms, some of which remain resistant to treatment. Increased risk of neurodevelopmental disorders such as schizophrenia has been observed following gestational infection in humans, leading to development of maternal immune activation (MIA) animal models. Increased density of the serotonin 5-HT2AR receptor (5-HT2AR), the primary target of hallucinogenic drugs and a key target of atypical antipsychotics, has been observed in postmortem antipsychotic-free prefrontal cortex samples from schizophrenia subjects, a change reflected in frontal cortex of adult MIA offspring. To model MIA, we administered 20 mg/kg i.p. of the viral mimetic poly-(I:C) …

Overcoming Mechanisms Of Acquired And Innate Doxorubicin Resistance Using Nanomedicine And Tumor-Associated Macrophage Immunotherapy, Rashed M. Almuqbil

Theses and Dissertations

ABSTRACT

Overcoming Mechanisms of Acquired and Innate Doxorubicin Resistance Using Nanomedicine and Tumor-Associated Macrophage Immunotherapy

By Rashed M. Almuqbil, Pharm.D.

Director: Sandro R.P. da Rocha, PhD

Cancer is a leading cause of death worldwide. The available treatment for solid tumors may include surgery, radiotherapy, immunotherapy, and chemotherapy or a combination of all those regimens. Chemotherapy is widely used in the treatment of both lung cancers and breast cancer, including metastases, irrespective of type and stage. The poor rates of survival can be attributed to late diagnosis, and due to the development of acquired and innate chemoresistance. Lung tumors are intrinsically …

Cardiac Arrest And Global Ischemia Reperfusion Injury: Role Of Mitochondria And Cannabinoid Receptor 2 Signaling., Jennifer L. Bradley

Theses and Dissertations

We explored the effects of cardiac arrest on mitochondria populations and heart whole tissue lysate proteomics utilizing the Weil Institute’s in vivo rat model of cardiac arrest and cardiopulmonary resuscitation. We have discovered that brain mitochondria are more sensitive to global ischemia compared to heart mitochondria. Additionally, complex I is the most sensitive electron transport chain complex to ischemic injury and is a major control point of the rate of oxidative phosphorylation following cardiac arrest and cardiopulmonary resuscitation. Preservation of brain mitochondrial activity and function during cardiac arrest may enhance outcomes and recovery.

A recent article focusing on acute myocardial …

Augmented Reality In Sport Broadcasting, Chad Goebert

Theses and Dissertations

For a large portion of its history, sport broadcasting has been stagnant when it comes to incorporating new and innovative technologies. However, due to declining viewership and consumer desire for customizable content, augmented reality graphics have begun to be incorporated into multiple sport broadcast products. In fact, the UEFA Champions League, NBA, NFL, and NHL have all used or indicated their intention to utilize AR graphics in future broadcasts. Considering that media rights revenue is the main source of revenue to sport properties and organizations, it is important to carefully consider how the core product (the broadcast) is presented. The …

Novel Roles Of Yy1 In Astrocytes, Karli A. Mockenhaupt

Theses and Dissertations

Astrocytes tile the entire central nervous system, are diverse across brain regions, and perform specialized functions fine-tuned for their neuronal circuit. Initially, astrocyte heterogeneity is generated through intrinsic programs specified by their progenitors. Then, as astrocyte mature, they are specialized by region-specific communication with surrounding cells. The molecular programs that regulate this diversity and allow for the accommodation to the needs of the local environment remains elusive. We explored a ubiquitously expressed zinc finger transcription factor, Yin Yang 1 (YY1), that both activates and represses transcription by regulating loops of active chromatin. This report describes the diverse functions of astrocytic …

Straight Through My Heart, Raul A. Aguilar Canela

Theses and Dissertations

Straight through my heart is an exhibition that explores the concept of heartbreak as a socio-political phenomenon. Through the affect of sadness the thesis analyses the way in which subjects are formed under cognitive capitalism. Paying particular interest to the collateral effects of neoliberal culture —hyper-stimulation, self-exploitation, competition, and obsession with productivity—and the pathologies they create —depression, anxiety, body aches, fatigue— this work shifts the burden of sadness from the individual to the community. By doing so it proposes heartbreak as a public feeling.

Tender Perception: The Ethics Of Existence And Nonliving Objects’ Movement In Gertrude Stein's Tender Buttons, Timothy Berge

Theses and Dissertations

In exploring the relationship between Gertrude Stein's and Henri Bergson's lectures on movement this posits a conception of democracy embedded in Stein's poetry where everything that moves exists and everything that exists has a stake in the landscape in which it exists. Tender Buttons describes objects in ways that highlight the movement of nonliving matter, evoking current scholarship in new materialism, particularly Jane Bennett. After establishing a relationship between Bergson and Stein, this thesis turns to Jane Bennett teasing out the political and ecological implications of Stein's conception of movement in inanimate objects.

Information Architecture For A Chemical Modeling Knowledge Graph, Adam R. Luxon

Theses and Dissertations

Machine learning models for chemical property predictions are high dimension design challenges spanning multiple disciplines. Free and open-source software libraries have streamlined the model implementation process, but the design complexity remains. In order better navigate and understand the machine learning design space, model information needs to be organized and contextualized. In this work, instances of chemical property models and their associated parameters were stored in a Neo4j property graph database. Machine learning model instances were created with permutations of dataset, learning algorithm, molecular featurization, data scaling, data splitting, hyperparameters, and hyperparameter optimization techniques. The resulting graph contains over 83,000 nodes …

Effect Of Kcc2-Enhancing Prodrug Clp290 On Tat ± Morphine Treated Female Mice At The Behavioral And Molecular Levels, Michael Marone

Theses and Dissertations

HIV-1 infection is highly comorbid with opioid use disorder. Prescription and illicit use of opioids are particularly risky for HIV-1 infected individuals due to potential synergistic neurotoxic effects mediated by viral proteins and opioids. Additionally, opiate drug abuse has been shown to exacerbate neuropathogenesis of HIV-1⁺ individuals. Development of combination antiretroviral therapies (cART) has drastically improved the life expectancy of these patients. Unfortunately, although the severity of neurological and neurocognitive complications has declined, the incidence of HIV-associated neurocognitive disorders (HAND) remains 30-50% in the post-cART era and is worsened by opioid use disorder. HIV-1 proteins, inflammatory mediators, and excitotoxins …

Muscarinic Excitation Of Dopamine Neurons In The Ventral Tegmental Area Via Activation Of A Trpc-Like Cation Conductance, Yu Tzu Chen

Theses and Dissertations

Dopaminergic (DA) neurons in the ventral tegmental area (VTA) play a crucial role in reward and motivational behaviors, including the development of drug addictions. VTA DA neurons receive excitatory cholinergic inputs from the mesopontine tegmentum. Blockage of the M5 muscarinic receptor in DA neurons has been shown to attenuate drug-induced DA release and abuse-related behaviors, but the molecular mechanism is unknown. In this study, experiments were designed to identify the electrophysiological effects of muscarinic agonism in the modulation of action potential kinetics and firing patterns in VTA DA neurons of mice. Pharmacology of the muscarinic receptor-evoked current was also characterized. …

Effect Of Stimulus Waveform On Transcranial Magnetic Stimulation Metrics In Proximal And Distal Arm Muscles, Christopher Lynch

Theses and Dissertations

Objectives: The purpose of this study was to determine the effect of common transcranial magnetic stimulation (TMS) waveforms (monophasic and biphasic) on resting motor threshold (RMT), active motor threshold (AMT), and motor evoked potential (MEP) amplitudes in the biceps and first dorsal interosseous (FDI) because waveforms may affect motor targets differently. Additionally, we determined the test-retest reliability of TMS metrics for each stimulation type and muscle.

Methods: Ten individuals participated in two sessions of single-pulse TMS delivered to the motor cortex perpendicular to the central sulcus. MEPs were normalized to the maximum EMG signal during contraction and were recorded at …

Fty720-Induced Antinociception In The Chronic Constrictive Injury (Cci) Mouse Model: Neuronal-Astroglial Mechanisms Through S1p1 Signaling, Lauren V. Moncayo

Theses and Dissertations

Novel pharmacological and genetic advancements increased interest in the sphingosine-1-phosphate receptor-1 (S1P₁) as a potential therapeutic target. S1P₁ plays a critical role in the mechanism of action of Fingolimod/FTY720, a therapy currently FDA-approved for the treatment of relapsing-remitting multiple sclerosis (RRMS) (Camm et al., 2014). To prevent RRMS, FTY720 downregulates S1P₁ on lymphocytes to impair their trafficking and sequester cells in the lymphoid organs to prevent further pathogenic attack (Brinkmann et al., 2010). Recent developments in pre-clinical models suggest FTY720 holds therapeutic potential to treat other diseases, such as neuropathic pain, a debilitating chronic pain …

Impact Of Targeting Glycosylated Ceramides On Tumorigenic Properties, And Characterization Of Sphingolipids In Head And Neck Tumors, Katherine E. Hylton

Theses and Dissertations

Sphingolipids play a crucial role in signaling, membrane structure, and migration, making them important molecules in cancer development, metastasis, and drug resistance. While some sphingolipids have been associated with pro-apoptotic or pro-survival behaviors, the role of many sphingolipids in cancer remains poorly defined. Chapter 1 of this study investigated the impact of three enzymes that compose most of the ceramide to Lc3 ceramide pathway – UGCG, GBA, and B3GNT5 – and how their alteration impacts chemoresistance and basal membrane invasion in vitro. It was found that the CΒE-induced inhibition of GBA, which converts glucosylceramide to ceramide, has no effects on …

The Effects Of Interleukin-1Β On Cardiac Reserve And Exercise Capacity In The Mouse, Habeebah Z. Vohra

Theses and Dissertations

Heart failure (HF) is characterized by dyspnea, fatigue, and exercise intolerance. Clinical evidence points to increased interleukin-1β (IL-1β) activity in patients with HF, with an IL-1 blockade improving the exercise capacity in HF patients. In healthy mice, recombinant-mouse IL-1β (rmIL-1β) induces acute systolic dysfunction, peaking 4 hours after administration. However, the direct effects of rmIL-1β on exercise capacity are unknown. We hypothesized that rmIL-1β diminishes the exercise capacity in the mouse. Adult mice were trained to run on a treadmill and exercise capacity was assessed before, 4 hours, and 96 hours after intraperitoneal administration of rmIL-1β (3 μg/kg) or vehicle …

Effects Of Petroleum By-Products And Dispersants On Ecosystems, Kenneth M. Halanych, Cameron H. Ainsworth, Erik E. Cordes, Richard E. Dodge, Markus Huettel, Irving A. Mendelssohn, Steven A. Murawski, Claire B. Paris-Limouzy, Patrick T. Schwing, Richard F. Shaw, Tracey Sutton

Marine Science Faculty Publications

Gulf of Mexico ecosystems are interconnected by numerous physical and biological processes. As a result of the Deepwater Horizon (DWH) spill, some normal ecological processes including resource connectivity and trophic interactions and were damaged or broken. A considerable portion of post-DWH research has focused on higher levels of biological organization (i.e., populations, communities, and ecosystems) spanning at least four environments (onshore, coastal, open ocean, and deep benthos). Damage wrought by the oil spill and mitigation efforts varied considerably across ecosystems. Whereas all systems show prolonged impacts because of cascading effects that impacted functional connections within and between communities, deep-sea and …

A Synthesis Of Deepwater Horizon Impacts On Coastal And Nearshore Living Marine Resources, Steven A. Murawski, Joshua P. Kilborn, Adriana C. Bejarano, David Chagaris, David Donaldson, Frank J. Hernandez, Timothy C. Macdonald, Craig Newton, Ernst Peebles, Kelly L. Robinson

Marine Science Faculty Publications

The 2010 Deepwater Horizon (DWH) oil blowout in the Gulf of Mexico began on April 20, originating in the deep sea 66 km off the Louisiana coast. By early June, DWH oil had spread to coastal Louisiana, Mississippi, Alabama and western Florida. An estimated 2,113 km of shoreline were oiled, making DWH the largest marine oil spill in global history by length of affected shoreline. Additionally, a series of oil spill response measures were deployed, including diversions of Mississippi River discharge to forestall oil coming ashore, and the establishment of large-scale fishery closures, with both affecting coastal resources to varying …

The Gulf Of Mexico: An Overview, Larry D. Mckinney, John G. Shepherd, Charles A. Wilson, William T T. Hogarth, Jeff Chanton, Steven A. Murawski, Paul A. Sandifer, Tracey Sutton, David Yoskowitz, Katya Wowk, Tamay M. Özgökmen, Samantha B. Joye, Rex Caffey

Marine Science Faculty Publications

The Gulf of Mexico is a place where the environment and the economy both coexist and contend. It is a resilient large marine ecosystem that has changed in response to many drivers and pressures that we are only now beginning to fully understand. Coastlines of the states that border the Gulf comprise about half of the US southern seaboard, and those states are capped by the vast Midwest. The Gulf drains most of North America and is both an economic keystone and an unintended waste receptacle. It is a renowned resource for seafood markets, recreational fishing, and beach destinations and …

Settled Law, G. Alexander Nunn, Alan M. Trammell

Scholarly Articles

“Settled law” appears frequently in judicial opinions—sometimes to refer to binding precedent, sometimes to denote precedent that has acquired a more mystical permanence, and sometimes as a substantive part of legal doctrine. During judicial confirmation hearings, the term is bandied about as Senators, advocacy groups, and nominees discuss judicial philosophy and deeper ideological commitments. But its varying and often contradictory uses have given rise to a concern that settled law is simply a repository for hopelessly disparate ideas. Without definitional precision, it risks becoming nothing more than empty jargon.

We contend that settled law is actually a meaningful concept, even …

References To Aesop's Fables In Judicial Opinions And Written Advocacy, Douglas E. Abrams

Faculty Publications

In several “Writing It Right” articles over the past few years, I have described how federal and state judges frequently accent their opinions' substantive or procedural points with careful references to cultural markers familiar to many Americans. This article continues traveling the literary lane by turning to Aesop’s Fables. By invoking a Fable, the Friends of Animals district court continued a tradition that began in 1823, when the Pennsylvania Supreme Court cited Aesop in a will contest.

Male And Female Genotype And A Genotype-By-Genotype Interaction Mediate The Effects Of Mating On Cellular But Not Humoral Immunity In Female Decorated Crickets, Kylie J. Hampton, Kristin R. Duffield, John Hunt, Scott K. Sakaluk, Ben M. Sadd

Faculty Publications – Biological Sciences

Sexually antagonistic coevolution is predicted to lead to the divergence of male and female genotypes related to the effects of substances transferred by males at mating on female physiology. The outcome of mating should thus depend on the specific combination of mating genotypes. Although mating has been shown to influence female immunity in diverse insect taxa, a male–female genotype-by-genotype effect on female immunity post mating remains largely unexplored. Here, we investigate the effects of mating on female decorated cricket baseline immunity and the potential for a male-genotype-by-female-genotype interaction affecting this response. Females from three distinct genotypic backgrounds were left unmated …