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2020

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Comparative Evaluation Of Mineral Trioxide Aggregate And Acemannam For Partial Pulpotomy In Permanent Teeth With Incomplete Root Formation, Thuy Tien Vu Jan 2020

Comparative Evaluation Of Mineral Trioxide Aggregate And Acemannam For Partial Pulpotomy In Permanent Teeth With Incomplete Root Formation, Thuy Tien Vu

Chulalongkorn University Theses and Dissertations (Chula ETD)

Mineral trioxide aggregate (MTA), the standard pulp capping material, has disadvantages, including long setting time and high cost. Along this line, acemannan, a polysaccharide extracted from aloe vera, would be a promising biomaterial for vital pulp therapy as it is shown to induce mineralized bridge formation in animal and clinical studies. In this study, the impact of MTA and acemannan sponges on partial pulpotomized permanent teeth has been evaluated. For the research design, fifty immature permanent teeth with caries or accident-induced pulp exposure were collected and assessed. After partial pulpotomy, the teeth were randomly allocated into the treatment group using …

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The Differential Dendritic Cell Properties In Response To Candida Albicans And Non-Albican Candida Β-Glucan, Truc Thi Huong Dinh Jan 2020

The Differential Dendritic Cell Properties In Response To Candida Albicans And Non-Albican Candida Β-Glucan, Truc Thi Huong Dinh

Chulalongkorn University Theses and Dissertations (Chula ETD)

Increased mortality and antifungal drug resistance of non-albicans Candidiasis patients have become an alarming in health problems nowadays, whereas profound knowledge of their pathogenesis mechanisms is still limited. The immune responses of innate and adaptive immunity play a crucial role in protecting from Candida infections. Dendritic cells (DCs) are the most notable because of their roles in bridging an innate immunity and specific adaptive immunity to eliminate fungal invasion. It is little known about DC functions in non-albicans Candida (NACs) infections. Besides, there is less study on evaluating the DC properties upon the interaction between DCs and NACs-derived ß-glucans. Therefore, …

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Servitization Model For Chemical Industry In Thailand, Tanyaporn Kanignant Jan 2020

Servitization Model For Chemical Industry In Thailand, Tanyaporn Kanignant

Chulalongkorn University Theses and Dissertations (Chula ETD)

Chemical industry traditionally produces and sells tangible goods in large volume and high price cometition. Recently, firms in chemical industry provide additional services to their customers. Several manufacturers change from tangible product suppliers to both product and service providers. This movement is called servitization (Vandermerwe & Rada, 1988). Chemical servitization levels can be classified into 4 categories which are product only, service added to the product, service differential the product and service is the product (Thoben, Eschenbacher, & Jagdev, 2001). The objectives of this paper are to construct servitization framework for chemical suppliers to shift to product service integration and …

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The Effects Of Project-Based Drama Approach Via Blended Learning Environment On Thai Efl Undergraduated Student's Speaking Skills, Tunyaphoom Phu-Ngamthong Jan 2020

The Effects Of Project-Based Drama Approach Via Blended Learning Environment On Thai Efl Undergraduated Student's Speaking Skills, Tunyaphoom Phu-Ngamthong

Chulalongkorn University Theses and Dissertations (Chula ETD)

The objectives of this study were 1) to examine the effectiveness of project-based drama approach via blended learning environment on English speaking skills, and 2) to investigate the students’ opinions towards project-based drama approach via blended learning environment on English speaking skills.The framework was derived from the combination of three models; Teaching English through Drama for Oral Skills Model, the Project-Based Learning framework, and the Blended Learning Model. The study was conducted face-to-face and online for 14 consecutive weeks in the second semester of Academic Year of 2020 at Ubon Ratchathani Rajabhat University. The participants were 51 third-year students who …

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Sustainable Business Development Through Sufficiency Economy Practice : A Case Study Of Thai Listed Companies, Veerawin Korphaibool Jan 2020

Sustainable Business Development Through Sufficiency Economy Practice : A Case Study Of Thai Listed Companies, Veerawin Korphaibool

Chulalongkorn University Theses and Dissertations (Chula ETD)

The purpose of the research is to determine the sufficiency economy philosophy (SEP) performance through annual and sustainable development reports and simplify the outcomes by representing through a scoring system. Each of the SEP elements was aligned with each GRI sub-topic to generate a SEP scoring system. Then, the results from the scoring system were verified by testing the relationship between SEP performance and firm-specific risk of 34 Thai listed companies from 2013 to 2018 via panel data analysis. The global reporting initiative (GRI) standards were used as the fundamental scoring system as it's widely used and accepted in academic …

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Parasite: A Reflection On Social And Economic Disparities In South Korea, Wilasinee Nichasuk Jan 2020

Parasite: A Reflection On Social And Economic Disparities In South Korea, Wilasinee Nichasuk

Chulalongkorn University Theses and Dissertations (Chula ETD)

The purpose of this research is to analyze a reflection of social problems in "Parasite" film. The study is a qualitative research that uses semiology theory to analyze the social problems in the film through elements such as visual sign, scene, dialogue etc. The results of these analyses show that "Parasite" film reflects the social problems in South Korea through a visual sign, scene, dialogue such as disparity social class problems. These problems that occur in South Korea are partly due to a result of the rapid change in South Korea society and adoption of the capitalist system to develop …

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Supply Chain Collaboration For Sustainability In Thailand's Dairy Industry, Virayos Vajirabhoga Jan 2020

Supply Chain Collaboration For Sustainability In Thailand's Dairy Industry, Virayos Vajirabhoga

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study gathered potential 95 variables from a literature review. Through the process of expert review, these were refined into 49 critical variables. Moreover, pilot study, with participation from co-operatives and farmers, aims to develop conceptual frameworks in six areas: performance and commitment, internal and external collaboration, measurement and evaluation, joint operation, sharing and innovation, and negotiation. Furthermore, 26 factors were identified clearly by exploratory factory analysis. The main study was conducted via a paper-based questionnaire with 1,224 respondents nationwide. The proposed 11 hypotheses attempted to identify the structural relationships among the constructs in the model. The result confirmed the …

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Neutrophil Extracellular Traps (Nets) Formation Of Fcgr2b Deficient Mice In Lupus Mouse Model With Ischemic Reperfusion Injury, Wilasinee Saisorn Jan 2020

Neutrophil Extracellular Traps (Nets) Formation Of Fcgr2b Deficient Mice In Lupus Mouse Model With Ischemic Reperfusion Injury, Wilasinee Saisorn

Chulalongkorn University Theses and Dissertations (Chula ETD)

Acute kidney injury (AKI) caused by renal ischemic reperfusion (I/R) is the most prevalent cause of morbidity and mortality in patients. Neutrophil extracellular traps (NETs) are important for the progression of lupus nephritis after renal I/R injury. Because neutrophils are the first immune cell that respond to tissue damage, neutrophils might be an important cell that determines renal I/R injury. Additionally, NET components, including cell-free DNA, histone, nucleosome, and cytoplasmic protein compartment release the auto-antigens that accelerate lupus disease activity. Therefore, this project aimed to compare NETs formation in several internal organs following renal I/R injury in Fcgr2b deficient (Fcgr2b-/-) …

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Avoidance Of The English Passive Construction By L1 Chinese Learners, Yang Wang Jan 2020

Avoidance Of The English Passive Construction By L1 Chinese Learners, Yang Wang

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research investigated avoidance behaviour as one of the strategies L2 learners may resort to because of L1-L2 differences, or the non-existence of L2 structures for L1 learners (Schachter 1974; Dagut and Laufer 1985). Schachter (1974) proposed the Avoidance Behaviour Hypothesis, whereby L2 learners were likely to avoid using some L2 structures due to the aforementioned difficulties in L2 acquisition. Later researchers, i.e. Dagut and Laufer (1985), and Laufer and Eliasson (1993), claimed that L1-L2 differences tended to play a role, or at least would be the 'best predictor' (1993, p46) of avoidance. However, recent researchers, i.e. Thiamtawan and Pongpairoj …

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Assessments Of Hydraulic Responses To Climate Variability Of Dominant Trees In Successional Forests In Khao Yai National Park For Environmental Management, Weerapong Unawong Jan 2020

Assessments Of Hydraulic Responses To Climate Variability Of Dominant Trees In Successional Forests In Khao Yai National Park For Environmental Management, Weerapong Unawong

Chulalongkorn University Theses and Dissertations (Chula ETD)

In Southeast Asia, tropical forests have been increasingly threatened by human disturbances and climate change-induced water stress. However, uncertainty remains as to how these forests would respond to environmental changes under water deficit conditions. Here, we conducted a study of seasonal variation in leaf water status and hydraulic properties of dominant tree species across forest successional stages in Khao Yai National Park, Thailand. Specifically, we measured midday leaf water potential (Ψmd) during the wet and dry season, and assessed branch xylem vulnerability at which 50% is lost (P50). The associations between P50 and maximum xylem hydraulic conductivity (Ksmax) and maximum …

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Innovative Zero-Waste System For Building Wastewater Recycling And Food Waste Management, Thammananya Sakcharoen Jan 2020

Innovative Zero-Waste System For Building Wastewater Recycling And Food Waste Management, Thammananya Sakcharoen

Chulalongkorn University Theses and Dissertations (Chula ETD)

Urbanization leads to concerns about environmental impacts due to the increasing food waste and wastewater generation. The study aims to develop an innovative zero-waste system for food waste and wastewater management in the building using the combination of a single-stage anaerobic digester and the Moving Bed Biofilm Reaction-Membrane Bioreactor (MBBR-MBR). The comprehensive analysis for innovative zero-waste system development is conducted including (1) survey and interview the target market group (universities) to determine the factors affecting the intention to use the zero-waste system ; (2) develop a zero-waste system prototype, and test operation for measuring the performances ; (3) evaluate the …

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Over-Expression Of Mir-223 Induces M2 Macrophage Through Glycolysis Alteration And Attenuates Lipopolysaccharide-Induced Sepsis Mouse Model, A Proposal Sepsis Cell-Based Therapy, Dang Phi Cong Jan 2020

Over-Expression Of Mir-223 Induces M2 Macrophage Through Glycolysis Alteration And Attenuates Lipopolysaccharide-Induced Sepsis Mouse Model, A Proposal Sepsis Cell-Based Therapy, Dang Phi Cong

Chulalongkorn University Theses and Dissertations (Chula ETD)

Sepsis, a systemic infection with excessive inflammatory symptoms due to dysregulation of immune responses, remains the most concerned health-care problem worldwide with the mortality rate critically beyond the number of death cases in HIV, cancers or stroke. While it is well documented that pathogenesis of sepsis is intimately involved in dysregulation of macrophages, great effort has been made to discover efficacious therapy to control macrophage responses. However, macrophages are the most versatile immune cells with large spectrum of heterogeneous phenotypes and functions. Recently, collection of insights unravel the crucial role of metabolism as an orchestrator of immune regulation, intervention on …

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High-Mobility Group Box 1 (Hmgb1) Mediates Dna Methylation Preventing Genomic Instability, Papitchaya Watcharanurak Jan 2020

High-Mobility Group Box 1 (Hmgb1) Mediates Dna Methylation Preventing Genomic Instability, Papitchaya Watcharanurak

Chulalongkorn University Theses and Dissertations (Chula ETD)

Global DNA hypomethylation promotes genomic instability through the accumulation of DNA damage and resulted in an increasing rate of mutation. To stabilize the genome, cells possess an epigenetic mechanism to reduce DNA tension that causes DNA damages, named Replication-Independent Endogenous DNA Double-Strand Breaks (RIND-EDSBs). Due to their biological roles, this type of physiologic EDSBs act as youth-associated genomic-stabilizing DNA gaps (Youth-DNA-GAPs). They are localized within methylated genome and maintained by non-histone HMGB1 and SIRT1 proteins. Reduction of RIND-EDSBs was found in hypomethylated genome, including cancer and aging. Therefore, this study aimed to explore the role of HMGB1-mediated DNA methylation in …

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Learning-Based Approach For Visual Quality Enhancement On High Efficiency Video Coding Standard, Sovann Chen Jan 2020

Learning-Based Approach For Visual Quality Enhancement On High Efficiency Video Coding Standard, Sovann Chen

Chulalongkorn University Theses and Dissertations (Chula ETD)

High Efficiency Video Coding (HEVC) has dramatically enhanced the coding efficiency compared to the previous video coding standard, H.264/AVC. However, the existing rate control updates its parameters according to a fixed initialization, which can cause error prediction of bit allocation to each coding tree unit (CTU) in frames. In this work, a learning-based mapping between rate control parameters and video contents is proposed to achieve an accurate target bit rate and good video quality. The proposed framework contains two main structural codings, including spatial and temporal coding. We initiate an effective learning-based particle swarm optimization for both spatial and temporal …

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Development Of An Integrated Microfluidic System For Cell Sorting And Trapping—Considering Sorting Efficacy And Cell Viability, Thammawit Suwannaphan Jan 2020

Development Of An Integrated Microfluidic System For Cell Sorting And Trapping—Considering Sorting Efficacy And Cell Viability, Thammawit Suwannaphan

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study is divided into two phases. The first phase is about the investigation of cell viability and damage of white blood cells after sorting in both a spiral microchannel and contraction and expansion array (CEA) at appropriate flow rates for cell separation. Three techniques such as Trypan Blue staining, Scanning Electron Microscopy (SEM) and Wright-Giemsa staining are employed in the experiments. After flowing the sample through a whole setup of spiral microchannel at 2 ml/min, 85% of cells are viable while 30% of cells are significantly deformed and 2% of cells are seriously damaged in their intracellular structures. In …

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Effect Of Food Impaction In The Interproximal Of Implant Supported Fixed Restoration Towards Oral Health Related Quality Of Life, Souknilan Chanthasan Jan 2020

Effect Of Food Impaction In The Interproximal Of Implant Supported Fixed Restoration Towards Oral Health Related Quality Of Life, Souknilan Chanthasan

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objectives: To investigate the effect of food impaction between dental implant and adjacent teeth to the patients’ quality of life and periodontal/peri-implant tissue conditions. Materials and methods: Patients with implant supported single crown (ISSC) having implant checkup at the Faculty of Dentistry, Chulalongkorn University between July 2019 and July 2020 were recruited. Food impaction was evaluated by either patients’ experience or clinical examination by dentist. Self-administrative Oral impacts on Daily Performance questionnaire was used to assess the effect of food impaction to patients’ quality of life. Clinical and radiographic examination was performed to evaluate periodontal/peri-implant tissue conditions. Results: Totally 178 …

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The Minimum Wage Change Effect To The Household Saving Between 2011 And 2013, Soraphong Smitintu Jan 2020

The Minimum Wage Change Effect To The Household Saving Between 2011 And 2013, Soraphong Smitintu

Chulalongkorn University Theses and Dissertations (Chula ETD)

In 2013, Thailand's minimum wage legislation change from multiple minimum wage levels in each province to a single national minimum wage. This study paper presents analyses of the relationship between the minimum wage change and low-income household savings. By using ordinary least square regression analysis. Sample data by Household Socio-economic survey in 2013 from National Statistical Office. The household saving is average monthly total income per household minus average monthly total expenditures per household. For a household to be considered as a low-income household, the household head must be between the ages of 18 and 60, have completed less than …

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Metabolite Profiling And Gene Expression Analysis In Starch And Sugar Metabolisms Of Ripening Durian Durio Zibethinus Pulp, Lalida Sangpong Jan 2020

Metabolite Profiling And Gene Expression Analysis In Starch And Sugar Metabolisms Of Ripening Durian Durio Zibethinus Pulp, Lalida Sangpong

Chulalongkorn University Theses and Dissertations (Chula ETD)

Durian (Durio zibethinus L.), an economically important fruit of Southeast Asian countries, expresses unique flavor at the edible ripe stage, resulting from metabolic changes during the ripening process. Nevertheless, the study in such modulations is still limited. In the first manuscript, we profiled metabolites from unripe and ripe pulps of durian cv. Monthong using capillary electrophoresis- (CE) and gas chromatography- (GC) time-of-flight mass spectrometry (TOF/MS) and obtained the total 94 ripening-related metabolites from a combination of the two datasets, of which we focused on flavor-related metabolites. For sugar, sucrose is the most abundant sugar that increased during ripening, and the …

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The Deactivation Study Of Titanium Dioxide Catalyst In Thermochemical Processes Via Density Functional Theory, Chinanang Ngamlaor Jan 2020

The Deactivation Study Of Titanium Dioxide Catalyst In Thermochemical Processes Via Density Functional Theory, Chinanang Ngamlaor

Chulalongkorn University Theses and Dissertations (Chula ETD)

In this study, the investigation of catalytic deactivation of TiO2 by coking was performed using DFT. The effect of the Hubbard U, which was varied as U equal 4 to 6 eV and Van der Waal corrections on electronic properties were also investigated. The effect of temperature in the range of 400-1000°C was also studied. This work aims to understand relatives of coke formation, oxygen vacancy, phase transformation. The increment of the Hubbard U values provide a more accurate quantitative cited by the energy gap from the experimental investigation, the appropriate U value of the A-TiO2 (101) is 4 eV, …

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The Deactivation Of Gamma-Alumina Based Catalyst During Aqueous Phase Reaction Using Density Function Theory, Phakaorn Aphichoksiri Jan 2020

The Deactivation Of Gamma-Alumina Based Catalyst During Aqueous Phase Reaction Using Density Function Theory, Phakaorn Aphichoksiri

Chulalongkorn University Theses and Dissertations (Chula ETD)

Nowadays, biomass conversion has become a more attractive process to produce fuels and various high-value chemicals from biological materials. From many kinds of catalysts, the metal-supported gamma-alumina (γ-Al2O3) is a widely used catalyst for various transformation processes, especially in the aqueous phase reaction. Typically, coke formation on γ-Al2O3 causes catalyst deactivation in the thermal reaction process. Moreover, incorporation of aqueous phase medium initiates hydroxylation of γ-Al2O3 and phase transformation of γ-AlOOH, leading to the catalyst deactivation. Not only coke formation and phase transformation are the cause of catalytic deactivation, but the oxygen vacancy, changing the activity of the catalyst, should …

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Deactivation Of Manganese Dioxide Electrocatalyst In Zinc-Air Batteries Studied Via Density Functional Theory, Puwit Buapin Jan 2020

Deactivation Of Manganese Dioxide Electrocatalyst In Zinc-Air Batteries Studied Via Density Functional Theory, Puwit Buapin

Chulalongkorn University Theses and Dissertations (Chula ETD)

Manganese dioxide (MnO2) is the effective electrocatalysts used as a cathode for Zn-Air batteries (ZABs) accounted for the acceleration of the oxygen reduction reaction (ORR). There are various studies on the ORR activity of MnO2 rather than deactivation mechanisms. In this work, the deactivation mechanisms of α-MnO2 and β-MnO2 was investigated by density functional theory and computational hydrogen electrode. It was found that, the phase transformation from the α-MnO2 (211) to β-MnO2 (110) shows that the catalyst deactivation is due to the higher overpotential of β-MnO2 (110) making electrocatalyst efficiency low. For Ov surfaces, it illustrates that the performance is …

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Pelletization Of Cao Catalyst For Biodiesel Production Via Transesterification Of Palm Oil, Warisara Vornuch Jan 2020

Pelletization Of Cao Catalyst For Biodiesel Production Via Transesterification Of Palm Oil, Warisara Vornuch

Chulalongkorn University Theses and Dissertations (Chula ETD)

This thesis investigates biodiesel production from palm oil by transesterification using extruded CaO catalysts. The preparation parameters of extruded CaO catalysts were investigated including 1) binder type including activated alumina, diatomite and kaolin, 2) calcination temperature at 700, 800 and 900°C, 3) mass ratio of CaO to the binder at 1: 1, 3: 1 and 6: 1. The Effect of catalyst shape of the extruded CaO and the addition of pore forming (polyacrylamide) on the catalytic activity of extruded CaO were also studied using transesterification using methanol to palm oil. The ratio of methanol to palm oil was fixed at …

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ผลกระทบของมุมของหลุมจุลภาครูปร่างสี่เหลี่ยมข้าวหลามตัดในการสร้างกลุ่มเซลล์คล้ายเนื้อเยื่อ, ธนภัทร ชุนฟ้ง Jan 2020

ผลกระทบของมุมของหลุมจุลภาครูปร่างสี่เหลี่ยมข้าวหลามตัดในการสร้างกลุ่มเซลล์คล้ายเนื้อเยื่อ, ธนภัทร ชุนฟ้ง

Chulalongkorn University Theses and Dissertations (Chula ETD)

การศึกษานี้แบ่งออกเป็นสองวัตถุประสงค์หลัก วัตถุประสงค์แรกเป็นการศึกษาผลกระทบของมุมของหลุมจุลภาครูปร่างทรงพีระมิดฐานสี่เหลี่ยมข้าวหลามตัดทั้ง 3 รูปร่างคือ มุมแหลม (66 องศา) มุมด้านเท่า (90 องศา) และมุมป้าน (106 องศา) ต่อการสร้างกลุ่มเซลล์คล้ายเนื้อเยื่อสำหรับการเลี้ยงที่ใช้การไหลแบบต่อเนื่อง โดยแต่ละหลุมจุลภาควางเรียงชิดกันเพื่อลดพื้นที่ว่างไม่ให้เซลล์ไปเกาะหรือเกิดการสูญเสียเซลล์ไป ในบริเวณก้นหลุมจุลภาคมีทรงกระบอกรัศมี 450 ไมโครเมตร ติดตั้งอยู่ ซึ่งเป็นตำแหน่งที่จะเกิดการสร้างกลุ่มเซลล์คล้ายเนื้อเยื่อขึ้น และทำให้ความลึกรวมทั้งหมดของหลุมจุลภาคเท่ากับ 550 ไมโครเมตร ในการทดลองได้ใช้อัตราการไหลเท่ากับ 10 ไมโครลิตรต่อชั่วโมง ทั้งจากผลการคำนวณ และผลการทดลองพบว่า ในกรณีหลุมจุลภาคที่มีมุม 66 องศา ของไหลที่ไหลผ่านหลุมมีการเบี่ยงเบนทิศทางเข้าสู่กึ่งกลางหลุมมากกว่าหลุมแบบอื่น และน่าจะทำให้เกิดการสร้างกลุ่มเซลล์คล้ายเนื้อเยื่อของเซลล์ลำบาก เพราะถูกรบกวนจากของไหลค่อนข้างสูง ในกรณีหลุมจุลภาคที่มีมุม 90 องศา ของไหลมีการเบี่ยงเบนทิศทางเข้าสู่กึ่งกลางลดลง ทำให้มีการสร้างกลุ่มเซลล์คล้ายเนื้อเยื่อได้ดีขึ้น อย่างไรก็ตาม เมื่อหลุมจุลภาคมีมุม 106 องศา ของไหลมีการเบี่ยงเบนทิศทางเข้าหากึ่งกลางหลุมน้อยลงมาก ทำให้เซลล์บางส่วนไม่ถูกพัดพามารวมกันที่บริเวณก้นหลุมทรงกระบอก โดยเซลล์บางส่วนติดอยู่บนบริเวณผนังด้านข้าง ทำให้การสร้างกลุ่มเซลล์คล้ายเนื้อเยื่อลดต่ำลง ดังนั้นผลการศึกษาจึงบ่งชี้ว่าหลุมจุลภาคทรงพีระมิดฐานสี่เหลี่ยมข้าวหลามตัดมุม 90 องศา มีความเหมาะสมที่สุดในการสร้างกลุ่มเซลล์คล้ายเนื้อเยื่อ นอกจากนั้น ผลการทดลองยังแสดงให้เห็นด้วยว่าอัตราการรอดชีวิตของเซลล์มีแนวโน้มดีกว่าหลุมจุลภาคแบบอื่นอีกด้วย วัตถุประสงค์ที่สองคือการสร้างระบบของไหลจุลภาคที่ใช้ต้นทุนต่ำ และรวดเร็ว โดยการสร้างแม่พิมพ์ด้วยการพิมพ์สามมิติด้วยเรซิ่น สำหรับการพิมพ์สามมิติจะทำให้สร้างแม่พิมพ์ที่มีรูปร่างที่ซับซ้อนมากได้ แต่ขนาดที่เล็กสุดยังจำกัดอยู่ และความแข็งแรงทางกล และความทนทานต่อความร้อนไม่ดีนัก อย่างไรก็ตาม วิธีการที่พัฒนาที่ขึ้นสามารถใช้งานได้ดีในการหล่อสารพอลิไดเมทิลซิโลเซนสำหรับระบบของไหลจุลภาค ซึ่งใช้งานอย่างมากในงานวิจัยทางด้านนี้

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Comparison Of The Accuracy To Predict Falls Of The Figure Of 8 Walk Test With And Without Dual-Task In Older Adults, Tidarat Nualyong Jan 2020

Comparison Of The Accuracy To Predict Falls Of The Figure Of 8 Walk Test With And Without Dual-Task In Older Adults, Tidarat Nualyong

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: The figure of eight walk test (F8W) is a measurement tool that examines the ability to walk on a curved path. Adding secondary tasks to the F8W test may increase its ability to predict falls in older adults. This research aimed 1.) to examine the accuracy of the F8W test and the F8W test with dual-tasking for predicting future falls in older adults; 2.) to investigate the reliability and the concurrent validity of the F8W test with and without dual-task in older adults. Methods: Eighty older adults between the ages of 60 and 80 were recruited. At the beginning …

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ประสิทธิภาพการกำจัดไนเตรทและจลนพลศาสตร์ของถังปฏิกรณ์ชีวภาพแอน็อกซิกชนิดเบดเคลื่อนที่เมื่อใช้เม็ดพลาสติกชีวภาพเป็นแหล่งอินทรีย์คาร์บอน, มัลลิกา พั้วพวง Jan 2020

ประสิทธิภาพการกำจัดไนเตรทและจลนพลศาสตร์ของถังปฏิกรณ์ชีวภาพแอน็อกซิกชนิดเบดเคลื่อนที่เมื่อใช้เม็ดพลาสติกชีวภาพเป็นแหล่งอินทรีย์คาร์บอน, มัลลิกา พั้วพวง

Chulalongkorn University Theses and Dissertations (Chula ETD)

งานวิจัยนี้ศึกษาการนำเม็ดพลาสติกชีวภาพมาใช้เป็นแหล่งสารอินทรีย์คาร์บอนและตัวกลางในถังปฏิกรณ์ชีวภาพแอน็อกซิกชนิดเบดเคลื่อนที่ โดยเม็ดพลาสติกชีวภาพ 3 ชนิดที่ใช้ในการทดลอง ได้แก่ PLA, PHBV และ PBS แบ่งการทดลองออกเป็น 3 ช่วง การทดลองช่วงแรกศึกษาสมบัติทางกายภาพของเม็ดพลาสติกชีวภาพ พบว่าพลาสติกชีวภาพชนิด PBS มีสมบัติความชอบน้ำ ขณะที่ PLA และ PHBV ไม่ชอบน้ำ ผลการละลายน้ำของเม็ดพลาสติกชีวภาพพบว่า PBS ตรวจพบสารอินทรีย์คาร์บอนละลายในน้ำประปาและน้ำปราศจากไอออน เพิ่มขึ้นสูงกว่า PLA และ PHBV ตามลำดับ เมื่อทดสอบการดูดซับไนเตรทของเม็ดพลาสติกชีวภาพ พบว่าที่ค่า พีเอชในช่วงที่มากกว่า 4 พื้นผิวของเม็ดพลาสติกชีวภาพทั้ง 3 ชนิดจะแสดงประจุเป็นลบ จึงไม่พบการดูดซับหรือดูดติดผิวของไนเตรทบนตัวกลาง การทดลองช่วงที่สองศึกษาประสิทธิภาพการกำจัดไนเตรทในถังปฏิกรณ์ชีวภาพแอน็อกซิกชนิดเบดเคลื่อนที่เมื่อทำการเดินระบบแบบทีละเท พบว่าเม็ดพลาสติกชีวภาพชนิด PHBV และ PBS มีประสิทธิภาพการกำจัดไนเตรทมากกว่าร้อยละ 90 ในขณะที่ PLA กำจัดไนเตรทได้เพียงร้อยละ 48 เมื่อทำการศึกษาค่าจลนพลศาสตร์การกำจัดไนเตรท พบว่ากระบวนการดีไนตริฟิเคชันที่เกิดขึ้นเป็นปฏิกิริยาอันดับศูนย์ ความเข้มข้นไนเตรทคงเหลือของการทดลองแบบทีละเทเข้าใกล้ศูนย์ที่ระยะเวลา 12 และ 15 ชม. ตามลำดับ เมื่อใช้เม็ดพลาสติกชีวภาพชนิด PHBV และ PBS เป็นแหล่งสารอินทรีย์คาร์บอน การทดลองช่วงสุดท้ายเป็นการเดินระบบแบบต่อเนื่องในถังปฏิกรณ์ชีวภาพแอน็อกซิกชนิดเบดเคลื่อนที่ ผลการทดลองพบว่าถังปฏิกรณ์ที่บรรจุเม็ดพลาสติกชีวภาพ มีประสิทธิภาพการกำจัดไนเตรทที่สภาวะคงตัวเท่ากับร้อยละ 12.87±4.92, 8.11±5.31, 12.33±8.37 และ 84.83±4.58 มีระยะเวลากักน้ำ 12, 16, 20 และ 24 ชม. ตามลำดับ โดยจลนพลศาสตร์ของการกำจัดไนเตรทจัดเป็นปฏิกิริยาอันดับหนึ่ง เนื่องจากมีปริมาณของสารอินทรีย์คาร์บอนในระบบอย่างจำกัด ทำให้ปฏิกิริยาดีไนตริฟิเคชันเกิดได้ช้าลง ขณะที่เมื่อใช้เม็ดพลาสติกชีวภาพ PBS เป็นแหล่งอินทรีย์คาร์บอน ถังปฏิกรณ์ที่บรรจุตัวกลางดังกล่าวมีประสิทธิภาพการกำจัดไนเตรทร้อยละ 99.47±0.52, 99.34±1.83, 100 และ 98.91±0.95 ที่ระยะเวลากักน้ำ 12, 8, 4 และ 2 ชม. ตามลำดับ เนื่องจากในระบบมีสารอินทรีย์คาร์บอนเพียงพอต่อการเกิดกระบวนการดีไนตริฟิเคชันจึงทำให้ปฏิกิริยาเกิดขึ้นได้อย่างสมบูรณ์

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Classification Of Organoid Transcriptomic Profiles Unravelling Colorectal Cancer Molecular Subtypes, Pattarin Nuwongsri Jan 2020

Classification Of Organoid Transcriptomic Profiles Unravelling Colorectal Cancer Molecular Subtypes, Pattarin Nuwongsri

Chulalongkorn University Theses and Dissertations (Chula ETD)

Colorectal cancer (CRC) is genetically and transcriptomically heterogeneous disease. Molecular subtyping of colorectal cancer using consensus molecular subtype (CMS) system demonstrated the potential predictive value for tumor progression and treatment response. However, the CMS system was developed from data of whole tissues containing both cancer and non-tumor transcripts components for classification which does not directly represent intrinsic heterogeneity of cancer cells. In this study genetic profiles of CRC organoids were investigated first, and the results indicate chromosomal instability (CIN) and microsatellite instability (MSI) as pathogenic pathways of CRC. Furthermore, the results also revealed diverse patterns of somatic mutations of these …

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Clinical Parameters And Biological Markers Associated With Acute Severe Ocular Complications In Stevens-Johnson Syndrome And Toxic Epidermal Necrolysis In Thailand, Rawiphan Panpruk Jan 2020

Clinical Parameters And Biological Markers Associated With Acute Severe Ocular Complications In Stevens-Johnson Syndrome And Toxic Epidermal Necrolysis In Thailand, Rawiphan Panpruk

Chulalongkorn University Theses and Dissertations (Chula ETD)

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse drug reactions with high mortality rates. Sequelae such as blindness remained even after recovery. Patients with SJS/TEN should be accurately diagnosed and received appropriate treatment as soon as possible. Therefore, factors for severity prediction are necessary. This study aimed to clarify clinical parameters and biological markers that can predict acute severe ocular complications (SOCs) in SJS/TEN. This retrospective cross-sectional study enrolled forty-seven SJS/TEN patients and divided them into two groups according to ocular severity at the acute onset, non-severe ocular complications group (N = 27) and severe ocular …

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Virus Like Particle Displaying The Major Allergen Der P 1 As A Vaccine Candidate Against House Dust Mite Allergy, Sirikarn Jitthamstaporn Jan 2020

Virus Like Particle Displaying The Major Allergen Der P 1 As A Vaccine Candidate Against House Dust Mite Allergy, Sirikarn Jitthamstaporn

Chulalongkorn University Theses and Dissertations (Chula ETD)

House dust mite (HDM) represents one of the most important allergenic sources worldwide. HDM allergens trigger in atopic patients potent Th2-biased inflammatory responses leading to the development of allergic rhinitis/asthma and atopic dermatitis. The HDM allergic response is mediated mainly by the allergen-specific Th2 cells and IgE. Der p 1, a papain-like cysteine protease, is a major HDM allergen from the Dermatophagoides pteronyssinus species, inducing allergic sensitizations in around 80 percent of HDM allergic populations. Allergen-specific immunotherapy (AIT) represents a unique specific treatment capable to revert the house dust mite (HDM) allergic response into immune tolerance through repetitive subcutaneous or …

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G6pd Activity, Oxidative Stress, And Alu Methylation In Hbv-Related Hepatocellular Carcinoma, Watcharapong Jugnam-Ang Jan 2020

G6pd Activity, Oxidative Stress, And Alu Methylation In Hbv-Related Hepatocellular Carcinoma, Watcharapong Jugnam-Ang

Chulalongkorn University Theses and Dissertations (Chula ETD)

Hepatocellular carcinoma (HCC) is the third leading caused cancer death in worldwide. The effective diagnosis markers are needed because of the late diagnosis and low survival time. G6PD is the rate-limiting enzyme in pentose phosphate pathway (PPP) that elevated in several cancers including HCC. Alu element is a common repetitive sequence in human genome, that its methylation alteration has been reported in cancers. In this study, we aimed to investigate the level of blood G6PD activity, the expression of G6PD in HCC liver tissues, the level of Alu methylation in PBMCs and clinicopathological parameters of HCC patients. Blood G6PD activity …

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Characterization Of Outer Membrane Vesicles From Escherichia Coli Bzb1107 And Bl21-De3 Strains, Sunisa Hankan Jan 2020

Characterization Of Outer Membrane Vesicles From Escherichia Coli Bzb1107 And Bl21-De3 Strains, Sunisa Hankan

Chulalongkorn University Theses and Dissertations (Chula ETD)

Vaccine is a prerequisite enhancer of acquired immunity used to protect against pathogen. The outer membrane vesicles (OMVs) are currently used for developing vaccine delivery system. Nevertheless, OMVs also contains outer membrane proteins (OMPs), which may be able to alter immunogenic effects and stability. The main objective of this study was to characterize OMVs for vaccine delivery system. Here, we compared OMV produced from BL21-DE3 and BZB1107 strains of Escherichia coli with or without expression of outer membrane proteins (OMPs), respectively. ClyA-GPF-6xhistidine tag gene was inserted into the vector. GFP was used as a representative antigen and an outer membrane …

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