Digital Commons Network^™

The Grimpen Mire Vs. Minefield: An Analysis Of Setting And Nature In Sherlock's "The Hounds Of Baskerville" In Relation To Conan Doyle's The Hound Of The Baskervilles, Rosa Canales

Articulāte

Winner of the 2019-2020 Robert T. Wilson Award for Scholarly Writing

Chemistry Majors Set Sights On Graduate School, Sarah Moss

The Voice

No abstract provided.

Perspectives In A Pandemic, Kevin M. Cahill M.D.

International Affairs

Perspectives in a Pandemic is a series of enlightening essays written by Kevin M. Cahill, M.D., providing a unique insight into the early phase of the COVID-19 pandemic. Dr. Cahill draws on his extensive experiences in earlier epidemics, natural disasters, and armed conflicts to offer lessons, wisdom, guidance, and support to frontline workers. While he wrote the essays as weekly reflections in the early months of the pandemic for the thousands of humanitarian-relief workers he has trained around the world, this book is a must-read for anyone seeking to understand and make some sense of the complexities and chaos inevitable …

September 8, 2020, University Of Mississippi. Faculty Senate

Meeting Minutes

Minutes for the September 2020 meeting of the University of Mississippi Faculty Senate.

Covid-19 Newsletter (Vol. 36), Center For Disaster Medicine, New York Medical College

COVID-19 Newsletter

No abstract provided.

Taylor Alumna Awarded Medical Physics Teacher Of The Year, Taylor University

2020 Website News Stories

No abstract provided.

The Utah Statesman, September 8, 2020, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

Genome-Wide Analyses Reveal Drivers Of Penguin Diversification, Juliana A. Vianna, Flávia A.N. Fernandes, María José Frugone, Henrique V. Figueiró, Luis R. Pertierra, Daly Noll, Ke Bi, Cynthia Y. Wang-Claypool, Andrew Lowther, Patricia Parker, Celine Le Bohec, Francesco Bonadonna, Barbara Wienecke, Pierre Pistorius, Antje Steinfurth, Christopher P. Burridge, Gisele P.M. Dantas, Elie Poulin, W. Brian Simison, Jim Henderson, Eduardo Eizirik, Mariana F. Nery, Rauri C.K. Bowie

Biology Department Faculty Works

Penguins are the only extant family of flightless diving birds. They currently comprise at least 18 species, distributed from polar to tropical environments in the Southern Hemisphere. The history of their diversification and adaptation to these diverse environments remains controversial. We used 22 new genomes from 18 penguin species to reconstruct the order, timing, and location of their diversification, to track changes in their thermal niches through time, and to test for associated adaptation across the genome. Our results indicate that the penguin crown-group originated during the Miocene in New Zealand and Australia, not in Antarctica as previously thought, and …

A Novel Bioaugmentation Technique Effectively Increases The Skin-Associated Microbial Diversity Of Captive Eastern Hellbenders, Erin K. Kenison, Obed Hernandez-Gomez, Rod N. Williams

Natural Sciences and Mathematics | Faculty Scholarship

Captive environments are maintained in hygienic ways that lack free-flowing microbes found in animals’ natural environments. As a result, captive animals often have depauperate host-associated microbial communities compared to conspecifics in the wild and may have increased disease susceptibility and reduced immune function. Eastern hellbenders (Cryptobranchus alleganiensis alleganiensis) have suffered precipitous population declines over the past few decades. To bolster populations, eastern hellbenders are reared in captivity before being translocated to the wild. However, the absence of natural microbial reservoirs within the captive environment diminishes the diversity of skin-associated bacteria on hellbender skin and may negatively influence their ability to …

Acute And Chronic Dosing Of A High-Affinity Rat/Mouse Chimeric Transferrin Receptor Antibody In Mice, Demi M. Castellanos, Jiahong Sun, Joshua Yang, Weijun Ou, Alexander C. Zambon, William M. Pardridge, Rachita K. Sumbria

Pharmacy Faculty Articles and Research

Non-invasive brain delivery of neurotherapeutics is challenging due to the blood-brain barrier. The revived interest in transferrin receptor antibodies (TfRMAbs) as brain drug-delivery vectors has revealed the effect of dosing regimen, valency, and affinity on brain uptake, TfR expression, and Fc-effector function side effects. These studies have primarily used monovalent TfRMAbs with a human constant region following acute intravenous dosing in mice. The effects of a high-affinity bivalent TfRMAb with a murine constant region, without a fusion partner, following extravascular dosing in mice are, however, not well characterized. Here we elucidate the plasma pharmacokinetics and safety of a high-affinity bivalent …

A Blubber Gene Expression Index For Evaluating Stress In Marine Mammals, Laura Pujade Busqueta, Daniel E. Crocker, Cory D. Champagne, Molly C. Mccormley, Jared S. Deyarmin, Dorian S. Houser, Jane I. Khudyakov

Pacific Faculty Work

Evaluating the impacts of anthropogenic disturbance on free-ranging marine mammal populations, many of which are in decline, requires robust diagnostic markers of physiological stress and health. However, circulating levels of canonical 'stress hormones' such as glucocorticoids, which are commonly used to evaluate animal health, do not capture the complexity of species-specific responses and cannot be easily measured in large, fully aquatic marine mammals. Alternatively, expression of stress-responsive genes in hormone target tissues such as blubber, the specialized subcutaneous adipose tissue that can be manually or remotely sampled from many marine mammals, may be a more informative and sensitive indicator of …

Two C-Terminal Sequence Variations Determine Differential Neurotoxicity Between Human And Mouse Α-Synuclein, Natalie Landeck, Katherine E. Strathearn, Daniel Ysselstein, Kerstin Buck, Sayan Dutta, Siddhartha Banerjee, Zhengjian Lv, John D. Hulleman, Jagadish Hindupur, Li-Kai Lin, Sonal Padalkar, Lia A. Stanciu, Yuri L. Lyubchenko, Deniz Kirik, Jean-Christophe Rochet

Journal Articles: Pharmaceutical Sciences

BACKGROUND: α-Synuclein (aSyn) aggregation is thought to play a central role in neurodegenerative disorders termed synucleinopathies, including Parkinson's disease (PD). Mouse aSyn contains a threonine residue at position 53 that mimics the human familial PD substitution A53T, yet in contrast to A53T patients, mice show no evidence of aSyn neuropathology even after aging. Here, we studied the neurotoxicity of human A53T, mouse aSyn, and various human-mouse chimeras in cellular and in vivo models, as well as their biochemical properties relevant to aSyn pathobiology.

METHODS: Primary midbrain cultures transduced with aSyn-encoding adenoviruses were analyzed immunocytochemically to determine relative dopaminergic neuron viability. …

Development And Implementation Of A Coarse-Grained Markov State Model, Brian Chen

Theses and Dissertations

Markov State Models (MSMs) are constructed from Molecular Dynamics (MD) simulation data, high-resolution spatial and temporal information stored in the form of trajectories, of biological processes, such as ligand-receptor bonding, as a model to understand detailed kinetic information. Traditional MSM implementations involve a clustering step that clusters the MD trajectories into thousands of experimentally unverifiable clusters known as "microstates" before lumping them together into "macrostates". This work details a novel software implementation, using a combination of R, Python, and Tcl, that I have created for the purpose of creating a coarse-grained MSM that directly clusters the MD trajectories into a …

Method Of Stem Cell Delivery Into The Brain During Chronic Disease Using Blood Brain Barrier Permeabilizers, Cesario Venturina Borlongan, Paul R. Sanberg

USF Patents

Blood brain barrier (BBB) permeabilizers, such as mannitol, can facilitate the entry of stem cells from the periphery to the stroke brain. It is unknown whether BBB permeation in the chronic stage of the disease still facilitates the entry of stem cells from the periphery to the injured brain. Evidence herein shows BBB permeation in the chronic stage of stroke assisted in the entry of stem cells from the periphery to the stroke brain. Stroke models treated with human umbilical cord stem cells (hUCBC) only (2 million viable cells), mannitol or a combination. Results revealed that hUCBC alone or combined …

Ammonia Removal In Freshwater And Saltwater Systems, Norma A. Alcantar, Wen Zhao, Sarina Joy Ergas

USF Patents

An ammonia adsorption product is described which may be used for fresh caught fish and bait. The product may comprise functionalized tectosilicate compound and a buffer. High concentrations of ammonia produced by fish waste can be lethal, even though oxygen availability is rich enough to keep fish breathing. The product is a user-friendly, sustainable, affordable product which is able to extend the life of the fish by safely removing ammonia by an ion-exchange mechanism. This product can convert toxic ammonia into ammonium and uptake ammonium by releasing sodium ions in the water.

Preparation And Characterization Of Methylene Blue Nanoparticles For Alzheimer's Disease And Other Tauopathies, Umesh Kumar Jinwal, Vijaykumar Bhadabhai Sutariya

USF Patents

A delivery system of coated and uncoated nanoparticles (NP) for delivery of methylene blue (MB). The delivery system was developed using PLGA-based polymer that was repeatedly shown to be biocompatible and biodegradable. The parameters of synthesized NPs were within the suitable range for BBB permeation—specifically, the NPs were monodispersed, with slight negative charge, and with the size within 100-150 nm range suitable for intravenous delivery and delivery to the brain. The coating on the nanoparticle did not have a significant impact on the nanoparticle size and zeta potential. Based on the immunoblotting experiments using AD cellular model, the GSH coated …

Climatic Influence On The Growth Pattern Of Panthasaurus Maleriensis From The Late Triassic Of India Deduced From Paleohistology, Elżbieta M. Teschner, Sanjukta Chakravorti, Dhurjati P. Sengupta, Dorota Konietzko-Meier

Journal Articles

Metoposaurids are representatives of the extinct amphibian clade Temnospondyli, found on almost every continent exclusively in the Late Triassic deposits. Osteohistologically, it is one of the best-known temnospondyl groups, analyzed with a wide spectrum of methods, such as morphology, morphometry, bone histology or computed modelling. The least known member of Metoposauridae is Panthasaurus maleriensis from the Pranhita-Godavari basin in Central India, being geographically the most southern record of this family. For the first time the bone histology of this taxon was studied with a focus on the intraspecific variability of the histological framework and the relationship between the observed growth …

Synthesis Of New Pyrazole & Thiazole Derivatives As Antimicrobial And Anticancer Agents, Ibrahim Saleh Alkhaibari

Student Theses and Dissertations

This thesis contains two chapters. In chapter one, we are reporting an efficient synthesis of eighty new pyrazole derivatives: sixty 4-trifluoromethyl and 3,5 bis(trifluoromethyl)phenyl substituted pyrazole-derived anilines, and twenty 4-trifluoromethyl-phenyl substituted pyrazole-derived hydrazones. Some of the pyrazole derivatives have been tested against several bacterial strains and have shown promising results. In Chapter two, we are reporting a synthesis of novel fused-thiazole- nootkatone derivatives. These compounds have been tested as well against a broad spectrum of Gram-positive and Gram-negative bacteria. However, they have just shown activity against some of the Gram-positive bacteria. Further anti-cancer and toxicity studies of these compounds are …

Fertility Awareness And Parenting Intentions Among Mexican Undergraduate And Graduate University Students, J. M. Place, Brennan D. Peterson, B. Horton, M. Sanchez

Marriage and Family Therapy Faculty Articles and Research

An online, cross-sectional survey was carried out between November 2017 and January 2018 to assess fertility awareness among students attending the National Autonomous University of Mexico (UNAM) in Mexico City. A total of 371 students participated in the survey (n = 228 females, 143 males). 75% of females and 74% of males believed a woman’s fertility begins to decline markedly after age 40. Over 75% of all participants overestimated the probability of couples having a live birth after undergoing one cycle of IVF. With regard to parenting intentions, only 48% of females wished to have children compared to 59% …

Β-Catenin And Associated Proteins Regulate Lineage Differentiation In Ground State Mouse Embryonic Stem Cells., Fang Tao, Jelly Soffers, Deqing Hu, Shiyuan Chen, Xin Gao, Ying Zhang, Chongbei Zhao, Sarah E. Smith, Jay R. Unruh, Da Zhang, Dai Tsuchiya, Aparna Venkatraman, Meng Zhao, Zhenrui Li, Pengxu Qian, Tari Parmely, Xi C. He, Michael Washburn, Laurence Florens, John M. Perry, Julia Zeitlinger, Jerry Workman, Linheng Li

Manuscripts, Articles, Book Chapters and Other Papers

Mouse embryonic stem cells (ESCs) cultured in defined medium resemble the pre-implantation epiblast in the ground state, with full developmental capacity including the germline. β-Catenin is required to maintain ground state pluripotency in mouse ESCs, but its exact role is controversial. Here, we reveal a Tcf3-independent role of β-catenin in restraining germline and somatic lineage differentiation genes. We show that β-catenin binds target genes with E2F6 and forms a complex with E2F6 and HMGA2 or E2F6 and HP1γ. Our data indicate that these complexes help β-catenin restrain and fine-tune germ cell and neural developmental potential. Overall, our data reveal a …

The Current - Volume 31 Issue 5, Nova Southeastern University

Student Newspapers

No abstract provided.

Modification Of Irisin Level In Overweight/Obese Women During Pregnancy And Its Association With Some Metabolic Risk Factors, Mohammad Ahmad Hamza, Yassar Yahya Al Tamer, Omar Abdulmajeed Al Habib

Baghdad Science Journal

Irisin is a novel myokine and adipokine, its role during pregnancy and its association with some metabolic risk factors especially pre-pregnancy body mass index (pre-BMI) need more evaluation. The aim of the study is to find whether the pre-BMI could predict irisin levels during normal pregnancy and to clarify associations of irisin with some pathological parameters. Irisin levels were estimated by ELISA in sera of 59 normal pregnant women who enrolled from December 2016 to May 2017 at Maternity Hospital, Zakho city, Kurdistan region (Iraq). Thirty-two normal-weight pregnant (pre-BMI≤24.9 kg/m2, Age=24.03 mean±3.7standard deviation) and 27 overweight/obese-pregnant (pre-BMI>25 kg/m2, Age=27.6 …

Using Constructed Soils For Green Infrastructure – Challenges And Limitations, Maha Deeb, Peter M. Groffman, Manuel Blouin, Sara Perl Egendorf, Alan Vergnes, Viacheslav Vasenev, Donna L. Cao, Daniel Walsh, Tatiana Morin, Geoffroy Séré

Advanced Science Research Center

With the rise in urban population comes a demand for solutions to offset environmental problems caused by urbanization. Green infrastructure (GI) refers to engineered features that provide multiecological functions in urban spaces. Soils are a fundamental component of GI, playing key roles in supporting plant growth, infiltration, and biological activities that contribute to the maintenance of air and water quality. However, urban soils are often physically, chemically, or biologically unsuitable for use in GI features. Constructed Technosols (CTs), consisting of mixtures of organic and mineral waste, are man-made soils designed to meet specific requirements and have great potential for use …

Fat Mass And Obesity Association Gene Polymorphism In Pcos Iraqi Women, Qais Ahmed Ibraheem, Luma Hasan Alwan Al Obaidy, Gulboy Abdolmageed Nasir, Manal Taha Meteab Al-Obaidi

Baghdad Science Journal

Polycystic syndrome (PCOS) is a considerable infertility disorder in adolescents and adult women in reproductive age. Obesity is a vigorous risk factor related to POCS. This study aims to evaluate the association of obesity and PCOS by investigating several parameters including: anthropological, biochemical (lipid profile, fasting blood sugar, glucose tolerance test, and hormone levels (LH, FSH, LH/FSH ratio, Estradiol2 and Testosterone),and genetic parameters (Fat mass and Obesity associated gene (FTO) polymorphism at rs17817449) in 63 obese and non-obese PCOS women. The biochemical tests were investigated by colorimetric methods while FTO gene polymorphism was detected by PCR–RFLP. Lipid profile, FBS, GTT, …

A Comparison Between Two Shape Parameters Estimators For (Burr-Xii) Distribution, Shurooq Ahmed Kareem

Baghdad Science Journal

This paper deals with defining Burr-XII, and how to obtain its p.d.f., and CDF, since this distribution is one of failure distribution which is compound distribution from two failure models which are Gamma model and weibull model. Some equipment may have many important parts and the probability distributions representing which may be of different types, so found that Burr by its different compound formulas is the best model to be studied, and estimated its parameter to compute the mean time to failure rate. Here Burr-XII rather than other models is consider because it is used to model a wide variety …

Evaluation Of Different Nitrogen Management On Yield And Some Of The Yield Components Of Rice (Shiroudi Cultivar), Elham Modiri, Davood Barari Tari, Ebrahim Amiri, Yousof Nicknejad, Hormoz Fallah

Baghdad Science Journal

Nitrogen (N) is a key growth and yield-limiting factor in cultivated rice areas. This study has been conducted to evaluate the effects of different conditions of N application on rice yield and yield components (Shiroudi cultivar) in Babol (Mazandaran, Iran) during the 2015- 2016 season. A factorial experiment executed of a Randomized Complete Block Design (RCBD) used in three iterations. In the first factor, treatments were four N amounts (including 50, 90, 130, and 170 kg N ha-1), while in the second factor, the treatments consisted of four different fertilizer splitting methods, including T1:70 % at the basal stage + …

Measurement Of Human Walking Movements By Using A Mobile Health App: Motion Sensor Data Analysis, Sungchul Lee, Ryan M. Walker, Yoohwan Kim, Hyunhwa Lee

Computer Science Faculty Research

Background: This study presents a new approach to measure and analyze the walking balance of humans by collecting motion sensor data in a smartphone. Objective: We aimed to develop a mobile health (mHealth) app that can measure the walking movements of human individuals and analyze the differences in the walking movements of different individuals based on their health conditions. A smartphone's motion sensors were used to measure the walking movements and analyze the rotation matrix data by calculating the variation of each xyz rotation, which shows the variables in walking-related movement data over time. Methods: Data were collected from 3 …

Perinatal Palliative Care Birth Planning As Advance Care Planning., Donnamaria E. Cortezzo, Kelstan Ellis, Amy Schlegel

Manuscripts, Articles, Book Chapters and Other Papers

Purpose of Review: A significant number of pregnancies are complicated by a fetus with a life-limiting diagnosis. As diagnoses are made earlier in the pregnancy, families experience anticipatory grief and are faced with navigating goals of care for a baby that has yet to be born. With the support of the care team, families can begin to grieve, plan, and make meaningful memories during the duration of the pregnancy, the birth of their baby, and life of the child. Creating a palliative care birth plan, which expands beyond the traditional concept for delivery planning to include prenatal, perinatal, and neonatal …

A Survey Of Public Datasets For Computer Vision Tasks In Precision Agriculture, Yuzhen Lu, Sierra N. Young

Civil and Environmental Engineering Faculty Publications

Computer vision technologies have attracted significant interest in precision agriculture in recent years. At the core of robotics and artificial intelligence, computer vision enables various tasks from planting to harvesting in the crop production cycle to be performed automatically and efficiently. However, the scarcity of public image datasets remains a crucial bottleneck for fast prototyping and evaluation of computer vision and machine learning algorithms for the targeted tasks. Since 2015, a number of image datasets have been established and made publicly available to alleviate this bottleneck. Despite this progress, a dedicated survey on these datasets is still lacking. To fill …

Capitalizing On Healthy Lawyers: The Business Case For Law Firms To Promote And Prioritize Lawyer Well-Being, Jarrod F. Reich

Villanova Law Review (1956 - )

No abstract provided.