Digital Commons Network^™

Virtual And In Vitro Antiviral Screening Revive Therapeutic Drugs For Covid-19, Giovanni Bocci, Steven B. Bradfute, Chunyan Ye, Matthew J. Garcia, Jyothi Parvathareddy, Walter Reichard, Surekha Surendranathan, Shruti Bansal, Cristian G. Bologa, Douglas J. Perkins, Colleen B. Jonsson, Tudor I. Oprea, Larry A. Sklar

Pathology Research and Scholarship

The urgent need for a cure for early phase COVID-19 infected patients critically underlines drug repositioning strategies able to efficiently identify new and reliable treatments by merging computational, experimental, and pharmacokinetic expertise. Here we report new potential therapeutics for COVID-19 identified with a combined virtual and experimental screening strategy and selected among already approved drugs. We used hydroxychloroquine (HCQ), one of the most studied drugs in current clinical trials, as a reference template to screen for structural similarity against a library of almost 4000 approved drugs. The top-ranked drugs, based on structural similarity to HCQ, were selected for in vitro …

The Flowering Of Ecology: Maria Sibylla Merian's Caterpillar Book, Kay Etheridge

Gettysburg College Faculty Books

The Flowering of Ecology presents an English translation of Maria Sibylla Merian’s 1679 ‘caterpillar’ book, Der Raupen wunderbare Verwandelung und sonderbare Blumen–Nahrung. Her processes in making the book and an analysis of its scientific content are presented in a historical context. Merian raised insects for five decades, recording the food plants, behavior and ecology of roughly 300 species. Her most influential invention was an 'ecological' composition in which the metamorphic cycles of insects (usually moths and butterflies) were arrayed around plants that served as food for the caterpillars. Kay Etheridge analyzes the 1679 caterpillar book from the viewpoint of …

Uab To Provide First Vaccine Doses To Front Line And Clinical Staff, Ems And Other Birmingham-Area Hospitals, Tyler Greer

Browse All News

No abstract provided.

Exposure To Pesticides And Hepatocellular Carcinoma (Hcc) Risk In And Around Monroe County, Ny, Theodros Woldeyohannes

Theses

The impact of long-term exposure and persistence of pesticides in the environment on human biology is not completely understood. With the proliferation of pesticide application technologies, there have been documented associations between exposure to every major functional group of pesticide and adverse health effects in humans such as cancer and neurological disease. Of observed pesticide-induced cancer health-risks, hepatocellular carcinoma (HCC) has shown some of the most significant associations. Epidemiological study is complex, especially when examining pesticide health risks. It is difficult to understand the significance behind interactions between the large list of pesticide compounds, external environmental factors, and biological variables. …

Niche Dynamics Of The Felid Guild Following The Pleistocene Megafaunal Extinction, Nicholas A. Freymueller

Biology ETDs

The loss of large carnivores is fundamentally restructuring modern mammal communities. However, large carnivore removal is not exclusively a modern trend. The Pleistocene Megafaunal Extinction (PME) resulted in a near-eradication of hyper-carnivorous felids such as saber-toothed cats. However, it is unclear if smaller surviving meso-felids began to infill this ecological vacuum post-PME. I apply Ecological Niche Modeling (ENM) to test evaluate whether surviving felids filled in vacant niches post-extinction, and hypothesize that they ought to have shown increased niche-overlap patterns with mega-felids post-extinction. I model species’ fundamental niches using a multi-temporal approach, and develop a novel test to model realized …

Thaw Publications, Carl Landwehr, David Kotz

Computer Science Technical Reports

In 2013, the National Science Foundation's Secure and Trustworthy Cyberspace program awarded a Frontier grant to a consortium of four institutions, led by Dartmouth College, to enable trustworthy cybersystems for health and wellness. As of this writing, the Trustworthy Health and Wellness (THaW) project's bibliography includes more than 130 significant publications produced with support from the THaW grant; these publications document the progress made on many fronts by the THaW research team. The collection includes dissertations, theses, journal papers, conference papers, workshop contributions and more. The bibliography is organized as a Zotero library, which provides ready access to citation materials …

An Online Self-Directed Learning Module For Regional Stroke Survey Success, Winchell Rodriguez Kuttner

Doctor of Nursing Practice (DNP) Projects

The lack of a standardized education for stroke coordinators focusing on The Joint Commission (TJC) standards and requirements in preparation for the stroke program disease-specific care (DSC) certification survey every two years has led to undue added stress prior to survey. The development of tools and resources has been identified to address the current educational gap in stroke coordinator orientation. This project addressed the gap by creating an online, self-directed learning module to assist the stroke coordinators in knowledge acquisition of the stroke standards and requirements.

A stroke coordinator plays a critical role in stroke care delivery. An educational module …

Valley Fever: Education For Primary Care Providers And Allied Health Care Professionals, Michelle Elizabeth Bergen

Doctor of Nursing Practice (DNP) Projects

Valley Fever: Educating Primary Care Providers and Allied Healthcare Professionals

Abstract

Problem: Coccidioidomycosis (cocci), informally Valley Fever (VF), infects the lungs with the fungal spore coccidioides. It is prevalent in areas where soil disturbance occurs. Currently, there are no related educational or standardized guidelines exist for primary care providers (PCPs) in California’s Central Valley, where VF is highly endemic (Centers for Disease Control and Prevention, 2018).

Context: A Doctor of Nursing Practice project educational program for PCPs and allied healthcare workers (AHWs) at the Adventist Health Central Valley Network (AHCVN) clinics. The project aimed to educate PCPs to …

Characterizing Patterns In Texas Gulf Coast Beach Dune Plant Species Composition, Cody Foster

Electronic Theses and Dissertations

Regional vegetation patterns of Texas beach plant communities were analyzed using cluster analysis, ANOSIM, SIMPER, NMDS, and ISA for fives zones representing the foredune complex of twenty Gulf Coast beaches. ANOVA revealed that zones differ in terms of percent bare sand, percent vegetative cover, and species richness. Cluster Analysis, ANOSIM, and SIMPER results indicate that Texas beaches can be divided into northern and southern regions based on differences in species composition of plant communities. Indicator Species Analysis (ISA) indicates that northern beaches are characterized by the presence of Rayjacksonia phyllocephala, Ambrosia Strophostyles, Ambrosia psilostachya, and Panicum amarum …

Impact Of Cd82 Expression On Acute Myeloid Leukemia Chemosensitivity And Quiescence, Muskan Floren

Biomedical Sciences ETDs

Acute Myeloid Leukemia (AML) patients respond favorably to induction chemotherapy, however, long-term outcomes remain poor due to a high rate of chemoresistance and bone marrow minimal residual disease. To improve long-term patient outcomes, it’s critical to identify regulators of chemotherapy resistance in AML and develop therapies that are directed towards bone marrow resident AML cells. In Chapter 2, we uncover the impact of CD82 expression in AML response to chemotherapeutic treatment and the contribution of Protein Kinase C α (PKCα) and β1 integrin signaling in promoting p38 MAPK activation to support CD82-mediated AML cell survival. In Chapter 3, we …

The Evolution Of A Tropical Biodiversity Hotspot, M G. Harvey, G A. Bravo, S Claramunt, A M. Cuervo, M G. Harvey, J Battilana, G F. Seeholzer, J S. Mckay, B C. O'Meara, B C. Faircloth, S V. Edwards, J Perez-Eman, R G. Moyle, F H. Sheldon, A Aleixo, B T. Smith, R T. Chesser, L F. Silveira, J Cracraft, R T. Brumfield, E P. Derryberry

Faculty Publications

The tropics are the source of most biodiversity yet inadequate sampling obscures answers to fundamental questions about how this diversity evolves. We leveraged samples assembled over decades of fieldwork to study diversification of the largest tropical bird radiation, the suboscine passerines. Our phylogeny, estimated using data from 2389 genomic regions in 1940 individuals of 1287 species, reveals that peak suboscine species diversity in the Neotropics is not associated with high recent speciation rates but rather with the gradual accumulation of species over time. Paradoxically, the highest speciation rates are in lineages from regions with low species diversity, which are generally …

Functional Investigations Of Proteins And Enzymatic Toxins From Full-Length-Enriched Cdna Of Timber Rattlesnake (Crotalus Horridus), Joshua Osula

Theses

Snake Venom is a highly modified form of saliva, contains hundreds of zootoxins, necrotoxins, cytotoxins, neurotoxins, and mytotoxins, all of which are primarily made up of mostly proteins, polypeptides, and other components such as enzymes, lipids, and carbohydrates. Although snake venom is known for its harmful effects, it has also had a positive impact in scientific discovery and medicine. Some toxins from snakes function to inhibit pain, and this means they can be very effective analgesics. For instance, crotalphine is considered a 14-amino-acid-peptide that has a disulfide bond and shows analgesic properties through TRPA1 desensitization. This …

The Impact Of Gratitude On Body Image, Exercise, And Eating Behaviors, Alisha M. Wenger

Doctor of Psychology (PsyD)

Individuals with higher body dissatisfaction have higher disordered eating, excessive exercise, mental health concerns, and lower self-esteem. Gratitude interventions have been used to decrease body shame (objectified body consciousness), body dissatisfaction and increase positive body image. Gratitude interventions have primarily focused on changing state gratitude, leading to quick short changes. Individuals with long term, trait gratitude may have lower levels of excessive exercise, disordered eating, and a more positive body image. The current research is focused on better understanding the relationship between trait gratitude, body image, excessive exercise and disordered eating. In total 268 students from a university lifelong fitness …

Board Of Trustees Meeting Minutes, December 11, 2020

Board of Trustees Minutes

Minutes from the Wright State University Board of Trustees Meeting held on December 11, 2020

Divorce, Academic Performance, And Attachment Styles In College Students, Pavllo Neco

Honors Theses

For years, social scientists have pondered the impacts of a parental divorce on the students’ academic performance, as well as their attachment style (Fomby, 2010). In the current study, it is hypothesized that students who experience a parental divorce will perform lower on academic performance and higher on the insecure attachment styles than students whose parents are still intact or remarried. Participants were 73 college students, ages ranging in age from 18-29. More than half of the study consisted of student’s ages 18-19 years. 65% of students who participated were female, and an overwhelming majority of participants were white, with …

Ultracontinuous Single Haplotype Genome Assemblies For The Domestic Cat (Felis Catus) And Asian Leopard Cat (Prionailurus Bengalensis), Kevin R. Bredemeyer, Andrew J. Harris, Gang Li, Le Zhao, Nicole M. Foley, Melody E. Roelke-Parker, Stephen James O'Brien, Leslie A. Lyons, Wesley C. Warren, William J. Murphy

Biology Faculty Articles

In addition to including one of the most popular companion animals, species from the cat family Felidae serve as a powerful system for genetic analysis of inherited and infectious disease, as well as for the study of phenotypic evolution and speciation. Previous diploid-based genome assemblies for the domestic cat have served as the primary reference for genomic studies within the cat family. However, these versions suffered from poor resolution of complex and highly repetitive regions, with substantial amounts of unplaced sequence that is polymorphic or copy number variable. We sequenced the genome of a female F1 Bengal hybrid cat, the …

Exposing Lettuce Plants To Cyanobacteria In A Closed Hydroponics System To Reduce Cyanobacterial Growth And Production, Emily Eberly

Honors Projects

Sandusky Bay is largely populated by cyanobacterial algal blooms, mainly formed by Planktothrix. Fertilizers containing nitrogen and phosphorus run from agricultural lands into the bay, building up excess nutrients forming eutrophic waters. The Planktothrix feed off these nutrients and grow into algal blooms. To determine a potential solution to the growth of these blooms, I implemented a hydroponics system involving Lactuca Sativa for analysis of Planktothrix growth and productivity. Four different nutrient conditions were added to a Planktothrix-only solution and a solution growing Planktothrix with the lettuce in the hydroponics system. The four conditions consisted of no nutrient …

Exploring The Relationships Between And Among Registered Nurses' Spiritual Well-Being, Spiritual Care Perspectives, And Their Provision Of Spiritual Care In Acute Care Settings, Barbara J. Kitchener

Dissertations

Despite acknowledgment that spiritual care is an essential aspect of holistic nursing care, nurses often feel ill-prepared for, uncomfortable with, and uncertain about providing spiritual care. Studies have indicated that nurses who have a strong sense of their own spiritual well-being and/or a positive perspective [attitude, value, belief] about spiritual care are more inclined to provide spiritual care to their patients. However there is a scarcity of such studies among acute care nurses. This descriptive correlational study aimed to explore relationships between and among acute care nurses' spiritual well-being (SWB), spiritual care perspectives (SCP), and their provision of spiritual care …

Effects Of Eye Imagery On Criminal Justice And Forensic Students Cheating In Online Testing, Kortni Larue

Theses

Crime Prevention Through Environmental Design (CPTED) is a well-established subsection of environmental criminology in which aspects of the environment are altered in order to prevent crimes before they happen. This is primarily accomplished in two ways: physical and psychological. CPTED strategies often utilize both in order to prevent crime, but there is a lack of primarily psychologically based research in circulation. This includes the manipulation of the biopsychological response to gaze detection in order to increase prosocial behavior. Additionally, there is a lack of studies indicating if CPTED strategies are effective in a classroom setting and even less concerning online …

Long-Term Exposure Of Human Endothelial Cells To Metformin Modulates Mirnas And Isomirs., Angelica Giuliani, Eric Londin, Manuela Ferracin, Emanuela Mensà, Francesco Prattichizzo, Deborah Ramini, Fiorella Marcheselli, Rina Recchioni, Maria Rita Rippo, Massimiliano Bonafè, Isidore Rigoutsos, Fabiola Olivieri, Jacopo Sabbatinelli

Computational Medicine Center Faculty Papers

Increasing evidence suggest that the glucose-lowering drug metformin exerts a valuable anti-senescence role. The ability of metformin to affect the biogenesis of selected microRNAs (miRNAs) was recently suggested. MicroRNA isoforms (isomiRs) are distinct variations of miRNA sequences, harboring addition or deletion of one or more nucleotides at the 5' and/or 3' ends of the canonical miRNA sequence. We performed a comprehensive analysis of miRNA and isomiR profile in human endothelial cells undergoing replicative senescence in presence of metformin. Metformin treatment was associated with the differential expression of 27 miRNAs (including miR-100-5p, -125b-5p, -654-3p, -217 and -216a-3p/5p). IsomiR analysis revealed that …

Identification Of Genes That Determine Fitness, Virulence, And Disease Outcomes In Mastitis Associated Eschericia Coli, Michael Andrew Olson

Theses and Dissertations

Escherichia coli is an incredibly diverse group of bacteria that consist of both commensal and pathogenic strains that cause disease in a wide variety of tissues in many different animals. The current dogma, based on years of extensive molecular and genetic studies, is that individual strains have adapted to specific environments through acquisition of specific genes or come from lineages that are particularly suited to a unique tissue or host. However, mastitis-associated E. coli (MAEC) have thus far resisted such descriptions. The fitness and virulence factors of MAEC are poorly understood and molecular tools are rarely applied. This dissertation reports …

Publication Productivity Trend Of Indian Institute Of Technology, Delhi During 2015 To 2019: A Scientometric Study, Chaitanya D. Veer, Jagdish N. Kulkarni

Library Philosophy and Practice (e-journal)

The present paper reveals the research productivity of scientists from the Indian Institute of Technology (IIT), Delhi during 2015 to 2019. Computational analysis carried out in Microsoft Excel. The required bibliographic information collected from the Clarivate Analytics's Web of Science database. The data analysis has done with the help of Scientometrics methodology and computational analysis. This study aims to find out the research productivity of IIT Delhi in terms of publication year-wise analysis, National and International collaboration, authorship pattern. It is found that international research collaboration of IITD faculties with USA, Germany, England, France and more countries. It is found …

Chamaecyparis Obtusa (False Cypress-Hinoki), Id #982, Margaret O. Kimball

BIO 140 Arboretum Project

Location: West of Misto Gatehouse, on Bellevue Avenue.

Knowledge, Attitudes, And Practices Against The Growing Threat Of Covid-19 Among Medical Students Of Pakistan, Khola Noreen, Zil-E Rubab, Muhammad Umar, Rehana Rehman, Mukhtiar Baig, Fizzah Baig

Department of Biological & Biomedical Sciences

Background: On account of the COVID-19 pandemic, many changes have been implicated in university medical students. We are cognizant that pandemic can be controlled with dedicated contributions from all involved in the healthcare profession. Therefore, it is important to know the pandemic and application of knowledge by the medical students to formulate a further line of management in Pakistan.
Objective: We aimed toinvestigate the knowledge, attitudes, and practices (KAP) regarding COVID-19 and its impact on medical students of Pakistan.
Methods: A cross-sectional survey was conducted in June 2020 by a validated self-administered questionnaire. The survey instrument was tailored from a …

In Silico Apc/C Substrate Discovery Reveals Cell Cycle-Dependent Degradation Of Uhrf1 And Other Chromatin Regulators, Jennifer L. Franks, Raquel C. Martinez-Chacin, Xianxi Wang, Rochelle L. Tiedemann, Thomas Bonacci, Rajarshi Choudhury, Derek L. Bolhuis, Taylor P. Enrico, Ryan D. Mouery, Jeffrey S. Damrauer, Feng Yan, Joseph S. Harrison, M. Ben Major, Katherine A. Hoadley, Aussie Suzuki, Scott B. Rothbart, Nicholas G. Brown, Michael J. Emanuele

College of the Pacific Faculty Articles

The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase and critical regulator of cell cycle progression. Despite its vital role, it has remained challenging to globally map APC/C substrates. By combining orthogonal features of known substrates, we predicted APC/C substrates in silico. This analysis identified many known substrates and suggested numerous candidates. Unexpectedly, chromatin regulatory proteins are enriched among putative substrates, and we show experimentally that several chromatin proteins bind APC/C, oscillate during the cell cycle, and are degraded following APC/C activation, consistent with being direct APC/C substrates. Additional analysis revealed detailed mechanisms of ubiquitylation for UHRF1, a key chromatin …

Solutions For Imperiled Bat Conservation: Integrating Ecology, Technology, And The Public, Amy Hammesfahr

Electronic Theses & Dissertations

Bat populations have plummeted in Missouri since the introduction of white-nose syndrome (WNS) in 2012, presenting challenges in researching understudied species’ habitat ecology. Frequently incorporated survey techniques, such as mist netting and radio-telemetry, have become unreliable post-WNS. In response to address the challenge of studying rare species, we explored the alternative strategies of acoustic monitoring, acoustic lures, and human dimension surveys that may enhance surveys. Our goals from these objectives included comparing the methods to recommend better management decisions for imperiled bat species post-WNS. For Chapter I, we surveyed three imperiled bat species in southeastern Missouri, including the northern long-eared …

Comparison Of Threatened Neosho Madtom Densities Between Riverscapes Differing In Anthropogenic Stressors, With A Particular Focus On Recovery From Mining-Derived Metal Pollution, Kali Boroughs

Electronic Theses & Dissertations

Water pollution imperils the Neosho Madtom (Noturus placidus), which is threatened in Kansas and federally. Within Kansas madtom densities were historically lower in the Spring River compared to the Cottonwood and Neosho Rivers, especially within the Spring River below tributary inputs that delivered cadmium, lead, and zinc pollution from the Tri-State Mining District. Studies suggest that madtoms are less numerous in waters containing elevated metal concentrations because of direct toxicity and lower benthic macroinvertebrate availability, which is also depressed by elevated metal concentrations. However, long-term reductions in metal concentrations in the Spring River have occurred, but to date …

Translating Evidence-Based Guidelines Into Practice—Are We Getting It Right? A Multi-Centre Prospective International Audit Of Nutrition Care In Patients With Foregut Tumors (Inform), Merran Findlay, Judith D. Bauer, Rupinder Dhaliwal, Marian De Van Der Schueren, Alessandro Laviano, Adrianne Widaman, Lisa Martin, Andrew G. Day, Leah M. Gramlich

Faculty Research, Scholarly, and Creative Activity

Malnutrition is highly prevalent in patients with foregut tumors comprising head and neck (HNC) and esophageal (EC) cancers, negatively impacting outcomes. International evidence-based guidelines (EBGs) for nutrition care exist; however, translation of research evidence into practice commonly presents considerable challenges and consequently lags. This study aimed to describe and evaluate current international nutrition care practices compared with the best-available evidence for patients with foregut tumors who are at high risk of malnutrition. A multi-centre prospective cohort study enrolled 170 patients commencing treatment of curative intent for HNC (n = 119) or EC (n = 51) in 11 cancer …

Taxonomic Review Of South American Butter Frogs: Phylogeny, Geographic Patterns, And Species Delimitation In The Leptodactylus Latrans Species Group (Anura: Leptodactylidae), Felipe De M. Magalhães, Mariana L. Lyra, Thiago R. De Carvalho, Diego Baldo, Francisco Brusquetti, Pamela Burella, Guarino R. Colli, Marcelo C. Gehara, Rafael O. De Sá, Et Al.

Biology Faculty Publications

The Leptodactylus latrans species group currently comprises eight medium- to large-sized frog species with a convoluted taxonomic history, particularly related to the specific limits of the L. latrans complex, and the species pair Leptodactylus chaquensis–Leptodactylus macrosternum. Their homogeneous external morphology and continental geographic distribution in South America have posed severe limitations to a comprehensive review, such that taxonomic consensus and species limits remain uncertain. This is further worsened by the presence of chromatic polymorphism among coexisting species that can hardly be distinguished by external morphology. Based on a large-scale geographic sampling including multilocus DNA analyses, and acoustic …

Applying Web Technologies For Data Mining Of Models Of Advancement Over Time In Space Exploration Technology, Peng-Hung Tsai

Theses and Dissertations

The development of web technologies has progressed rapidly in the past few decades. As a result, these technologies have increasingly gained popularity among researchers as an instrument for data analysis and visualization to aid their work. The purpose of this project is to pursue a new method for mining time-based data to perform curve fitting, using web client technology. This requires comparing the advantages and disadvantages of different JavaScript software designs to determine which is best. Based on the results, we emphasize developing a client-side web application and demonstrate its use through fitting a curve for a new metric to …