Digital Commons Network^™

Lipidomic Profiling Of The Epidermis In A Mouse Model Of Dermatitis Reveals Sexual Dimorphism And Changes In Lipid Composition Before The Onset Of Clinical Disease., Jackeline Franco, Bartek Rajwa, Christina R Ferreira, John P Sundberg, Harm Hogenesch

Faculty Research 2020

Atopic dermatitis (AD) is a multifactorial disease associated with alterations in lipid composition and organization in the epidermis. Multiple variants of AD exist with different outcomes in response to therapies. The evaluation of disease progression and response to treatment are observational assessments with poor inter-observer agreement highlighting the need for molecular markers. SHARPIN-deficient mice (Sharpincpdm) spontaneously develop chronic proliferative dermatitis with features similar to AD in humans. To study the changes in the epidermal lipid-content during disease progression, we tested 72 epidermis samples from three groups (5-, 7-, and 10-weeks old) of cpdm mice and their WT littermates. …

Inter-Strain Epigenomic Profiling Reveals A Candidate Iap Master Copy In C3h Mice., Rita Rebollo, Mariana Galvão-Ferrarini, Liane Gagnier, Ying Zhang, Ardian Ferraj, Christine R Beck, Matthew C Lorincz, Dixie L Mager

Faculty Research 2020

Insertions of endogenous retroviruses cause a significant fraction of mutations in inbred mice but not all strains are equally susceptible. Notably, most new Intracisternal A particle (IAP) ERV mutagenic insertions have occurred in C3H mice. We show here that strain-specific insertional polymorphic IAPs accumulate faster in C3H/HeJ mice, relative to other sequenced strains, and that IAP transcript levels are higher in C3H/HeJ embryonic stem (ES) cells compared to other ES cells. To investigate the mechanism for high IAP activity in C3H mice, we identified 61 IAP copies in C3H/HeJ ES cells enriched with H3K4me3 (a mark of active promoters) and, …

Volume 4, Chapter 1-1: Aquatic And Wetland: Anthocerotophyta, Janice M. Glime

Bryophyte Ecology Subchapters

No abstract provided.

Volume 4, Chapter 1-4: Aquatic Wetlands: Marchantiophyta, Order Jungermanniales – Jungermanniineae, Janice M. Glime

Bryophyte Ecology Subchapters

No abstract provided.

Vaccine-Preventable Diseases In The Time Of Covid, Thaddeus Zajdowicz, Margan Zajdowicz

The University of Louisville Journal of Respiratory Infections

No abstract provided.

2020 July 21 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

Harrington Appointed To Nih Centers External Advisory Committee, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Nicotine Exposure During Pregnancy And Risk Of Behavioral Disorders In Offspring, Bailey Eklund

Theses and Graduate Projects

Background: Smoking during pregnancy has been linked to various health outcomes in offspring. The relationship between nicotine (smoke) exposure during pregnancy and behavioral disorders, such as attention deficit hyperactivity disorder (ADHD), has been studied for years yielding mixed results. These studies have varied in quality of design and methods, alluding to varied association conclusions. The purpose of this summative review is to determine the association between prenatal nicotine exposure and risk of developing behavioral disorders, such as ADHD.

Methods: A systematic search using Lindell Library and PubMed was used to find peer- reviewed studies on the topics of maternal nicotine …

From Tangled Banks To Toxic Bunnies; A Reflection On The Issues Involved In Developing An Ecosystem Approach For Environmental Radiation Protection, Carmel E. Mothersill, Deborah H. Oughton, Paul N. Schofield, Michael Abend, Christelle Adam-Guillermin, Kentaro Ariyoshi, Nicholas A. Beresford, Andrea Bonisoli-Alquati, Jason Cohen, Yuri Dubrova, Stanislav A. Geras’Kin, Tanya Helena Hevrøy, Kathryn A. Higley, Nele Horemans, Awadhesh N. Jha, Lawrence A. Kapustka, Juliann G. Kiang, Balázs G. Madas, Gibin Powathil, Elena I. Sarapultseva, Colin B. Seymour, Nguyen T.K. Vo, Michael D. Wood

School of Biological and Marine Sciences

No abstract provided.

Use Of Viologens In Mediated Glucose Fuel Cells And In Aqueous Redox Flow Batteries To Improve Performance, Meisam Bahari

Theses and Dissertations

This dissertation presents my efforts to use viologens to improve the performance of glucose fuel cells and aqueous redox flow batteries. These two electrochemical systems have the potential to efficiently exploit renewable sources of energy. The contributions and significance of this work are briefly described below. Glucose Fuel cells. For glucose fuel cells, viologens were adopted as an electron mediator to facilitate the transfer of electrons from glucose to electrodes for power generation. Use of a mediator circumvents the need for precious metal electrodes to catalyze glucose oxidation. Both the oxidation efficiency and rate of glucose oxidation are important to …

Evolutionary Algorithms Converge Towards Evolved Biological Photonic Structures, Mamadou Aliou Barry, Vincent Berthier, Bobo D. Wilts, Marie-Claire Cambourieux, Pauline Bennet, Rémi Pollès, Olivier Teytaud, Emmanuel Centeno, Nicolas Biais, Antoine Moreau

Publications and Research

Nature features a plethora of extraordinary photonic architectures that have been optimized through natural evolution in order to more efciently refect, absorb or scatter light. While numerical optimization is increasingly and successfully used in photonics, it has yet to replicate any of these complex naturally occurring structures. Using evolutionary algorithms inspired by natural evolution and performing particular optimizations (maximize refection for a given wavelength, for a broad range of wavelength or maximize the scattering of light), we have retrieved the most stereotypical natural photonic structures. Whether those structures are Bragg mirrors, chirped dielectric mirrors or the gratings on top of …

Danzantes Aztecas Y Promotoras Tradicionales: The Ritual Performances And Identity Politics Of A Mexican American Danzantes Aztecas Y Promotoras Tradicionales: The Ritual Performances And Identity Politics Of A Mexican American Ceremonial Community, Dina K. Barajas

American Studies ETDs

This dissertation is an ethnographic study which examined the ritual performances of an interconnected Mexican American and Mexican immigrant danza Azteca and curanderismo ceremonial community located in central and northern New Mexico, and central México. This project also explored if and how these rituals recognize the practitioners’ indigeneity. As a Mexican American and Native scholar and ceremonial participant of this community, I provided an “insider’s” understanding of the epistemologies and ontologies that inform these ceremonies. My positionality and methodology acted as a lens to critically examine danzantes’ and promotoras tradicionales’ claims of indigeneity. Importantly, this work provides a fluid conceptualization …

Evaluation Of Biased And Balanced Salvinorin A Analogs In Preclinical Models Of Pain, Kelly F. Paton, Andrew Biggerstaff, Sophia Kaska, Rachel S. Crowley, Anne C. La Flamme, Thomas E. Prisinzano, Bronwyn M. Kivell

Pharmaceutical Sciences Faculty Publications

In the search for safer, non-addictive analgesics, kappa opioid receptor (KOPr) agonists are a potential target, as unlike mu-opioid analgesics, they do not have abuse potential. Salvinorin A (SalA) is a potent and selective KOPr agonist, however, clinical utility is limited by the short duration of action and aversive side effects. Biasing KOPr signaling toward G-protein activation has been highlighted as a key cellular mechanism to reduce the side effects of KOPr agonists. The present study investigated KOPr signaling bias and the acute antinociceptive effects and side effects of two novel analogs of SalA, 16-Bromo SalA and 16-Ethynyl SalA. 16-Bromo …

Continuum - Summer 2020

Continuum - A Newsletter from the Historical Resources Center

No abstract provided.

A Phenomenological Study Of Executive Loneliness Among Female Educational Leaders Who Have Transitioned From A Teaching Position To A Leadership Position Within The Organization, Cathy Lea Riggins

Student Theses and Dissertations

This phenomenological study highlighted the perceptions of female educational leaders concerning the presence of executive loneliness when individuals transitioned from a teaching position to a leadership position. The study examined the perceptions of female educators as to the impact executive loneliness has on leader effectiveness, health and well-being, and longevity in the profession. The sample for this study was female educational leaders who have transitioned from a teaching position to a leadership position within the same organization. Using a phenomenological approach, each selected female educator participated in an in-depth interview and the researcher transcribed, coded, and synthesized the interviews in …

Local Lagged Adapted Generalized Method Of Moments Dynamic Process, Gangaram S. Ladde, Olusegun Michael Otunuga, Nathan G. Ladde

USF Patents

Aspects of a local lagged adapted generalized method of moments (LLGMM) dynamic process are described herein. In one embodiment, the LLGMM process includes obtaining a discrete time data set as past state information of a continuous time dynamic process over a time interval, developing a stochastic model of the continuous time dynamic process, generating a discrete time interconnected dynamic model of local sample mean and variance statistic processes (DTIDMLSMVSP) based on the stochastic model, and calculating a plurality of admissible parameter estimates for the stochastic model using the DTIDMLSMVSP. Further, in some embodiments, the process further includes, for at least …

Climatic Variability And Climate Change: U.S. College Freshmen Attitudes And Spatio-Temporal Effects On Cavity-Nesting Passerines, Sara Elizabeth Harrod

Student Theses and Dissertations

Despite the scientific consensus that human activities are the primary cause, many people deny the problem of climate change. If mitigation efforts are to be successful, we need to determine young individuals’ attitudes toward and knowledge of climate change. Successful mitigation efforts are important for humans, as well as wildlife and the environment. Wildlife populations are already being affected, with many documented cases of negative impacts. Effects on populations can occur through impacts on demographic parameters, and if parameters are synchronized across species or populations, this could prove disastrous if climate change negatively affects these parameters. Here, I surveyed first-semester …

Quantitatively Motivated Model Development Framework: Downstream Analysis Effects Of Normalization Strategies, Jessica M. Rudd

Doctor of Data Science and Analytics Dissertations

Through a review of epistemological frameworks in social sciences, history of frameworks in statistics, as well as the current state of research, we establish that there appears to be no consistent, quantitatively motivated model development framework in data science, and the downstream analysis effects of various modeling choices are not uniformly documented. Examples are provided which illustrate that analytic choices, even if justifiable and statistically valid, have a downstream analysis effect on model results. This study proposes a unified model development framework that allows researchers to make statistically motivated modeling choices within the development pipeline. Additionally, a simulation study is …

Postglacial Recolonization Of North America By Spadefoot Toads: Integrating Niche And Corridor Modeling To Study Species’ Range Dynamics Over Geologic Time, Iulian Gherghel, Ryan Andrew Martin

Faculty Scholarship

Understanding the factors that shape species’ distributions is a key topic in biogeography. As climates change, species can either cope with these changes through evolution, plasticity or by shifting their ranges to track the optimal climatic conditions. Ecological niche modeling (ENM) is a widespread technique in biogeography that estimates the niche of the organism by using occurrences and environmental data to estimate species’ potential distributions. ENMs are often criticized for failing to take species’ dispersal abilities into consideration. Here, we attempt to fill this gap by combining ENMs with dispersal and corridor modeling to study the range dynamics of North …

Strategic Plan, Nelson Poynter Memorial Library Final Report, 2017-2020, Catherine Cardwell, Kaya Van Beynen

Library Strategic Planning and Background Materials

The final report of the strategic plan for 2017-2020 for the University of South Florida St. Petersburg's Nelson Poynter Memorial Library.

An Ontology Of Human Flourishing: Economic Development And Epistemologies Of Faith, Hope, And Love, Jan Van Vliet

Faculty Work Comprehensive List

This chapter demonstrates that the presence of poverty, and its associated pathologies, is of concern to all humankind whose innate desire is to seek the flourishing of fellow humanity. The traditional, often unsuccessful, methods of poverty alleviation have been challenged in creative, bold, and refreshing ways that are superior in both identifying poverty and moving agencies and pathways toward greater success. This involves a technical application of quantitative microeconomics which is paired with expertise and insights on human behavior gleaned from the behavioral sciences. It turns out that human behavior is often better explained by behavioral categories such as hope …

Design Of Electrolarynx To Increase Energy Efficiency By Varying The Driving Source, Madhushankara Maila, Somashekara Bhat, Keerthana Prasad

Open Access archive

The larynx is an organ in the human respiratory system that forms the basis of the speech production system. An electrolarynx is a device used by most laryngectomees to regain their verbal communication. Our objective was to design an electrolarynx with increased energy efficiency by modifying the driving source. Initially, we designed the electrolarynx to accommodate various driving signals. We then compared the voice output obtained by different input signals for quality and measured energy consumption using a digital multimeter. When compared to existing methods, the proposed driving source was found to be 11.1% more energy efficient. Voice quality was …

Lyssavirus Vaccine With A Chimeric Glycoprotein Protects Across Phylogroups, Christine R Fisher, David E Lowe, Todd G Smith, Yong Yang, Christina L Hutson, Christoph Wirblich, Gino Cingolani, Matthias J. Schnell

Department of Biochemistry and Molecular Biology Faculty Papers

Rabies is nearly 100% lethal in the absence of treatment, killing an estimated 59,000 people annually. Vaccines and biologics are highly efficacious when administered properly. Sixteen rabies-related viruses (lyssaviruses) are similarly lethal, but some are divergent enough to evade protection from current vaccines and biologics, which are based only on the classical rabies virus (RABV). Here we present the development and characterization of LyssaVax, a vaccine featuring a structurally designed, functional chimeric glycoprotein (G) containing immunologically important domains from both RABV G and the highly divergent Mokola virus (MOKV) G. LyssaVax elicits high titers of antibodies specific to both RABV …

Topological And System‑Level Protein Interaction Network (Pin) Analyses To Deduce Molecular Mechanism Of Curcumin, Anupam Dhasmana, Swati Uniyal, Anukriti -, Vivek Kumar Kashyap, Pallavi Somvanshi, Meenu Gupta, Uma Bhardwaj, Meena Jaggi, Murali M. Yallapu, Shafiul Haque, Subhash C. Chauhan

School of Medicine Publications

Curcumin is an important bioactive component of turmeric and also one of the important natural products, which has been investigated extensively. The precise mode of action of curcumin and its impact on system level protein networks are still not well studied. To identify the curcumin governed regulatory action on protein interaction network (PIN), an interectome was created based on 788 key proteins, extracted from PubMed literatures, and constructed by using STRING and Cytoscape programs. The PIN rewired by curcumin was a scale-free, extremely linked biological system. MCODE plug-in was used for sub-modulization analysis, wherein we identified 25 modules; ClueGo plug-in …

Trans-Axonal Signaling In Neural Circuit Wiring, Olivia Spead, Fabienne E. Poulain

Faculty Publications

The development of neural circuits is a complex process that relies on the proper navigation of axons through their environment to their appropriate targets. While axon–environment and axon–target interactions have long been known as essential for circuit formation, communication between axons themselves has only more recently emerged as another crucial mechanism. Trans-axonal signaling governs many axonal behaviors, including fasciculation for proper guidance to targets, defasciculation for pathfinding at important choice points, repulsion along and within tracts for pre-target sorting and target selection, repulsion at the target for precise synaptic connectivity, and potentially selective degeneration for circuit refinement. This review outlines …

Can Contrast Enhanced Ultrasound Differentiate Intrahepatic Cholangiocarcinoma From Hepatocellular Carcinoma?, Jia-Yan Huang, Jia-Wu Li, Wen-Wu Ling, Tao Li, Yan Luo, Ji-Bin Liu, Qiang Lu

Department of Radiology Faculty Papers

BACKGROUND: Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) differ in treatment and prognosis, warranting an effective differential diagnosis between them. The LR-M category in the contrast-enhanced ultrasound (CEUS) liver imaging reporting and data system (LI-RADS) was set up for lesions that are malignant but not specific to HCC. However, a substantial number of HCC cases in this category elevated the diagnostic challenge.

AIM: To investigate the possibility and efficacy of differentiating ICC from HCC classified in the LR-M category according to the CEUS LI-RADS.

METHODS: Patients with complete CEUS records together with pathologically confirmed ICC and LR-M HCC (HCC classified …

“Ripssl”: A New Reflective Inquiry Protocol To Lift The Lid On Students’ Significant Extra-Curricular Learning Outcomes From Study Abroad, Andrea Reid, Christine Slade, Susan L. Rowland

The Qualitative Report

Education abroad generally has no overarching curriculum outside the formal study component. This paper presents the Reflective Inquiry Protocol for Surfacing Significant Learning (RIPSSL), a new approach for understanding and articulating significant learning from education abroad. Tests of RIPSSL show education abroad students use it to move beyond “it was great” when considering learning from their experiences. Our findings are important for educators and students as they work to recognize and articulate the value of education abroad. RIPSSL provides a reflective educational approach to evidence learning from life experiences by surfacing students’ significant learning in their own words.

Composing Popular Music With Physarum Polycephalum-Based Memristors, S Venkatesh, E Braund, Er Miranda

School of Art, Design and Architecture

Creative systems such as algorithmic composers often use Artificial Intelligence models like Markov chains, Artificial Neural Networks, and Genetic Algorithms in order to model stochastic processes. Unconventional Computing (UC) technologies explore non-digital ways of data storage, processing, input, and output. UC paradigms such as Quantum Computing and Biocomputing delve into domains beyond the binary bit to handle complex non-linear functions. In this paper, we harness Physarum polycephalum as memristors to process and generate creative data for popular music. While there has been research conducted in this area, the literature lacks examples of popular music and how the organism’s non-linear behaviour …

Collaborative Research: Diverse Selective Pressure On Fruit Chemical Traits From Mutualists And Antagonists As A Major Driver Of Chemical Evolution At The Whole Plant Level, Noelle G. Beckman

Funded Research Records

No abstract provided.

Using A Crosswalk To Organize The Literature Review, Shirley M. Matteson, Sheri L. Warren

The Qualitative Report

A literature crosswalk is a valuable tool for researchers, whether novice or seasoned scholars, that can be used in organizing and synthesizing existing literature. This article provides practical advice for creating a literature crosswalk and how to use the tool to develop a literature review. Benefits of using a literature crosswalk include organizing a great deal of information in an easily searchable format, developing deeper understanding of the literature, and finding trends across multiple research studies in regard to methodology, theories used, types of participants, settings, and so forth.