Digital Commons Network^™

Nuclear Factor Kappa-B Contributes To Cigarette Smoke Tolerance In Pancreatic Ductal Adenocarcinoma Through Cysteine Metabolism, Venugopal Gunda, Yashpal S Chhonker, Nagabhishek Sirpu Natesh, Pratima Raut, Sakthivel Muniyan, Todd A. Wyatt, Daryl J. Murry, Surinder K. Batra, Satyanarayana Rachagani

Journal Articles: Environmental, Agricultural & Occupational Health

BACKGROUND: Retrospective studies revealed that cigarette smoking enhances risk of incidence and worsens prognosis in pancreatic cancer (PC) patients. Poor prognosis in smoker cohort of PC patients indicates prevalence of cigarette smoke stimulated survival mechanisms yet to be explored in PC. In this study, cigarette smoke induced metabolic pathways were explored and targeted in PC.

METHODS: Human pancreatic ductal adenocarcinoma cell (PDAC) lines, genetically engineered mice models (GEMMs), mass spectrometry based heavy isotope-based metabolite analysis, cytotoxicity assays and Nuclear factor kappa-B (NF-kB) targeting were utilized in this study. Cigarette smoke extract (CSE) was prepared fresh each day by bubbling cell …

Office Of Sponsored Programs And Research Annual Report 2021, Office Of Sponsored Programs And Research

Office of Sponsored Programs and Research - Reports

This annual report is meant to provide a brief snapshot of the strong faculty and staff sponsored programs and research activities, much of which is focused on providing GSU students with opportunities to be competitive in the world.

From Stigma To Dignity? Transforming Workfare With Universal Basic Income And A Federal Job Guarantee, Lynn D. Lu

Publications and Research

As the COVID-19 pandemic takes a catastrophic toll on lives and livelihoods across the United States, the harshest impact of the unpredictable virus has disproportionately fallen with foreseeable accuracy on Black, immigrant, poor, and elderly people, who are most likely to live and work in close contact with others and to have less access to health care or emergency savings. The speed and severity of the viral contagion has rendered devastatingly, undeniably visible the vast, racial gap between those with reliable health care, child care, housing, nutrition, household wealth, and income and those without, but that gap was already widening …

Cas Accents, Vol. 23, No. 4 (Special Issue - Cas 49th Foundation Anniversary), College Of Arts And Sciences, University Of The Philippines Los Baños

CAS Accents

No abstract provided.

Cas Accents, Vol. 23, No. 3 (Special Issue - Uplb Loyalty Day 2021), College Of Arts And Sciences, University Of The Philippines Los Baños

CAS Accents

Contents:

• CAS Alumni honored at the 103rd UPLB Loyalty Day
• CINTERLABS hosts its first ACRES
• IMSP holds its first webinar on Advanced Functional Materials and their Applications
• Dr. Paller leads IBS as New Director
• Dr. Liza N. Comia reappointed as INSTAT's Director

Town Of Surry Annual Report Town Officers And Inventory Of Ratable Property Of Surry, New Hampshire For The Year Ending December 31, 2020 And School District Officers For The Year Ending June 30, 2020., Surry Town Representatives

Surry, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Conceptual Math For The Math-Anxious Teacher, Rebecca Chapman, Heather Thomas, Barbara Clarke

Instructional Modules for Professional learning Responding to Opportunities and Valuing Educators (IMPROVE)

In this module we will explore many concepts supporting conceptual instruction of math from middle-elementary levels to lower-secondary level math. We help you teach not just how the math concepts work but why they work so students are empowered to engage! (Boaler, 2016)

View professional learning module.

Patterns Of Serum Immune Biomarkers During Elephant Endotheliotropic Herpesvirus Viremia In Asian And African Elephants, Katie L. Edwards, Erin M. Latimer, Jessica Siegal-Willott, Wendy Kiso, Luis R. Padilla, Carlos R. Sanchez, Dennis Schmitt, Janine L. Brown

College of Agriculture

Hemorrhagic disease (HD) caused by a group of elephant endotheliotropic herpesviruses (EEHV) is one of the leading causes of death for young elephants in human care. These viruses are widespread and typically persist latently in adult elephants with no negative effects; however, in juvenile Asian and more recently young African elephants, the onset of disease can be rapid and the mortality rate high. Measuring biomarkers associated with the immune response could be beneficial to understanding underlying disease processes, as well as the management of infection and HD. The goal of this study was to measure acute phase proteins and cytokines …

No. 53: Changing Priorities In Urban Food Security Research: A Bibliometric Analysis, Bruce Frayne, Truzaar Dordi, Cameron Mccordic, Naomi Sunu, Clare Williamson

Hungry Cities Partnership

The study of urban food security has evolved dramatically over the past few decades. This evolution has been punctuated, and catalyzed, by insights into the dynamic transformation of food systems in cities across the Global South. The evolution of this field provides an important vantage point for understanding both the dynamic transformation of urban food systems as well as the lens through which that transformation has been understood. This investigation of the field adopted a bibliometric methodology, blending quantitative and qualitative analytical techniques, to assess the dynamic evolution of the literature over time. The methodology included a quantitative analysis of …

No. 51: State-Led Localization Of Food Provisioning And Food Security In Urban China, Taiyang Zhong, Steffanie Scott, Zhenzhong Si, Jonathan Crush

Hungry Cities Partnership

Food localization has been extensively studied and advocated in Western countries, focusing on its oppositional stance to food system globalization, long food supply chains and agribusiness, the disconnect between producers and consumers, and a desire to reconnect urban consumers with small farmers in the hinterland of cities. More recently, these localization models have been taken up by international agencies and others and “exported” to the Global South. Rapid urbanization in the Global South has led to a major and growing crisis of food insecurity, which these models and approaches are ill-equipped to address. Hence, it is important to examine other …

The Financial Reality Of A Career In Veterinary Medicine For Kentucky Residents, Shelby Ackermann

Mahurin Honors College Capstone Experience/Thesis Projects

The financial burden of a veterinary medical education continues to increase with rising tuition prices. According to the American Veterinary Medical Association, the average educational debt of a veterinary student graduating in 2020 was approximately $157,000 (Bain, 2020). Studies published by the Journal of the American Veterinary Medical Association suggest that suicide rates among veterinarians are higher than that of the general population and list debt as a primary contributing factor. The purpose of this project is to expose students to the financial reality of veterinary medicine, increase awareness of financial and career opportunities, and compile information gathered from interviews …

Emmie And The Enchanted Orchid: Portraying Positive Disability Representation In Children's Media, Adrianna Waters

Mahurin Honors College Capstone Experience/Thesis Projects

Disability representation in media and storytelling is often negative or inaccurate, with disability narratives equating disability to evil or lesser than abled bodies. The harmful representation is especially prevalent and dangerous in children’s media as the depiction of characters with disabilities may be children’s first introduction to disability, and thus the portrayal is likely to stay with them, especially as stories for adults continue to perpetuate the inaccurate representation of disabilities. “Emmie and the Enchanted Orchid”: Portraying Positive Disability Representation in Children’s Media seeks to examine the harmful portrayal of disabilities in children’s media while also recognizing how disability can …

Exploring Microbiome Functional Dynamics Through Space And Time With Trait-Based Theory, Leonora S. Bittleston, Zachary B. Freedman, Jessica R. Bernardin, Jacob J. Grothjan, Erica B. Young, Sydne Record, Benjamin Baiser, Sarah M. Gray

Biology Faculty Research and Scholarship

Microbiomes play essential roles in the health and function of animal and plant hosts and drive nutrient cycling across ecosystems. Integrating novel trait-based approaches with ecological theory can facilitate the prediction of microbial functional traits important for ecosystem functioning and health. In particular, the yield-acquisition-stress (Y-A-S) framework considers dominant microbial life history strategies across gradients of resource availability and stress. However, microbiomes are dynamic, and spatial and temporal shifts in taxonomic and trait composition can affect ecosystem functions. We posit that extending the Y-A-S framework to microbiomes during succession and across biogeographic gradients can lead to generalizable rules for how …

The Dual Nature Of Metacommunity Variability, Thomas Lamy, Nathan I. Wisnoski, Riley Andrade, Max C. N. Castorani, Aldo Compagnoni, Nina Lany, Luca Marazzi, Sydne Record, Christopher M. Swan, Jonathan D. Tonkin, Nicole Voelker, Shaopeng Wang, Phoebe L. Zarnetske, Eric R. Sokol

Biology Faculty Research and Scholarship

There is increasing interest in measuring ecological stability to understand how communities and ecosystems respond to broad-scale global changes. One of the most common approaches is to quantify the variation through time in community or ecosystem aggregate attributes (e.g. total biomass), referred to as aggregate variability. It is now widely recognized that aggregate variability represents only one aspect of communities and ecosystems, and compositional variability, the changes in the relative frequency of species in an assemblage, is equally important. Recent contributions have also begun to explore ecological stability at regional spatial scales, where interconnected local communities form metacommunities, a key …

Harnessing The Neon Data Revolution To Advance Open Environmental Science With A Diverse And Data-Capable Community, R. Chelsea Nagy, Jennifer K. Balch, Erin K. Bissell, Megan E. Cattau, Nancy F. Glenn, Benjamin S. Halpern, Nayani Ilangakoon, Brian Johnson, Maxwell B. Joseph, Sergio Marconi, Catherine O'Riordan, Sydne Record

Biology Faculty Research and Scholarship

It is a critical time to reflect on the National Ecological Observatory Network (NEON) science to date as well as envision what research can be done right now with NEON (and other) data and what training is needed to enable a diverse user community. NEON became fully operational in May 2019 and has pivoted from planning and construction to operation and maintenance. In this overview, the history of and foundational thinking around NEON are discussed. A framework of open science is described with a discussion of how NEON can be situated as part of a larger data constellation—across existing networks …

Energy Islands: Metaphors Of Power, Extractivism, And Justice In Puerto Rico, Catalina M. De Onís

University of Montana Staff Publications

Energy Islands provides an urgent and nuanced portrait of collective action that resists racial capitalism, colonialism, and climate disruption. Weaving together historical and ethnographic research, Catalina M. de Onís challenges the master narratives of Puerto Rico as a tourist destination and site of “natural” disasters. She demonstrates how fossil-fuel economies are inextricably entwined with colonial practices and policies and how local community groups in Puerto Rico have struggled against energy coloniality and energy privilege to mobilize and transform power from the ground up. This work decenters continental contexts and deconstructs damaging hierarchies that devalue and exploit disenfranchised rural, coastal communities. …

Literacy At Home: Reading And Writing Activities For Family Time, Philip H. Swartz, Kathy Pitchford, Daniel P. Swartz, Stanley L. Swartz

Special Education, Rehabilitation & Counseling Faculty Publications

Reading and writing activities for family time.

Bottom Feeders, Cheyenne Taylor

Birmingham Poetry Review

p. 168

Something Will Survive Us, Kathleen Balma

Nelle (literary magazine)

p. 135

Neuroendocrine Response To Exogenous Ghrelin Administration, Combined With Alcohol, In Heavy-Drinking Individuals: Findings From A Randomized, Double-Blind, Placebo-Controlled Human Laboratory Study, Mehdi Farokhnia, Kelly M. Abshire, Aaron Hammer, Sara L. Deschaine, Anitha Saravanakumar, Enoch Cobbina, Zhi-Bing You, Carolina L. Haass-Koffler, Mary R. Lee, Fatemeh Akhlaghi, Lorenzo Leggio

Biomedical and Pharmaceutical Sciences Faculty Publications

Background: Accumulating evidence has established a role for the orexigenic hormone ghrelin in alcohol-seeking behaviors. Accordingly, the ghrelin system may represent a potential pharmacotherapeutic target for alcohol use disorder. Ghrelin modulates several neuroendocrine pathways, such as appetitive, metabolic, and stress-related hormones, which are particularly relevant in the context of alcohol use. The goal of the present study was to provide a comprehensive assessment of neuroendocrine response to exogenous ghrelin administration, combined with alcohol, in heavy-drinking individuals.

Methods: This was a randomized, crossover, double-blind, placebo-controlled human laboratory study, which included 2 experimental alcohol administration paradigms: i.v. alcohol self-administration and i.v. alcohol …

Vaccine Delivery Alerts Innate Immune Systems For More Immunogenic Vaccination, Zhoufan Li, Yan Cao, Yibo Li, Yiwen Zhao, Xinyuan Chen

Biomedical and Pharmaceutical Sciences Faculty Publications

Vaccine delivery technologies are mainly designed to minimally invasively deliver vaccines to target tissues with little or no adjuvant effects. This study presents a prototype laser-based powder delivery (LPD) with inherent adjuvant effects for more immunogenic vaccination without incorporation of external adjuvants. LPD takes advantage of aesthetic ablative fractional laser to generate skin microchannels to support high-efficient vaccine delivery and at the same time creates photothermal stress in microchannel-surrounding tissues to boost vaccination. LPD could significantly enhance pandemic influenza 2009 H1N1 vaccine immunogenicity and protective efficacy as compared with needle-based intradermal delivery in murine models. The ablative fractional laser was …

Cytochrome P450 Enzyme Inhibition And Herb-Drug Interaction Potential Of Medicinal Plant Extracts Used For Management Of Diabetes In Nigeria, Ogochukwu Amaeze, Heather Eng, Lauren Horlbogen, Manthena V.S. Varma, Angela Slitt

Biomedical and Pharmaceutical Sciences Faculty Publications

Background and Objective

The use of herbal medicines is common in Africa, and patients often use a combination of herbs and drugs. Concurrent herbal and pharmaceuticals treatments can cause adverse effects through herb-drug interactions (HDI). This study evaluated the potential risk of HDI for five medicinal plants, Vernonia amygdalina, Ocimum gratissimum, Moringa oleifera, Azadirachta indica, and Picralima nitida, using in vitro assays. Patients with diabetes and some other disease conditions commonly use these medicinal plants in Nigeria, and little is known regarding their potential for drug interaction, despite their enormous use.

Methods

Crude extracts of the medicinal plants were …

A Large-Scale Validation Of The Relationship Between Cross-Disciplinary Research And Its Uptake In Policy-Related Documents, Using The Novel Overton Altmetrics Database, Henrique Pinheiro, Etienne Vignola-Gagné Phd, David Campbell

Peer Reviewed Papers

Cross-disciplinary research (multi-/interdisciplinarity) is incentivized by funding agencies to foster research outcomes addressing complex societal challenges. This study focuses on the link between cross-disciplinary research and its uptake in a broad set of policy-related documents. Using the new policy-oriented database Overton, matched to Scopus, logistic regression was used in assessing this relationship in publications from FP7- and H2020-supported projects. Cross-disciplinary research was captured through two lenses at the paper level, namely from the disciplinary diversity of contributing authors (DDA) and of cited references (DDR). DDA increased the likelihood that publications were cited in policy documents, with DDR possibly making a …

Market Efficiency: Its Economic And Theological Implications, Fan Fei

Faculty Tenure Papers

In finance, market efficiency, or equivalently, the Efficient Market Hypothesis, assumes that the market can transmit information completely, instantly, and freely so that asset prices reflect the fair value of the investment. An efficient market would imply that the prices were always right and that no group of investors should be able to consistently beat the market. In this article, I review the evolution of modern finance and the evidence for and against the Efficient Market Hypothesis. Decades of empirical research and historical events, such as dot-com bubble and the 2007-2008 Global Financial Crisis, resulted in a paradigm shift and …

Beyond Calculation: A Review Of Robert J. Sawyer’S Calculating God, Jeff Lindsay

Interpreter: A Journal of Latter-day Saint Faith and Scholarship

In an entertaining and provocative science fiction novel, Calculating God, Robert J. Sawyer presents us with a likable alien scientist visiting earth to obtain more data about God’s ongoing work of creation. The alien is astounded that a human scientist does not believe in God despite the obvious evidence. Sawyer’s work introduces a variety of reasonable scientific arguments for the existence of God in a series of cleverly conceived dialogs and uses dramatic events to develop some perspectives on God. Sawyer’s purpose is not to evangelize, and the troubling concept of an utterly impersonal God who emerges in Sawyer’s interplay …

Demythicizing The Lamanites’ “Skin Of Blackness”, Gerrit M. Steenblik

Interpreter: A Journal of Latter-day Saint Faith and Scholarship

Racial bias is antithetical to the Book of Mormon’s cardinal purpose: to proclaim the infinite grandeur of the atonement of Jesus Christ. The book teaches that the Lord welcomes and redeems the entire human family, “black and white, bond and free” — people of all hues from ebony to ivory. Critical thinkers have struggled to reconcile this leitmotif with the book’s mention of a “skin of blackness” that was “set upon” some of Lehi’s descendants. Earlier apologetics for that “mark” have been rooted in Old World texts and traditions. However, within the last twenty years, Mesoamerican archaeologists, anthropologists, and ethnohistorians …

“Wherefore, For This Cause”: The Book Of Mormon As Anti-Type Of The Brass Serpent, Scott Stenson

Interpreter: A Journal of Latter-day Saint Faith and Scholarship

Nephi1 represents the sacred record that becomes the Book of Mormon as a new brass serpent to heal the nations. Nephi’s typological project is reasonable given that he self-identifies with Moses, his family’s scriptures and compass are made of brass, and he consistently describes reading as an act of seeing, looking, or believing. Nephi understands from Isaiah that the book he (Nephi) prepares — and that he has so much to say about — will become an ensign, or sign, that will be lifted up and heal the nations that have stumbled in blindness. Nephi’s project emerges most fully in …

Nibley’S Early Education, Zina Nibley Petersen

Interpreter: A Journal of Latter-day Saint Faith and Scholarship

In this intimate glimpse of Hugh Nibley’s childhood, written by his daughter Zina, we read of what it was like for Hugh to grow up as a gifted child with Victorian parents and, in turn, what it was like for Zina and her siblings to grow up as a child in the home of Hugh and Phyllis. These poignant, never-before-told stories reveal why, in Zina’s words, “Hugh’s uniqueness lay as much in his inabilities as in his abilities, as much in what he refused to learn as what he refused to allow to remain unexamined.” And though it was obvious …

If God Does Not Exist, Is Everything Permitted?, Daniel C. Peterson

Interpreter: A Journal of Latter-day Saint Faith and Scholarship

Can people be good without believing in God? Obviously, yes. They can. Is atheistic naturalism capable of supplying a foundation for morality? That is a separate question, to which more than a few theists have answered No. However, a relatively new book by a very prominent student of religion and society suggests otherwise. A rational morality can, it argues, be founded upon atheistic naturalism — but it will necessarily be a modest and quite limited one, lacking universal scope and without a belief in human rights as objective “moral facts.”

Full Issue

Interpreter: A Journal of Latter-day Saint Faith and Scholarship

No abstract provided.