Digital Commons Network^™

Almost-Common Denominators, Nat Banting

Colorado Mathematics Teacher

This article describes a classroom episode where a student’s unanticipated reasoning reminds us that foregrounding student sensemaking requires more than listening for strategies from a prepared list. Student knowing can be abrupt and surprising, and the teacher must honor and accentuate mathematical sense as it emerges.

The 2019 Top Three Altmetric Attention Score Articles - An Overview, Stephen G, Susheela P

Library Philosophy and Practice (e-journal)

Altmetrics are data that can explain both the volume and nature of attention that research receives online. Certain kinds of altmetrics are also indicators for potential downstream impact. Altmetrics are complementary to citation-based metrics, and distinct from social media metrics and usage statistics. In this paper presented the 2019 top three research articles attention in the online. The highest Altmetric attention score received for the article of Few-shot adversarial learning of realistic neural Talking Head Models with attention score of 13,415 with huge number of twitter mentioned and it was published arXiv, May 2019. Within seven months crossed high attention …

Acute Pancreatitis, Noah Prebish

Nursing Student Class Projects (Formerly MSN)

The continents of the poster are the result of a literature search that was conducted to find the most up to date information on various aspects of acute pancreatitis. Acute pancreatitis can be categorized as mild, moderate and severe cases. Mild and moderate cases of acute pancreatitis usually subside spontaneously and have no residual effects on patients. Severe acute pancreatitis is a potentially life-threatening disorder that results in the autodigestion of the pancreas. Autodigestion of the pancreas causes a systemic inflammatory response that usually results in rapid deterioration of patient’s hemodynamic status. Severe pancreatitis often leads to long hospital stays …

Association Between Single Nucleotide Polymorphisms In Sirt1 And Sirt2 Loci And Growth In Tibetan Sheep, Lin-Sheng Gui, Sayed Haidar Abbas Raza, Li Zhou, Matthew Garcia, Ayman Hassan Abd El-Aziz, Dawei Wei, Shengzhen Hou, Jianlei Jia, Zhiyou Wang

Animal, Dairy, and Veterinary Science Faculty Publications

Silent information regulator 1 and 2 (SIRT1, 2) were NAD+-dependent histone or non-histone deacetylase, which emerged as key metabolic sensors in several tissues of mammals. In the present study, the search for polymorphisms within the ovine SIRT1 and SIRT2 loci as well as association analyses between SNPs and growth-related traits were performed in Tibetan sheep. To determine the expression pattern of SIRT1 and SIRT2 genes in Tibetan sheep, the quantitative real-time polymerase chain reaction (qPCR) analysis revealed that those two genes were widely expressed in diverse tissues. Expression of SIRT1 was less in abomasum of lamb, whereas it …

Selective Inhibition Of Mtorc1 In Tumor Vessels Increases Antitumor Immunity, Shan Wang, Ariel Raybuck, Eileen Shiuan, Sung Hoon Cho, Qingfei Wang, Dana M Brantley-Sieders, Deanna Edwards, Margaret M Allaman, James Nathan, Keith T Wilson, David Denardo, Siyuan Zhang, Rebecca Cook, Mark Boothby, Jin Chen

Open Access Publications

A tumor blood vessel is a key regulator of tissue perfusion, immune cell trafficking, cancer metastasis, and therapeutic responsiveness. mTORC1 is a signaling node downstream of multiple angiogenic factors in the endothelium. However, mTORC1 inhibitors have limited efficacy in most solid tumors, in part due to inhibition of immune function at high doses used in oncology patients and compensatory PI3K signaling triggered by mTORC1 inhibition in tumor cells. Here we show that low-dose RAD001/everolimus, an mTORC1 inhibitor, selectively targets mTORC1 signaling in endothelial cells (ECs) without affecting tumor cells or immune cells, resulting in tumor vessel normalization and increased antitumor …

Rothwell Co-Authors Two Articles Identifying Fossilized Plant Species, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Sediment Transport Near Ship Shoal For Coastal Restoration In The Louisiana Shelf: A Model Estimate Of The Year 2017–2018, Haoran Liu, Kehui Xu, Yanda Ou, Robert Bales, Zhengchen Zang, Z. George Xue

Faculty Publications

No abstract provided.

Developing A Yeast Two-Hybrid System To Study Molluscum Contagiosum Virus Protein-Protein Interactions With Human Proteins, Eric Bryan

Seton Hall University Dissertations and Theses (ETDs)

The human immune system acts as our primary defense against invading pathogens including bacteria, parasites, and viruses. Molluscum Contagiosum Virus (MCV) is a poxvirus that causes persistent skin lesions in humans that can last for many months at a time. Persistence of MCV infections is attributed in part to the ability of the virus to suppress human immune signaling. Many MCV genes, including MC159, MC160, and MC163, code for products that inhibit several important innate immune signaling pathways and consequently reduce inflammation, leukocyte infiltration, and chemokine production. However, due to lack of a tissue culture system in which to propagate …

Knowlesi Malaria, Yee Ling Lau

Archival Material (2020s)

Originally a simian malaria, Plasmodium knowlesi is now known as the fifth human malaria species. Since the report of a large focus of human knowlesi cases in Sarawak in 2004, many more human cases have been reported in all of the countries in Southeast Asia and in travellers returning from these countries. The zoonotic nature of this infection hinders malaria elimination efforts. In order to grasp the current perspective of knowlesi malaria, this inaugural lecture explores the different aspects of the disease including risk factors, diagnosis, treatment, molecular and functional studies. Current studies do not provide sufficient data for an …

The Weekly Challenger, August 6, 2020, The Weekly Challenger, Et Al

Weekly Challenger Newspaper Collection

The August 6, 2020, issue of The Weekly Challenger.

Ptsd And Depressive Symptoms As Potential Mediators Of The Association Between World Trade Center Exposure And Subjective Cognitive Concerns In Rescue/Recovery Workers, Ankura Singh, Rachel Zeig-Owens, Laura Rabin, Theresa Schwartz, Mayris P. Webber, David Appel, David J. Prezant, Charles B. Hall

Publications and Research

We observed that World Trade Center (WTC) exposure, post-traumatic stress disorder (PTSD) symptoms and depressive symptoms were associated with subjective cognitive concerns in Fire Department of the City of New York (FDNY) rescue/recovery workers. This follow-up study examined whether PTSD symptoms and/or depressive symptoms mediate the observed association between WTC exposure and subjective cognitive concerns. We included WTC-exposed FDNY workers who completed the Cognitive Function Instrument (CFI), measuring self-perceived cognitive decline (N = 9516). PTSD symptoms and depressive symptoms were assessed using the PCL-S and CES-D, respectively. Multivariable linear regression estimated the association between WTC exposure and CFI score, adjusting …

The Effect Of Bacterial Endotoxin Lps On Serotonergic Modulation Of Glutamatergic Synaptic Transmission, Jate Bernard, Abigail Greenhalgh, Oscar Istas, Nicole T. Marguerite, Robin L. Cooper

Biology Faculty Publications

The release of the endotoxin lipopolysaccharides (LPS) from gram-negative bacteria is key in the induction of the downstream cytokine release from cells targeting cells throughout the body. However, LPS itself has direct effects on cellular activity and can alter synaptic transmission. Animals experiencing septicemia are generally in a critical state and are often treated with various pharmacological agents. Since antidepressants related to the serotonergic system have been shown to have a positive outcome for septicemic conditions impacting the central nervous system, the actions of serotonin (5-HT) on neurons also exposed to LPS were investigated. At the model glutamatergic synapse of …

Bisphenol-A (Bpa) And Breast Cancer: Utilizing Risk Assessment And Education To Improve Preventative Care, Ashley Catherine Babcock

Doctor of Nursing Practice (DNP) Projects

Breast cancer places a large burden on many communities, causing mortalities, and lasting physical, mental, and financial damage. The majority of cases are not caused by a genetic risk factor, which speaks to the importance of addressing environmental risk factors to reduce disease burden. Bisphenol-A (BPA) is linked to increase risk for and metastasis of breast cancer. BPA is widely used in plastics, exposing a huge portion of the United States population. This project used the model developed for the Green Choices program to trial response to the use of an environmental risk survey and education tool that can be …

Assessing Sex Differences In The Effects Of Short-Term Rem Sleep On Anxiety- And Depressive-Like Behaviors In Rats, Nadia Meshkati

Seton Hall University Dissertations and Theses (ETDs)

Findings from both human and animal studies suggest rapid eye movement (REM) sleep disturbances following a traumatic event can lead to inability to extinguish the fear association, and eventually influence the development of post-traumatic stress disorder (PTSD). Additionally, research has demonstrated that sleep disruptions, including REM sleep deprivation (RSD), increases anxiety- and depressive-like behaviors and states in animals and people, with evidence of sex differences. Furthermore, it has yet to be determined whether short-term RSD, a more natural animal model of PTSD, can influence affective state of subjects. The present study applied short-term RSD to investigate sex differences in the …

Oral Cancer: Clinicopathological Features And Associated Risk Factors In A High Risk Population Presenting To A Major Tertiary Care Center In Pakistan, Namrah Anwar, Shahid Pervez, Qurratulain Chundriger, Mohammad Sohail Awan, Tariq Moatter, Tazeen Saeed Ali

Department of Pathology and Laboratory Medicine

Oral squamous cell carcinoma (OSCC) has the highest prevalence in head and neck cancers and is the first and second most common cancer in males and females of Pakistan respectively. Major risk factors include peculiar chewing habits like areca nut, betel quid, and tobacco. The majority of OSCC presents at an advanced stage with poor prognosis. On the face of such a high burden of this preventable cancer, there is a relative lack of recent robust data and its association with known risk factors from Pakistan. The aim of this study was to identify the socioeconomic factors and clinicopathological features …

Multi-Criteria Optimization – Improved Knowledge For Knowledge-Based Planning, Meredith Ollerich, Shuo Wang, Chi Lin

Posters: 2020 Summer Undergraduate Research Program

Multi-Criteria Optimization (MCO) is a new and upcoming way to quickly create and assign radiotherapy treatment plans to patients. How does it compare clinical treatment plans? MCO allows the user to adjust various treatment plans that the computer has created based on upper and lower dose limits. Varian, the program that houses MCO treatment plans, has an easy to use interface to determine the best individualized plans for each cancer patient. Clinical treatment planning may take longer than MCO-generated plans, with possible inconsistent and suboptimal quality.

The Effects Of Ethanol On The Pancreatic Cell Line Transcriptomes, Shea Thompson, Emalie Clement, Nicholas Woods

Posters: 2020 Summer Undergraduate Research Program

Pancreatic Ductal Adenocarcinoma (PDAC) is a highly aggressive cancer that develops from cells in the pancreas. Currently, PDAC has a 5-year survival rate of only 10% and it makes up about 7% of all cancer deaths (1). Certain risk factors are associated with PDAC development, including family history of cancer, obesity, diabetes, pancreatitis, alcohol consumption, and smoking. While several studies have assessed alcohol consumption and its contribution to PDAC development, there is conflicting evidence to whether or not alcohol actually promotes PDAC. Work from our lab indicates that specific subtypes of pancreatic cancer are associated with a patient’s drinking status, …

Statistical Analysis And Visualization Of Mass Spectrometry Data Using R, Joseph Hennessey, Linda Berg Luecke, Rebekah Gundry

Posters: 2020 Summer Undergraduate Research Program

Mass spectrometry (MS) identifies the mass-to-charge ratio of ions. In proteomic research, MS can be used to identify proteins in a sample by digesting proteins into peptides, ionizing the peptides, then detecting the peptides and fragments of peptides via a mass spectrometer. However, most proteomic experiments identify large numbers of proteins and at times it can be difficult to efficiency communicate results of large datasets. Therefore, we sought to apply various visualization techniques in R to allow for fast and effective processing of large MS datasets.

Does Heparin Cause Essential Fatty Acid Loss During Therapeutic Plasma Exchange?, Drew Hedstrom, Nathan Bills

Posters: 2020 Summer Undergraduate Research Program

No abstract provided.

Bioenergetic And Proteomic Analysis Of Striatal Synaptosomes From Pink1/Parkin Double Knockout Rats, Jacob Shomali, Steven Totusek, Kelly Stauch

Posters: 2020 Summer Undergraduate Research Program

Parkinson’s disease (PD) patients exhibit dopaminergic (DA) neuron degeneration in the substantia nigra pars compacta (SNpc) and loss of associated terminals in the striatum, which results in motor deficits. Loss-of-function gene mutations in PINK1 and Parkin (proteins relevant to mitochondrial quality control) have been identified in hereditary PD patients and show promise for PD animal models. Without a reproducible PD mammalian model, previous studies have failed to observe the mechanisms of progressive neurodegeneration. Therefore, we created and characterized a PINK1/Parkin double knockout (DKO) rat that reproducibly (100% of males) exhibits PD-relevant pathology, including striatal nerve terminal bioenergetic deficits prior to …

Plasticity Ensures Robust Cell Wall Metabolism In Escherichia Coli, Elizabeth A. Mueller

Arts & Sciences Graduate Student Theses and Dissertations

Single-celled organisms must adapt their physiology to persist and propagate across a wide range of environmental conditions. The growth and division of bacterial cells depends on continuous synthesis of an essential extracellular barrier: the peptidoglycan cell wall, a polysaccharide matrix that counteracts turgor pressure and confers cell shape. This dissertation identifies mechanisms that ensure robust peptidoglycan integrity and metabolism in Escherichia coli across growth environments and examines how these adaptations impact cell growth, division, morphogenesis, and antimicrobial resistance. The majority of enzymes involved in synthetizing and remodeling the peptidoglycan cell wall appear functionally redundant. In this dissertation (Chapters 2 and …

Recent Advances In The Management Of Gastrointestinal Stromal Tumor., Monjur Ahmed

Division of Gastroenterology and Hepatology Faculty Papers

Gastrointestinal stromal tumor (GIST) is a rare but an important clinical entity seen in our clinical practice. It is the most common mesenchymal tumor of the gastrointestinal tract and most common malignancy of the small intestine. Although the exact prevalence of GIST is not known, the incidence of GIST has been increasing. GISTs arise from interstitial cells of Cajal. Most of the GISTs occur due to mutation in c-kit gene or platelet derived growth factor receptor alpha gene. 15% of GISTs do not have these mutations and they are called wild-type GISTs. Almost all GISTs express KIT receptor tyrosine kinase. …

Exploiting Somatic Pirnas In Bemisia Tabaci Enables Novel Gene Silencing Through Rna Feeding, Mosharrof Mondal, Judith K. Brown, Alex Flynt

Faculty Publications

© This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/). RNAi promises to reshape pest control by being nontoxic, biodegradable, and species specific. However, due to the plastic nature of RNAi, there is a significant variability in responses. In this study, we investigate small RNA pathways and processing of ingested RNAi trigger molecules in a hemipteran plant pest, the whitefly Bemisia tabaci. Unlike Drosophila, where the paradigm for insect RNAi technology was established, whitefly has abundant somatic piwi-associated RNAs (piRNAs). Long regarded as germline restricted, piRNAs are common in the …

Soluble Neprilysin And Long-Term Clinical Outcomes In Patients With Coronary Artery Disease Undergoing Percutaneous Coronary Intervention: A Retrospective Cohort Study, Ik Jun Choi, Sungmin Lim, Youngdeok Hwang, Dongjae Lee, Won Jik Lee, Kwan Yong Lee, Mi-Jeong Kim, Doo Soo Jeon

Publications and Research

Background: Neprilysin has an essential role in regulating fluid balance and vascular resistance, and neprilysin inhibitors have shown beneficial effects in patients with heart failure. However, the potential predictive value of neprilysin levels as a biomarker for cardiovascular risk remains unclear. The aim of this study was to assess the prognostic value of soluble neprilysin (sNEP) levels in patients with ischemic heart disease.

Methods: Neprilysin levels were measured in 694 consecutive patients with coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI). These patients were classified into two groups according to their serum levels of neprilysin and categorized into the …

The Investigation Of Surface Structures On Various Pathogens And Their Interactions With The Human Immune System, Carmen M. Villalobos

Biomedical Engineering ETDs

The cell surface is the first interface the host immune system encounters and

its investigation has led to a better understanding of cellular biology and types of

pathways that pathogens target in a host cell. The cell surface has evolved to include

many functions such as manipulation of the cytoskeleton, cell signaling, membrane

trafficking, adhesion, and integration into host tissue. The pathogens of interest are

the pathogenic fungus, Candida albicans, and the parasite, Giardia lamblia and we

investigate the consequences of drug treatments on the cell surface, leading to

promising new targets.

Hormonal Reactivity To Social Contexts In Caregivers And Healthy Adults, Shalmali Mirajkar, Janelle Beadle

Posters and Presentations: College of Medicine Students

Providing care to older adults with chronic conditions can be emotionally meaningful and stressful. The tend-and-befriend theory highlights the role of affiliation/empathy in stress reduction, but it has not been established whether this theory extends to caregivers for older adults. Addressing this gap, we assessed caregiver empathy and stress through behavioral, hormone, and neuroimaging measures. In Experiment 1, we compared 19 caregivers (Mage=67.1) to 24 non-caregivers (Mage=72.6), and found that caregivers with a greater reduction in cortisol to an empathic context showed greater prosocial behavior (r2=0.3). In experiment 2 (N=32), we examined differences between caregivers and non-caregivers in whole brain …

Comparing The Use And Survival Outcome Of Stereotactic Radiosurgery And Stereotactic Radiation Therapy, Garrett Ostdiek-Wille, Saber A. Amin

Posters: 2020 Summer Undergraduate Research Program

Brain metastases are common in many types of cancer. Treatment for this condition is usually through surgical resection, whole brain radiation treatment (WBRT), stereotactic radiosurgery (SRS), or stereotactic radiation therapy (SRT). SRS (15 to 24 Gy in 1 fraction) and SRT (21, 24 or 30 Gy in 3 fractions or 25, 30 Gy in 5 fractions) have similar biological equivalent doses but differ in the number of treatments the radiation is delivered over. The objective of this study is to use national cancer database (NCDB) to examine the factors associated with receiving SRS as compared to SRT, and to compare …

How Does The Effect Of Hurricane Katrina Influence Healthcare Infrastructure And Resilience?, Sean Y. Wei

University Honors Theses

In August 2005, Hurricane Katrina brought upon the city of New Orleans, LA one of the costliest natural disasters in U.S. history. This paper looks at how hospitals were prepared before Katrina, responded to, and grappled with the aftermath of this natural disaster. In the aftermath of Katrina, careful investigation of the healthcare system along with its hospitals, physicians, patients, and residents allow us to take innovative measures and provide guidance to create recommendations to better monitor and care for individuals in the future. Frameworks of resilience theories, studies, and recommendations display how and why disaster planning is essential. The …

Prioritizing The Largest, Oldest Corals For Disease Intervention In A Coral Disease-Ravaged Area: Southeast Florida Coral Reef Ecosystem Conservation Area, Alysha Brunelle

All HCAS Student Capstones, Theses, and Dissertations

Coral diseases appear to be more devastating than ever before. When a virulent disease ravages a coral ecosystem, it can significantly change the population’s demographics and cause local extinctions. Disease intervention response during such an event is impossible at a landscape scale, therefore priorities must be considered. Saving the largest, oldest colonies of reef-building species is a good choice due to their high fecundity and ecological function. Their size, as a proxy for age, is an indicator of their resistance to previous perturbations which may indicate higher fitness. Their size also provides habitat to many organisms and wave resistance in …

Synchronization Of Mothers And Offspring Promotes Tolerance And Limits Allergy, Kathryn A Knoop, Keely G Mcdonald, Paige E Coughlin, Devesha H Kulkarni, Jenny K Gustafsson, Brigida Rusconi, Vini John, I Malick Ndao, Avraham Beigelman, Misty Good, Barbara B Warner, Charles O Elson, Chyi-Song Hsieh, Simon P Hogan, Phillip I Tarr, Rodney D Newberry

Open Access Publications

Allergic disorders, characterized by Th2 immune responses to environmental substances, are increasingly common in children in Western societies. Multiple studies indicate that breastfeeding, early complementary introduction of food allergens, and antibiotic avoidance in the first year of life reduces allergic outcomes in at-risk children. Why the benefit of these practices is restricted to early life is largely unknown. We identified a preweaning interval during which dietary antigens are assimilated by the colonic immune system. This interval is under maternal control via temporal changes in breast milk, coincides with an influx of naive T cells into the colon, and is followed …