Digital Commons Network^™

The Role Of Homologous Cyclin B’S In The Cell Cycle And, In Their Absence, The Effect On Zebrafish Early Development, Tetiana Petrachkova

Dissertations

Regulation of cell division is essential for normal embryo development. The Cyclins and their Cyclin-dependent kinases are key regulators controlling this process. In this thesis, I examine the role of cyclin B1 and cyclin B2 in zebrafish development. It is thought that both Cyclins are necessary for a cell to progress past the G2/M checkpoint into mitosis. First, I show that zygotic Cyclin B1 is essential for normal cell cycle progression, but not for cells to enter mitosis. Lack of zygotic Cyclin B1 in the early arrest mutant specter, which carries a nonsense mutation in the cyclin B1 gene, …

A Comprehensive Security Approach On Data Race Detection And Deepfake Defense, Yu Guo

Dissertations

In the past decades, even the computer techniques have a significant improvement. The topic about security will be never out of date.

To meet with the requirement of computation, the number of CPU cores has changed from single core to multi-cores. At the same time, the multi-thread programs are also proposed to maximize the advantages of multi-core computing power. While even the performance has been improved, but it also brings some new issues which were never happened on sequential programs called current bugs. Data race is a major type of current bugs, it is happened when multiple threads access the …

2020 August, Morehead State University. Office Of Communications & Marketing.

Morehead State Press Release Archive, 1961 to the Present

Press releases for August of 2020.

Connexin-46/50 In A Dynamic Lipid Environment Resolved By Cryoem At 1.9 Å, Jonathan A. Flores, Bassam G. Haddad, Kimberly A. Dolan, Janette Bernadette Myers, Craig C. Yoshioka, Jeremy Yoshioka, Daniel M. Zuckerman, Steve L. Reichow

Chemistry Faculty Publications and Presentations

Gap junctions establish direct pathways for cells to transfer metabolic and electrical messages. The local lipid environment is known to affect the structure, stability and intercellular channel activity of gap junctions; however, the molecular basis for these effects remains unknown. Here, we incorporate native connexin-46/50 (Cx46/50) intercellular channels into a dual lipid nanodisc system, mimicking a native cell-to-cell junction. Structural characterization by CryoEM reveals a lipid-induced stabilization to the channel, resulting in a 3D reconstruction at 1.9 Å resolution. Together with all-atom molecular dynamics simulations, it is shown that Cx46/50 in turn imparts long-range stabilization to the dynamic local lipid …

Countering Exclusivism, Promoting Inclusivism: The Way Forward For Singapore, Lily Kong, Orlando Woods, Acmal Zuheyr Iefan Abdul Wahid

Research Collection School of Social Sciences

This paper addresses the situation in Singapore, where a state of religious harmony has prevailed over the past few decades, though evidencing skirmishes and tensions periodically. These skirmishes are a consequence of exclusivist attitudes held by those with religion and those without religion. While some of the strategies that have been in place to address such exclusivist behaviours have been largely effective, the extent to which they have been successful in addressing, more fundamentally, exclusivist attitudes and beliefs is more questionable. Three key dialectics that operate in everyday interreligious encounter are identified to be consequential in countering exclusivism and promoting …

Genotoxic And Hematological Effects Of Aluminium And Lead Exposure In Red Hybrid Tilapia (Oreochromis Sp.), Mohamad Zaid Faten Fatehah

Student Works (2020-2029)

This study was conducted to investigate the genotoxic effects of single aluminium (Al), 25.00 mg/l, single lead (Pb), 18.75 mg/l and binary mixtures of Al and Pb (25.00 mg/l + 18.75 mg/l) and to determine their hematological effects on the tilapia fish as test subjects after 96 h exposure to these heavy metals. Oreochromis sp. was selected as the test subjects because of its adaptability to the environment and it can be easily found as it is the most common species of freshwater fish being cultured and farmed. Two different methods, micronucleus test and comet assay, were used for the …

Non-Invasive Tests For The Detection Of Nasopharyngeal Carcinoma, Mohan Sivanesan Vijaya

Student Works (2020-2029)

Nasopharyngeal carcinoma (NPC) is a malignancy that arises in the epithelium of the nasopharynx. Diagnosis is often delayed due to inaccessibility of primary tumour site which leads to inaccurate biopsy. The pathogenesis of NPC is linked to the Epstein-Barr virus (EBV) and studies have shown the employability of plasma EBV DNA for the detection and monitoring of NPC. MicroRNAs (miRNA) are a class of small non-coding RNA that are dysregulated in various cancers and have been extensively studied as biomarker due to their stability in various biospecimens. The aim of this project is to evaluate the load of EBV DNA …

Differentiation Propensity, Safety, And Therapeutic Potential Of Mesenchymal Stem Cells Of Dental Origin, Musa Sabri

Student Works (2020-2029)

Introduction: A new area in medical research has emerged with the discovery of mesenchymal stem cells (MSCs) and their ability to differentiate into other cell types. Specifically, these cells are found in various tissues and have been utilized in the field of regenerative medicine to support tissue repair as well as in cell replacement. Lately, MSCs of dental origin have been the main players used for regenerative purposes although subtle differences based on their tissue source separate them. Objectives: This study aims to determine the differential propensity, safety, and potential therapeutic applications of dental-derived MSCs. This involves examining various aspects …

Genotoxic And Hematological Effects Of Endocrine Disruptive Chemicals, Bisphenol A And Nonylphenol, On Nile Tilapia (Oreochromis Niloticus), Sahardin Muhammad Faris

Student Works (2020-2029)

This study was performed to evaluate the genotoxicity and hematology effects of single and binary exposure of bisphenol A and nonylphenol towards Oreochromis niloticus. O. niloticus was singly exposed to bisphenol A at concentration of 2 mg/l and nonylphenol at concentration of 0.04 mg/l in 16 L glass tank. O. niloticus was also synergistically exposed to the both concentration of 2 mg/l of bisphenol A and 0.04 mg/l of nonylphenol. Four fishes were randomly used for four exposures after two weeks acclimatization. All of them were exposed to the compound for 96 hours without water change prior observation. Fishes were …

Educational Benefits And Cognitive Health Life Expectancies: Racial/Ethnic, Nativity, And Gender Disparities, Marc A. Garcia, Brian Downer, Chi-Tsun Chiu, Joseph L. Saenz, Kasim Ortiz, Rebeca Wong

Department of Sociology: Faculty Publications

Background and Objectives: To examine racial/ethnic, nativity, and gender differences in the benefits of educational attainment on cognitive life expectancies among older adults in the United States.

Design and Methods: We used data from the Health and Retirement Study (1998-2014) to estimate Sullivan-based life tables of cognitively healthy, cognitively impaired/no dementia (CIND), and dementia life expectancies by gender for older White, Black, U.S.-born and foreign-born Hispanic adults with less than high school, high school, and some college or more.

Results: White respondents lived a greater percentage of their remaining lives cognitive healthy than their minority Black or Hispanic counterparts, regardless …

Role Of Oxidative Stress And Altered Thyroid Hormones In Unexplained Infertility, Rehana Rehman, Hiba Ismail Rajpar, Mussarat Ashraf, Najeeha Talat Iqbal, Salima Lalani, Faiza Alam

Department of Biological & Biomedical Sciences

Objective: To explore the link between altered thyroid profile and oxidative stress marker in females with unexplained infertility.
Methods: The cross-sectional case-control study was carried out at the Islamabad Clinic Serving Infertile Couples, Islamabad, Pakistan, from June 2016 to August 2017, and comprised women aged 18-40 years regardless of ethnic background who were divided into two groups; those with unexplained infertility were the cases, while fertile women acted as the controls. Serum was analysed for triiodothyronine, thyroxine and thyroid stimulating hormone as well as for oxidative stress markers including manganese superoxide dismutase, glutathione reductase and adrenaline using enzymelinked immunosorbent assay. …

Aging, Gait Variability, And Adaptability, Collin Douglas Bowersock

Health Services Research Dissertations

The purpose of this work was to study the relationships between age, measures of gait variability, and locomotor adaptability. Measures of gait variability are used to identify maladapted locomotor behavior, motor disease, and risk of falls. The first aim was to determine the relationships between age and measures of gait variability. Thirty-four participants (23-71 years old) walked on a treadmill for 6 minutes at their preferred speed. Variability of stride times and lengths was computed via linear measures (standard deviation and coefficient of variation) and nonlinear measures (sample entropy and detrended fluctuation analysis). Movement trajectory variability of the dominant knee …

The Role Of Masculinity In The Development Of Capability For Suicide, Claire Houtsma

Dissertations

Males account for over two-thirds of suicide deaths annually. Additionally, more than 50% of American suicide deaths annually are firearm-related. Suicide risk is elevated within firearm owning households and men are more likely to own firearms, which suggests that male firearm owners are at disproportionate risk for suicide. Prior research has argued that certain stereotypically male traits (e.g., lack of help-seeking) may explain sex differences in suicide death; however, this remains a poorly understood phenomenon. Male gender norms (e.g. physical toughness, self-reliance) may contribute to the development or expression of capability for suicide, primarily through their impact on behavior. The …

Real-World Cost Of Treatment For Multiple Sclerosis Patients Initiating And Receiving Infused Disease-Modifying Therapies Per Recommended Label In The United States., Jacqueline Nicholas, Rachel Halpern, Marina Ziehn, Jesse Peterson-Brandt, Michael Leszko, Chinmay Deshpande

Neuroscience Articles

Aims: The study evaluated the real-world cost of treatment in multiple sclerosis (MS) patients initiating infused disease-modifying-therapies (DMT) in the United States.Materials and Methods: This retrospective cohort study using administrative claims data included adult patients with MS initiating index infusion DMT (ocrelizumab (OCR), natalizumab (NTZ) or alemtuzumab (ATZ)) from April 2017-September 2018 with 6-months pre/12-months post-index continuous enrollment. The primary cohort included patients who had prescribed annual dosing visits indicated by the approved product label (PL): 3 OCR, 5 ATZ, and 12-13 NTZ infusion visits within the first year of initiation. Annual treatment cost was the sum of all …

Comparison Of Retention Rates Between Traditional On-Ground And Online Biology Laboratory Courses In The Community College Setting, Megan Davis Winborne

Dissertations

Community colleges provide vital educational resources to students across the nation. Online learning has become an integral part of the course offerings for community colleges. With regards to online learning, there is a lack of empirical evidence and research focused on community college offered biology laboratories, particularly concerning retention rates of these students. Means, Toyama, Murphy, and Bakia. (2013) found that even though there are copious amounts of studies dedicated to evaluation of evidence-based practices in online learning formats, many of them neglected to review retention rates associated with online educational courses.

The purpose of this study was to determine …

A Novel Quantitative Real-Time Pcr Diagnostic Assay For Fecal And Nasal Swab Detection Of An Otariid Lungworm, Parafilaroides Decorus, Kalani M. Williams, M. K. Fessler, R. A. Bloomfield, William D. Sandke, Clara R. Malekshahi, Caroline D. Keroack, Pádraig J. Duignan, Samantha D. Torquato, Steven A. Williams

Biological Sciences: Faculty Publications

Parafilaroides decorus, also known as sea lion lungworm, is a metastrongyloid nematode that infects otariid hosts, such as the charismatic California sea lion, Zalophus californianus. P. decorus causes bronchointerstitial pneumonia, respiratory distress, reduced ability to swim, dive and hunt and as a result, increased mortality particularly in young animals. Respiratory disease is a leading cause of stranding and admission to rehabilitation centers on the Pacific coast. Low-coverage genomic sequencing of four P. decorus individuals analyzed through Galaxy's RepeatExplorer identified a novel repeat DNA family we employed to design a sensitive quantitative PCR (qPCR) assay for diagnosing infections from fecal or …

Cardiovascular End Points And Mortality Are Not Closer Associated With Central Than Peripheral Pulsatile Blood Pressure Components, Qi-Fang Huang, Lucas S. Aparicio, Lutgarde Thijs, Fang-Fei Wei, Jesus D. Melgarejo, Yi-Bang Cheng, Chang-Sheng Sheng, Wen-Yi Yang, Natasza Gilis-Malinowska, José Boggia

School of Medicine Publications

Pulsatile blood pressure (BP) confers cardiovascular risk. Whether associations of cardiovascular end points are tighter for central systolic BP (cSBP) than peripheral systolic BP (pSBP) or central pulse pressure (cPP) than peripheral pulse pressure (pPP) is uncertain. Among 5608 participants (54.1% women; mean age, 54.2 years) enrolled in nine studies, median follow-up was 4.1 years. cSBP and cPP, estimated tonometrically from the radial waveform, averaged 123.7 and 42.5 mm Hg, and pSBP and pPP 134.1 and 53.9 mm Hg. The primary composite cardiovascular end point occurred in 255 participants (4.5%). Across fourths of the cPP distribution, rates increased exponentially (4.1, …

Illinois State, August 2020, Illinois State University, University Marketing And Communications

State: The Magazine of Illinois State University (1999-present)

Illinois State University alumni magazine

Estimating The Heritability Of Experiencing Child Maltreatment In An Extended Family Design, Katharina Pittner, Marian J. Bakermans-Kranenburg, Lenneke R. A. Alink, Renate S. M. Buisman, Lisa J. M. Van Den Bergo, Laura H. C. G. C. Compier-De Block, Alexandra Voorthuis, Bernet M. Elzinga, Jolanda Lindenberg, Marieke S. Tollenaar, Marielle Linting, Vincent P. Diego, Marinus H. Van Ijzendoorn

School of Medicine Publications

Child-driven genetic factors can contribute to negative parenting and may increase the risk of being maltreated. Experiencing childhood maltreatment may be partly heritable, but results of twin studies are mixed. In the current study, we used a cross-sectional extended family design to estimate genetic and environmental effects on experiencing child maltreatment. The sample consisted of 395 individuals (225 women; M _age = 38.85 years, range_age = 7–88 years) from 63 families with two or three participating generations. Participants were oversampled for experienced maltreatment. Self-reported experienced child maltreatment was measured using a questionnaire assessing physical and emotional abuse, and physical …

“Tomorrow Never Dies”: Recent Advances In Diagnosis, Treatment, And Prevention Modalities Against Coronavirus (Covid-19) Amid Controversies, Partha Laskar, Murali M. Yallapu, Subhash C. Chauhan

School of Medicine Publications

The outbreak of novel coronavirus disease (2019-nCoV or COVID-19) is responsible for severe health emergency throughout the world. The attack of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is found to be responsible for COVID-19. The World Health Organization has declared the ongoing global public health emergency as a pandemic. The whole world fights against this invincible enemy in various capacities to restore economy, lifestyle, and safe life. Enormous amount of scientific research work(s), administrative strategies, and economic measurements are in place to create a successful step against COVID-19. Furthermore, differences in opinion, facts, and implementation methods laid additional layers …

Dementia Prevention, Intervention, And Care: 2020 Report Of The Lancet Commission, G Livingston, J Huntley, A Sommerlad, Et Al

Peninsula Medical School

The number of older people, including those living with dementia, is rising, as younger age mortality declines. However, the age-specific incidence of dementia has fallen in many countries, probably because of improvements in education, nutrition, health care, and lifestyle changes. Overall, a growing body of evidence supports the nine potentially modifiable risk factors for dementia modelled by the 2017 Lancet Commission on dementia prevention, intervention, and care: less education, hypertension, hearing impairment, smoking, obesity, depression, physical inactivity, diabetes, and low social contact. We now add three more risk factors for dementia with newer, convincing evidence. These factors are excessive alcohol …

Change In Implicit Alcohol Associations Over Time: Moderation By Drinking History And Gender, Scott A. Baldwin, Kristen P. Lindgren, Kirsten P. Peterson, Reinout W. Wiers, Bethany A. Teachman

Faculty Publications

Implicit measures of alcohol-related associations or implicit alcohol associations are associated with drinking outcomes over time and can be understood as vulnerability markers for problem drinking. Longitudinal research remains rare, leaving open questions about how implicit alcohol associations themselves change over time and what factors moderate that change. We examined these questions with data from a larger study of first and second year U.S. college students. We investigated how these implicit alcohol associations change over time and potential moderators of those changes (gender, lifetime drinking history, family history of problem drinking, and class standing). A sample of 506 students (57% …

Predicting The Exposure Of Diving Grey Seals To Shipping Noise, Leah E. Trigg, Feng Chen, Georgy I. Shapiro, Simon N. Ingram, Cécile Vincent, David Thompson, Debbie J.F. Russell, Matt I.D. Carter, Clare B. Embling

School of Biological and Marine Sciences

There is high spatial overlap between grey seals and shipping traffic, and the functional hearing range of grey seals indicates sensitivity to underwater noise emitted by ships. However, there is still very little data regarding the exposure of grey seals to shipping noise, constraining effective policy decisions. Particularly, there are few predictions that consider the at-sea movement of seals. Consequently, this study aimed to predict the exposure of adult grey seals and pups to shipping noise along a three-dimensional movement track, and assess the influence of shipping characteristics on sound exposure levels. Using ship location data, a ship source model, …

Barriers And Facilitators To Gp–Patient Communication About Emotional Concerns In Uk Primary Care: A Systematic Review, Daisy Parker, Richard Byng, Chris Dickens, Debbie Kinsey, Rose Mccabe

Peninsula Medical School

AbstractBackgroundIn the UK, general practitioners (GPs) are the most commonly used providers of care for emotional concerns.ObjectiveTo update and synthesize literature on barriers and facilitators to GP–patient communication about emotional concerns in UK primary care.DesignSystematic review and qualitative synthesis.MethodWe conducted a systematic search on MEDLINE (OvidSP), PsycInfo and EMBASE, supplemented by citation chasing. Eligible papers focused on how GPs and adult patients in the UK communicated about emotional concerns. Results were synthesized using thematic analysis.ResultsAcross 30 studies involving 342 GPs and 720 patients, four themes relating to barriers were: (i) emotional concerns are difficult to disclose; (ii) tension between understanding …

Examining Provider Perceptions And Roles Associated To Breastfeeding Support And Medical Management In Primary Care, Meghan Ganio Molinari

Graduate Theses

Background: Human milk is recommended as the exclusive source of nutrition for all infants in the first six months of life. Current rates of exclusive breastfeeding at six months are well below the public health recommendations (24.9% as of 2015). New mothers may experience many challenges which impact both breastfeeding initiation and duration rates in the postpartum period. Studies indicate that breastfeeding rates improve when women receive a combination of prenatal education coupled with postnatal support. Primary care practitioners in outpatient settings have a unique opportunity to provide lactation education, support, and medical management for their patients to improve …

Marketing To The New Generations Of Lgbtq+ Tourists, George Smith

Master's Theses

As social acceptance for LGBTQ+ people grows, it is essential to research and understand more about tourism and its important role in the lives of LGBTQ+ populations. There are tourism communities around the country that may not be familiar with this market segment and are not sure where to start. This can leave the LGBTQ+ market segment under-represented in the tourism industry. This research sets out to answer the question, “Can tourism communities who wish to expand to newer generations of LGBTQ+ travelers market to them successfully?” Mixed research methods include an exploration of city tourism websites, interviews with tourism …

Development Of Thrombocytopenia Is Associated With Improved Survival In Patients Treated With Immunotherapy, Hussein A. Assi

School of Medicine Publications

Background:

Immune-related adverse events are associated with efficacy of immune checkpoint inhibitors (ICIs). We hypothesize that immune-mediated thrombocytopenia could be a biomarker for response to ICIs.

Materials & methods:

This retrospective study included 215 patients with metastatic malignancies treated with ICIs. Patients were stratified by nadir platelet count. Outcomes of interest were progression-free survival and overall survival.

Results:

On multivariate analysis, grade 1 thrombocytopenia was positively associated with overall survival compared with patients who did not develop thrombocytopenia (hazard ratio [HR]= 0.28 [95% CI: 0.13–0.60]; p = 0.001), while grade 2–4 thrombocytopenia was not (HR= 0.36 [95% CI: 0.13–1.04]; p …

Investigation Of Strength And Fatigue Life Of Rubber Asphalt Mixture, Jiang Yuan, Songtao Lv, Xinghai Peng, Lingyun You, Milkos Borges Cabrera

Michigan Tech Publications, Part 1

Strength and fatigue life are essential parameters of pavement structure design. To accurately determine the pavement structure resistance of rubber asphalt mixture, the strength tests at various temperatures, loading rate, and fatigue tests at different stress levels were conducted in this research. Based on the proposed experiments, the change law of rubber asphalt mixture strength with different temperatures and loading rates was revealed. The phenomenological fatigue equation of rubber asphalt mixture was established. The genetic algorithm optimized backpropagation neural network (GA-BPNN) is highly reliable for optimizing production processes in civil engineering, and it has a remarkable application effect. A GA-BPNN …

Evaluation Of Gammah2ax In Buccal Cells As A Molecular Biomarker Of Dna Damage In Alzheimer’S Disease In The Aibl Study Of Ageing, Mohammad Sabbir Siddiqui, Maxime Francois, Stephanie Rainey-Smith, Ralph Martins, Colin L. Masters, David Ames, Christopher C. Rowe, Lance S. Macaulay, Michael F. Fenech, Wayne R. Leifert

Research outputs 2014 to 2021

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. In response to double-stranded breaks (DSBs) in chromosomal DNA, H2AX (a member of histone H2A family) becomes phosphorylated to form γH2AX. Although increased levels of γH2AX have been reported in the neuronal nuclei of Alzheimer’s disease (AD) patients, the understanding of γH2AX responses in buccal nuclei of individuals with mild cognitive impairment (MCI) and AD remain unexplored. In the current study, endogenous γH2AX was measured in buccal cell nuclei from MCI (n = 18) or AD (n = 16) patients and in healthy controls (n = 17) using laser scanning cytometry …

Involving International Students In Designing And Implementing International Extension Tours, Giovani Stefani Faé, Gregory W. Roth

Journal of Extension

International Extension experiences can provide valuable outcomes to clientele. Careful planning is necessary to maximize the benefits to participants and the potential impacts of the tour. International agricultural sciences students can benefit from participating in these tours and greatly add to their success. In this article, we describe the main organizational steps we used and lessons we learned while planning and executing a comprehensive tour program to Brazil involving substantial contribution by an international student.