Digital Commons Network^™

Fda Regulation Impact On Early Stage Medical Device Innovation In Academia, Keyana Fariello

Theses

The commercialization of medical products at the university level is a multilayered and challenging process. One barrier to commercialization is the difficulty of meeting Food and Drug Administration (FDA) regulatory requirements. Regulations and standards are undoubtedly necessary to maintain the highest product safety levels, but it creates many obstacles. This paper will analyze how researchers involved with early-stage medical device innovation in a university setting deal with FDA compliance issues and the implications of this engagement for innovation. I conducted an exploratory case study of ten medical product development projects at the Rochester Institute of Technology (RIT). Overall, I found …

The Utilization And Challenges Of Application Of Geographic Information Systems (Gis) In The Library Scenario: Case Study, Devashri Shastri

Library Philosophy and Practice (e-journal)

This study aims to describe the fundamentals of Geographic Information Systems (GIS) technology, to look into the purpose of application of Geographic Information Systems (GIS) in the context of the library and collected data about spatial information resources and services offer by the Dornsife School of Public Health Library, Drexel University. The study also discusses challenges and solutions about the implementation of GIS in the Indian library scenario. The application of GIS to provide spatial information services requires a long term strategic plan, investment and skilled personnel in the library scenario.

Probing The Impacts Of Ultra-Low Platinum Loadings On Membrane Degradation Mechanisms, Andre J. Spears

Nanoscience and Microsystems ETDs

Membrane chemical degradation is one of many factors that can impact fuel cell durability. The fuel cell’s performance and lifetime heavily depends on the membrane and its ability to maintain chemical and mechanical integrity. In Nafion^® membranes, hydroxyl radicals are the primary cause of chemical membrane degradation as they attack the membrane’s polymer structure. Radical formation can ensue via peroxide decomposition at the cathode or gases reacting on Pt particles or contaminants like Fe (a fenton's reagent) within the membrane. As radicals attack the membrane’s polymer structure the membrane thins, and fluoride and sulfate ions are released. This consequently …

What Uab Academic Campus Looks Like During Covid-19, Brianna Hoge

Browse All News

No abstract provided.

Fracture Properties And Process Zone Length Of High Strength Concrete Using Size Effect Method., Ahmed Hassan Abdel-Reheem, Mohamed Gamal Mohamed Mahdy

Mansoura Engineering Journal

This paper gives a report on a fracture mechanics study of legal strength concrete with compressive strength up 80 MPa.. 6 mixes were selected, designed to achieve a slump above 100 mm and strength up to 80 MPa.. The investigation used tiered levels of silica fume(0, 10%, 20% by weight of cement) and two coarse aggregate proportions of local aggregate (0.48, 0.65 by volume) In each case, compressive strength, splitting tensile strength, flexural strength fracture energy Gr and Fracture process zone Cr were determined. A test method for determining fracture energy Gr and process zone length Cr, defined by the …

Monitoring Urbon Exponsion For Irbid City By Using Remote Sensing & Gis (1953-1999)., S. Duheisat, O. Dhaimat

Mansoura Engineering Journal

This study was related to the urban development of Irbid City during 1955 - 1999 by using remote sensing technique and geographic information system. The results of the study indicated that the size of the city was increased 46 times through various directions based on images of 1978, towards south and east by using images of 1984, and towards north and east up to 1989. But images of 1995 showed that the urban development relatively covered the cold agricultural lands and connected with surrounded villages such as Saal, Bushra, Howaru, Aidon, Hakama, and Baitras. Besides that, images of 1999 indicated …

Optimal Operation For A Faulted Pv System Using Genetic Algorithm., Sahar Sidky Kaddah

Mansoura Engineering Journal

The need to optimize the operation of PV systems is justified by the fact that PV systems are expensive to build, fuel- free source, and it is therefore natural that user of sulci systems would want them to perform it their most optimal point. Under the faulted condition, the power curve has a multi-picture; conventional optimization techniques can easily fall down in local optimal and initial point problems. Genetic algorithm as a global optimization technique is adopted to optimize photovoltaic power system under different faulted conditions. The proposed PV system and GA scheme is tested for the three-array PV system …

Integration Of Brain Based Learning And Intelligent Tutoring System For Developing Pedagogical Software., A. El-Gamal

Mansoura Engineering Journal

The development of intelligent tutoring systems and learning environments has become an important issue in both computer science and education. This paper presents pedagogical software for a secondary school biology course. The proposed system integrates the concepts of Brain Based Learning (BBL) and intelligent tutoring system to adapt the learning interface according to the student thinking style. The system is formalized as finite automata with some attributes that allow lemur interaction (image, video, text, color, sound and contents) and some user's brain characteristics (right, left, and integrated thinking style). For the same contents and strategy the information of the learner …

Theoretical And Experimental Lnvestigation On The Absorption Refrigeration Systems., A. Elzahaby, Ahmed Mohamed Kandel, A. Kabeel, M. Elseady

Mansoura Engineering Journal

In the present work, a theoretical model is developed to study the single-effect absorption refrigeration cycle from the thermodynamic point of view for lithium bromide-water pair und lithium chloride-water pair. The effect of different operating (temperatures on the coefficient of performance (COP) and low ratio (FR) (the weak solution mass flow rate with reference to the refrigerant 113ss low rule) are investigated. This generation process in cui absorption refrigeration cycle using lithium chloride-Water solution is the working pair is experimentally studied. From the theoretical study, it is found that the COP increases an within increases in generation temperature until a …

Emission Characteristics From Vehicles At Idling Condition., A. Elzahaby, A. Bawady, A. Kabeel, S. Wilson, A. El Dabaa

Mansoura Engineering Journal

The present study aims to evaluate the emission characteristics for gasoline-fueled vehicles at idling condition. Factors influencing the formation of emissions at different operating conditions are examined. The study is focused on the ignition parameters as well as the mixture quality which are the most important factors affecting the engine performance and emission. A wide range of spark plug gap(0.3- 1.9) mm and ignition timing (10- 1900 BTDC)were employed in the present study. The mixture quality at idling is varied along the flammability limit to clarify its effect on the combustion products concentration. The measurements were carried out on a …

Influence Of Microstructural Characteristics On Electrical Discharge Wire Cutting Condition Of A390 Al-Si Hypereutectic Alloy., Hossam El-Din Zakaria, Ahmed Gafaar, Sameh Habib, Tamer Mahmoud

Mansoura Engineering Journal

The paper presents the results of an experimental investigation on the machinability of A390 hypereutectic Al-Si alloy using wire electrical discharge machining (WEDM). The effect of the modification and grain refinement treatments on the microstructure and also on the machining conditions has been evaluated. The process parameters taken into consideration are the average gap voltage (A;), surface finish type (SF), pulse frequency (F), cutting speed (CS), material removal rate (MRR) and finally the kerf size (KS). The results show that the modification process of 4390 alloy has a significant effect on the electrical discharge wire cutting (EDWC) parameters. It has …

Evaluating Emission Characteristics From Vehicles At Road Test With Different Operating Conditions., A. El-Zahaby, A. Kabeel, A. Bawady, S. Wilson, A. Eidabaa

Mansoura Engineering Journal

The present work aims to introduce a new method to evaluate emission characteristics from vehicles al road test condition. The technique is characterized by introducing unique factors representing the equivalent toxic effect of the exhaust species. The method depends on measuring the concentration of exhaust species and calculating a factor called 'conditioned ton" taking into consideration the toxic weight of each species relative to CO. For this purpose, a series of measurements were carried out on a specified vehicle to prevent vehicle to-vehicle variation. The vehicle is equipped with an infrared gas analyzer and a magnetic pickup transducer to measure …

Modeling Fluidized Bed Combustion Of Liquid Fuel., Farouk Mohamed El-Sayed

Mansoura Engineering Journal

A mathematical model has been developed 10 predict the combustion of liquid fuel in a fluidized bed. From the fluid-dynamic point of view, the model is based on the modified two-phase theory of fluidization where the gas in the bed is assumed to have three phases. A jet-bubble phase which is fuel rich bubbles formed at fuel feeding jet, a distributor-bubble phase which is fuel free bubbles generated at distributor plate and an emulsion phase. Each phase has its composition and exchanges masses with the other two ones. The bubble is assumed to have a constant size throughout the bed. …

Modeling Combustion Of Straw-Bitumen-Pellets In A Fluidized Bed., Farouk Okasha

Mansoura Engineering Journal

Recently straw-bitumen-pellets have been proposed as an alternative fuel. This work presents a mathematical model for steady state combustion of straw-bitumen-pellets in a bubbling fluidized bed. The combustor is divided into three zones; dense bed, splashing zone and freeboard. Important processes including volatile segregation, char comminution and elutriation, bed particles ejection; and post-combustion in splashing zone and freeboard have been considered and simplified. Submodels for hydrodynamic, volatile release and combustion, and char consumption have been implemented. Energy balance for splashing zone and freeboard has been set to predict axial temperature profile. Model results demonstrate that about 53% of volatiles combustion …

Large-Scale Characterization Of Drug Responses Of Clinically Relevant Proteins In Cancer Cell Lines, Wei Zhao, Jun Li, Mei-Ju M Chen, Yikai Luo, Zhenlin Ju, Nicole K Nesser, Katie Johnson-Camacho, Christopher T Boniface, Yancey Lawrence, Nupur T Pande, Michael A Davies, Meenhard Herlyn, Taru Muranen, Ioannis K Zervantonakis, Erika Von Euw, Andre Schultz, Shwetha V Kumar, Anil Korkut, Paul T Spellman, Rehan Akbani, Dennis J Slamon, Joe W Gray, Joan S Brugge, Yiling Lu, Gordon B Mills, Han Liang

Faculty, Staff and Students Publications

Perturbation biology is a powerful approach to modeling quantitative cellular behaviors and understanding detailed disease mechanisms. However, large-scale protein response resources of cancer cell lines to perturbations are not available, resulting in a critical knowledge gap. Here we generated and compiled perturbed expression profiles of ∼210 clinically relevant proteins in >12,000 cancer cell line samples in response to ∼170 drug compounds using reverse-phase protein arrays. We show that integrating perturbed protein response signals provides mechanistic insights into drug resistance, increases the predictive power for drug sensitivity, and helps identify effective drug combinations. We build a systematic map of "protein-drug" connectivity …

Reflections On Political Policies And Statements In Arts And Literature In Prc, Jiangang Yang, Gongyan Jiang

CLCWeb: Comparative Literature and Culture

This paper investigates the political policies and statements in arts and literature in the People’s Republic of China (1949-present). The Chinese Communist Party (CCP) has always taken arts and literature as essential parts of its political and ideological rule, and, as such, they constitute a distinct Chinese model or Chinese path in the studies of arts and literature in the modern world. This paper examines the four stages of the political discourse and statements of literature: (1) as an engine of the revolutionary machine in the Mao era (1949-76); (2) as an object of aesthetic appreciation in the decade of …

The System Of Music Education In Azerbaijan: The Role Of Sound Engineering And Concert Sound Engineering In The Educational Process, Aleksey Khmirov

Eurasian music science journal

The article considers the sphere of education, culture and art of Azerbaijan. The sphere of sound engineering, the issues of formation and development, tasks, and practical activities are studied. The research laboratory (acoustics laboratory) "Study of the Azerbaijan oral tradition of professional music and its new directions: organology and acoustics" is considered. Education, culture, art and music are the main objects of research in the artistic universities of Azerbaijan. A comparative analysis of the artistic universities of the Republic of Azerbaijan and Uzbekistan revealed the achievements and shortcomings of the two systems. The acoustic capabilities of concert halls and outdoor …

Operationalizing Niche Construction Theory With Stone Tools, Radu Lovita, David R. Braun, Matthew J. Douglass, Simon J. Holdaway, Sam C. Lin, Deborah I. Olsezewski, Zeljko Rezek

School of Natural Resources: Faculty Publications

One of the greatest difficulties with evolutionary approaches in the study of stone tools (lithics) has been finding a mechanism for tying culture and biology in a way that preserves human agency and operates at scales that are visible in the archaeological record. The concept of niche construction, whereby organisms actively construct their environments and change the conditions for selection, could provide a solution to this problem. In this review, we evaluate the utility of niche construction theory (NCT) for stone tool archaeology. We apply NCT to lithics both as part of the “extended phenotype” and as residuals or precipitates …

Dysregulated Interferon Response Underlying Severe Covid-19, Leann Lopez, Peter C. Sang, Yun Tian, Yongming Sang

Agricultural and Environmental Sciences Faculty Research

Innate immune interferons (IFNs), including type I and III IFNs, constitute critical antiviral mechanisms. Recent studies reveal that IFN dysregulation is key to determine COVID-19 pathogenesis. Effective IFN stimulation or prophylactic administration of IFNs at the early stage prior to severe COVID-19 may elicit an autonomous antiviral state, restrict the virus infection, and prevent COVID-19 progression. Inborn genetic flaws and autoreactive antibodies that block IFN response have been significantly associated with about 14% of patients with life-threatening COVID-19 pneumonia. In most severe COVID-19 patients without genetic errors in IFN-relevant gene loci, IFN dysregulation is progressively worsened and associated with the …

Southern Adventist University Commencement Program December 13, 2020, Southern Adventist University

Commencement Programs

Program for Southern Adventist University December graduation. The commencement service took place on December 13, 2020.

Adaptive Ensemble Of Classifiers With Regularization For Imbalanced Data Classification, Chen Wang, Chengyuan Deng, Zhoulu Yu, Dafeng Hui, Xiaofeng Gong, Ruisen Luo

Biology Faculty Research

The dynamic ensemble selection of classifiers is an effective approach for processing label-imbalanced data classifications. However, such a technique is prone to overfitting, owing to the lack of regularization methods and the dependence on local geometry of data. In this study, focusing on binary imbalanced data classification, a novel dynamic ensemble method, namely adaptive ensemble of classifiers with regularization (AER), is proposed, to overcome the stated limitations. The method solves the overfitting problem through a new perspective of implicit regularization. Specifically, it leverages the properties of stochastic gradient descent to obtain the solution with the minimum norm, thereby achieving regularization; …

Krs Flow Junction Case Study And Simulation, Byeongmok (Brad) Kim, Madhi Moghaddam, Maitreya Sreeram, Shimon Y. Nof

Production, Robotics, and Integration Software for Manufacturing & Management Center

No abstract provided.

Possible Transmission Flow Of Sars-Cov-2 Based On Ace2 Features, Sk Sarif Hassan, Shinjini Ghosh, Diksha Attrish, Pabitra Pal Choudhury, Alaa A A Aljabali, Bruce D Uhal, Kenneth Lundstrom, Nima Rezaei, Vladimir N Uversky, Murat Seyran, Damiano Pizzol, Parise Adadi, Antonio Soares, Tarek Mohamed Abd El-Aziz, Ramesh Kandimalla, Murtaza M Tambuwala, Gajendra Kumar Azad, Samendra P Sherchan, Wagner Baetas-Da-Cruz, Kazuo Takayama, Ángel Serrano-Aroca, Gaurav Chauhan, Giorgio Palu, Adam M Brufsky

All publications

Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that is engendering the severe coronavirus disease 2019 (COVID-19) pandemic. The spike (S) protein receptor-binding domain (RBD) of SARS-CoV-2 binds to the three sub-domains viz. amino acids (aa) 22-42, aa 79-84, and aa 330-393 of ACE2 on human cells to initiate entry. It was reported earlier that the receptor utilization capacity of ACE2 proteins from different species, such as cats, chimpanzees, dogs, and cattle, are different. A comprehensive analysis of ACE2 receptors of nineteen species was carried out in this study, and the …

Intelligent Networks For High Performance Computing, William Whitney Schonbein

Computer Science ETDs

There exists a resurgence of interest in `smart' network interfaces that can operate on data as it flows through a network. However, while smart capabilities have been expanding, what they can do for high-performance computing (HPC) is not well-understood. In this work, we advance our understanding of the capabilities and contributions of smart network interfaces to HPC. First, we show current offloaded message demultiplexing can mitigate (but not eliminate) overheads incurred by multithreaded communication. Second, we demonstrate current offloaded capabilities can be leveraged to provide Turing complete program execution on the interface. We elaborate with a framework for offloading arbitrary …

No More Funeral Marches: How An Orchestra Conductor Is Using Music To Heal His City, Carolyn Brown

Capstones

In the wake of the Breonna Taylor grand jury decision, the city of Louisville became, as Louisville Orchestra conductor Teddy Abrams put it, "the epicenter of journalism." Abrams, the youngest conductor of a major orchestra in the United States, has hundreds of thousands of fans across the country. He's also an ardent political activist. By making the Orchestra's 2020 season virtual, diversifying their featured composers and works, and providing free one-on-one "comfort concerts" over Zoom, Abrams has been working to make the traditionally White space of classical music more inclusive, safe, and accessible. https://www.cebrownphoto.com/no-more-funeral-marches

Giftedness In Young Children: What Do Parents And Teachers Know?, Katie Goodman

Departmental Honors & Graduate Capstone Projects

Abstract

Past research has explored how young children express giftedness as well as how parents and teachers can best meet the needs of these children once they have been identified. However, there is a distinct lack of literature on what parents and teachers actually know about how giftedness manifests in the youngest learners. This research investigates the background knowledge that teachers and parents of preschoolers hold on the notion of giftedness. Parents and teachers of young children were surveyed using online survey software by contacting a diverse set of private preschools within the Northern Virginia area. Parents and teachers at …

Induced Flow In Coaxial Rotor Systems, Andrew Bergantz

Mechanical Engineering and Materials Science Independent Study

In coaxial rotor helicopter systems, both rotors of the helicopter spin in opposite directions on the same vertical axis, requiring the bottom rotor to spin faster with a higher blade pitch angle and the top rotor to spin slower with a lower blade pitch angle. This was proven by Peters and Seidel [1]. As both blades are spinning, there is an induced flow of air between the rotors. The solution of the potential flow equations shows that the flow induced by the upper rotor on the lower is related to the adjoint velocity above the rotors and the time delays …

Pertumbuhan Dan Hasil Benih Kentang G0 Kultivar Medians Pada Berbagai Komposisi Media Tanam Dan Interval Pemberian Air Di Dataran Medium, Jajang Sauman Hamdani, Sumadi, Kusumiyati, Haifa Ruwaidah

Jurnal Kultivasi

Benih merupakan kunci sukses budidaya kentang. Salah satu faktor yang mempengaruhi dan menjadi kendala produksi kentang di Indonesia adalah ketersediaan benih kentang yang memiliki kualitas dan kuantitas baik serta belum memenuhi kebutuhan permintaan benih petani kentang. Permasalahan produksi benih kentang generasi ke-0 (G0) adalah rendahnya jumlah ubi benih yang dihasilkan. Percobaan ini bertujuan untuk mengetahui interaksi antara komposisi media tanam dengan interval pemberian air terhadap produksi benih kentang G0 di dataran medium. Percobaan dilaksanakan di Kebun Percobaan, Fakultas Pertanian, Universitas Padjadjaran, Kampus Jatinangor. Rancangan percobaan yang digunakan yaitu Split Plot. Petak utama adalah komposisi media tanam yang terdiri dari campuran …

Nyc Communities Battle Flooding, But Not From Coastal Storms, Danielle C. Cruz

Capstones

A look at the impact high-tide flooding and inland flooding has on various communities in New York City. This article also looks into what city officials are doing and not doing to address the concerns of residents who have had to deal with recurring flooding in their community.

Link to Capstone: https://danielle-cruz.format.com/nyc-communities-battle-flooding

Bibliometric Survey On Effect Of Climate Factors On Spread Of Coronavirus (Covid-19), Seema Patil, Jay Makwana, Manish Attri

Library Philosophy and Practice (e-journal)

The new SARS-CoV-2 COVID-19 has spread quickly around the globe since it was first reported in Wuhan city of China, in December 2019 subsequent to being contracted from a zoonotic source. The main focus of this bibliometric survey is to recognize the few studies which have upheld the epidemiological hypothesis that the effect of climatic factors is playing a crucial role in the spreading of COVID-19. The analysis is done on the basis of 412 documents such as journals, articles, editorials, short surveys and some review papers. The United States contributes to the maximum number of publications followed by the …