Digital Commons Network^™

Effects Of Exercise On Myeloid-Derived Suppressor Cell-Related Tumor Progression And Metastasis, Jacob Garritson

Dissertations

Garritson, Jacob. Effects of Exercise on Myeloid-Derived Suppressor Cell-Related Tumor Progression and Metastasis. Published Doctoral Dissertation, University of Northern Colorado, 2020. Myeloid-derived suppressor cells (MDSCs) are potent suppressors of immune function and may play a key role in the development and progression of metastatic cancers. Aerobic exercise has been shown to have anticancer effects, yet the mechanisms behind this protection are largely unknown. Purpose: to determine the effects of physical activity on MDSC accumulation and function. Methods: Female BALB/c mice were assigned to one of two primary groups: sedentary tumor (SED+TUM) or wheel run tumor (WR+TUM). After 6 weeks of …

August 2020 News Releases, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.

Using Novel Mouse Knockout Models To Study The Roles Of Asm (Acid Sphingomyelinase) In The Regulation Of Multiple Stem Cell Compartments In Vivo, Amro Abdalla

UNLV Theses, Dissertations, Professional Papers, and Capstones

Acid Sphingomyelinase (ASM) is a lipid-modifying enzyme that breaks down sphingomyelin lipids into ceramide and phosphorylcholine. Genetic mutations in the human ASM gene leads to Niemann pick diseases (NPD) type A & B. In NPD type A, patients die between 1-2 years old due to severe neurological complications, while NPD type B patients live to adulthood but suffer from severe visceral organ complications. Type A is usually associated with complete inactivation of the ASM gene. The hallmark of NPD is Purkinje neuron (PN) death. PNs, the major neurons in the cerebellum part of the brain, regulate the balance and fine …

Network Analysis Of Cognitive Symptom Domains In Alzheimer's Disease (Ad), Abigail Rose Baily

UNLV Theses, Dissertations, Professional Papers, and Capstones

Alzheimer’s Disease (AD) is a degenerative neurological disease process that results in cognitive and functional declines and ultimately results in death. The pattern and course of cognitive and functional decline has been well characterized in AD, however little is known about the interactions between the symptoms. Network Analysis is a recently developed mathematical approach of examining the interactions between symptoms, by exploring the covariance of symptoms. The current study utilized network analysis to examine the multivariate structural dependencies among cognitive domains known to be affected in Alzheimer’s disease. The sample consisted of 864 older adults (60-90 years old), selected from …

How Did The Nra Employ Presidential Election Year Propaganda Against Barack Obama Within The Shifting Paradigm Of The Digital Age?, Rodney James Edgar

UNLV Theses, Dissertations, Professional Papers, and Capstones

The National Rifle Association is one of the most successful lobbying groups in the United States of America. There are a few key elements that contribute to this perfect storm of passion, constitutional rights, misinformation and social division. Perception is often credited with being synonymous with reality. As an influential organization, the NRA has used its platform to spread communication, a practice which is enabled and enhanced by the technology, speed of delivery and vast reach that comes with the information age. The focus of this study will be on two artifacts from the digital archives of the NRA. For …

A Chc Theoretical Approach To Examining Cognitive And Academic Deficits Among Students With Adhd Using A Three-Battery Approach, Jacqueline Scott Hart

UNLV Theses, Dissertations, Professional Papers, and Capstones

Current research into ADHD and Cattell-Horn-Carroll (CHC) factor scores has been examined (Rowland, 2013; Sjöwall, Roth, Lindqvist, & Thorell, 2013), but few studies have evaluated the discrepancies in CHC factor scores of students diagnosed with ADHD compared to healthy controls using the updated Woodcock-Johnson ® IV (WJ IV™) three-battery configuration. With little research on the WJ-IV three-battery configuration, this study expands on the limited research into the discrepancies among students with ADHD compared to healthy controls using CHC factor scores.

Subjects for this study were obtained from 12 schools in a large urban district in northwestern Arizona and standardization data …

Does Wearing Multiple Pairs Of Shoes Influence Injury Rates?, Julien Mihy

UNLV Theses, Dissertations, Professional Papers, and Capstones

Running research has attempted to better understand the causes of movement-related injuries and a large segment of this research revolves around footwear and training regimens. A survey has reported lower injury rates in runners who wore multiple shoes with in a 5-month period. Previous literature lacks the analysis of variables leading to training related decisions and whether wearing multiple pairs of shoes can have an extended influence on injury rates. PURPOSE: To determine whether wearing multiple pairs of shoes has an influence on injury rates. METHODS: A survey was developed to ask participant’s injury related history along with their footwear, …

Sexually Transmitted Infections And The 65 And Older Population: Knowledge And Perceived Risk, Alexus Miranda

UNLV Theses, Dissertations, Professional Papers, and Capstones

Sexually transmitted infections (STI) can impact all persons. Since 2000, the number of STIs has steadily increased among persons aged 50 years and older in the United States (Purpora, 2012). Persons over the age of 60 accounted for the biggest increase of in-office treatments of STIs between 2014 and 2017 (Howley, 2018). The purpose of this study was to use the Sexual Health Model to examine the relationship between various predictors and these persons’ perceived risk of STIs, their STI knowledge, and other barriers that impact the sexual health of persons 65 years of age and older. This study used …

Managing Cultural Resources On The Alaska Peninsula, Laura Stelson, William L. Rice, B. Derrick Taff

Society and Conservation Faculty Publications

Twentieth-century cultural resources provide physical evidence of human relationships with a landscape that has shaped the wilderness areas we know today. These cultural resources enrich the meaning of an area as wilderness, but also present multiple management challenges surrounding visitor use in designated wilderness areas. The National Geographic Society Katmai Expeditions of the 1910s present a case study of how historic trails and their associated artifacts interact not only with present issues toward the dual-enforcement of the National Historic Preservation Act and Wilderness Act, but also with the management of visitor use along a corridor containing relatively recent traces of …

The "Challenge" Of Depletion: Why The Oyster Fishery Is Not Self-Regulating, Eric N. Powell, John M. Klinck, Leanne M. Poussard

Faculty Publications

© 2020 National Shellfisheries Association. All rights reserved. The possibility that the economics of the oyster fishery impose a self-limitation on overharvesting has been proffered on occasion. The inefficiency of harvesting by the fishery has been evaluated and estimates of the exploitation rate permissible under conditions of maximum sustainable yield have been obtained in previous studies. The question becomes to what extent does the inefficiency of harvest interact with the economics of the fishery to compromise ready detection of overfishing? This study explores the possibility that the constraint of economics on the fishery occurs at oyster exploitation rates that are …

“Toxic” Schools? How School Exposures During Adolescence Influence Trajectories Of Health Through Young Adulthood, Courtney E. Boen, Karen Kozlowski, Karolyn D. Tyson

Faculty Publications

© 2020 The Author(s) A large body of research identifies the critical role of early-life social contexts such as neighborhoods and households in shaping life course trajectories of health. Less is known about whether and how school characteristics affect individual health and contribute to population health inequality. However, recent scholarship argues that some school environments are so stressful due to high levels of violence, disorder, and poverty that they may be “toxic” to student health, but this hypothesis has not been tested using population data. Integrating insights from the life course perspective and stress process model, we use rich longitudinal …

A Metanalysis Of Sequences Of Vascular Plants In The World’S Biodiversity Hotspots With A Special Section On Madagascar, John Michael Adrian Wojahn

Boise State University Theses and Dissertations

Humans have become a major factor in reshaping the Earth’s biosphere. One of the major effects of human changes to the environment is an increase in the rate of species extinction as compared to background rates. Biodiversity hotspots are areas whose species assemblages are very rich (50% of the world’s plants and 42% of land vertebrates) yet very threatened with extinction ( > 70% habitat destruction), and which ought to be foci for conservation efforts. The intense peril in which the flora of these endangered regions are requires an equally intense response from the scientific community. This study investigated the benefits …

Design And Testing Of A Multi-Depth Soil Temperature Sensor Array Intended As A Candidate Irrigation Scheduling Tool, Lillian Glaeser

Biological and Agricultural Engineering Undergraduate Honors Theses

A crucial measure in the advancement of water conservation and sustainable agricultural strategies is increasing efficiencies of irrigation systems. Because of the lack of availability of affordable, durable, and scalable soil moisture monitoring devices, this thesis proposes a low-cost, multi-depth soil temperature sensor array as a candidate for monitoring soil moisture content and guiding farmer’s irrigation scheduling. Propagation of diurnal temperature waves through soil is dependent on the thermal diffusivity of the soil, which can be determined by examining temperature waves at different soil depths. Thermal diffusivity is dependent on several factors, though, in undisturbed soil, water has the largest …

Prevalence Of Anticoagulant Rodenticides In Ferruginous Hawk Nestlings And Evaluation Of A Novel Method To Rapidly Assess Exposure, Ariana Joyce Dickson

Boise State University Theses and Dissertations

Anticoagulant rodenticides (ARs) are compounds commonly used to control rodent pests by inhibiting an enzyme critical for synthesis of clotting factors in their blood. Secondary and tertiary poisoning of non-target species frequently occur, especially of predators that consume rodents, including many species of raptors. Although raptor exposure to ARs has been documented on at least three continents, patterns, pathways and the sub-lethal effects of exposure are not well studied. This has created a substantial need to monitor the effects of ARs in free-living populations. I evaluated the prevalence of secondary, non-target exposure to anticoagulant rodenticides experienced by a predatory raptor, …

Learning From Chemical Coping Behaviors Of Wildlife To Discover New Approaches For Pest Management, Britt Pendleton

Boise State University Theses and Dissertations

Pests, such as parasites and pathogens, persist throughout time and space as threats to public health and food security. The need for novel and sustainable approaches to managing these threats are in high demand. The current approach of discovering and developing chemical treatments to manage pests is tedious, not efficient, and often outpaced by traits of resistance in pests. Here, we propose a new approach to discovering new chemical pest management solutions by observing chemical coping behaviors in wildlife. We define a chemical coping behavior as the exploitation of naturally occurring chemicals within a host’s environment to manage pests. Specifically, …

A Symbiosis Between A Dark Septate Fungus, An Arbuscular Mycorrhiza, And Two Plants Native To The Sagebrush Steppe, Craig Lane Carpenter

Boise State University Theses and Dissertations

Plant roots form symbioses with various fungi, including arbuscular mycorrhizae (AMFs) and dark septate endophytes (DSEs). The symbiosis between plants and AMFs has been extensively studied and is generally considered to be mutualistic. Much less is known about the symbiosis between plants and DSE. In sagebrush habitats, DSEs are common, but their effects on the vegetation are unclear. As a first step to study these effects, I isolated and cultured a DSE from the roots of the shrub Artemisia tridentata. Based on partial sequences of five genes and phylogenetic analyses, the isolated fungus was a non-described species within the …

Dimerization Of The Notch Intracellular Domain Results In Distinct Signaling Activity, Jacob Jeffery Crow

Boise State University Theses and Dissertations

The Notch signaling pathway is a core component of multicellularity; enabling cells to directly communicate with both their neighbors and the surrounding microenvironment. These signals are translated directly through the Notch proteins, where a fragment of Notch transitions into the nucleus to act as a co-transcription factor, setting into motion a host of physiological responses. Commonly involved in pathways that define a cell’s identity and fate decisions, what appears to be a simplistic pathway instead exists in a state of high-tunability and strict control. Missteps in this pathway are generally embryonically lethal or lead to a suite of congenital disorders …

Factors Affecting Esophageal Tissue Radiation Response, Latisha T. Pryor

UNLV Theses, Dissertations, Professional Papers, and Capstones

Radiation-induced esophageal cancer can be a deadly and unfortunate secondary outcome of radiotherapy or chronic occupational exposure to radiation. Although the esophagus is known to be a radiosensitive organ, it is under studied and further information regarding how dose and radiation quality impact its sensitivity may provide strategies to prevent esophageal cancer. The purpose of this thesis was to understand factors that play a role in the tissue’s radiosensitivity that may relate to its cancer risk. In this study, we used two esophageal 3D models, as well as both human and mouse cells, to define radiation quality and dose dependent …

Transposable Element Expression In Human Embryo Single-Cell Rna-Seq Data, Corinne Sexton

UNLV Theses, Dissertations, Professional Papers, and Capstones

Transposable elements (TEs) are genetic sequences which are mobile within the genome, including DNA transposons and retrotransposons. Though the vast majority are no longer able to move or duplicate in humans, they still are actively transcribed in both germline and somatic cells, particularly in early human development. TEs are expressed in an extremely cell-type and stage specific pattern during embryogenesis, suggesting that they may either have a regulatory role in the cell or be transcribed along with cell-specific genes. However, earlier studies have focused on hESC models or early embryos up to day 6, with differing patterns of TE expression. …

Genomic Analysis Of The Only Blind Cichlid Reveals Extensive Inactivation In Eye And Pigment Formation Genes, Matthew L. Aardema, Melanie L J Stiassny, S Elizabeth Alter

Biology, Agriculture and Chemistry Faculty Publications and Presentations

Trait loss represents an intriguing evolutionary problem, particularly when it occurs across independent lineages. Fishes in light-poor environments often evolve “troglomorphic” traits, including reduction or loss of both pigment and eyes. Here, we investigate the genomic basis of trait loss in a blind and depigmented African cichlid, Lamprologus lethops, and explore evolutionary forces (selection and drift) that may have contributed to these losses. This species, the only known blind cichlid, is endemic to the lower Congo River. Available evidence suggests that it inhabits deep, low-light habitats. Using genome sequencing, we show that genes related to eye formation and pigmentation, …

Therapeutic Plasma Exchange Taper Does Not Decrease Exacerbations In Immune Thrombotic Thrombocytopenic Purpura Patients, Jay S. Raval, Marshall A. Mazepa, Marian A. Rollins-Raval, Raj S. Kasthuri, Yara A. Park

Pathology Research and Scholarship

BACKGROUND: Despite rapid and intensive treatments with therapeutic plasma exchange (TPE) and immunosuppression, immune thrombotic thrombocytopenic purpura (TTP) patients are at risk of disease exacerbation, i.e., early recurrence of TTP within 30 days of achieving treatment response. TPE taper, a practice of performing additional TPE procedures after achieving treatment response, is commonly performed for decreasing exacerbations, although no evidence supports this practice.

STUDY DESIGN AND METHODS: In this prospective observational investigation over four years, our center switched its standard of care for treating all TTP patients from not performing TPE taper after achieving treatment response (i.e., no-taper cohort) to performance …

Feral Swine, Michael P. Glow, Nathan P. Snow, Kurt C. Vercauteren

Wildlife Damage Management Technical Series

Feral swine (Sus scrofa; Figure 1), also known as feral hogs, feral pigs, wild pigs, wild boar, or other similar derivations, are a non-native species considered to be one of the most destructive invasive terrestrial vertebrates in North America. While feral swine populations remained relatively small and confined in the continental United States following initial introductions by European explorers during the 15th century, substantial range expansion has occurred across every geographical region of the United States (Figure 2). This expansion has primarily been attributed to human-mediated movements, predominately for the purpose of establishing populations for recreational hunting, and facilitated by …

Making The Case For A Right To A Healthy Environment For The Protection Of Vulnerable Communities: A Case Of Coal-Ash Disaster In Puerto Rico, Sarah Dávila-Ruhaak

Michigan Journal of Environmental & Administrative Law

The connection between the environment and human rights is not a surprising one. The enjoyment of human rights depends on a person’s ability to live free from interference and to have his or her rights protected. The interdependence of human rights and the protection of the environment is manifested in the full and effective enjoyment of the right to a healthy environment. This article argues that in order to protect vulnerable persons and communities facing environmental harm, a human rights framework—specifically the right to a healthy environment—must be applied. A human rights approach complements environmental justice work, recognizing that individuals …

Application Of Carbon Nanoparticles As Dna Detection Probe And Fluorescent Ink, Luckio Frank Owuocha

Graduate Theses/Dissertations

There is a significant interest in developing a sensitive, selective, efficient, and inexpensive method for rapid molecular diagnostic tests. This research aims to develop an inexpensive nucleic acid detection method by using DNA-conjugated carbon nanoparticles that exhibit fluorescence in the visible region. Carbon nanoparticles of this class can be detected without specialized equipment and have great promise toward the development of analytical methods that can be used in resource-limited environments with a lack of access to proper diagnostic and healthcare. We employed EDC-NHS (two-step) and EDC (one-step) coupling techniques to prepare DNA-conjugated carbon nanoparticles. The dot blotting method was adapted …

Mapping Covid-19 Related Research From Saudi Arabia, A Scoping Review: Between Reality And Dreams, Ibrahim Almaghlouth, Tahera Islam, Nurah Alamro, Abdulrahman Alsultan, Assim Alfadda, Saleh Al-Muhsen, Abeer Almasry, Majid A. Almadi, Ahmad Hersi, Ahmed Bahammam

Saudi Medical Journal

Objectives: To map research production by Saudi-affiliated investigators in order to identify areas of strength and weakness. Method: We followed the Arksey and O’Malley (2005) framework. Medline and Cochrane databases were searched with a focus on identifying articles related to COVID-19 and Saudi Arabia following the PRISMA protocol. The study was conducted at King Saud University, Riyadh, Saudi Arabia between March and May 2020. Results: A total of 53 articles were ultimately included. Most of the research production from Saudi Arabia was opinion and narrative reviews related to the clinicopathological features of COVID-19 as well as control and prevention of …

Electrocortical Changes Observed In The N2 As An Outcome Of Attention Bias Modification Training, Hayley Gilbertson

All NMU Master's Theses

Anxiety disorders are currently one of the most predominant mental health conditions worldwide. Increased anxiety is associated with elevated attentional focus to threat also known as attentional bias to threat. Attention Bias Modification (ABM) is a type of computerized training, attempting to reduce attentional focus for threatening stimuli and has been found to successfully reduce symptoms of anxiety. Past studies have implemented ABM training as a possible tool to modulate attention away from threat in attempt to decrease pathological anxiety. The N2 is an event-related potential (ERP) detected in scalp EEG recordings that is associated with conflict monitoring and complex …

Environmental Monitoring Plan For Work Performed July 1 2020 Through June 30, 2021, Tennessee. Department Of Environment And Conservation.

Environmental Monitoring Report

No abstract provided.

Distribution Of Heavy Metals, Soil Microbial Enzymes And Their Relationship In Kano, Northwestern Nigeria, Mansur Abdul Mohammed, Emmanuel Adewale Olowolafe

Jurnal Geografi Lingkungan Tropik (Journal of Geography of Tropical Environments)

The increase in population and industrial growth has led to increased production of industrial and domestic waste which contain heavy metals in various forms. Therefore, affect the diversity and activities of soil microbes and subsequently affect environmental sustainability. This research aimed at assessing the distribution of heavy metals, soil enzymes, and evaluate the functional relationship if any. The study area was divided into two locations as contaminated and control; thus, each location one square kilometre was demarcated and divided into 25 small square (grid). A Sample was collected in each grid from 0 – 15 cm depth using point composite …

An End-To-End Trainable Method For Generating And Detecting Fiducial Markers, J. Brennan Peace

Department of Electrical and Computer Engineering: Dissertations, Theses, and Student Research

Existing fiducial markers are designed for efficient detection and decoding. The methods are computationally efficient and capable of demonstrating impressive results, however, the markers are not explicitly designed to stand out in natural environments and their robustness is difficult to infer from relatively limited analysis. Worsening performance in challenging image capture scenarios - such as poorly exposed images, motion blur, and off-axis viewing - sheds light on their limitations. The method introduced in this work is an end-to-end trainable method for designing fiducial markers and a complimentary detector. By introducing back-propagatable marker augmentation and superimposition into training, the method learns …

Application Of Software Engineering Principles To Synthetic Biology And Emerging Regulatory Concerns, Justin Firestone

School of Computing: Dissertations, Theses, and Student Research

As the science of synthetic biology matures, engineers have begun to deliver real-world applications which are the beginning of what could radically transform our lives. Recent progress indicates synthetic biology will produce transformative breakthroughs. Examples include: 1) synthesizing chemicals for medicines which are expensive and difficult to produce; 2) producing protein alternatives; 3) altering genomes to combat deadly diseases; 4) killing antibiotic-resistant pathogens; and 5) speeding up vaccine production.

Although synthetic biology promises great benefits, many stakeholders have expressed concerns over safety and security risks from creating biological behavior never seen before in nature. As with any emerging technology, there …