Digital Commons Network^™

Modeling Residence Time Distribution Of Chromatographic Perfusion Resin For Large Biopharmaceutical Molecules: A Computational Fluid Dynamic Study, Kevin Vehar

KGI Theses and Dissertations

The need for production processes of large biotherapeutic particles, such as virus-based particles and extracellular vesicles, has risen due to increased demand in the development of vaccinations, gene therapies, and cancer treatments. Liquid chromatography plays a significant role in the purification process and is routinely used with therapeutic protein production. However, performance with larger macromolecules is often inconsistent, and parameter estimation for process development can be extremely time- and resource-intensive. This thesis aimed to utilize advances in computational fluid dynamic (CFD) modeling to generate a first-principle model of the chromatographic process while minimizing model parameter estimation's physical resource demand. Specifically, …

Adaptive Courseware Implementation: Investigating Alignment, Course Redesign, And The Student Experience, Patricia O'Sullivan, Janelle De Carrico Voegele, Tonya Buchan, Raiza Dottin, Kari Goin Kono, Misty Hamideh, Wendy S. Howard, Jennifer Todd, Stanley Kruse, Johannes De Gruyter, Kevin Berg

Curriculum and Instruction Faculty Publications and Presentations

In this paper, four institutions share student and faculty feedback on the implementation of adaptive courseware through a common case study: biology for undergraduate non-majors. Additionally, each institution has provided a second case study of their choice. Together, researchers at Colorado State University in Fort Collins, CO, Portland State University in Portland, OR, University of Central Florida in Orlando, FL, and the University of Mississippi in Oxford, MS consider student perception of the benefits to the implementation of adaptive courseware, and how the deliberate alignment between adaptive courseware and course organization and structure impacts student experience. This paper highlights the …

Designing And Teaching Adaptive+Active Learning Effectively, Peter Van Leusen, James Cunningham, Dale P. Johnson

Current Issues in Emerging eLearning

To fulfill the promise of providing all learners with access to education, institutions of higher education are exploring personalized learning for individuals with different skills, abilities, and interests. These universities have turned to an instructional model that combines adaptive courseware and learner-centered instruction. This is often referred to as active learning. Despite growth in adaptive courseware and generous support through national organizations, successful implementation of adaptive systems is mixed (SRI Education, 2016). This article highlights the need for a systems approach and illustrates this approach through design and pedagogy decisions that have contributed to the success of adaptive learning at …

Llamas Are Having A Moment In The Us, But They’Ve Been Icons In South America For Millennia, Emily Wakild

History Faculty Publications and Presentations

With their long eyelashes, banana-shaped ears, upturned mouths and stocky bodies covered with curly wool, llamas look like creatures that walked out of a Dr. Seuss story. And now they’re celebrities in the U.S.

2020-12-18_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

The webpage was obtained from Michigan's Coronavirus Cumulative Data page, under the link Hospitals. Data is self-reported by hospitals daily to the EM Resource System per MDHHS Director Robert Gordon's Emergency Order.

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

2020-12-18_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. It is updated Monday - Saturday.
This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) and rapid virus antigen detection point of …

Teaching Strategies Of English Tag Questions, Xinyun Wang

Education Division Scholarship

No abstract provided.

Coronavirus Update 12-18-2020, The Coronavirus Planning Team

University Briefings & Virtual Events

As we conclude the semester, the dashboard shows us with 63 active cases. During the break, we will be updating the dashboard weekly on Thursdays. We will go back to daily updates once we are back on campus for spring.

Roy Goines, Kelli Johnson

Publications

Roy Goines was born on January 3,1938 in Barboursville, West Virginia, to a family with five sisters and two brothers. Goines attended Douglass High School in Huntington, West Virginia and graduated in 1955. He received a scholarship to play football at Marshall University where he studied accounting. At Marshall University, Goines was on the Dean’s List, listed on the Who’s Who list of students, and was second in command of the ROTC.

2020-12-18_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

By-Laws & Standing Order Review Committee Meeting - Packet 12/18/2020, Uc Hastings Board Of Directors

2020 Board of Directors Agenda and Materials

No abstract provided.

Zhaojin Ke V. Philadelphia Parking Authority

2020 Decisions

USDC for the Eastern District of Pennsylvania

Richard Thompson V. Administrator New Jersey State

2020 Decisions

USDC for the District of New Jersey

Utility Workers United Associa V. Pennsylvania American Water Co

2020 Decisions

USDC for the Western District of Pennsylvania

Screen Actors Guild American F V. Sheridan Broadcasting Networks

2020 Decisions

USDC for the Western District of Pennsylvania

Core Commitments For Field Trials Of Gene Drive Organisms, Kanya C. Long, Luke Alphey, George J. Annas, Cinnamon S. Bloss, Karl J. Campbell, Jackson Champer, Chun-Hong Chen, Amit Choudhary, George M. Church, James P. Collins, Kimberly L. Cooper, Jason A. Delborne, Owain R. Edwards, Claudia I. Emerson, Kevin Esvelt, Sam Weiss Evans, Robert M. Friedman, Valentino M. Gantz, Fred Gould, Sarah Hartley, Elizabeth Heitman, Janet Hemingway, Hirotaka Kanuka, Jennifer Kuzma, James V. Lavery, Yoosook Lee, Marce Lorenzen, Jeantine E. Lunshof, John M. Marshall, Philipp W. Messer, Craig Montell, Kenneth A. Oye, Megan J. Palmer, Philippos Aris Papathanos, Prasad N. Paradkar, Antoinette J. Piaggio, Jason L. Rasgon, Gordana Rašić, Larisa Rudenko, J. Royden Saah, Maxwell J. Scott, Jolene T. Sutton, Adam E, Vorsino, Omar S. Akbari

United States Department of Agriculture Wildlife Services: Staff Publications

We must ensure that trials are scientifically, politically, and socially robust, publicly accountable, and widely transparent.

Gene drive organisms (GDOs), whose genomes have been genetically engineered to spread a desired allele through a population, have the potential to transform the way societies address a wide range of daunting public health and environmental challenges. The development, testing, and release of GDOs, however, are complex and often controversial. A key challenge is to clarify the appropriate roles of developers and others actively engaged in work with GDOs in decision-making processes, and, in particular, how to establish partnerships with relevant authorities and other …

Jellison Duerr Recognized For Media Mentions, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

By-Laws Standing Order Review Committee Meeting - Agenda 12/18/2020, Uc Hastings Board Of Directors

2020 Board of Directors Agenda and Materials

No abstract provided.

The Crossroads Of Wellness And Second Victim Syndrome: Identifying Factors That Alter The Pathway Of Caregiver Recovery Following An Unanticipated Adverse Patient Outcome, Kimia Zarabian, A. Katharine Hindle, Ivy Benjenk, Anita Vincent, Jamil M. Kazma, Benjamin Shambon, Raymond Pla, Eric Heinz

Journal of Wellness

Introduction: Second Victim Syndrome (SVS) describes the phenomenon in which a caregiver experiences a traumatic psychological and emotional response to an adverse patient event or medical error. Using quantitative survey analysis, we aim to better understand the personal factors that affect SVS development and recovery.

Methods: Caregivers at a small urban academic medical center who had experienced an adverse patient event in the past six months were invited to take part in this institution-wide, voluntary, quantitative, cross-sectional study. Three surveys were administered; the Holmes-Rahe Life Stress Inventory (HRLSI) was used as a surrogate to measure stressful life events. The …

Reciprocal Empathy: Reversing Antipathy Towards Immigrants In Emotion And Votes, Amanda Gach

Undergraduate Honors Theses

The topic of immigration politics has gained traction in recent years as surges of immigrants are introduced to new homes—often with a long road of integration into the host country ahead. As a result, debates emerged on how to effectively “humanize” members of these outgroups – which include immigrants and refugees alike—while also being able to forge lasting cooperation between these ethnic groups allowing for peaceful integration. Previous attempts to achieve this goal have used various forms of visual and sensory media to generate empathy towards these outgroup members. These approaches have proven to be ineffective when not met with …

In Re: Jeremey Melvin

2020 Decisions

USDC for the Middle District of Pennsylvania

Loss-Of-Function Genomic Variants Highlight Potential Therapeutic Targets For Cardiovascular Disease, Jonas B. Nielsen, Oren Rom, Ida Surakka, Sarah E. Graham, Wei Zhou, Tanmoy Roychowdhury, Lars G. Fritsche, Sarah A. Gagliano Taliun, Carlo Sidore, Yuhao Liu, Maiken E. Gabrielsen, Anne Heidi Skogholt, Brooke Wolford, William Overton, Ying Zhao, Jin Chen, He Zhang, Whitney E. Hornsby, Akua Acheampong, Austen Grooms, Amanda Schaefer, Gregory J. M. Zajac, Luis Villacorta, Jifeng Zhang, Ben Brumpton, Mari Løset, Vivek Rai, Pia R. Lundegaard, Morten S. Olesen, Kent D. Taylor, Donna K. Arnett

Epidemiology and Environmental Health Faculty Publications

Pharmaceutical drugs targeting dyslipidemia and cardiovascular disease (CVD) may increase the risk of fatty liver disease and other metabolic disorders. To identify potential novel CVD drug targets without these adverse effects, we perform genome-wide analyses of participants in the HUNT Study in Norway (n = 69,479) to search for protein-altering variants with beneficial impact on quantitative blood traits related to cardiovascular disease, but without detrimental impact on liver function. We identify 76 (11 previously unreported) presumed causal protein-altering variants associated with one or more CVD- or liver-related blood traits. Nine of the variants are predicted to result in loss-of-function of …

The Survival Rate Of Colorectal Cancer In Dr. Cipto Mangunkusumo Hospital, Wifanto S. Jeo, Feyona H. Subrata

The New Ropanasuri Journal of Surgery

Introduction. Colorectal cancer (CC) is a malignancy with the third highest incidence and the second cause of death. 1.4 million new cases of colorectal cancer occurred in 2012, increasing to 1.8 million new cases in 2019, with almost 900,000 deaths caused by CC in the world. In Indonesia, there were 30,017 new cases of CC in 2019, with fatalities reaching nearly 16,000 cases. There are differences in the survival rates of the CC between developed countries and Indonesia. This study aims to determine the survival rate of CC patients in Indonesia.

Method. A retrospective cohort study design with …

The Efficiency Of Well-Written Manuals Aided-Hand Knotting Skills Acquisition For Undergraduates, Theddeus O.H Prasetyono, Putri Rezkini

The New Ropanasuri Journal of Surgery

Introduction. Standard procedural skills training methods include tutorial, workshop, and feedback. Written manuals might add value to those standard methods; nevertheless, depends on how well they are composed. This research is aimed to evaluate the efficiency of well-written manuals of hand knotting skills in order to improve students’ procedural skills learning and competency.

Methods. This research was conducted through preliminary study to identify the assessor reliability and main study to evaluate the students’ scores for reef and surgeon’s knots using an objective structured assessment of technical skills (OSATS). Subjects’ preparedness and perception of the quality of the manuals …

The Application Of Bromelain Enzyme On Pig Skin To Be Used As Surgery Training Model, Theddeus O.H Prasetyono, Christopher R. Andrian, Elisabet L.A Kinanthi, Siti R.K Putri

The New Ropanasuri Journal of Surgery

Introduction. Postmortem changes in pigskin made it difficult to be manipulated as a model for advanced technique in surgery training. The use of bromelain enzyme on these pigskins could be an alternative way to obtain the ideal surgery training model.

Method. Thirty-five pigskin-blocks (10×15cm) was divided evenly into seven groups consisted of six groups of different bromelain enzyme treatment (4g/20min, 4g/40min, 8g/20min, 8g/40min, 12g/20min, 12g/40min) and one group of control. Then five chief-plastic-surgery-residents blindly assessed and scored each pigskin and compared its likeliness to the back of human skin. The scores were then analyzed with an interrater reliability …

The Use Of Laparoscopy In Treatment Of Perforated Peptic Ulcer: A Literature Review, Alif R. Soeratman, Agi S. Putranto

The New Ropanasuri Journal of Surgery

No abstract provided.

Management Of Uncomplicated Stanford Type B Aortic Dissection : A Literature Review:, Zamzania A. Shalih, Akhmadu Muradi

The New Ropanasuri Journal of Surgery

No abstract provided.

Atypical Presentation Of Acute Appendicitis: A Case Report, Yudhistira Pradnyan Kloping, R. Cita Resti Anantia Putri

The New Ropanasuri Journal of Surgery

Despite the fact that acute appendicitis is one of the most common surgical emergencies worldwide, delays in establishing a diagnosis still occur. We report a case of acute appendicitis with an atypical presentation based on the patient’s clinical and laboratory findings. A 25-year-old male was brought with pain in his right lower quadrant. Pain migration, fever, anorexia, nausea, vomiting, or dysuria were denied. Laboratory results were within normal limits. USG examination was not able to visualize the appendix. An abdominal CT-Scan showed a sign of acute appendicitis. The patient was planned for appendectomy. It is important to not immediately rule …

Transanastomotic Feeding Tube In Surgical Management Of Congenital Duodenal Obstruction: Case Series, Hardian Gunardi, Asri D. Rachmawati, Nanok E. Susilo, Riana P. Tamba

The New Ropanasuri Journal of Surgery

Introduction. Prolonged fasting is a major concern in the postoperative management of congenital duodenal obstruction. Massive dilatation of the proximal segment would lead to diameter discrepancy and lack of propulsion, thus delaying enteral feeding. A transanastomotic feeding tube is an option to deliver early enteral feeding after surgical correction. The study evaluates the effectiveness and safety of a transanastomotic feeding tubes in the surgical management of congenital duodenal obstruction.

Method. The transanastomotic feeding tube's effectiveness in cases of congenital duodenal obstruction of the newborn underwent surgical correction was evaluated. Those managed from January 2016 to December 2018 at …

Final Outcome Of Hybrid Laparoscopic For Colorectal Cancer: A Literature Review, Dyan Novitalia, Yarman Mazni

The New Ropanasuri Journal of Surgery

No abstract provided.