Digital Commons Network^™

Developing A Targeted Ultrasound-Responsive Nanobubble-Based Gene Delivery System For Osteoporosis Treatment, Angela Shar

Honors Undergraduate Theses

The overall goal of this project was to develop, optimize, and test an ultrasound-responsive targeted nanobubble for delivering osteoporosis-related silencing genes such as Cathepsin K small interfering RNA (CTSK siRNA) for osteoporosis treatment. The nanobubbles were synthesized using an in situ sonochemical method. The nanobubble (NB) is composed of a gas core made from perfluorocarbon, stabilized with albumin, encapsulated with CTSK siRNA, and embedded with alendronate (AL) for bone targeting (CTSK siRNA-NB-AL). Following its development, the responsiveness of CTSK siRNA-NB-AL to a therapeutic ultrasound probe was examined. The results of biocompatibility tests with human bone marrow-derived mesenchymal stem cells proved …

Application Of Analogical Reasoning For Use In Visual Knowledge Extraction, Kara Lian Combs

Browse all Theses and Dissertations

There is a continual push to make Artificial Intelligence (AI) as human-like as possible; however, this is a difficult task because of its inability to learn beyond its current comprehension. Analogical reasoning (AR) has been proposed as one method to achieve this goal. Current literature lacks a technical comparison on psychologically-inspired and natural-language-processing-produced AR algorithms with consistent metrics on multiple-choice word-based analogy problems. Assessment is based on “correctness” and “goodness” metrics. There is not a one-size-fits-all algorithm for all textual problems. As contribution in visual AR, a convolutional neural network (CNN) is integrated with the AR vector space model, Global …

Southern Adventist University Undergraduate Handbook 2021-2022, Southern Adventist University

Student Handbooks, Undergraduate

No abstract provided.

Coastal And Marine Socio-Ecological Systems: A Systematic Review Of The Literature, Sonia Refulio-Coronado, Katherine Lacasse, Tracey Dalton, Austin T. Humphries, Suchandra Basu, Hirotsugu Uchida, Emi Uchida

Environmental and Natural Resource Economics Faculty Publications

The socio-ecological systems (SESs) framework provides cross-disciplinary insight into complex environmental problems. Numerous studies have applied the SES framework to coastal and marine environments over the last two decades. We review and analyze 98 of those studies to (i) describe how SES concepts were examined and measured, (ii) describe how the studies included feedbacks and thresholds, and (iii) identify and analyze elements unique to coastal and marine SES frameworks. We find that progress has been made in understanding key SES properties in coastal and marine ecosystems, which include resilience, adaptive capacity, vulnerability, and governance. A variety of methods has been …

Annual Report Year Ending December 31, 2020., Rollinsford Town Representatives

Rollinsford, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Annual Report Of The Town Of Roxbury, New Hampshire For The Year Ending December 31, 2020., Roxbury Town Representatives

Roxbury, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Annual Report For The Year Ending 2020 Town Of Rindge., Rindge Town Representatives

Rindge, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Agronomic Response Of Camelina To Nitrogen And Seeding Rate On The Northern Great Plains, Thandiwe Nleya, Dwarika Bhattarai, Phillip Alberti

Agronomy, Horticulture and Plant Science Faculty Publications

Camelina (Camelina sativa L. Crantz,) a new oilseed crop in the Brassicaceae family has favorable agronomic traits and multiple food and industrial uses. Appropriate production practices for optimal camelina yield in temperate climates of North America are lacking. This study investigated the response of camelina seed yield and quality, and agronomic traits to applied N (5 levels, 0, 28, 56, 84, 140 kg ha−1) and four seeding rates (4.5, 9, 13, 17.5 kg ha−1). Separate experiments were conducted at four environments (site-years) for N and three environments for seeding rate in South Dakota. In three of the four environments, the …

Synovial Fibrosis In Osteoarthritis Of The Knee: Mechanism Of Development And Potential Therapeutic Targets, Marwa Qadri

Pharmaceutical Sciences (PhD) Dissertations

Synovial tissue fibrosis is an immune mediated disease characterized by fibroblast cell migration, proliferation and transition to a myofibroblast phenotype characterized by alpha smooth muscle actin (a-SMA) upregulation and stress fiber formation. Transforming growth factor-β (TGF-b) plays an important role in mediating the pathogenesis of synovial fibrosis. Synoviocytes produce proteoglycan-4 (PRG4; lubricin), a heavily glycosylated mucinous glycoprotein, and hyaluronic acid (HA). Both PRG4 and HA compete for binding to the CD44 receptor. Furthermore, rhPRG4 binds to TLR2 and TLR4 and acts as an antagonist to prevent TLR2 and TLR4 activation by bacterial ligands. In this work, we aimed to investigate …

Günther Anders’S Epitaph For Aikichi Kuboyama, Babette Babich

Articles and Chapters in Academic Book Collections

Günther Anders’s poem Du kleiner Fischerman is read here as a text contribution to the irruption that is violence and its enduring (omnipresent) aftermath. The essay includes a discussion of transmedial expression, including dramatization, or television and social media, text and subtext, as well as the inspiration of Anders’s poem as a work of art continuing in our times: the ongoing exclusion(s) of certain names and certain thinkers as of certain musical modes, including electronic musical works, as of voices and of collective memory, or oblivion. Reading Raymond Williams along with Anders and Adorno on television updated in today’s era …

Serial-Multiple Mediation Of Enjoyment And Intention On The Relationship Between Creativity And Physical Activity, Myungjin Jung, Han Soo Kim, Paul D. Loprinzi, Minsoo Kang

Faculty and Student Publications

The purpose of the present study was to examine a serial-multiple mediation of physical activity (PA) enjoyment and PA intention in the relationship between creativity and PA level (i.e., moderate-to-vigorous PA). A total of 298 undergraduate and graduate students completed a selfreported questionnaire evaluating creativity, PA enjoyment, PA intention, and PA level. Data analysis was conducted using descriptive statistics, Pearson correlation coefficient, ordinary leastsquares regression analysis, and bootstrap methodology. Based on the research findings, both PA enjoyment (β = 0.06; 95% CI [0.003, 0.12]) and PA intention (β = 0.08; 95% CI [0.03, 0.13]) were found to be a mediator …

The Predictive And Diagnostic Accuracy Of Long Pentraxin-3 In Covid-19 Pneumonia, Ahmed Bi̇lal Genç, Selçuk Yaylaci, Hamad Dhei̇r, Ahmed Ci̇had Genç, Kubi̇lay İşsever, Deni̇z Çeki̇ç, Havva Kocayi̇ği̇t, Erdem Çokluk, Alper Karacan, Mehmet Ramazan Şekeroğlu, Hande Toptan, Ertuğrul Güçlü

Turkish Journal of Medical Sciences

Background/aim: The purpose of this study is to evaluate serum pentraxin-3 (PTX-3) levels in Sars-CoV-2 virus infection (COVID-19) patients and to investigate whether PTX-3 predicts the disease prognosis. Materials and methods: This study was conducted on 88 confirmed COVID-19 patients who were hospitalized due to symptomatic pneumonia between April 15 and August 15, 2020. The patients were divided into two groups as survived patients and non-survived patients. Both groups were compared according to demographic features, comorbid conditions and measurement of the PTX-3 and other laboratory parameters of the patients. Results: Of 88 patients with COVID-19, 59 (67%) were discharged with …

Factors Affecting Mortality In Geriatric Patients Hospitalized With Covid-19, Rabi̇a Bağ Soytaş, Damla Ünal, Pinar Arman, Veysel Suzan, Tuğçe Emi̇roğlu Gedi̇k, Günay Can, Bora Korkmazer, Ridvan Karaali̇, Şermi̇n Börekçi̇, Mert Ahmet Kuşkucu, Hakan Yavuzer, Ülev Deni̇z Erdi̇nçler, Alper Döventaş

Turkish Journal of Medical Sciences

Background/aim: We aimed to investigate the factors affecting the mortality of patients aged 65 years or older who were hospitalized with the diagnosis of new coronavirus pneumonia (COVID-19). Materials and methods: This is a retrospective study of patients 65 years old or older with COVID-19 who were hospitalized in İstanbul University-Cerrahpaşa, Cerrahpaşa Medical Faculty Hospital, between March 11 and May 28, 2020. Demographic, clinical, treatment, and laboratory data were extracted from electronic medical records. We used univariate and multivariate logistic regression methods to explore the risk factors for in-hospital death. Results: A total of 218 patients (112 men, 106 women) …

Umbilical Cord Levels Of Macrophage Migration Inhibitory Factor In Neonatal Respiratorydistress Syndrome, Süleyman Bayraktar, Bi̇lge Bayraktar, Ülkan Kiliç

Turkish Journal of Medical Sciences

Background/aim: We aimed to evaluate the association of the umbilical cord macrophage migration inhibitory factor (MIF) with the respiratory distress syndrome (RDS) in preterm infants. Materials and methods: A total of eighty six preterm infants (38 with RDS and 48 without RDS) were involved in the study. ELISA is the technique assaying MIF values. Results: The mean of the infants' gestational ages and birth weights were significantly different (P = 0.0001). There were no significant differences in sex, delivery mode or exposure to antenatal steroid among the groups (P > 0.05). Umbilical cord MIF levels of the infants were not correlated …

Global Perspectives On Harmful Algal Blooms: Impacts And Responses, Ryan Mitchell

Sustainability and Social Justice

Harmful algal blooms (HABs) can have devastating effects on aquatic ecosystems, economies, and communities. In general, their effects are also likely to worsen and become more frequent because of climate change. This paper will examine contemporary attempts to predict, prevent, monitor, control, and adapt to HABs.

Human-Robot Collaboration: A Multilevel And Integrated Leadership Framework, Chou-Yu (Joey) Tsai, Jason D. Marshall, Anwesha Choudhury, Andra Serban, Yoyo Tsung-Yu Hou, Malte F. Jung, Shelley D. Dionne, Francis J. Yammarino

Management and Accounting Faculty Scholarship

In an era of rapid advances in artificial intelligence, the deployment of robots in organizations is accelerating. Further, robotic capabilities are expanding to serve a broader range of leadership behaviors related to task accomplishment and relationship support. Despite the increasing use of robots in various roles across different industries, research on human-robot collaboration in the workplace is lagging behind. As such, the current research aims to provide a state-of-the-science review and directions for future work in this underdeveloped area. Drawing on current leadership paradigms, we review human-robot collaboration studies from four academic disciplines with a history of publishing such work …

Old Meets New: Bringing Ancient Studies To Life In The Hybrid Classroom, Shane M. Thompson

JRCA Pedagogy

The 2020-2021 academic year will forever be remembered as the “COVID-year,” which, in academia, forced instructors to rethink the ways we have taught for generations. Personally, the Fall 2020 semester presented an opportunity to teach fully in-person classes (in a Hyflex model as not all students were able to attend), fully online classes, and – the most foreign to us – hybrid classes. As the hybrid model is one with which almost no one had any experience, I will focus my reflection on one particular hybrid course, urging instructors to incorporate Active Learning strategies into their courses – both hybrid …

Indispensable Statistics For The Behavioral Sciences ~With Spss 26, Howard Reid Ph.D.

Open Educational Resources (OER)

While there are many fine introductory statistics books, undergraduate students often continue to view statistics courses negatively. And many fear they will be unable to master the basic level of understanding that is essential to progress in their majors. The present text is an attempt to rethink what students majoring in the behavioral sciences absolutely must learn in an introductory statistics course and how best to organize the presentation of this material so they can succeed in their chosen field of study.

Every book is written from some perspective. The perspective of this book is that a first course in …

Characteristics Of Particle Emissions From Light Duty Diesel Vehicle Fueled With Ultralow Sulphur Diesel And Biodiesel Blend, Bei, Helen Wang, Or Wing-Hong, Shun-Cheng Lee, Yiu-Cheong Leung, Bruce Organ, Kin-Fai Ho

Faculty of Science & Technology (THEi)

This study investigates the particle emissions from a diesel vehicle fueled with ultralow sulphur diesel (B0, ULSD) and 5 % biodiesel blend (B5) by a chassis dynamometer test under three driving conditions. Elemental carbon (EC), organic carbon (OC), 30 species of polycyclic aromatic hydrocarbon (PAH) and 10 species of oxygenated PAH (oxy-PAH) were analyzed to quantify the chemical compositions of the collected particulate matter (PM). The emission factors (EFs) of OC were increased with B5 by a range between 39.5 % and 113.7 %, compared with B0. Both fuel blends recorded a trace amount of EC (0.25 mg/kg or less). …

The Impact Of Supply Chain Disruptions On Stock Market Returns During Covid-19, Hélène Flore Nguemgaing, Ana Claudia Sant’Anna

Faculty & Staff Scholarship

Purpose: How has Covid-19 impacted meat processors’ stock returns? We evaluate the effects of supply chain disruptions (e.g., lockdowns and Covid-19 incidences among workers) on stock market prices of meat processors during the COVID-19 pandemic.

Design/methodology/approach This study uses an event study approach to examine the disruptions from COVID-19 through events such as plant shutdowns, the pandemic announcement, lockdown dates, and the first case of Covid-19 outbreaks in meat processing plants. Our dataset includes S&P 500, Google Trends, financial beta, and data collected for 14 U.S. Publicly traded meat processing companies.

Findings Results show that nationwide events (e.g., announcement of …

Diverse Demographic Factors Influence Apparent Juvenile Survival In A Migratory Songbird, Emma M. White, Noah G. Perlut, Steven E. Travis, Allan Strong

Environmental Studies Faculty Publications

To better understand the dynamics of avian populations and their role in population trends, we require an in-depth understanding of the factors influencing the survival of adults and juveniles. How-ever, assessing survival in juveniles is often challenging, especially in small, migratory species where individuals typically disperse from the study area and are not available for recapture in subsequent years. Bobolinks (Dolichonyx oryzivorus) are a long-distance migrant that exhibits natal philopatry in at least one population, allowing for more comprehensive juvenile survival analyses than in many other long-distance avian migrants. Using a 17-yr dataset from two sites representing a …

Management Schemes, Not Philopatry Or Breeding Experience, Affect Nest Success Of Two Songbirds In Vermont Hayfields, Kylie Denny, Noah G. Perlut, Allan Strong

Environmental Studies Faculty Publications

Songbirds can benefit from natal philopatry through prior knowledge about site‐specific resources and local adaptation to environmental conditions. Likewise, breeding experience may also play a role in reproductive success. However, for birds that breed in managed habitats, management activities may overwhelm any potential benefits of philopatry or breeding experience. We examined the effect of site fidelity on reproductive success in 1,823 bobolink and Savannah sparrow nests in agricultural grasslands in Vermont, USA. From 2003–2019 we monitored the nests of 51 female Savannah sparrows and 72 female bobolinks that returned to breed on or near fields in which they hatched between …

Adaptive Training With Cloud-Based Simulators In Maritime Education, Simen Hjellvik, Steven Mallam

International Maritime Lecturers' Association (IMLA) 2021 Joint Conference With IMEC32, ICERS15 and INSLC21

Maritime cloud-based simulation is an emerging technological development that creates a new condition for decentralized interaction where it's content and functionality mirrors traditional on-site-simulator software. This paper uses a quasi-experimental study to examine a training design that is adaptive to the trainee. The training goal is to deliver traditional learning outcomes of comprehension and familiarity with the operation of steering gear systems. The simulator training was administered through novel cloud-based simulator technology to a sample comprising of first year students in nautical sciences (n=12) and marine engineering (n=6) at the college and university level in Norway who had no previous …

Upadacitinib, Inderbir S. Padda, Rajat Bhatt, Mayur S. Parmar

HPD Articles

No abstract provided.

The Effects Of Roadways On The Spatial And Temporal Movement Patterns Of Timber Rattlesnakes (Crotalus Horridus), Anna F. Tipton, Dominic L. Desantis

Graduate Research Showcase

Roadways are among the most widespread and disruptive anthropogenic land use features that influence the behavior and movement of wildlife. Negative impacts include vehicle-induced mortality, habitat destruction and fragmentation, and creating barriers to movement which can have far-reaching sub-lethal effects. In an effort to improve upon historical methods of evaluating the influence of prominent landscape features, such as roads, on the movement of small and secretive wildlife, we are using a novel integration of emerging spatial analyses and tri-axial accelerometry in Timber Rattlesnakes (Crotalus horridus) from central Georgia. We used dynamic Brownian Bridge Movement Models to estimate motion …

Of Prosecutors And Prejudice (Or "Do Prosecutors Have An Ethical Obligation Not To Say Racist Stuff On Social Media?"), Alex B. Long

Scholarly Works

Over the past few years, there have been numerous news stories about prosecutors posting racially inflammatory content on their social media accounts. There have also been several incidents in recent years in which prosecutors have commented on matters of public concern on social media in a way that is not overtly racist but nonetheless raises legitimate concerns over the prosecutors’ integrity and appreciation of the special role that prosecutors play. Concerns over the extent to which prosecutors bring their personal biases into the courtroom have only increased in recent years and have contributed to the doubts as to the overall …

Vectra 3d (Dinotefuran, Pyriproxyfen And Permethrin) Prevents Acquisition Of Borrelia Burgdorferi Sensu Stricto By Ixodes Ricinus And Ixodes Scapularis Ticks In An Ex Vivo Feeding Model, Djamel Tahir, Btissam Asri, Leon Nicolaas Meyer, Alec Evans, Thomas N. Mather, Byron Blagburn, Reinhard K. Straubinger, Valérie Choumet, Frans Jongejan, Marie Varloud

Plant Sciences and Entomology Faculty Publications

Background

We evaluated the efficiency of an ex vivo feeding technique using a silicone membrane-based feeding chamber to (i) assess the anti-feeding and acaricidal efficacy of a spot-on combination of dinotefuran, pyriproxyfen and permethrin (DPP, Vectra® 3D) against adult Ixodes scapularis and Ixodes ricinus ticks, and to (ii) explore its effect on blocking the acquisition of Borrelia burgdorferi sensu stricto.

Methods

Eight purpose-bred dogs were randomly allocated to two equal-size groups based on body weight assessed on day 2. DPP was administered topically, as spot-on, to four dogs on day 0. Hair from the eight dogs was collected individually by …

How Music Theory Sequencing Can Improve Classroom Management And Attention Issues In Beginner Students' Piano Lessons, Greta Dilyte

Musicology and Ethnomusicology: Student Scholarship

This research has been inspired by an observation of the different music-theoretical concepts and their sequencing in different piano methods. After working in three different countries as a piano teacher I wanted to explore differences and similarities as well as improve my lesson engagement level by beginning students, which is admittedly the most complicated level to teach mainly due to the focus maintenance issues. This is the evidence of my preliminary research which can be used and explored by any piano teacher who is interested in incorporating music theory concepts in their classroom, to help with attention issues, more all-rounded …

Center For Community Engagement And Social Change End Of Year Report 2020 - 2021, Lawrence University

CCE Annual Reports

No abstract provided.

A Democratic Turn Within Democratic Socialism? State-Centric And Anti-Statist Visions Of Socialism And The Challenge Of Democratic Mirroring, Ali Aslam, David W. Mcivor, Joel Alden Schlosser

Political Science Faculty Research and Scholarship

In this paper, we theorize the democratic aspect of democratic socialism through some of its recent, theoretical articulations and several of its historical, fugitive appearances. To illustrate a potential democratic turn, we highlight how these moments reflect a paradox of democratic spirit: the necessity of cultivating collective consciousness of popular power, while also acknowledging the limits of this power through a lingering attachment to the liberal democratic state as the means of achieving or supporting a democratic socialist vision. We call this democratic mirroring, which exceeds a concept of representation centered on the constitutional state. Although the state should be …