Digital Commons Network^™

The "Evergreening" Metaphor In Intellectual Property Scholarship, Erika Lietzan

Akron Law Review

This article is a plea for changes in the scholarly dialogue about “evergreening” by drug companies. Allegations that drug companies engage in “evergreening” are pervasive in legal scholarship, economic scholarship, medical and health policy scholarship, and policy writing, and they have prompted significant policymaking proposals. This Article was motivated by concern that the metaphor has not been fully explained and that policymaking in response might therefore be premature. It canvasses and assesses the scholarly literature—more than 300 articles—discussing or mentioning “evergreening.” It catalogues the definitions, the examples, and the empirical studies. Scholars use the term when describing certain actions taken …

Imagining Margaret Garner: The Tragic Life Of An American Woman, Cecilia M. Smith

History in the Making

There is limited information on the life of the nineteenth century female slave with most details compiled from the narratives of well-known women such as Sojourner Truth. Professor Erlene Stetson and other historians argue that scholars treat slavery as a male phenomenon and the female is merely looked upon as a breeder, while noted African-American activist Angela Davis calls for a more accurate portrayal to debunk derogatory myths. This paper addresses the issue of image with the argument that the enslaved African-American woman possessed no image of her own. It focuses on the story of a runaway female slave named …

Shared Spaces, Separate Lives: Community Formation In The California Citrus Industry During The Great Depression, David Shanta

History in the Making

The California citrus industry was the engine for the economic and cultural development of twentieth century Southern California. Studies have also focused on citrus as specialty crop agriculture. Its labor usage pattern required the economic, social, and political powerlessness of its workers. Growers and workers shared the spaces of the citrus groves and packinghouses, but otherwise led largely separate lives, delineated by class and race. Community formation during the Great Depression is examined from each perspective – dominant Anglo grower society and workers of Mexican descent. Benedict Anderson’s Imagined Communities: Reflections on the Origin and Spread of Nationalism provides a …

Respect And The Mengzian Conception Of Yi As A Rule-Related Virtue, Meng Zhang

Comparative Philosophy

This paper focuses on Meng Zi’s idea of yi (義) as a virtue. In it, I first briefly examine two influential interpretations of yi – the “appropriateness” approach that views yi as a disposition to do what is fitting in a given situation and the shame-centered approach that understands yi as a disposition to avoid what is shameful in the moral life. The first approach is too thin to distinguish yi from acting properly in general and the second reading confines the definitive feeling involved in yi to a too moralized understanding of shame. Moreover, both fail to …

What Kind Of An Illusion Is The Illusion Of Self, Karsten J. Struhl

Comparative Philosophy

Both early and later forms of Buddhism developed a set of arguments to demonstrate that the self is an illusion. This article begins with a brief review of some of the arguments but then proceeds to show that these arguments are not themselves sufficient to dispel the illusion. It analyzes three ways in which the illusion of self manifests itself – as wish fulfillment, as a cognitive illusion, and as a phenomenal illusion (what might be called the “I” sense). With respect to this last, the article reviews some recent developments in cognitive neuropsychology and neuroscience to discuss the way …

The Yi-Jing Cosmic Model: With An Application Of An Alternative To Neoliberalism, Harry Donkers

Comparative Philosophy

Based on Yi-Jing we present an elaborated version of the Diagram of the Supreme Polarity that consists of immanent and transcendent processes via the void (Wu-ji), the oneness (Tai-ji), the twofold (Yin and Yang), the fourfold (duograms) and the Five Phases in combination with the eight trigrams (Ba-Gua) to reproduction and the innumerable beings. The duograms are further discussed in a quadrant system with axes derived from pattern li and vital energy qi. The model has similarities with Libbrecht’s model of comparative philosophy, but also differences. It is further consistent with the quadrant system …

Development Of The Life After Sports Transition (Last) Online Course For Collegiate Student-Athletes: Pretest-Posttest Study, Michael Stellefson, Trevor Bopp, Michael Odio, Min Qi Wang, Linxi Zhang

Journal of Athlete Development and Experience

Transitioning into athletic retirement can have negative impacts on college student-athletes’ psychological, social, emotional, and physical well-being, yet few educational programs exist to help augment college student-athlete preparation for embracing life after sports. The objective of this study was to develop and evaluate a new Life After Sports Transition (LAST) online course for college student athletes. A single group pretest-post-test study evaluated effects of the LAST course among a convenience sample of college student-athletes (n=10) attending a NCAA Division I university. Paired sample t-tests examined changes in athletic identity, psychological well-being, hope, and self-reflection/insight. Propensity score matching …

Impact Of Ramadan Fasting On Biochemical And Exercise Parameters Among Patients Undergoing Exercise-Based Cardiac Rehabilitation, Hazem Khorshid, Adel Shabana, Osama Rifaie, Yasser Abdellatif

Journal of the Saudi Heart Association

Background: Ramadan fasting is an important worship activity for Muslims. It is not known if fasting could have deleterious effect on cardiac patients joining cardiac rehabilitation (CR) program, especially during summer season.

Aim: To assess the effect of Ramadan fasting on biochemical and exercise parameters among patients undergoing 12- week exercise-based CR program. Patients and methods: 53 patients joining CR program in university hospital were included in the study. The patients were divided into two groups according to their Ramadan fasting status. Fasting group included 32 patients, while nonfasting group included 21 patients. All patients underwent supervised exercise-based CR during …

In Silico Investigation Of First-Pass Effect On Selected Small Molecule Excipients And Structural Dynamics Of P-Glycoprotein, Toluwase Hezekiah Fatoki, Omodele Ibraheem, Oladoja A. Awofisayo, Abiodun Samuel Oyedele, Olapade Samuel Akinlolu

Chemistry Student Research

In this study, the interaction of selected pharmaceutical excipients on the function of P-glycoprotein (P-gp) and activity of 6 cytochrome P450 (CYP) isoforms were computationally investigated. At binding free energy cut-off value of −5.0 kcal/mol, the result showed possible modulatory or inhibitory effect by cethyl alcohol on CPY3A4 and P-gp; cetyltrimethyl-ammonium bromide (CTAB) on CYP1A2 and P-gp; dibutyl sebacate on CYP2C9, CYP2E1, and P-gp; sodium caprylate on CYP1A2 and CYP3A4; while most of the tested excipients have good interaction with the cytochromes and P-gp. The predicted pharmacokinetics provided possible inhibitors of the CYPs and P-gp and suggested that aspartame and …

Is Sars-Cov-2 A Neurotropic Virus And A Potential Facilitator Of Cns Infection For Other Pathogens?, Jose Bordon

The University of Louisville Journal of Respiratory Infections

No abstract provided.

Bayesian Model Selection Reveals Biological Origins Of Zero Inflation In Single-Cell Transcriptomics., Kwangbom Choi, Yang Chen, Daniel A Skelly, Gary A Churchill

Faculty Research 2020

BACKGROUND: Single-cell RNA sequencing is a powerful tool for characterizing cellular heterogeneity in gene expression. However, high variability and a large number of zero counts present challenges for analysis and interpretation. There is substantial controversy over the origins and proper treatment of zeros and no consensus on whether zero-inflated count distributions are necessary or even useful. While some studies assume the existence of zero inflation due to technical artifacts and attempt to impute the missing information, other recent studies argue that there is no zero inflation in scRNA-seq data.

RESULTS: We apply a Bayesian model selection approach to unambiguously demonstrate …

Covid-19, The Global Pandemic, Canceled The Annual Rowan University Student Scholars Symposium (Russs): Rowan Digital Works Fills The Void, Daniel G. Kipnis

Libraries Scholarship

COVID-19 canceled Rowan University Student Scholar Symposium in March 2020. This presentation will highlight how Rowan Digital Works archived students posters from Biological Sciences.

Gw Covid-19 Intelligence Reports: July 27, 2020, George Washington University

GW COVID-19 Intelligence Reports

No abstract provided.

The Anthropocene, Affect, And Autoethnography?, Ken Gale

Plymouth Institute of Education

No abstract provided.

Large-Diameter Trees Dominate Snag And Surface Biomass Following Reintroduced Fire, James A. Lutz, Soren Struckman, Tucker J. Furniss, C. Alina Cansler, Sara J. Germain, Larissa L. Yocom Kent, Darren Mcavoy, Crystal A. Kolden, Alistair M. S. Smith, Mark E. Swanson, Andrew J. Larson

Wildland Resources Faculty Publications

The reintroduction of fire to landscapes where it was once common is considered a priority to restore historical forest dynamics, including reducing tree density and decreasing levels of woody biomass on the forest floor. However, reintroducing fire causes tree mortality that can have unintended ecological outcomes related to woody biomass, with potential impacts to fuel accumulation, carbon sequestration, subsequent fire severity, and forest management. In this study, we examine the interplay between fire and carbon dynamics by asking how reintroduced fire impacts fuel accumulation, carbon sequestration, and subsequent fire severity potential. Beginning pre-fire, and continuing 6 years post-fire, we tracked …

Orda Weekly Update, 2020.07.27, Office Of Research And Development Administration

ORDA Weekly Update

No abstract provided.

Imperial Myths, Abject Devotion: Mapping Affect In New Mexican Visual Culture And Discourse, N. C. Lira-Pérez

American Studies ETDs

New Mexican visual art and culture, as molded by state-sanctioned endeavors, is often casted in order to conceal the tension, conflict, and violence of settler colonialism and imperialism. Widely known myths of empire, such as the Tricultural myth, create a visualizing enterprise through which settler colonial logics transit and create political material reality. This thesis explores the following questions: How do New Mexican Hispanos and queer Chicanxs position themselves in relation to the logics of settler colonialism and empire? How are they positioned in relation to settler colonialism and empire? On the one hand, I argue that the state of …

Beneficial Effect Of Injected Air Into Subsurface Drip Irrigation (Sdi) On Plant Growth Using Runoff From A Feedlot, D. Dissanayake

School of Natural Resources: Dissertations, Theses, and Student Research

Due to water scarcity and increasing food demand, nonconventional water sources (e.g., human and animal wastewater) represent a valuable alternative to traditional water resources for agricultural use. Among these alternatives, treated animal wastewater, particularly feedlot runoff may represent a valuable solution in states like Nebraska due to its abundance. Subsurface drip irrigation (SDI) is a low-pressure micro-irrigation system that delivers water to the crop root zone through buried drip tapes with embedded emitters at fixed intervals. Despite multiple advantages (great water application uniformity, high water use efficiency, and improve fertilizer application), SDI can lead to poor aeration in the rhizosphere …

Interprofessional Collaboration For Oral Health Education And Screening Of Children With Special Health Care Needs, Lamia Habib

Master's Theses

In 2016, National Survey of Children’s Health conducted by the U.S. Department (HRSA MCHB) identified 18.8% of children aged 0-17 years old with Special Health Care Needs (CSHCN). Of these children, 83.4% are not receiving adequate healthcare. It has been well established that oral health is an integral part of the child’s general health. Medical primary care physicians may play an important role in improving oral health outcomes through oral screening, referral, oral health education and promotion. CSHCN may be at an increased risk for oral health problems throughout their life which may negatively impact their quality of life and …

Be Good For Goodness' Sake: Parenting Practices That Promote Value-Congruent Behavior During Adolescence, Ryan David Mclean

Theses and Dissertations

Research indicates that adolescence is an especially crucial time for developing habits of values congruent behavior that will persist throughout the lifespan. Past research has suggested that parents may play an important role in socializing their children, however few studies have looked at the mechanism through which this socialization occurs. The current study explored associations between different types of proactive and reactive parenting and value congruent behavior using nationally representative data from across three years during adolescence. Additionally, the current study attempted to further explain these associations through the mechanism of extrinsic and intrinsic values regulation. The current sample included …

At Ages 1-2, Will Tv Impact If I Help You? Prosocial Media, Joint Media Engagement, And Infant Prosocial Development During The Second Year, Sara Catherine Brown

Theses and Dissertations

Prosocial behavior typically emerges during an infant's second year. Because it is posited to be continuous from infancy to adulthood, and past research has identified numerous positive outcomes associated with prosocial behavior, it is important to understand the mechanisms involved in early prosocial behavior, such as prosocial media. Past research has examined the relation between prosocial media and prosocial behavior in preschool children, but no studies have explored this association with infants. The current study includes 60 infants and their primary caregivers. Data about media use, parent-infant media interactions, and infant prosocial helping was collected through survey and observational measures. …

Week Of July 27, 2020, New York Medical College

InTouch

• Research on Rapid Diagnostic Test for COVID-19 Underway at NYMC
• D.P.T. Students Offer Health and Wellness Tips on Social Media
• Open Letter To Medical Students On The Road Ahead To Becoming Professional Physicians

Statistical Modeling Of Historical Daily Water Temperatures In The Lower Columbia River, Malia Hanae Scott

Dissertations and Theses

Water temperature affects numerous aspects of aquatic life, and its stability is critical to cold water fish such as salmonids. With rising anthropogenic influence in natural environments, the future existence of these organisms is becoming less certain. In this study, I examined the evolution of historical water temperatures in the lower Columbia River by creating a statistical model to estimate daily historical water temperatures between the 1850s and 2010s. Daily air temperature and river flow measurements were used as inputs to the model, which estimated daily water temperatures at Bonneville Dam. The model used time lags between air temperature and …

State V. Anderson Appellant's Brief Dckt. 47769

Not Reported

No abstract provided.

Mir-365 (Microrna): Potnetial Biomarker In Oral Squamous Cell Carcinoma Exosomes And Extracellular Vesicles, Jeffery Coon, Karl Kingsley, Katherine M. Howard

Dental Medicine Faculty Research

Introduction: miR-365 is a non-coding microRNA that regulates transcription and has been demonstrated to promote oncogenesis and metastasis in some cancers, while suppressing these effects in others. Many microRNAs are produced and then exported extracellularly in exosomes, which are small extracellular vesicles ranging from 30 to 100 nm that are found in eukaryotic fluids and facilitate many cellular functions. Exosomes and extracellular vesicles are produced by many cell types, including oral cancer cells—although no study to date has evaluated miR-365 and oral cancer exosomes or extracellular vesicles. Based on this information, our research question was to evaluate whether oral cancers …

Domain-Specific Creativity And Vocational Interests: How Do Creativity And Related Factors Relate To Vocational Interests And Different Latent Riasec Profiles?, Xiaochen Liu

Doctoral Dissertations

Creativity has potential as a key element in understanding students’ vocational interests but has yet to be fully studied. Two questions were proposed: (1) Can potential predictors (demographics, academic achievements, domain-general and domain-specific creativity factors, and the interactions between gender and creativity-related factors) significantly predict vocational interests as derived from Holland’s RIASEC Model and (2) do domain-general and domain-specific creativity factors exhibit differential mean levels across distinct latent vocational profiles?

This dissertation drew on a dataset that collected 4,052 valid responses from grade 9 to 12 students who registered American College Testing (ACT) in the United States for the June …

Report On The 2018 Rapid Assessment Survey Of Introduced, Cryptogenic, And Native Marine Species At New England Marinas Massachusetts To Maine, Cristina Kennedy, Adrienne Pappal, Carolina Bastidas, James Carlton, Andrew David, Jennifer A. Dijkstra, Sean Duffey, Jennifer Gibson, Sara Grady, Lindsay Green-Gavrielidis, Larry Harris, Niels-Viggo Hobbs, Alec Mauk, Megan Mcculler, Chris Neefus, Brandon O’Brien, Kristin Osborne, Judy Pederson, Jaclyn Robidoux, Matt Tyler, Kaitlin S. Van Volkom

Center for Coastal and Ocean Mapping

No abstract provided.

No Oxygen, No Water: The Unique Physiology Of Annual Killifish Embryos Across Development, Daniel Erik Zajic

Dissertations and Theses

For most vertebrates, an abundance of oxygen is necessary for the production of ATP and the maintenance of cellular homeostasis. The absence of oxygen, even for brief periods, quickly leads to ATP depletion which can lead to irreparable damages to sensitive organs, such as the brain and heart. However, certain vertebrates demonstrate an extraordinary ability to thrive and recover fully from periods of no oxygen (anoxia). The annual killifish (Austrofundulus limnaeus) lives in ephemeral ponds in the Maracaibo basin of Venezuela and their embryos have the remarkable ability to not only survive anoxic periods for months, but also …

Implementing Parasite Genotyping Into National Surveillance Frameworks: Feedback From Control Programmes And Researchers In The Asia-Pacific Region, Rintis Noviyanti, Olivo Miotto, Alyssa Barry, Jutta Marfurt, Sasha Siegel, Nguyen Thuy-Nhien, Huynh Hong Quang, Nancy Dian Anggraeni, Ferdinand Laihad, Najia Karim Ghanchi

Department of Pathology and Laboratory Medicine

The Asia-Pacific region faces formidable challenges in achieving malaria elimination by the proposed target in 2030. Molecular surveillance of Plasmodium parasites can provide important information on malaria transmission and adaptation, which can inform national malaria control programmes (NMCPs) in decision-making processes. In November 2019 a parasite genotyping workshop was held in Jakarta, Indonesia, to review molecular approaches for parasite surveillance and explore ways in which these tools can be integrated into public health systems and inform policy. The meeting was attended by 70 participants from 8 malaria-endemic countries and partners of the Asia Pacific Malaria Elimination Network. The participants acknowledged …

Elucidating Novel Mechanisms And Pathways Of Pathogenesis, Hdaci Resistance, And Disease Progression In B And T Cell Lymphomas Through Integrated ‘Omics Analyses, Jared Andrews

Arts & Sciences Graduate Student Theses and Dissertations

Dynamic changes to the epigenome are essential regulators of cell differentiation and, when disrupted, can be oncogenic. Pervasive epigenetic alternations are a hallmark of many Non-Hodgkin Lymphomas (NHLs), a heterogeneous group of B and T cell cancers with an incidence of 80,000 new cases and 20,000 deaths in the U.S. per year. My thesis studies have defined the epigenetic landscapes of primary human B and T cell lymphomas and linked them to dynamic changes in the transcriptomes of these cancers. The first of these projects focused on mature B cell lymphoma/leukemia (BCL). To identify common and distinct epigenetic perturbations that …