Digital Commons Network^™

Is Direct Transport To A Level I Trauma Center Associated With Better Outcomes In Patients With Traumatic Brain Injury Compared To Patients That Are Transferred To Trauma Level I From Other Hospitals, Narad Mishra

Theses and Dissertations

Transferring patients with traumatic brain injury (TBI) to trauma level I hospital from other lower level hospitals has been shown to increase the mortality compared to when patients are directly transported to trauma centers. Despite the results from studies and the field triage recommendation of transporting the TBI patients to trauma center, nearly half of the TBI cases are transported to other hospitals before transferring to the trauma center. A retrospective analysis of patients with TBI in the state of Virginia was carried out to access if direct transport of patients with TBI to trauma center improves the outcome compare …

Come And Get Your Capital, Sis: The Use Of Twitter To Compensate For Gendered And Racialized Job Networks Among Creatives, Sasha A. Pierre- Louis

Theses and Dissertations

Due to racialized and gendered exclusion and discrimination, Black and women jobseekers do not have the same access to social ties in the labor market as white men. A number of Black Twitter users, particularly Black women, have cultivated networks on Twitter and elsewhere as explicit alternatives to this old boys’ network. This study aimed to understand how workers in creative industries—which tend to be more reliant on referrals—use Twitter to expand their social networks and gain access to job opportunities, and how their use of Twitter differed by race and gender. Four hashtags were queried through the Twitter application …

Fool's Rest, Aidan Quinlan

Theses and Dissertations

The text calls itself a guide, but it is no guide. From the genre of guide, it borrows the outlines and silhouettes and lines between things and spaces and ideas. It lingers on the shadows of its subject(s); it is attentive to the periphery of its world; but it cannot take you there. There is no there. It lacks the authority of the guide; it lacks the lucidity, the efficiency, the false totality of the guide; it lacks the confidence.

The guide embodies its own anxieties. This makes sense, as its reason to exist was born on the one-way highway …

Implementation Of A Hierarchical, Embedded, Cyber Attack Detection System For Spi Devices On Unmanned Aerial Systems, Jeremy J. Price

Theses and Dissertations

Unmanned Aerial Systems (UAS) create security concerns as their roles expand in commercial, military, and consumer spaces. The need to secure these systems is recognized in the architecture for a Hierarchical, Embedded, Cyber Attack Detection (HECAD) system. HECAD passively monitors the communication between a flight controller and all its peripherals like sensors and actuators. It ensures the functionality of a UAS is within the set of defined behavior and reports all potential problems, whether the errors were caused by cyber attacks or other physical faults. A portion of the design for Serial Peripheral Interface (SPI) devices on board a flight …

Library By Day, Theater By Night, Julia Moncure Jones Mishler

Theses and Dissertations

This project will re-conceive a historic movie theater, honoring the program of the building as it was originally intended, while introducing a new programmatic element: the library. Instead of this large space only being used in the evenings for movie showings, it will now also be a place for the public to gather during the day as a popular materials library. This project is an exploration of diversion through literature and cinema. This space will continue to be a landmark in Richmond and a place community members visit on a regular basis.

How do new elements introduced into a historic …

Development Of Dexamethsone Sodium Phosphate Loaded Nanoparticles For Treating Corneal Allograft Rejection, Vineet R. Kulkarni

Theses and Dissertations

Corneas are the most commonly transplanted tissue worldwide, with approximately 80,000 transplantations performed in the United States in 2018 alone. Corneal transplantation is used to restore the vision due to opaque corneas in various diseases such as fungal keratitis, keratoconus, Fuchs’s dystrophy, corneal ulceration, traumatic injury, abrasions or scarring, inflammation, and infection. Corneal transplant surgery could involve replacing the entire cornea (penetrating keratoplasty) or selective replacement of the corneal layers (e.g. Descemet’s membrane endothelial keratoplasty and deep anterior lamellar keratoplasty). Immunologic graft rejection is one of the main causes of graft failure in these corneal transplantations. The 2-year rejection rate …

Reclaiming Beercraft- A Sensory Experience, Zishan Zeng

Theses and Dissertations

The senses are mainly a source of arousal, enjoyment and pain and are of vital importance for the human body. They are also important because sensory perception is typical of many cultural artifacts and is given unique intensities and extensions, shapes and meanings through them (Heywood, 2017). As Finnish architect Juhani Pallasmaa stated, “architecture is the art of reconciliation between ourselves and the world, and this mediation takes place through the senses” (Pallasmaa, 2012). To make architecture truly meaningful, it should be able to awaken all the senses.

The way we feel, smell, and even taste is hard to capture. …

A Qualitative Analysis Of Caregiver Goals For Urban Children With And Without Asthma, Megan M. Carlson

Theses and Dissertations

Pediatric asthma is a major public health concern that disproportionately affects children of color and youth living in low-income, urban areas. The implications for public health, child health, and family functioning necessitates our understanding and addressing experiences by families who are facing barriers within their socio-demographic context in addition to the stressors associated with managing pediatric asthma. The current study applied qualitative methods to interviews with caregivers of children with and without asthma in an effort to more deeply connect with caregivers’ experiences and yield richer information about the intersection of identities as Black caregivers living in an urban setting …

Reaction Profiling Of Extracellular Protein Phosphorylation Through A Microfluidic Reactor Coupled With Raman Spectroscopy, Abigail Casey

Theses and Dissertations

Diseases and disorders in the human body are considered abnormalities of proper cellular function. Understanding the signal transduction mechanisms that cause these abnormalities is crucial to developing earlier detection methods, better treatment options and effective cures. While current diagnostic procedures are powerful tools in diagnosing diseases, they are ineffective in informing physicians on the real-time behavior of the signal transduction mechanisms associated with diseases and disorders. Currently, disease progression is monitored over time through routine patient visits and testing by one or more of the above techniques. By developing an approach that can monitor structural and conformational changes of proteins …

Dendrimer-Based Therapeutic Delivery Vehicle For The Treatment Of Ocular Diseases, Remy C. Cooper

Theses and Dissertations

The treatment of ocular diseases poses a significant challenge to drug delivery design, due to the eye’s complex anatomy, with a semi-permeable blood-ocular barrier and associated immune privilege. To address some of the delivery challenges, polycationic dendrimers are explored as vehicle for the treatment of posterior chamber disease. Dendrimers are a class of polymeric nanoparticles that are highly branched, multivalent and monodisperse, whose three-dimensional globular architecture has given them the nickname of “synthetic proteins”. Dendrimers are synthesized by reacting monomers in a step-wise fashion to produce generationally and radially increasing structures, with core, interior and surface chains that are highly …

Education Support For Foster Care Youth: The Impact Of Federal Spending On Employment Outcomes, Carlisle C. Bates

Theses and Dissertations

This study examined the extent to which supportive services funded through the federal John H. Chafee Foster Care Independence Program (CFCP) are associated with academic success and employment in foster care youth. Studies suggest that this group experiences poorer employment outcomes (Gypen, Vanderfaeillie, De Maeyer, Belenger, & Van Holen, 2017; Okpych & Courtney, 2014) and earn less money annually (Gypen et al., 2017; Okpych & Courtney, 2014; Pecora, 2012). Despite a 29.4-billion-dollar annual budget for foster care services, individuals with a foster care history struggle after they transition out of care.

The CFCP is intended to help states improve education …

Characterization Of The Gonococcal Calprotectin Zn-Acquisition System, Tdfh, And The Efficacy Of Metal Starvation For Treating Gonococcal Disease, Michael T. Kammerman

Theses and Dissertations

Abstract

Characterization of the Gonococcal Calprotectin Zn-Acquisition System, TdfH, and the Efficacy of Metal Starvation for Treating Gonococcal Disease.

By Michael T. Kammerman, B.S.

A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University

Virginia Commonwealth University, 2020

Major Director: Cynthia Nau Cornelissen, Ph.D.

Professor, Department of Microbiology and Immunology

Neisseria gonorrhoeae, the bacterial agent that is responsible for the human disease gonorrhea, has had a steady increase in the number of infections per year. In 2018 the WHO estimated over 87 million infections occurred world-wide, and the CDC …

Metal-Oxide Nanostructures Fabricated From Reactive Laser Ablation In Liquid, Mallory G. John

Theses and Dissertations

The development of metal-oxide nanostructures is a growing area due to their applications in diverse fields spanning energy conversion and storage, chemical manufacturing, and en- vironmental technology. This interest in catalytically active nanomaterials has prompted the synthesis and investigation of highly functionalized nanoparticles (NPs), including core- shell, silicate-stabilized, and bi- and multi-metallic nanocomposites. While wet-chemical synthesis methods of metal-oxide nanostructures have led to several morphologies, compositions, and shapes, these syntheses often require high temperatures, toxic solvents or reducing agents, and long reaction times.

Laser synthesis and processing of colloids (LSPC) encompasses both ‘top down’ and ‘bottom up’ approaches to synthesize …

The Influence Of Breeding Density On Female Aggression, Parental Care, And Ornamentation In A Secondary-Cavity Nesting Warbler, Elsa B. Chen

Theses and Dissertations

Tradeoffs between individual survival and reproductive success associated with aggressive behaviors are a driving force of evolution, but these tradeoffs are often overlooked for aggressive conspecific interactions between females. For avian males, it is well documented that more aggressive individuals tend to provide less parental care. In the few studies that address this in females, the tradeoffs seem to be more context-dependent, varying due to factors such as predation pressure and habitat quality. The relationship between female ornamentation and aggression is similarly understudied, but evidence suggests that both aggression and ornamentation are important traits involved in social selection – the …

Improving Grid Hosting Capacity And Inertia Response With High Penetration Of Renewable Generation, Hamidreza Sadeghian

Theses and Dissertations

To achieve a more sustainable supply of electricity, utilizing renewable energy resources is a promising solution. However, the inclusion of intermittent renewable energy resources in electric power systems, if not appropriately managed and controlled, will raise a new set of technical challenges in both voltage and frequency control and jeopardizes the reliability and stability of the power system, as one of the most critical infrastructures in the today’s world. This dissertation aims to answer how to achieve high penetration of renewable generations in the entire power system without jeopardizing its security and reliability. First, we tackle the data insufficiency in …

Surrogate Memories In Animation And Sound, Jared Duesterhaus

Theses and Dissertations

A document in support of my exploration into memory in relation to the mediums of animation, sound, and theater. A reflection on remembering as a creative act.

Parakupa Vena - Fall From The Highest Point, Mariana Parisca Englert

Theses and Dissertations

This document is a collection of the ideas and research that drive my artistic practice. My research focuses on investigating the power structures, historical roots, and existential implications of the current Venezuelan economic crisis, one of the most drastic economic collapses of modern times. The ideological rifts created in the Cold War era created a deep anti-socialist sentiment that inhibits our ability to responsibly acknowledge global interdependence. I visualize collective belief systems that gain power from their proposed neutrality. I point to the existence of value beyond the parameters and measures of global capitalism that encourage dependence. I see the …

It’S Funny Because It’S True: The Transmission Of Explicit And Implicit Racism In Internet Memes, Tabitha Fairchild

Theses and Dissertations

Video games are traditionally seen as the domain of heteronormative white males. The purpose of this study is to explore how racism is transmitted and reproduced within digital communities, and how humor is being used to frame racist discourse in virtual spaces. Digitally, internet memes are widely used rhetorical vehicles, reaching large and broad audiences. The roles these artifacts play in the reproduction and transmission of racist ideology is often obfuscated by the perception that internet memes are "just jokes." This study analyzes internet memes collected from 16 months of communication between members of Discord servers that self-identify as communities …

Investigation Into The Reaction Profile Of A Bioinspired Nickel Complex, Denver Heitger

Theses and Dissertations

Metal complexes that can activate natural oxidants like H₂O₂ and O₂ have become a key research topic in many labs in hope of mimicking nature, by generating a bioinspired complex that can perform unique chemistry through green processes. To prepare the perfect catalyst, this has lead scientists to explore numerous avenues, including the use of both natural and artificial oxidants, to tease apart the reaction pathway taking place. A ligand system dear to the Lucas Lab (13-DOB) has been metalated with nickel, a cheap and earth abundant transition metal. Our bioinspired metal-(di)oxygen adducts can be formed …

The Quantified Elf, Umico Niwa

Theses and Dissertations

The Quantified Elf is an ongoing collection of scientific, medical, archaeological articles and excerpts from my personal journal. It is a way by which I explore the various ways Western notions of personhood subsume human life into constructs of sexuality and gender, overlooking the various other modes of unbridled existence: plant, microbial. fungal, animal, celestial bodies. The speculative medical papers propose novel forms of body modification to combat gender dysphoria.

Comparing Coastal Storm Impact To Decadal Change In Barrier Island Ecosystems, Philip A. Tuley

Theses and Dissertations

Highly dynamic coastal systems respond to disturbance events with a combination of topographic and vegetative changes. Sea level rise impacts on barrier islands have been quantified, but storm effects on vegetation are limited. Here we quantified barrier island vegetation change in response to an isolated storm event and compared to long-term periods. We hypothesized that disturbance-resisting areas with high woody vegetation cover and/or high foredune elevation would experience minimal transitions after a storm event, whereas disturbance-reinforcing areas with low vegetation cover and low foredune elevation would experience greater transitions between ecosystem states after a storm event. Patterns of dissonance were …

A Story About A Girl With Snakes For Hair, Kate M. Turner

Theses and Dissertations

My work is autobiographical. I use various art making processes to create a visual archive of my life. By abstracting these memories and experiences, I can examine how culture works surrounding issues of identity. This is my story.

The Program, Aaron Douglas Estrada

Theses and Dissertations

In my work, I explore the engineering of identity and socioeconomics that are programed into Black and Brown communities. I refer to this as “The Program”. The Program validates, breaks, codes, and critiques the system that divided us. The Program is identifying with the struggle of growing up in a system that is programmed to see you fail. So if you get caught up in that system it’s a natural death within the program. But you can break and make your own program. If you stick to the program.

The paper's use of language is coded. Text has been written …

Predators And Principles: Think Tank Influence, Media Visibility, And Political Partisanship, Timothy Beryl Bland

Theses and Dissertations

By some measures, the major U.S. political parties have become more extreme in their political positions in recent decades, and scholars have raised concerns about whether the policy expertise provided by today’s think tanks has become similarly partisan and polarized. Furthermore, there is a perception that certain overtly partisan and highly visible think tanks wield considerable and growing influence over the policy platforms of the major U.S. parties, using their media presence to shape public and policymaker views of particular issues. Using publicly accessible tax, media, and congressional data, my proposed study assesses the extent to which media visibility and …

A Meta-Analysis Investigating The Correlation Between Treatment Integrity And Youth Client Outcomes, Ruben G. Martinez

Theses and Dissertations

Objective: The relation between treatment integrity and youth client outcomes in psychosocial treatment research has implications for therapist training, study design, and study interpretation. Despite work done in this area, this relation remains unclear. The aim of the current study was to meta-analyze and describe characteristics of investigations of integrity and outcome in youth.

Method and Analytic Plan: A total of N = 30 studies were identified. Conceptual and methodological factors were coded. Pearson’s r represented the magnitude of the integrity-outcome correlation. Robust variance estimation was used to account for dependency of within-study effect sizes. Two models were run with …

Biophysical Characterization Of Mphr(A) And A Novel Clarithromycin Selective Mphr(A), Megan R. Reed

Theses and Dissertations

Transcription factor, MphR(A), can be used in the aid for new antibiotic discovery in the form of biosensors. This dissertation discusses the role of MphA in our biosensors as well as the a newly discovered MphR(A) variant with specificity to the semi-synthetic clarithromycin.

I See God Everywhere, Jason Wright

Theses and Dissertations

I would like to share with you how I was able to shed my suffering skin for a life beyond my wildest dreams. My work is about the letting go, my work is about altering perception, my work is about exploring the depths of one’s psyche. My experience is there in every atom of my output and is there for the taking.

Blaise Pascal said “All of humanity’s problems stem from man’s inability to sit quietly in a room alone.” I am not well-read in the works of Pascal, I became aware of this quote through HBO’s hit period drama …

Why We Use A New Currency: The Role Of Trust And Control In Explaining The Perception And Usage Of Bitcoin, Joseph B. Walton

Theses and Dissertations

Social media, e-commerce, global peer-to-peer technologies, and the near ubiquity of computers and smartphones allow people to interact, trust, and exchange value across traditional socio-economic control boundaries and over significant distances. Since the creation in 2008 of a new cryptographic currency system called Bitcoin, a financial technology market sector of about 250 billion USD has rapidly emerged, raising questions about the nature of currency in society and whether new types of non-national money are warranted and viable. This debate has pitted heterodox economic interests against orthodox economic interests while it has rekindled interest in theories that view money as a …

The Impact Of Aging And Mechanical Injury On Alveolar Epithelial And Macrophage Responses In Acute Lung Injury And Inflammation, Michael S. Valentine

Theses and Dissertations

Patients with severe lung pathologies, such as Acute Respiratory Distress Syndrome (ARDS), often require mechanical ventilation as a clinical intervention; however, this procedure frequently exacerbates the original pulmonary issue and produces an exaggerated inflammatory response that potentially leads to sepsis, multisystem organ failure, and mortality. This acute lung injury (ALI) condition has been termed Ventilator-Induced Lung Injury (VILI). Alveolar overdistension, cyclic atelectasis, and biotrauma are the primary injury mechanisms in VILI that lead to the loss of alveolar barrier integrity and pulmonary inflammation. Stress and strains during mechanical ventilation are believed to initiate alveolar epithelial mechanotransduction signaling mechanisms that contribute …

How Many Licks, Ashley Goodwin

Theses and Dissertations

Arts communities are currently reevaluating and restructuring power dynamics within their systems to accommodate a broader range of experience and subjectivity. However, the forces of control are still largely dictated by a broader patriarchal culture. This complicated, tangled dynamic is the focus of my research. Female artists who make work about men or about patriarchy more generally, are consistently subjected to its influence as the dominant cultural experience—the invisible “truth” that everything either is, or acts in reaction to its position. In reality, patriarchy is no longer gender specific. I will be addressing my relationship to it as well as …