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2020

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Usp <800> Compliance: A Hazardous Drug Safe Handling Ppe Toolkit For Infusion Nurses, Cynthia Huff Dec 2020

Usp <800> Compliance: A Hazardous Drug Safe Handling Ppe Toolkit For Infusion Nurses, Cynthia Huff

Doctor of Nursing Practice (DNP) Projects

Problem: Safety concerns have existed for more than 40 years about how hazardous drug (HD) exposure contributes to long- and short-term adverse health outcomes for healthcare workers (HCWs). Careless handling may cause toxic residues to infiltrate hospital environments and patient care areas, and can even be traced to patients’ homes. New government regulations will require healthcare organizations to minimize exposure risks to HCWs by fully implementing the U.S. Pharmacopeia (USP) Convention Chapter 800: Hazardous Drugs: Handling in Healthcare Settings (USP, 2016) on December 1, 2019. According to Polovich and Olsen (2017), “The implementation of the USP <800> Standards will represent …


Molecular Variation Of Rh, Mn, Duffy, Kidd, Kell, And Lutheran Blood Groups In The Human Population Of Bosnia And Herzegovina, Lejla Lasic, Abdurahim Kalajdzic, Belma Kalamujic Stroil, Lejla Pojskic, Jasna Hanjalic, Lejla Usanovic, Naris Pojskic Dec 2020

Molecular Variation Of Rh, Mn, Duffy, Kidd, Kell, And Lutheran Blood Groups In The Human Population Of Bosnia And Herzegovina, Lejla Lasic, Abdurahim Kalajdzic, Belma Kalamujic Stroil, Lejla Pojskic, Jasna Hanjalic, Lejla Usanovic, Naris Pojskic

Human Biology Open Access Pre-Prints

Six blood groups (Rh, MN, Duffy, Kidd, Kell and Lutheran) were investigated among three major ethnic groups (Bosniaks, Bosnian Croats, and Bosnian Serbs) as well as ten regional subpopulations across Bosnia and Herzegovina (Krajina, Posavina, North-Eastern Bosnia, Eastern Bosnia, Middle Bosnia, Central Bosnia, Sarajevo Region, Eastern Herzegovina, Central Herzegovina, and Western Herzegovina). This is the first study that introduces the molecular genetic typing of five blood groups within the population of Bosnia and Herzegovina with the exception of RhD blood group. The sample consisted of 450 buccal swabs from unrelated individuals. Five blood group systems (RhD, RhC, …


The Impact Of Knowledge Management Practices On The Survival And Sustenance Of Construction Organisations, Onyealilam Onyeagam, William Nwaki, Bernard Obonadhuze, Mohammed Zakariyau Dec 2020

The Impact Of Knowledge Management Practices On The Survival And Sustenance Of Construction Organisations, Onyealilam Onyeagam, William Nwaki, Bernard Obonadhuze, Mohammed Zakariyau

CSID Journal of Infrastructure Development

The dynamics in technological advancement and innovations in construction methods have caused construction organizations to operate in a highly competitive environment. As knowledge is an essential asset for surviving and remaining competitive in the construction industry, this study investigates the impact of knowledge management practices on the survival and sustenance of construction organizations. Construction professionals in Abuja-Nigeria were sampled using a well-structured questionnaire and multi-sampling techniques. The results of the study show that there is a low level of implementation of Knowledge Management among the construction organizations. Furthermore, it is found that the significant benefits of KM implementation are to …


Organisational Culture Characterisation Of Construction Firms In Nigeria, Adebisi Abosede Bamgbade, Richard Ajayi Jimoh, Luqman Oyekunle Oyewobi, Maroof Anifowose Dec 2020

Organisational Culture Characterisation Of Construction Firms In Nigeria, Adebisi Abosede Bamgbade, Richard Ajayi Jimoh, Luqman Oyekunle Oyewobi, Maroof Anifowose

CSID Journal of Infrastructure Development

Organisational culture characterisation is indispensable for aspiring organisations that want to measure up with the contemporary business trend in terms of performance. This paper aims to determine the organisational culture characterisation of construction firms in Nigeria to improve the organisational culture power to drive organisational performance of the firms. Thus the objectives are to enumerate the factors that contribute to the organisational culture capability and to determine the organisational culture characterisation of construction firms in Nigeria. A quantitative method was adopted for this research in which 113 questionnaires from a sample size of 254 disseminated informed by purposive random sampling …


Experimental Studies On The Homogeneity And Compressive Strength Prediction Of Recycled Aggregate Concrete (Rac) Using Ultrasonic Pulse Velocity (Upv), Nuraziz Handika, Balqis Fara Norita, Elly Tjahjono, Essy Arijoeni Dec 2020

Experimental Studies On The Homogeneity And Compressive Strength Prediction Of Recycled Aggregate Concrete (Rac) Using Ultrasonic Pulse Velocity (Upv), Nuraziz Handika, Balqis Fara Norita, Elly Tjahjono, Essy Arijoeni

CSID Journal of Infrastructure Development

The reuse of material from collapsed building debris as a natural aggregate substituent has been an alternative to solve concrete waste in Indonesia. However, its use in larger structures needs further research. The objectives of this research are to study the concrete homogeneity at a certain sample height and to find the strength prediction of Recycled Aggregate Concrete (RAC). In the previous laboratory study, the obtained concrete compressive strength with 20% RAC substitution (from the concrete ruins with fc’ = 30 MPa) was 27-30 MPa. Since, RAC contains natural aggregates and mixed cement paste, it is important to research the …


Improving The Cost Performance Of Mechanical Electrical And Plumbing (Mep) Works Buildings In Hotel Based On Building Information Modeling (Bim) 5d, Albert Eddy Husin, Syamsir Abe Sihombing, Bernadette Detty Kussumardianadewi, Diah Ika Rahmawati Dec 2020

Improving The Cost Performance Of Mechanical Electrical And Plumbing (Mep) Works Buildings In Hotel Based On Building Information Modeling (Bim) 5d, Albert Eddy Husin, Syamsir Abe Sihombing, Bernadette Detty Kussumardianadewi, Diah Ika Rahmawati

CSID Journal of Infrastructure Development

High-rise building projects expose a high risk due to structural design complexity, large workloads, and long project duration. The complexity of the work includes the design of Mechanical, Electrical, Plumbing (MEP), HVAC (Heating, Ventilation and Air Conditioning) systems, early warning, watering systems, hydrants, sprinklers, evacuation routes in the form of emergency stairs and fire doors. This research focuses on the application of BIM 5D to estimate and improve the cost performance of MEP work in high-rise hotel buildings. This research combines qualitative and quantitative approaches through in-depth interviews and BIM 5D modelling to achieve the research objective. The results showed …


Outlier Concepts Auditing Methodology For A Large Family Of Biomedical Ontologies, Ling Zheng, Hua Min, Yan Chen, Vipina Keloth, James Geller, Yehoshua Perl, George Hripcsak Dec 2020

Outlier Concepts Auditing Methodology For A Large Family Of Biomedical Ontologies, Ling Zheng, Hua Min, Yan Chen, Vipina Keloth, James Geller, Yehoshua Perl, George Hripcsak

Publications and Research

Background: Summarization networks are compact summaries of ontologies. The “Big Picture” view offered by summarization networks enables to identify sets of concepts that are more likely to have errors than control concepts. For ontologies that have outgoing lateral relationships, we have developed the "partial-area taxonomy" summarization network. Prior research has identified one kind of outlier concepts, concepts of small partials-areas within partial-area taxonomies. Previously we have shown that the small partial-area technique works successfully for four ontologies (or their hierarchies).

Methods: To improve the Quality Assurance (QA) scalability, a family-based QA framework, where one QA technique is potentially applicable to …


Missing Lateral Relationships In Top‑Level Concepts Of An Ontology, Ling Zheng, Yan Chen, Hua Min, P. Lloyd Hildebrand, Hao Liu, Michael Halper, James Geller, Sherri De Coronado, Yehoshua Perl Dec 2020

Missing Lateral Relationships In Top‑Level Concepts Of An Ontology, Ling Zheng, Yan Chen, Hua Min, P. Lloyd Hildebrand, Hao Liu, Michael Halper, James Geller, Sherri De Coronado, Yehoshua Perl

Publications and Research

Background: Ontologies house various kinds of domain knowledge in formal structures, primarily in the form of concepts and the associative relationships between them. Ontologies have become integral components of many health information processing environments. Hence, quality assurance of the conceptual content of any ontology is critical. Relationships are foundational to the definition of concepts. Missing relationship errors (i.e., unintended omissions of important definitional relationships) can have a deleterious effect on the quality of an ontology. An abstraction network is a structure that overlays an ontology and provides an alternate, summarization view of its contents. One kind of abstraction network is …


Extending Import Detection Algorithms For Concept Import From Two To Three Biomedical Terminologies, Vipina K. Keloth, James Geller, Yan Chen, Julia Xu Dec 2020

Extending Import Detection Algorithms For Concept Import From Two To Three Biomedical Terminologies, Vipina K. Keloth, James Geller, Yan Chen, Julia Xu

Publications and Research

Background: While enrichment of terminologies can be achieved in different ways, filling gaps in the IS-A hierarchy backbone of a terminology appears especially promising. To avoid difficult manual inspection, we started a research program in 2014, investigating terminology densities, where the comparison of terminologies leads to the algorithmic discovery of potentially missing concepts in a target terminology. While candidate concepts have to be approved for import by an expert, the human effort is greatly reduced by algorithmic generation of candidates. In previous studies, a single source terminology was used with one target terminology.

Methods: In this paper, we are extending …


The Problem Of Foreign Convictions In U.S. Immigration Law, Geoff Cebula Dec 2020

The Problem Of Foreign Convictions In U.S. Immigration Law, Geoff Cebula

Notre Dame Law Review

Part I argues that the definition of “conviction” in the INA implicitly leaves room for courts to inquire into the procedural fairness underlying a foreign conviction. Part II surveys the traditional standards for evaluating the sufficiency of foreign convictions in the contexts of extradition and international comity, two areas where U.S. courts have had to decide when to honor foreign judgments for centuries. These longstanding criteria formed the background against which the INA definition was adopted and may provide guidance on how to apply this definition. Accordingly, Part III derives from this analysis suggestions for how the Department of State …


Enhancement Of Photocatalytic Effect With Surface Roughness In Photocatalytic Reactors, Dharendra Yogi Goswami, Elias K. Stefanakos, Yangyang Zhang Dec 2020

Enhancement Of Photocatalytic Effect With Surface Roughness In Photocatalytic Reactors, Dharendra Yogi Goswami, Elias K. Stefanakos, Yangyang Zhang

USF Patents

Photocatalysis is a promising technique for remediation of indoor air pollution. The present invention focuses on the enhancement of the effectiveness of the photocatalytic process by the introduction of artificial roughness on the interior reactor surface. Artificial roughness elements on the catalytic surface enhance the turbulence intensity close to the catalytic surface. The enhanced turbulence intensity translates to an increase in the mass transfer of airborne contaminants to the catalyst surface, improving the efficiency of photocatalysis.


Metabolic Therapy For Wound Healing, Dominic Paul D'Agostino, Shannon Kesl Dec 2020

Metabolic Therapy For Wound Healing, Dominic Paul D'Agostino, Shannon Kesl

USF Patents

Ketone supplementation, such as through use of precursors of beta-hydroxybutyrate (BHB) and acetoacetate (AcAc), increased blood levels of ketone bodies, increases blood flow and wound closure in ischemic young and aged fisher rats significantly earlier compared to standard diet in aged rats. In vitro experiments with ketone bodies demonstrate decreased mitochondrial and cytosolic ROS in young and aged primary human dermal fibroblasts (PHDF). Ketone bodies increased migration in young and aged PHDFs.


Biomimetic Transfemoral Knee With Gear Mesh Locking Mechanism, Tyagi Ramakrishnan, Kyle B. Reed Dec 2020

Biomimetic Transfemoral Knee With Gear Mesh Locking Mechanism, Tyagi Ramakrishnan, Kyle B. Reed

USF Patents

A prosthetic knee having a passive knee locking mechanism that uses the same four-bar mechanics found in a natural knee. The flexible four-bar mechanism guides the motion of the knee, aids in the return of the knee from full flexion to extension, and connects a femoral gear to a tibial gear. The gears have a circular radius and are connected using parallel links to keep the femur and tibia together when the knee is active. The knee stays locked throughout the stance phase. At toe off, no weight is applied on the prosthetic knee allowing the knee to flex. The …


Marine Heatwaves, Sewage And Eutrophication Combine To Trigger Deoxygenation And Biodiversity Loss: A Sw Atlantic Case Study, Kalina M. Brauko, Alex Cabral, Natasha V. Costa, Juliana Hayden, Carlos E.P. Dias, Edilene S. Leite, Renan D. Westphal, Carolina M. Mueller, Jason M. Hall-Spencer, Regina R. Rodrigues, Leonardo R. Rörig, Paulo R. Pagliosa, Alessandra L. Fonseca, Orestes E. Alarcon, Paulo A. Horta Dec 2020

Marine Heatwaves, Sewage And Eutrophication Combine To Trigger Deoxygenation And Biodiversity Loss: A Sw Atlantic Case Study, Kalina M. Brauko, Alex Cabral, Natasha V. Costa, Juliana Hayden, Carlos E.P. Dias, Edilene S. Leite, Renan D. Westphal, Carolina M. Mueller, Jason M. Hall-Spencer, Regina R. Rodrigues, Leonardo R. Rörig, Paulo R. Pagliosa, Alessandra L. Fonseca, Orestes E. Alarcon, Paulo A. Horta

School of Biological and Marine Sciences

Marine heatwaves (MHWs) are a major concern worldwide due to their increasing impacts in recent years, and these extreme events may trigger deoxygenation of coastal waters affected by sewage and eutrophication. Here we investigate the combined effects of MHWs and nutrient enrichment on the water quality and biodiversity of the Bay of Santa Catarina Island (Brazil). We used historical (1994–2020) sea surface temperature data from satellites and in situ physical, chemical and biological parameters to assess temporal trends. Oxygen levels have been decreasing whilst phosphorus levels have been increasing in the bay. During the austral summer of 2020 a regional …


Department Of Communication Sciences And Disorders Soars In Rankings, Meaghan Flores Dec 2020

Department Of Communication Sciences And Disorders Soars In Rankings, Meaghan Flores

University of Mississippi News

UM program makes improvements on research, clinical spaces


Compact Floating Wave Energy Converter Arrays: Mooring Loads And Survivability Through Scale Physical Modelling, Rui P.F. Gomes, Luís M.C. Gato, João C.C. Henriques, Juan C.C. Portillo, Ben D. Howey, Keri M. Collins, Martyn R. Hann, Deborah M. Greaves Dec 2020

Compact Floating Wave Energy Converter Arrays: Mooring Loads And Survivability Through Scale Physical Modelling, Rui P.F. Gomes, Luís M.C. Gato, João C.C. Henriques, Juan C.C. Portillo, Ben D. Howey, Keri M. Collins, Martyn R. Hann, Deborah M. Greaves

School of Engineering, Computing and Mathematics

No abstract provided.


Hydrodynamics Of Onshore Oscillating Water Column Devices: A Numerical Study Using Smoothed Particle Hydrodynamics, Guixun Zhu, David Graham, Siming Zheng, Jason Hughes, Deborah Greaves Dec 2020

Hydrodynamics Of Onshore Oscillating Water Column Devices: A Numerical Study Using Smoothed Particle Hydrodynamics, Guixun Zhu, David Graham, Siming Zheng, Jason Hughes, Deborah Greaves

School of Engineering, Computing and Mathematics

No abstract provided.


Development Of A Fully Nonlinear, Coupled Numerical Model For Assessment Of Floating Tidal Stream Concepts, S. A. Brown, E. J. Ransley, S. Zheng, N. Xie, B. Howey, D. M. Greaves Dec 2020

Development Of A Fully Nonlinear, Coupled Numerical Model For Assessment Of Floating Tidal Stream Concepts, S. A. Brown, E. J. Ransley, S. Zheng, N. Xie, B. Howey, D. M. Greaves

School of Engineering, Computing and Mathematics

No abstract provided.


Destabilizing Effects On A Classic Tri-Trophic Oyster Reef Cascade, Virginia R. Schweiss, Chet F. Rakocinski Dec 2020

Destabilizing Effects On A Classic Tri-Trophic Oyster Reef Cascade, Virginia R. Schweiss, Chet F. Rakocinski

Faculty Publications

How interactions among multiple predators affect the stability of trophic cascades is a topic of special ecological interest. To examine factors affecting the stability of the classic tri-trophic oyster reef cascade within a different context, configurations of three predators, including the Gulf toadfish, Gulf stone crab, and oystershell mud crab, were manipulated together with either oyster shell or limestone gravel substrate within a multiple predator effects (MPE) experiment. Additionally, a complimentary set of trait-mediated-indirect interaction (TMII) experiments examined the inhibition of oyster consumption relative to mud-crab size and top predator identity in the absence of other cues and factors. The …


Root Cause Analysis And Classification Of Single Point Failures In Designs Applying Triple Modular Redundancy In Sram Fpgas, James D. Swift Dec 2020

Root Cause Analysis And Classification Of Single Point Failures In Designs Applying Triple Modular Redundancy In Sram Fpgas, James D. Swift

Theses and Dissertations

Radiation effects encountered in space or aviation environments can affect the configuration bits in Field Programmable Gate Arrays (FPGA) causing errors in FPGA output. One method of increasing FPGA reliability in radiation environments includes adding redundant logic to mask errors and allow time for repair. Despite the redundancy added with triple modular redundancy (TMR) and configuration scrubbing there exist some configuration bits that individually affect multiple TMR domains causing errors in FPGA output. A new tool called DeBit is introduced that identifies hardware resources associated with a single bit failure. This tool identifies a novel failure mode involving global routing …


Arch Proposal Course List Draft, December 15, 2020, General Education Committee Dec 2020

Arch Proposal Course List Draft, December 15, 2020, General Education Committee

General Education Committee

No abstract provided.


Web-Based Interactive Mapping From Data Dictionaries To Ontologies, With An Application To Cancer Registry, Shiqiang Tao, Ningzhou Zeng, Isaac Hands, Joseph Hurt-Mueller, Eric B. Durbin, Licong Cui, Guoqiang Zhang Dec 2020

Web-Based Interactive Mapping From Data Dictionaries To Ontologies, With An Application To Cancer Registry, Shiqiang Tao, Ningzhou Zeng, Isaac Hands, Joseph Hurt-Mueller, Eric B. Durbin, Licong Cui, Guoqiang Zhang

Internal Medicine Faculty Publications

BACKGROUND: The Kentucky Cancer Registry (KCR) is a central cancer registry for the state of Kentucky that receives data about incident cancer cases from all healthcare facilities in the state within 6 months of diagnosis. Similar to all other U.S. and Canadian cancer registries, KCR uses a data dictionary provided by the North American Association of Central Cancer Registries (NAACCR) for standardized data entry. The NAACCR data dictionary is not an ontological system. Mapping between the NAACCR data dictionary and the National Cancer Institute (NCI) Thesaurus (NCIt) will facilitate the enrichment, dissemination and utilization of cancer registry data. We introduce …


Data Analysis Of Nebraska Pavements Containing Rap, Abdullah Azzam, Yong-Rak Kim, Mohammad Rahmani, Jiong Hu Dec 2020

Data Analysis Of Nebraska Pavements Containing Rap, Abdullah Azzam, Yong-Rak Kim, Mohammad Rahmani, Jiong Hu

Nebraska Department of Transportation: Research Reports

Nebraska has used reclaimed asphalt pavement (RAP) materials (in a range of 20-50%) over more than 10 years in pavement construction. Despite the immediate economic and environmental benefits it has been reported that incorporating RAP may reduce pavement durability and crack resistance. This study used NDOT’s database to investigate the effect of RAP amount on the overall behavior of pavement performance. Toward that end, we collected data of pavement performance, mixture design, traffic, and environment of a total 254 pavement projects constructed between 2009 and 2012. Using the data, several analyses (such as descriptive, inferential, and life cycle cost) were …


Cyndee Gruden Named Dean Of The College Of Engineering And Physical Sciences, Unh Communications And Public Affairs Dec 2020

Cyndee Gruden Named Dean Of The College Of Engineering And Physical Sciences, Unh Communications And Public Affairs

UNH Today Archive

No abstract provided.


Emerald Ash Borer Specific Gene Silencing Has No Effect On Non-Target Organisms, Flavia Pampolini, Lynne K. Rieske Dec 2020

Emerald Ash Borer Specific Gene Silencing Has No Effect On Non-Target Organisms, Flavia Pampolini, Lynne K. Rieske

Entomology Faculty Publications

The sequence complementarity of the RNA interference (RNAi) pathway allows for targeted suppression of genes essential for insect survival, and enables development of pest management strategies specific to a given species while reducing the likelihood of adversely impacting non-target organisms (NTOs). The feasibility of manipulating the RNAi pathway to cause mortality in the highly invasive emerald ash borer (EAB) has been demonstrated. Here the spectrum of activity of three double stranded RNAs (dsRNAs) targeting the genes hsp, shi, and sn-rnp in EAB was evaluated in model insects representing five functional guilds including herbivore, predator, detritivore, pollinator, parasitoid; …


Social Inclusion-Based Library Transformation: A National Library Of Indonesia’S Role To Support Sustainable Development Goals (Sdgs), Reza Mahdi, Muakibatul Hasanah, Andi Asari Dec 2020

Social Inclusion-Based Library Transformation: A National Library Of Indonesia’S Role To Support Sustainable Development Goals (Sdgs), Reza Mahdi, Muakibatul Hasanah, Andi Asari

Library Philosophy and Practice (e-journal)

Since 2015, all countries that are members of the United Nations have participated in one of the programs to support human and environmental benefit, Sustainable Development Goals (SDGs). Indonesia as a member of the United Nations supports the course of the program with the release of Presidential Regulation No. 59 year 2017 in which all institutions and ministers follow tpb in accordance with their respective basic duties. The National Library of Indonesia is one of the institutions affected by the regulation. As a building library and network between libraries in accordance with Law No. 43 year 2007 on Libraries, Perpusnas …


The Decision Maker: Understanding The Role Of Ifrd1 In Urothelial Plasticity And Regeneration, Bisiayo Erionmwon Fashemi Dec 2020

The Decision Maker: Understanding The Role Of Ifrd1 In Urothelial Plasticity And Regeneration, Bisiayo Erionmwon Fashemi

Arts & Sciences Graduate Student Theses and Dissertations

The bladder urothelium forms a highly specialized watertight barrier to urinary wastes. The urothelium offers an unusual example of tissue regeneration: although urothelial cells do not rapidly turn over under physiological conditions, they have an impressive capacity to regenerate tissue upon injury. Even more remarkable, depending on the modality of injury (sterile, infectious) there appear to be two distinctive modes of urothelial regeneration. We have previously shown that in response to a urinary tract infection (UTI), the urothelial stem cell niche becomes activated and induces rapid restoration of the urothelium, whereas, regeneration following sterile injury does not involve stem cell …


Condition Rating Prediction Using An Interactive Deterioration Model Development Package, Minwoo Chang, Mitchell S. Maguire Dec 2020

Condition Rating Prediction Using An Interactive Deterioration Model Development Package, Minwoo Chang, Mitchell S. Maguire

Durham School of Architectural Engineering and Construction: Faculty Publications

This paper presents an advanced method to determine explanatory variables required for developing deterioration models without the interference of human bias. Although a stationary set of explanatory variables is ideal for long-term monitoring and asset management, the penalty regression results vary annually due to the innate bias in the inspection data. In this study, weighting factors were introduced to consider the inspection data collected for several years, and the most stationary set was identified. To manage the substantial amount of inspection data effectively, we proposed a software package referred to as the Deterioration Model Development Package (DMDP). The objective of …


Investigation Of Coronavirus Deposition In Realistic Human Nasal Cavity And Impact Of Social Distancing To Contain Covid-19: A Computational Fluid Dynamic Approach, Mohammad Zuber, John Valerian Corda, Milad Ahmadi, B. Satish Shenoy Dec 2020

Investigation Of Coronavirus Deposition In Realistic Human Nasal Cavity And Impact Of Social Distancing To Contain Covid-19: A Computational Fluid Dynamic Approach, Mohammad Zuber, John Valerian Corda, Milad Ahmadi, B. Satish Shenoy

Open Access archive

The novel coronavirus responsible for COVID-19 has spread to several countries within a considerably short period. The virus gets deposited in the human nasal cavity and moves to the lungs that might be fatal. As per safety guidelines by the World Health Organization (WHO), social distancing has emerged as one of the major factors to avoid the spread of infection. However, different guidelines are being followed across the countries with regards to what should be the safe distance. Thus, the current work is an attempt to understand the virus deposition pattern in the realistic human nasal cavity and also to …


Mir15a/Mir16-1 Cluster And Its Novel Targeting Molecules Negatively Regulate Cardiac Hypertrophy., Hongchang Guo, Ke Ma, Wenjing Hao, Yao Jiao, Ping Li, Jing Chen, Chen Xu, Fu-Jian Xu, Wayne Bond Lau, Jie Du, Xin-Liang Ma, Yulin Li Dec 2020

Mir15a/Mir16-1 Cluster And Its Novel Targeting Molecules Negatively Regulate Cardiac Hypertrophy., Hongchang Guo, Ke Ma, Wenjing Hao, Yao Jiao, Ping Li, Jing Chen, Chen Xu, Fu-Jian Xu, Wayne Bond Lau, Jie Du, Xin-Liang Ma, Yulin Li

Department of Emergency Medicine Faculty Papers

In response to pathological stimuli, the heart develops ventricular hypertrophy that progressively decompensates and leads to heart failure. miRNAs are increasingly recognized as pathogenic factors, clinically relevant biomarkers, and potential therapeutic targets. We identified that mir15a/mir16-1 cluster was negatively correlated with hypertrophic severity in patients with hypertrophic cardiomyopathy. The mir15a/mir16-1 expression was enriched in cardiomyocytes (CMs), decreased in hypertrophic human hearts, and decreased in mouse hearts after transverse aortic constriction (TAC). CM-specific mir15a/mir16-1 knockout promoted cardiac hypertrophy and dysfunction after TAC. CCAAT/enhancer binding protein (C/EBP)β was responsible for the downregulation of mir15a/mir16-1 cluster transcription. Mechanistically, mir15a/mir16-1 cluster attenuated the insulin/IGF1 …