Digital Commons Network^™

Knee Joint Loading Following Anterior Cruciate Ligament Reconstruction: Link To Patient Reported Outcomes And A Novel Method To Monitor With Wearable Sensors, Alex Spencer

Theses and Dissertations--Kinesiology and Health Promotion

Recovery from anterior cruciate ligament reconstruction (ACLR) commonly results in undesirable physical and patient-reported outcomes (PROs). Identification of modifiable factors such as knee contact force (KCF) early in rehabilitation that can improve these outcomes is important due to the rapid decrease in function, quality of life, and joint health in this population. Additionally, if noninvasive measurement of KCFs outside of a traditional laboratory were possible, clinicians could optimize patient treatment with personalized care. Therefore, there are two primary aims to this thesis: 1) quantify the link between KCF and PROs which measure pain, ability to perform activities of daily living, …

A Systematic Review Of Mindfulness Interventions’ Impact On Athlete Emotional Distress & Wellbeing, Trevor Nathan Tierney

Theses and Dissertations--Kinesiology and Health Promotion

Mindfulness-based interventions’ (MBIs) effectiveness for improving wellbeing and reducing emotional distress is well-documented in both clinical and non-clinical sections of the general population (McAlarnen & Longshore, 2017). Although mindfulness has been shown to be effective with these populations, less is known about the specific effects for athletes. The effects of MBI’s for athletes may be different given that the intention for MBIs in the sport context is typically to improve performance, where in most other contexts it is not (Gardner & Moore, 2012). Furthermore, athletes are a distinct population who possess unique factors on which their wellbeing and mental health …

Exploring Positive Identity And Relationship Satisfaction In Bisexual Women In Relationships With Men, Kamryn Michel

Theses and Dissertations--Kinesiology and Health Promotion

Bi-negative discrimination, negative attitudes, and beliefs regarding bisexual individuals are at least partially responsible for mental and physical distress in the bisexual community (Friedman et al., 2014). Romantic relationships can act as a buffer against negative health outcomes as well as increase overall well-being (Dush & Amato, 2005). However, research has shown that binegitive attitudes can impact a person’s willingness to begin relationships with bisexual individuals (Fienstein et al., 2014). This study aimed to explore the impact of positive identity on relationship satisfaction of bisexual women in relationships with men. In particular, we investigated five possible facets of positive identity: …

Capitalizing On Healthy Lawyers: The Business Case For Law Firms To Promote And Prioritize Lawyer Well-Being, Jarrod F. Reich

Georgetown Law Faculty Publications and Other Works

This Article is the first to make the business case for firms to promote and prioritize lawyer well-being. For more than three decades, quantitative research has demonstrated that lawyers suffer from depression, anxiety, and addiction far in excess of the general population. Since that time, there have been many calls within and outside the profession for changes to be made to promote, prioritize, and improve lawyer well-being, particularly because many aspects of the current law school and law firm models exacerbate mental health and addiction issues, as well as overall law student and lawyer distress. These calls for change, made …

Health Priorities, Current Lifestyle Behaviors, And Barriers To A Healthy Lifestyle Among Emergency Department Nurses, Shannon C. White

Theses and Dissertations--Kinesiology and Health Promotion

Background: Emergency nurses are tasked with managing the hectic, unpredictable, and constantly changing environment of an ED. In addition, emergency nurses have been shown to have high levels of stress, irregular meal schedules, rotating shift work, long hours, and a lack of physical activity. Furthermore, research has suggested that nurses are at an increased risk for non-communicable diseases, such as diabetes, hypertension, and coronary heart disease (Phiri, et al., 2014), in addition to a high prevalence of obesity (Kyle, et al., 2016).

Methodology: In this study, 23 emergency nurses completed a 43-item survey regarding current behaviors and constructs of …

Childminders’ Close Relationship Model Of Praxis: An Ecocultural Study In Ireland, Miriam O'Regan, Ann Marie Halpenny, Nóirín Hayes

Articles

The present study seeks to address the dearth of research focussed on childminding (family day care or family childcare) in Ireland, despite its significant role in national childcare provision. One overarching aim was to explore childminders’ cultural models of praxis and pedagogy in the Irish context. The research was conducted within the theoretical framework of Ecocultural Theory (ECT) (Weisner, 2002. “Ecocultural Understanding of Children’s Developmental Pathways.” Human Development 1759: 275–281), referencing concepts in Attachment Theory, in the context of historical and current policy in Ireland, Europe and the US over the last 30 years. A mixed method approach was adopted …

Towards A Social Justice Agenda: Intimate Partner Violence Among Rural, African American Women, Shani Collins Woods

Contemporary Rural Social Work Journal

The social work profession is rooted in community-based work that seeks to eradicate social injustice everywhere. Intimate partner violence (IPV) is a global phenomenon which impacts women from diverse socio-economic and racial/ethnic backgrounds. It involves power and control, economic abuse, and physical and sexual violence. When compared to other racial and ethnic groups, African American women are likelier to experience physical violence, rape, and homicide. Intimate partner violence among African American women is a social justice issue.

When compared to other racial and ethnic groups, rural and/or low-income African American women are likelier to experience IPV. They are also likelier …

Online Polarity-Dependent Effects Of Cerebellar Transcranial Direct Current Stimulation On Motor Speed And Fine Manual Dexterity: A Randomized Controlled Trial, Aysha N. Kinakool, Turki S. Abualait

Saudi Medical Journal

Objectives: To investigate the role of cerebellar transcranial direct current stimulation (ctDCS) in modulating cerebellar functions in the motor domains of fine motor dexterity and motor speed. Methods: A single-blind, randomized sham-controlled study was conducted between January and July 2018 at the neuroscience laboratory of Imam Abdulrahman Bin Faisal University. A total of 63 healthy participants were assessed for eligibility. Sixty subjects met the criteria of the study and were randomly divided into 3 groups that received anodal, cathodal or sham ctDCS. Subjects performed 2 motor tasks, The Grooved Pegboard test (GPT) assessed fine manual dexterity and the Finger Tapping …

Nitric Oxide, Asymmetric Dimethylarginine, Symmetric Dimethylarginine And L-Arginine Levels In Psychotic Exacerbation Of Schizophrenia And Bipolar Disorder Manic Episode, Mehmet F. Ustundag, Halil Ozcan, Ali G. Gencer, Enver D. Yilmaz, Kerim Uğur, Elif Oral, Mustafa Bilici

Saudi Medical Journal

Objectives: To examine the changes in nitric oxide (NO), asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), and L-arginine levels in schizophrenia during acute psychotic exacerbation and in bipolar disorder during mania and to compare those changes to healthy controls. Methods: Thirty schizophrenia patients with acute psychotic exacerbation and 30 bipolar disorder patients with mania, who attended the Psychiatry Department, Erenköy Hospital for Mental and Nervous Diseases, Istanbul, Turkey, in 2010. Thirty healthy controls were included. The diagnosis was made using the Structured Clinical Interview for Axis I Disorders (SCID-I) interviews. Patients’ demographic data were recorded, and NO, SDMA, L-arginine, and ADMA …

Does Spending More Time On Electronic Screen Devices Determine The Weight Outcomes In Obese And Normal Weight Saudi Arabian Children?, Hmidan A. Alturki, Denise S.K. Brookes, Peter S.W. Davies

Saudi Medical Journal

Objectives: To gather data and investigate if ownership and duration of using electronic devices determines the weight status in an urban Saudi school-aged child. Methods: A multicenter, cross-sectional study conducted in Riyadh, Saudi Arabia between December 2015 and March 2016. A total of 1023 child were randomly selected, aged 9.00 to 11.99 years. The participants were divided into 2 groups (normal weight and obese), and further stratified by gender. As self-paced questionnaire was used to collect sedentary behaviors data, in addition to the anthropometric measurements and body fat composition of the participants. Results: Hours spent watching TV/DVD/videos were not significantly …

Applying Dimensional Psychopathology: Transdiagnostic Associations Among Regional Homogeneity, Leptin And Depressive Symptoms, Yan-Ge Wei, Jia Duan, Fay Y. Womer, Yue Zhu, Zhiyang Yin, Lingling Cui, Chao Li, Zhuang Liu, Shengnan Wei, Xiaowei Jiang, Yanbo Zhang, Xizhe Zhang, Yanqing Tang, Fei Wang

Open Access Publications

No abstract provided.

Individualization Of Attention-Deficit/Hyperactivity Disorder Treatment: Pharmacotherapy Considerations By Age And Co-Occurring Conditions, Greg W Mattingly, Joshua Wilson, Leticia Ugarte, Paul Glaser

Open Access Publications

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that manifests in childhood and can persist into adolescence and adulthood. Impairments associated with ADHD can impact quality of life, social interactions, and increase the risk of morbidity and mortality; however, for many patients, effective treatment can lessen these effects. Pharmacotherapy with stimulants or nonstimulants is recommended in conjunction with psychosocial therapy for most patients. Determining the optimal pharmacotherapy can be complex, and the clinician needs to consider many factors such as the patient's age, comorbidities, and lifestyle. Furthermore, the needs of the patient with ADHD will change over time, with specific challenges …

Evaluation Of Naturalistic Driving Behavior Using In-Vehicle Monitoring Technology In Preclinical And Early Alzheimer's Disease, Jennifer D Davis, Ganesh M Babulal, George D Papandonatos, Erin M Burke, Christopher B Rosnick, Brian R Ott, Catherine M Roe

Open Access Publications

Cognitive impairment is a significant risk factor for hazardous driving among older drivers with Alzheimer's dementia, but little is known about how the driving behavior of mildly symptomatic compares with those in the preclinical, asymptomatic phase of Alzheimer's disease (AD). This study utilized two in-car technologies to characterize driving behavior in symptomatic and preclinical AD. The goals of this pilot study were to (1) describe unsafe driving behaviors in individuals with symptomatic early AD using G-force triggered video capture and (2) compare the driving habits of these symptomatic AD drivers to two groups of cognitively normal drivers, those with and …

Self-Reported Sleep Disturbance In Crohn’S Disease Is Not Confrmed By Objective Sleep Measures, Heba N. Iskandar, Emily E. Linan, Ami Patel, Renee Moore, Yi Lasanajak, C. Prakash Gyawali, Gregory S. Sayuk, Matthew A. Ciorba

Open Access Publications

No abstract provided.

The At(N) Framework For Alzheimer's Disease In Adults With Down Syndrome, Michael S Rafii, Beau M Ances, Et Al

Open Access Publications

The National Institute on Aging in conjunction with the Alzheimer's Association (NIA-AA) recently proposed a biological framework for defining the Alzheimer's disease (AD) continuum. This new framework is based upon the key AD biomarkers (amyloid, tau, neurodegeneration, AT[N]) instead of clinical symptoms and represents the latest understanding that the pathological processes underlying AD begin decades before the manifestation of symptoms. By using these same biomarkers, individuals with Down syndrome (DS), who are genetically predisposed to developing AD, can also be placed more precisely along the AD continuum. The A/T(N) framework is therefore thought to provide an objective manner by which …

Relationships Between Big-Five Personality Factors And Alzheimer's Disease Pathology In Autosomal Dominant Alzheimer's Disease, Andrew J Aschenbrenner, Jennifer Petros, Eric Mcdade, Guoqiao Wang, David A Balota, Tammie Ls Benzinger, Carlos Cruchaga, Chengjie Xiong, Richard Perrin, Anne M Fagan, John C Morris, Randall Bateman, Jason Hassenstab, Et Al

Open Access Publications

Introduction: Changes in personality characteristics are associated with the onset of symptoms in Alzheimer's disease (AD) and may even precede clinical diagnosis. However, personality changes caused by disease progression can be difficult to separate from changes that occur with normal aging. The Dominantly Inherited Alzheimer Network (DIAN) provides a unique cohort in which to relate measures of personality traits to in vivo markers of disease in a much younger sample than in typical late onset AD.

Methods: Personality traits measured with the International Personality Item Pool at baseline from DIAN participants were analyzed as a function of estimated years to …

Use Of Neuroimaging To Inform Optimal Neurocognitive Criteria For Detecting Hiv-Associated Brain Abnormalities, Laura M Campbell, David B Clifford, Et Al, Charter Group

Open Access Publications

OBJECTIVE: Frascati international research criteria for HIV-associated neurocognitive disorders (HAND) are controversial; some investigators have argued that Frascati criteria are too liberal, resulting in a high false positive rate. Meyer et al. recommended more conservative revisions to HAND criteria, including exploring other commonly used methodologies for neurocognitive impairment (NCI) in HIV including the global deficit score (GDS). This study compares NCI classifications by Frascati, Meyer, and GDS methods, in relation to neuroimaging markers of brain integrity in HIV.

METHOD: Two hundred forty-one people living with HIV (PLWH) without current substance use disorder or severe (confounding) comorbid conditions underwent comprehensive neurocognitive …

A Framework For Applying Natural Language Processing In Digital Health Interventions, Burkhardt Funk, Shiri Sadeh-Sharvit, Ellen E Fitzsimmons-Craft, Mickey Todd Trockel, Grace E Monterubio, Neha J Goel, Katherine N Balantekin, Dawn M Eichen, Rachael E Flatt, Marie-Laure Firebaugh, Corinna Jacobi, Andrea K Graham, Mark Hoogendoorn, Denise E Wilfley, C Barr Taylor

Open Access Publications

BACKGROUND: Digital health interventions (DHIs) are poised to reduce target symptoms in a scalable, affordable, and empirically supported way. DHIs that involve coaching or clinical support often collect text data from 2 sources: (1) open correspondence between users and the trained practitioners supporting them through a messaging system and (2) text data recorded during the intervention by users, such as diary entries. Natural language processing (NLP) offers methods for analyzing text, augmenting the understanding of intervention effects, and informing therapeutic decision making.

OBJECTIVE: This study aimed to present a technical framework that supports the automated analysis of both types of …

A Mobile Health App For The Collection Of Functional Outcomes After Inpatient Stroke Rehabilitation: Pilot Randomized Controlled Trial, Li Li, Jia Huang, Jingsong Wu, Cai Jiang, Shanjia Chen, Guanli Xie, Jinxin Ren, Jing Tao, Chetwyn C H Chan, Lidian Chen, Alex W K Wong

Open Access Publications

BACKGROUND: Monitoring the functional status of poststroke patients after they transition home is significant for rehabilitation. Mobile health (mHealth) technologies may provide an opportunity to reach and follow patients post discharge. However, the feasibility and validity of functional assessments administered by mHealth technologies are unknown.

OBJECTIVE: This study aimed to evaluate the feasibility, validity, and reliability of functional assessments administered through the videoconference function of a mobile phone-based app compared with administration through the telephone function in poststroke patients after rehabilitation hospitalization.

METHODS: A randomized controlled trial was conducted in a rehabilitation hospital in Southeast China. Participants were randomly assigned …

Quality Of Life With Second Or Third Line Nab-Paclitaxel-Based Regimens In Advanced Non-Small-Cell Lung Cancer, Santiago Ponce Aix, Ramaswamy Govindan, Daniel Morgensztern, Et Al

Open Access Publications

No abstract provided.

A Mobile App Directory Of Occupational Therapists Who Provide Home Modifications: Development And Preliminary Usability Evaluation, An Thi Nguyen, Emily Kling Somerville, Sandra Martina Espín-Tello, Marian Keglovits, Susan Lynn Stark

Open Access Publications

BACKGROUND: Home modifications provided by occupational therapists (OTs) are effective in improving daily activity performance and reducing fall risk among community-dwelling older adults. However, the prevalence of home modification is low. One reason is the lack of a centralized database of OTs who provide home modifications.

OBJECTIVE: This study aimed to develop and test the usability of a mobile app directory of OTs who provide home modifications in the United States.

METHODS: In phase 1, a prototype was developed by identifying OTs who provide home modifications through keyword Web searches. Referral information was confirmed by phone or email. In phase …

Exercise Training Results In Lower Amyloid Plaque Load And Greater Cognitive Function In An Intensity Dependent Manner In The Tg2576 Mouse Model Of Alzheimer's Disease, Riya Thomas, Scott D Zimmerman, Kayla M Yuede, John R Cirrito, Leon M Tai, Benjamin F Timson, Carla M Yuede

Open Access Publications

Three months of exercise training (ET) decreases soluble Aβ

Human Brain Functional Network Organization Is Disrupted After Whole-Brain Radiation Therapy, Timothy J. Mitchell, Benjamin A. Seitzman, Nicholas Ballard, Steven E. Petersen, Joshua S. Shimony, Eric C. Leuthardt

Open Access Publications

No abstract provided.

Family Encouragement Of Healthy Eating Predicts Child Dietary Intake And Weight Loss In Family-Based Behavioral Weight-Loss Treatment, Sophia A. Rotman, Lauren A. Fowler, Mary Katherine Ray, Richard I. Stein, Jacqueline F. Hayes, Rachel P. Kolko, Katherine N. Balantekin, Alexis Engel, Brian E. Saelens, R. Robinson Welch, Michael G. Perri, Leonard H. Epstein, Denise E. Wilfley

Open Access Publications

No abstract provided.

Medulloblastoma Has A Global Impact On Health Related Quality Of Life: Findings From An International Cohort, Cynthia B De Medeiros, Josh Rubin, Et Al

Open Access Publications

BACKGROUND: Understanding the global impact of medulloblastoma on health related quality of life (HRQL) is critical to characterizing the broad impact of this disease and realizing the benefits of modern treatments. We evaluated HRQL in an international cohort of pediatric medulloblastoma patients.

METHODS: Seventy-six patients were selected from 10 sites across North America, Europe, and Asia, who participated in the Medulloblastoma Advanced Genomics International Consortium (MAGIC). The Health Utilities Index (HUI) was administered to patients and/or parents at each site. Responses were used to determine overall HRQL and attributes (ie specific subdomains). The impact of various demographic and medical variables …

Quantitative Definition Of Neurobehavior, Vision, Hearing And Brain Volumes In Macaques Congenitally Exposed To Zika Virus, Michelle R. Koenig, Kevin Noguchi, Et Al.

Open Access Publications

Congenital Zika virus (ZIKV) exposure results in a spectrum of disease ranging from severe birth defects to delayed onset neurodevelopmental deficits. ZIKV-related neuropathogenesis, predictors of birth defects, and neurodevelopmental deficits are not well defined in people. Here we assess the methodological and statistical feasibility of a congenital ZIKV exposure macaque model for identifying infant neurobehavior and brain abnormalities that may underlie neurodevelopmental deficits. We inoculated five pregnant macaques with ZIKV and mock-inoculated one macaque in the first trimester. Following birth, growth, ocular structure/function, brain structure, hearing, histopathology, and neurobehavior were quantitatively assessed during the first week of life. We identified …

Mental Health And Weather Extremes In A Southeastern U.S. City: Exploring Group Differences By Race, Lisa Reyes Mason, Bonita B Sharma, Jayme E Walters, Christine C Ekenga

Open Access Publications

The connection between mental health and weather extremes is a public health concern, but less studied to date than physical health. This exploratory study examines the mental health impacts of two kinds of weather extremes increasingly linked to climate change-summer heat waves and extreme winter weather-in a low- to middle-income population in the Southeastern U.S. The distribution of mental health impacts, and potential pathways to them, are examined with a focus on race. Data are from a random-sample survey of 426 participants and are analyzed with bivariate statistics and path analysis. Self-reported mental health impacts, in both seasons, were common …

Feasibility And Validity Of A Low-Cost Racing Simulator In Driving Assessment After Stroke, Jonathan Tiu, Annie C Harmon, James D Stowe, Amen Zwa, Marc Kinnear, Latch Dimitrov, Tina Nolte, David B Carr

Open Access Publications

There is a myriad of methodologies to assess driving performance after a stroke. These include psychometric tests, driving simulation, questionnaires, and/or road tests. Research-based driving simulators have emerged as a safe, convenient way to assess driving performance after a stroke. Such traditional research simulators are useful in recreating street traffic scenarios, but are often expensive, with limited physics models and graphics rendering. In contrast, racing simulators developed for motorsport professionals and enthusiasts offer high levels of realism, run on consumer-grade hardware, and can provide rich telemetric data. However, most offer limited simulation of traffic scenarios. This pilot study compares the …

Association Of Ptsd Symptom Groups With Functional Impairment And Distress In Trauma-Exposed Disaster Survivors, Carol S North, Erin Van Enkevort, Barry A Hong, Alina M Surís

Open Access Publications

BACKGROUND: In the nearly a quarter of a century since the addition of the clinically significant distress/impairment criterion to the definition of PTSD in DSM-IV, little research has been done to examine the association of this criterion with symptom group criteria and with the numbing subgroup specifically. This study was conducted to examine these relationships in a large database of disaster survivors consistently studied across 12 different incidents of the full range of disaster typology.

METHODS: Analysis was conducted on a merged database representing 1187 trauma-exposed survivors of 12 different disasters studied systematically. DSM-IV-TR criteria for disaster-related PTSD were assessed …

Expanding The Genetic Architecture Of Nicotine Dependence And Its Shared Genetics With Multiple Traits, Bryan C. Quach, Michael J. Bray, Pamela Madden, Laura J. Bierut, Nancy L. Saccone, Et Al.

Open Access Publications

No abstract provided.