Digital Commons Network^™

Vowel Dynamics Of The Low Vowels In Cowlitz County, Washington, Joseph A. Stanley

Faculty Publications

Q1: Does Cowlitz County participate in the Elsewhere Shift?

BOT/BOUGHT:

• Not 100% merged.
• Have been in a stable near-merger since the 1930s.
• Hypothesis: Started when area was being settled (1850s–1920s) because of the demographic shift.

/æ/ BAT:

• Slowly lowering over 4 generations (since at least the 1930s)
• Women consistently ahead of the men - change in progress for over 60 years.
• Hypothesis: Began in earnest when Longview was founded (mid 1920s), in addition to language-internal pressure.

Letter On “Protection By Exclusion? The (Lack Of) Inclusion Of Adults Who Lack Capacity To Consent To Research In Clinical Trials In The Uk”, Sarah Griffiths, Lorna Manger, Rebecca Chapman, Lauren Weston, Ian Sherriff, Cath Quinn, Paul Clarkson, Caroline Sutcliffe, Karen Davies, Richard Byng

Peninsula Medical School

Dear editors, We read with interest the recent article regarding the lack of inclusion of people who lack capacity in trials: ‘Protection by exclusion? The (lack of) inclusion of adults who lack capacity to consent in clinical trials in the UK’. As the authors so eloquently spotlight, those without capacity in many population groups are those who are likely to be most vulnerable to frailty, comorbidities and isolation. Their exclusion from research significantly limits the specific evidence base for their care. As a research team developing and evaluating a Dementia Support Worker intervention based in primary care, we appreciate the …

Fibroscan-Ast (Fast) Score For The Non-Invasive Identification Of Patients With Non-Alcoholic Steatohepatitis With Significant Activity And Fibrosis: A Prospective Derivation And Global Validation Study, Philip N. Newsome, Magali Sasso, Jonathan J. Deeks, Angelo Paredes, Jérôme Boursier, Wah Kheong Chan, Yusuf Yilmaz, Sébastien Czernichow, Ming Hua Zheng, Vincent Wai Sun Wong, Michael Allison, Emmanuel Tsochatzis, Quentin M. Anstee, David A. Sheridan, Peter J. Eddowes, Indra N. Guha, Jeremy F. Cobbold, Valérie Paradis, Pierre Bedossa, Véronique Miette, Céline Fournier-Poizat, Laurent Sandrin, Stephen A. Harrison

Peninsula Medical School

No abstract provided.

Ehealth Technologies And The Know-Do Gap: Exploring The Role Of Knowledge Mobilisation, Sheena Asthana, Rod Sheaff, Ray Jones, Arunangsu Chatterjee

Peninsula Medical School

Background: eHealth technologies are widely believed to contribute to improving health and patients’ experience of care and reducing health system costs. While many studies explore barriers to and facilitators of eHealth innovation, we lack understanding of how this knowledge can be translated into workable, practicable and properly resourced knowledge mobilisation (KM) strategies. Aims and objectives: This paper describes the aims, methods and outputs of a large European Union funded project (eHealth Productivity and Innovation in Cornwall and the Isles of Scilly (EPIC)) to support the development of a sustainable innovation ecosystem in Cornwall and the Isles of Scilly, in order …

Constitutive Activation Of The Egfr–Stat1 Axis Increases Proliferation Of Meningioma Tumor Cells, Sara Ferluga, Daniele Baiz, David A. Hilton, Claire L. Adams, Emanuela Ercolano, Jemma Dunn, Kayleigh Bassiri, Kathreena M. Kurian, Clemens O. Hanemann

Peninsula Medical School

Abstract Background Meningiomas are the most frequent primary brain tumors of the central nervous system. The standard of treatment is surgery and radiotherapy, but effective pharmacological options are not available yet. The well-characterized genetic background stratifies these tumors in several subgroups, thus increasing diversification. We identified epidermal growth factor receptor–signal transducer and activator of transcription 1 (EGFR–STAT1) overexpression and activation as a common identifier of these tumors. Methods We analyzed STAT1 overexpression and phosphorylation in 131 meningiomas of different grades and locations by utilizing several techniques, including Western blots, qPCR, and immunocytochemistry. We also silenced and overexpressed wild-type and mutant …

Is The Market Surprised By The Surprise?, Khine Kyaw, Mojisola Olugbode, Barbara Petracci

Plymouth Business School

This study examines how the market reacts to earnings surprises with different characteristics such as future earnings prospects and historical surprises embedded in the earnings announced. We also explore the effect of corporate governance on market reaction to earnings information disseminated through earnings announcements. The sample comprises of 1620 US firms for the period 2002–2016. Using a regression-based approach, the results reveal that the market reacts to earnings surprises, particularly, to their sign, magnitude, persistence, and the future earnings prospects. Moreover, these different characteristics of earnings surprises are more important for negative surprises than for positive surprises. Furthermore, we find …

Reforming Medical Regulation: A Qualitative Study Of The Implementation Of Medical Revalidation In England, Using Normalization Process Theory, Abigail Tazzyman, Jane Ferguson, Alan Boyd, Marie Bryce, John Tredinnick-Rowe, Tristan Price, Kieran Walshe

Peninsula Medical School

Objectives The introduction of medical revalidation in 2012 has been a controversial and radical change to medical regulation in the UK. It involved changes to the way organizations manage medical performance, and to the relationships between doctors, their employers and the professional regulatory body. In this paper, we explore the implementation of medical revalidation, analysing the change process and its consequences for doctors and organizations. Methods We conducted a qualitative investigation of the implementation of revalidation in 15 case study organizations in 2016–2017, collecting documents and undertaking a total of 80 interviews with medical and non-medical staff. We used Normalization …

Efficacy Of Three Neuroprotective Drugs In Secondary Progressive Multiple Sclerosis (Ms-Smart): A Phase 2b, Multiarm, Double-Blind, Randomised Placebo-Controlled Trial, Jeremy Chataway, Angelis F De, Peter Connick, Ra Parker, Domenico Plantone, Anisha Doshi, Nevin John, Jonathan Stutters, David Macmanus, Carrasco F Prados, Frederik Barkhof, Sebastien Ourselin, Marie Braisher, Moira Ross, Gina Cranswick, Sue H. Pavitt, Gavin Giovannoni, Wheeler-Kingshott Ca Gandini, Clive Hawkins, Basil Sharrack, Roger Bastow, Christopher J. Weir, Nigel Stallard, Siddharthan Chandran, Jeremy Chataway, Wheeler-Kingshott Cam Gandini, Angelis F De, Domenico Plantone, Anisha Doshi, Dawn Lyle, Thomas Williams, Marie Braisher, Tiggy Beyene, Vanessa Bassan, Alvin Zapata, Siddharthan Chandran, Peter Connick, Dawn Lyle, James Cameron, Daisy Mollison, Shuna Colville, Baljean Dhillon, Christopher J. Weir, Ra Parker, Moira Ross, Gina Cranswick, Gavin Giovannoni, Sharmilee Gnanapavan, Richard Nicholas, Waqar Rashid, Julia Aram, Helen Ford, James Overell, Carolyn Young, Heinke Arndt, Martin Duddy, Joe Guadagno, Nikolaos Evangelou, Matthew Craner, Jacqueline Palace, Jeremy Hobart, Basil Sharrack, David Paling, Clive Hawkins, Seema Kalra, B Mclean, Nigel Stallard, Roger Bastow

Peninsula Medical School

No abstract provided.

Cognition And Its Relation To Brain Health In Patients With Ms: Response To Letter, Jeremy Hobart, Gavin Giovannoni

Peninsula Medical School

No abstract provided.

Contrasting Impact Of Androgens On Male And Female Adiposity, Fat Distribution And Insulin Resistance In Childhood And Adolescence (Earlybird 75), Jade Chynoweth, Joanne Hosking, Alison Jeffery, Jonathan Pinkney

Peninsula Medical School

Objectives: To investigate associations between androgens (testosterone, dehydroepiandrosterone sulphate [DHEAS] and androstenedione), adiposity, fat distribution and insulin resistance (IR) during childhood and adolescence. Methods: Three hundred and seven children (170 [55.4%] boys; 137 [44.6%] girls)recruited at age 5 and studied annually until age 16: androgens (liquid chromatography tandem-mass spectrometry), anthropometry, body composition (dual-energy x-ray absorptiometry) and IR (homeostasis model assessment). Results: Early adiposity was associated with earlier detection of androstenedione in both sexes, and DHEAS in boys. At puberty, higher androgen levels were associated with favourable metabolic changes in boys, but adverse metabolic effects in girls. In boys, higher free …

Assessment Of Patients With Lower Urinary Tract Symptoms Where An Undiagnosed Neurological Disease Is Suspected: A Report From An International Continence Society Consensus Working Group, Holly A. Roy, Jeremy Nettleton, Camilla Blain, Catherine Dalton, Bilal Farhan, Ailton Fernandes, Petros Georgopoulos, Sabine Klepsch, John Lavelle, Evangelista Martinelli, Jalesh N. Panicker, Ivan Radoja, Christina Anastasia Rapidi, E Silva R Pereira, Katarina Tudor, Adrian S. Wagg, Marcus J. Drake

Peninsula Medical School

AimLower urinary tract symptoms (LUTS) are a common urological referral, which sometimes can have a neurological basis in a patient with no formally diagnosed neurological disease (“occult neurology”). Early identification and specialist input is needed to avoid bad LUTS outcomes, and to initiate suitable neurological management.MethodsThe International Continence Society established a neurological working group to consider: Which neurological conditions may include LUTS as an early feature? What diagnostic evaluations should be undertaken in the LUTS clinic? A shortlist of conditions was drawn up by expert consensus and discussed at the annual congress of the International Neurourology Society. A multidisciplinary working …

Β-Cell Glucose Sensitivity Determines Hyperglycaemia In Polycystic Ovary Syndrome, J Tomlinson, A Mari, A Tura, K Bond, E Stenhouse, T Dew, Rp Vincent, J Pinkney

Peninsula Medical School

Aims To investigate the mechanism of hyperglycaemia in women with Polycystic Ovary Syndrome (PCOS) by modelling physiological insulin secretion. Methods 45 non-diabetic women with PCOS (defined by Rotterdam criteria) and 47 controls were studied. Insulin secretion was modelled from glucose and C-peptide concentrations during a 6-point oral glucose tolerance test (OGTT) and insulin resistance (IR) was determined by the Matsuda Insulin Sensitivity Index (ISI). Results (1). β-Cell Glucose Sensitivity (βCGS) is not intrinsically impaired in PCOS, but IR is increased. (2) However, women with PCOS and 2-hour hyperglycaemia (glucose >7.5 mmol/l]) were characterized by worse βCGS compared with women with …

Ocd Candidate Gene Slc1a1/Eaat3 Impacts Dopamine Neuron Firing And Behavioral Flexibility, M Chohan, J Kopelman, E Kramer, P Balsam, S Ahmari, J Veenstra-Vanderweele

Peninsula Medical School

No abstract provided.

Applicability, Safety, And Biological Activity Of Regulatory T Cell Therapy In Liver Transplantation, A Sánchez‐Fueyo, Gavin Whitehouse, Nathali Grageda, Matthew E. Cramp, Tiong Y. Lim, Marco Romano, Sarah Thirkell, Katie Lowe, Laura Fry, Julie Heward, Alex Kerr, Jakia Ali, Chris Fisher, Gillian Lewis, Andrew Hope, Elisavet Kodela, Mike Lyne, Farzin Farzaneh, Shahram Kordasti, I Rebollo‐Mesa, Lozano J Jose, Niloufar Safinia, Nigel Heaton, Robert Lechler, M Martínez‐Llordella, Giovanna Lombardi

Peninsula Medical School

Regulatory T cells (Tregs) are a lymphocyte subset with intrinsic immunosuppressive properties that can be expanded in large numbers ex vivo and have been shown to prevent allograft rejection and promote tolerance in animal models. To investigate the safety, applicability, and biological activity of autologous Treg adoptive transfer in humans, we conducted an open-label, dose-escalation, Phase I clinical trial in liver transplantation. Patients were enrolled while awaiting liver transplantation or 6-12 months posttransplant. Circulating Tregs were isolated from blood or leukapheresis, expanded under good manufacturing practices (GMP) conditions, and administered intravenously at either 0.5-1 million Tregs/kg or 3-4.5 million Tregs/kg. …

The Effectiveness Of A Therapeutic Parenting Program For Children Aged 6-11 Years With Behavioural Or Emotional Difficulties: Results From A Randomized Controlled Trial, Nick Axford, Gretchen Bjornstad, Justin Matthews, Sarah Heilmann, Anam Raja, Obioha C. Ukoumunne, Vashti Berry, Tom Wilkinson, Luke Timmons, Tim Hobbs, Tim Eames, Angeliki Kallitsoglou, Sarah Blower, Georgina Warner

Peninsula Medical School

Objective The aim of the study was to evaluate the implementation and effectiveness of a therapeutic parenting program that targets parents of children aged 6 to 11 years identified as having behavioral and emotional difficulties. The intervention comprises two parts, delivered sequentially: a 10–12-week group-based program for all parents, and one-to-one sessions for up to 12 weeks with selected parents from the group-based element. Methods/Design In a randomized controlled trial, 264 participants were allocated to the Inspiring Futures program (intervention) or services as usual (control) arms with follow-up assessments at 16 (post-group program) and 32 (post-one-to-one sessions) weeks. The primary …

Disease Severity Accounts For Minimal Variance Of Quality Of Life In People With Dementia And Their Carers: Analyses Of Cross-Sectional Data From The Modem Study, N Farina, Derek King, C Burgon, S Berwald, E Bustard, Y Feeney, R Habibi, A Comas-Herrera, Martin Knapp, S Banerjee

Peninsula Medical School

No abstract provided.

Smartphone-Based Optical Assays In The Food Safety Field, J. L.D. Nelis, A. S. Tsagkaris, M. J. Dillon, J. Hajslova, C. T. Elliott

Peninsula Medical School

No abstract provided.

The Good Lawyer: State-Led Professional Socialization In Contemporary China, Lawrence J. Liu, Rachel E. Stern

Scholarship@WashULaw

How do authoritarian states define and communicate notions of appropriate work conduct and professional excellence? This article examines three channels of communication used by the Chinese state to signal professional expectations to the bar: the bar exam, the administrative rules governing lawyers, and the state-sanctioned National Outstanding Lawyer Award. We find that China’s state narrative about “the good lawyer” celebrates lawyers willing to work closely with the authorities and asks more stringent critics to separate private beliefs from public behavior. In contrast to assumptions often made in research on authoritarian law, this article highlights how lawyers can participate in politics …

Financial Freedom Suits: Bankruptcy, Race, And Citizenship In Antebellum America, Rafael I. Pardo

Scholarship@WashULaw

This Article presents a new frame of reference for thinking about how the federal government facilitated citizenship claims by free people of color in the antebellum United States. While scholars have accounted for various ways in which free black litigants may have made such claims, they have not considered how the Bankruptcy Act of 1841 enabled overindebted free people of color to reconstruct their economic lives, thereby restoring the financial freedom that was and continues to be an essential component of American citizenship. Relying on a variety of primary sources, including manuscript court records, this Article shows how six free …

A Reformulated Contextual Model Of Psychotherapy For Treating Anxiety And Depression, Michael E. Hyland

School of Psychology

This paper describes a reformulated contextual model that uses cognitive theory (dual process theory), motivation theory (personality) and behavioral adaptation (self-correcting control systems) to show how anxiety and depression are caused, treated and prevented by an interaction between people and contexts. Depression and anxiety are the result of implicit beliefs (not cognitions) that all experience is unrewarding and threatening, these being components of the implicit belief that life is bad. Implicit beliefs are formed automatically from contextual cues and in healthy individuals are consistent with rational appraisal. They become more negative than reality through a process of adaptation when behaviors, …

New Testament Interpretation, Terris Neuman

Syllabus Repository

No abstract provided.

Developmental Biology (Embryology) Course Syllabus And Policies, Steelman Library, Todd D. Schraw Dr.

Syllabus Repository

No abstract provided.

Beginning Hebrew B, Steelman Library, Daniel Mcnaughton Dr.

Syllabus Repository

No abstract provided.

Beginning Hebrew B, Steelman Library, Daniel Mcnaughton Dr.

Syllabus Repository

No abstract provided.

Annual Security Report For Calendar Year 2019, Illinois State University Police Department

Clery Act Annual Security Report

Illinois State University Police Department Annual Security Report

Who Benefits From A Prostate Rectal Spacer? Secondary Analysis Of A Phase Iii Trial, Thomas J. Quinn, Walter Bosch, Et Al.

2020-Current year OA Pubs

PURPOSE: Previously a phase III trial of a hydrogel rectal spacer during prostate radiation therapy found decreased toxicity and a clinically significant improvement in bowel quality of life (QOL) at 3 years by the Expanded Prostate Cancer Index. We performed a secondary analysis to identify men less likely to benefit.

METHODS AND MATERIALS: Clinical and dosimetric data for the 222 patients enrolled on the SpaceOAR phase III trial were analyzed. The volume of rectum treated to 70 Gy (V70) and the quantitative analysis of normal tissue effects in the clinic (QUANTEC) rectal dose goals were used as surrogates for clinical …

Bipa: The Most Important Biometric Privacy Law In The Us?, Woodrow Hartzog

Faculty Scholarship

In May 2020, Clearview AI abruptly ended all service contracts with all non-law enforcement entities based in Illinois. The reason? It hoped to avoid an injunction and potentially large damages under one of the most important privacy laws in America: the Illinois Biometric Information Privacy Act (BIPA).

Semi-Automated Segmentation Of The Lateral Periventricular Regions Using Diffusion Magnetic Resonance Imaging, Albert M Isaacs, Rowland H Han, Christopher D Smyser, David D Limbrick, Joshua S Shimony

2020-Current year OA Pubs

The lateral ventricular perimeter (LVP) of the brain is a critical region because in addition to housing neural stem cells required for brain development, it facilitates cerebrospinal fluid (CSF) bulk flow and functions as a blood-CSF barrier to protect periventricular white matter (PVWM) and other adjacent regions from injurious toxins. LVP injury is common, particularly among preterm infants who sustain intraventricular hemorrhage or post hemorrhagic hydrocephalus and has been associated with poor neurological outcomes. Assessment of the LVP with diffusion MRI has been challenging, primarily due to issues with partial volume artifacts since the LVP region is in close proximity …

Presidents Must Be Elected Popularly: Examining Proposals And Identifying The Natural Endpoint Of Electoral College Reform, Gianni Mascioli, Caroline Kane, Meira Nagel, Michael Mcgarry, Ezra Medina, Jenny Brejt, Siobhan D'Angelo

Faculty Scholarship

The Electoral College effectively disenfranchises voters who live outside the few states that decide presidential elections. This report endorses a change in the way electoral votes are allocated to ensure that Americans’ votes receive the same weight. States should sign on to the National Popular Vote Interstate Compact, an agreement among states to allocate their electoral votes to the winner of the national popular vote. Ranked choice voting should also be employed to ensure that candidates receive majority support.

This report was researched and written during the 2018-2019 academic year by students in Fordham Law School’s Democracy and the Constitution …

Primal-Dual 2-Approximation Algorithm For The Monotonic Multiple Depot Heterogeneous Traveling Salesman Problem, S. Rathinam, R. Ravi, J. Bae, K. Sundar

Michigan Tech Publications, Part 1

We study a Multiple Depot Heterogeneous Traveling Salesman Problem (MDHTSP) where the cost of the traveling between any two targets depends on the type of the vehicle. The travel costs are assumed to be symmetric, satisfy the triangle inequality, and are monotonic, i.e., the travel costs between any two targets monotonically increases with the index of the vehicles. Exploiting the monotonic structure of the travel costs, we present a 2-approximation algorithm based on the primal-dual method.