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Repurposing Anti-Inflammasome Nrtis For Improving Insulin Sensitivity And Reducing Type 2 Diabetes Development, Jayakrishna Ambati, Joseph Magagnoli, Hannah Leung, Shao-Bin Wang, Chris A. Andrews, Dongxu Fu, Akshat Pandey, Srabani Sahu, Siddharth Narendran, Shuichiro Hirahara, Shinichi Fukuda, Jian Sun, Lekha Pandya, Meenakshi Ambati, Felipe Pereira, Akhil Varshney, Tammy Cummings, James W. Hardin, Babatunde Edun, Charles L. Bennett, Kameshwari Ambati, Benjamin J. Fowler, Nagaraj Kerur, Christian Röver, Norbert Leitinger, Brian C. Werner, Joshua D. Stein, S. Scott Sutton, Bradley D. Gelfand

Ophthalmology and Visual Science Faculty Publications

Innate immune signaling through the NLRP3 inflammasome is activated by multiple diabetes-related stressors, but whether targeting the inflammasome is beneficial for diabetes is still unclear. Nucleoside reverse-transcriptase inhibitors (NRTI), drugs approved to treat HIV-1 and hepatitis B infections, also block inflammasome activation. Here, we show, by analyzing five health insurance databases, that the adjusted risk of incident diabetes is 33% lower in patients with NRTI exposure among 128,861 patients with HIV-1 or hepatitis B (adjusted hazard ratio for NRTI exposure, 0.673; 95% confidence interval, 0.638 to 0.710; P < 0.0001; 95% prediction interval, 0.618 to 0.734). Meanwhile, an NRTI, lamivudine, improves insulin sensitivity and reduces inflammasome activation in diabetic and insulin resistance-induced human cells, as well as in mice fed with high-fat chow; mechanistically, inflammasome-activating short interspersed nuclear element (SINE) transcripts are elevated, whereas SINE-catabolizing DICER1 is reduced, in diabetic cells and mice. These data suggest the possibility of repurposing an approved class of drugs for prevention of diabetes.

Problem To Product: Shielding Providers From Covid-19 Particles, Matt Windsor

Browse All News

No abstract provided.

Real-Time Time-Dependent Electronic Structure Theory, Xiaosong Li, Niranjan Govind, Christine Isborn, A. Eugene Deprince, Kenneth Lopata

Faculty Publications

Copyright © 2020 American Chemical Society. Real-time electronic structure methods provide an unprecedented view of electron dynamics and ultrafast spectroscopy on the atto- and femtosecond time scale with vast potential to yield new insights into the electronic behavior of molecules and materials. In this Review, we discuss the fundamental theory underlying various real-time electronic structure methods as well as advantages and disadvantages of each. We give an overview of the numerical techniques that are widely used for real-time propagation of the quantum electron dynamics with an emphasis on Gaussian basis set methods. We also showcase many of the chemical applications …

Daily Eastern News: September 23, 2020, Eastern Illinois University

September

No abstract provided.

Low Aflatoxin Levels In Aspergillus Flavus-Resistant Maize Are Correlated With Increased Corn Earworm Damage And Enhanced Seed Fumonisin, Subbaiah Chalivendra, Fangneng Huang, Mark Busman, W. Paul Williams, Jong Hyun Ham

Faculty Publications

Preharvest mycotoxin contamination of field-grown crops is influenced not only by the host genotype, but also by inoculum load, insect pressure and their confounding interactions with seasonal weather. In two different field trials, we observed a preference in the natural infestation of corn earworm (CEW; Helicoverpa zea Boddie) to specific maize (Zea mays L.) genotypes and investigated this observation. The field trials involved four maize lines with contrasting levels of resistance to Aspergillus flavus. The resistant lines had 7 to 14-fold greater infested ears than the susceptible lines. Seed aflatoxin B1 (AF) levels, in mock- and A. flavus-inoculated ears were …

Population, Development, And Policy, John Bongaarts, Michele Gragnolati, S. Amer Ahmed, Jamaica Corker

Poverty, Gender, and Youth

The extensive literature on population and development yielded few policy-relevant results before the discovery of the demographic dividend. This dividend refers to a rise in per capita income that results from an increase in workers per capita as a population’s fertility declines. This paper describes the role of the demographic dividend in economic development in developing countries and summarizes policy options for strengthening the dividend. The first section reviews the demographic transition with an emphasis on its later phases when declining fertility and a changing population age structure produce the dividend. Next, the demographic drivers of the dividend and its …

The Antelope, University Of Nebraska At Kearney

The Antelope

No abstract provided.

Effects Of Neuronic Shutter Observed In The Eeg Alpha Rhythm, Kevin E. Alexander, Justin R. Estepp, Sherif M. Elbasiouny

Neuroscience, Cell Biology & Physiology Faculty Publications

The posterior alpha (α) rhythm, seen in human electroencephalogram (EEG), is posited to originate from cycling inhibitory/excitatory states of visual relay cells in the thalamus. These cycling states are thought to lead to oscillating visual sensitivity levels termed the “neuronic shutter effect.” If true, perceptual performance should be predictable by observed α phase (of cycling inhibitory/excitatory states) relative to the timeline of afferentiation onto the visual cortex. Here, we tested this hypothesis by presenting contrast changes at near perceptual threshold intensity through closed eyelids to 20 participants (balanced for gender) during times of spontaneous α oscillations. To more accurately and …

The Role Of Nerves In Skeletal Development, Adaptation, And Aging., Ryan E Tomlinson, Blaine A Christiansen, Adrienne A Giannone, Damian C Genetos

Department of Orthopaedic Surgery Faculty Papers

The skeleton is well-innervated, but only recently have the functions of this complex network in bone started to become known. Although our knowledge of skeletal sensory and sympathetic innervation is incomplete, including the specific locations and subtypes of nerves in bone, we are now able to reconcile early studies utilizing denervation models with recent work dissecting the molecular signaling between bone and nerve. In total, sensory innervation functions in bone much as it does elsewhere in the body-to sense and respond to stimuli, including mechanical loading. Similarly, sympathetic nerves regulate autonomic functions related to bone, including homeostatic remodeling and vascular …

Expression Of Mir-720 Is Correlated With Dnmt3 In Oral Squamous Cell Carcinomas, Andrew Graves, Sukhdeep Sandhu, Karl Kingsley

Dental Medicine Faculty Research

Background: Many factors are involved with cellular differentiation and pluripotency, such as long non-coding and microRNAs (miRNA). miR-720 has been demonstrated to affect development, differentiation and pluripotency in dental pulp stem cells but has also been linked to many cancers (renal, prostate, skin, colorectal, breast, cervical and esophageal) through shared pathways including DNA methyltransferase family members (DNMT)3a and DNMT3b, which are highly upregulated in many oral cancers. However, little is known about the expression (or function, if expressed) of miR-720 in oral cancers. Based upon this lack of information, the primary objective of this project was to evaluate the expression …

Venturing Into Vaping, Kathryn Albritton

University of Mississippi News

Budding UM researcher pulls back the curtain on e-cigarettes

Being Twin Sisters At Um Is 'Twice As Nice', Edwin B. Smith

University of Mississippi News

Transfer students Jada and Jazmin King awarded multiple scholarships

Functional, Proteomic And Bioinformatic Analyses Of Nrf2- And Keap1- Null Skeletal Muscle, Lie Gao, Vikas Kumar, Neetha Nanoth Vellichirammal, Song-Young Park, Tara L. Rudebush, Li Yu, Won-Mok Son, Elizabeth J. Pekas, Ahmed M. Wafi, Juan Hong, Peng Xiao, Chittibabu Guda, Han-Jun Wang, Harold D. Scultz, Irving H. Zucker

Health and Kinesiology Faculty Publications

Key points

• Nrf2 is a master regulator of endogenous cellular defences, governing the expression of more than 200 cytoprotective proteins, including a panel of antioxidant enzymes.
• Nrf2 plays an important role in redox haemostasis of skeletal muscle in response to the increased generation of reactive oxygen species during contraction.
• Employing skeletal muscle-specific transgenic mouse models with unbiased-omic approaches, we uncovered new target proteins, downstream pathways and molecular networks of Nrf2 in skeletal muscle following Nrf2 or Keap1 deletion.
• Based on the findings, we proposed a two-way model to understand Nrf2 function: a tonic effect through a Keap1-independent mechanism under basal …

Targeted Engagement Of The Action Selection Network During Task-Oriented Arm Training After Stroke, Jill Campbell Stewart Pt,Phd, Kaci Handlery, Jessica F. Baird, Erika L. Blanck, Geetanjali Pathak, Stacy L. Fritz

Faculty Publications

Action selection (AS), or selection of an action from a set of alternatives, is an important movement preparation process that engages a frontal-parietal network. The addition of AS demands to arm training after stroke could be used to engage this motor planning process and the neural network that supports it. The purpose of this case series is to describe the feasibility and outcomes associated with task-oriented arm training aimed at engaging the AS behavioral process and the related neural network in three individuals with chronic stroke. Three participants with mild to moderate motor deficits completed 13 to 15 sessions of …

Midweek Memo, Georgia Southern University

Midweek Memo

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Germs 101, Jody Record

UNH Today Archive

No abstract provided.

Transposable Element Control Disrupted By Meiotic Drive In A Stalk-Eyed Fly Genome, Josephine A. Reinhardt

Biology

Some stalk-eyed flies in the genus Teleopsis carry selfish genetic elements that induce sex ratio (SR) meiotic drive and impact the fitness of male and female carriers. Here, we produce a chromosome-level genome assembly of the stalk-eyed fly, T. dalmanni, to elucidate the pattern of genomic divergence associated with the presence of drive elements. We find evidence for multiple nested inversions along the sex ratio haplotype and widespread differentiation and divergence between the inversion types along the entire X chromosome. In addition, the genome contains tens of thousands of transposable element (TE) insertions and hundreds of transcriptionally active TE …

Organic Field-Effect Transistors As Flexible, Tissue-Equivalent Radiation Dosimeters In Medical Applications, Andrew M. Zeidell, Tong Ren, David S. Filston, Hamna F. Iqbal, Emma Holland, J. Daniel Bourland, John E. Anthony, Oana D. Jurchescu

Chemistry Faculty Publications

Radiation therapy is one of the most prevalent procedures for cancer treatment, but the risks of malignancies induced by peripheral beam in healthy tissues surrounding the target is high. Therefore, being able to accurately measure the exposure dose is a critical aspect of patient care. Here a radiation detector based on an organic field‐effect transistor (RAD‐OFET) is introduced, an in vivo dosimeter that can be placed directly on a patient's skin to validate in real time the dose being delivered and ensure that for nearby regions an acceptable level of low dose is being received. This device reduces the errors …

Child (Un)Awareness Of Parental Incarceration As A Risk Factor: Evidence From South Korea, Youngki Woo, Melissa A. Kowalski

Criminal Justice Faculty Publications

A large body of research has been devoted to the relationship between parental incarceration and adverse outcomes for children, but such studies often compare children of incarcerated parents to those whose parents have never been imprisoned. Research is lacking regarding the effects of parental incarceration on children aware of their parent’s imprisonment compared to those who are unaware of their parent’s incarceration. In the current study we use propensity score weighting with a sample of 219 incarcerated Korean parents to examine differences in developmental outcomes between children cognizant of their parent’s incarceration and those who are unaware of parental imprisonment. …

Setting The Standard: Multidisciplinary Hallmarks For Structural, Equitable And Tracked Antibiotic Policy, Claas Kirchhelle, Paul Atkinson, Alex Broom, Komatra Chuengsatiansup, Jorge Pinto Ferreira, Nicolas Fortané, Isabel Frost, Christoph Gradmann, Stephen Hinchliffe, Steven J. Hoffman, Javier Lezaun, Susan Nayiga, Scott H. Podolsky, Kevin Outterson, Stephanie Raymond, Adam P. Roberts, Andrew C. Singer, Anthony D. So, Luechai Sringernyuang, Elizabeth Tayler, Susan Rogers Van Katwyk, Clare I. R. Chandler

Faculty Scholarship

There is increasing concern globally about the enormity of the threats posed by antimicrobial resistance (AMR) to human, animal, plant and environmental health. A proliferation of international, national and institutional reports on the problems posed by AMR and the need for antibiotic stewardship have galvanised attention on the global stage. However, the AMR community increasingly laments a lack of action, often identified as an ‘implementation gap’. At a policy level, the design of internationally salient solutions that are able to address AMR’s interconnected biological and social (historical, political, economic and cultural) dimensions is not straightforward. This multidisciplinary paper responds by …

Hepatic Lipocalin 2 Promotes Liver Fibrosis And Portal Hypertension, Jiegen Chen, Josepmaria Argemi, Gemma Odena, Ming-Jiang Xu, Yan Cai, Veronica Massey, Austin Parrish, Rajanikanth Vadigepalli, Jose Altamirano, Joaquin Cabezas, Pere Gines, Juan Caballeria, Natasha Snider, Pau Sancho-Bru, Shizuo Akira, Ivan Rusyn, Bin Gao, Ramon Bataller

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Advanced fibrosis and portal hypertension influence short-term mortality. Lipocalin 2 (LCN2) regulates infection response and increases in liver injury. We explored the role of intrahepatic LCN2 in human alcoholic hepatitis (AH) with advanced fibrosis and portal hypertension and in experimental mouse fibrosis. We found hepatic LCN2 expression and serum LCN2 level markedly increased and correlated with disease severity and portal hypertension in patients with AH. In control human livers, LCN2 expressed exclusively in mononuclear cells, while its expression was markedly induced in AH livers, not only in mononuclear cells but also notably in hepatocytes. Lcn2−/− mice were protected from liver …

Montana Kaimin, September 23, 2020, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

Ring Nmr Dynamics: Software For Analysis Of Multiple Nmr Relaxation Experiments, Martha A. Beckwith, Teddy Erazo-Colon, Bruce A. Johnson

Advanced Science Research Center

Molecular motions are fundamental to the existence of life, and NMR spectroscopy remains one of the most useful and powerful methods to measure their rates and molecular characteristics. Multiple experimental methods are available for measuring the NMR relaxation properties and these can require different methods for extracting model parameters. We present here a new software application, RING NMR Dynamics, that is designed to support analysis of multiple relaxation types. The initial release of RING NMR Dynamics supports the analysis of exponential decay experiments such as T₁ and T₂, as well as CEST and R₂ and R …

Evaluation Of Hardness And Wear Of Surface Treated Zirconia On Enamel Wear. An In-Vitro Study, Mostafa Aboushahba, Hesham Katamish, Mona Elagroudy

Future Dental Journal

Objective: The present study aimed to examine the effect of aged and polished surface treated full anatomical zirconia and veneered zirconia on wear of opposing natural human enamel surface, and investigate the surface hardness of different zirconia. Methods: Two types of zirconia blocks were used in this study (Incoris ZI and Incoris TZI), Stainless Steel dies with dimensions of maxillary molars were used, duplicated using addition silicon impression material to form twenty four epoxy dies, then dies were scanned by the OmniCam. Software designing of crowns and copings was performed, then milling of the presintered blocks was done followed by …

Comparative Evaluation Of Fracture Resistance Of Primary Anterior Teeth Restored With Long Dentine Posts And Teeth Restored With Short Fiber Posts: An In Vitro Study, Reham E.L. Ghazawy, Amira Badran

Future Dental Journal

Background: Badly broken primary teeth that require pulp therapy present a high-risk of biomechanical failure due to the loss of tooth substance resulting from pre-existing decay and endodontic therapy itself. The introduction of Biological dentine posts offered an excellent alternative for restoring such teeth. The ideal post material should have physical and mechanical properties that are similar to those of dentine. Accordingly there is no such material other than dentine itself. Another concern in restoring endodontically treated primary teeth is the need to find a material that can resorb in a similar way to natural tooth structure as a part …

Rantes Comparison In Patients With Periodontal Disease - A Prospective Clinical Study, Ena Sharma, Anuj Sharma, Manjari Nadela

Future Dental Journal

No abstract provided.

Stress Distribution Of Maxillary First Molar Pdl With Highpull Headgear Traction; A Finite Element Analysis, Shirin Shahnaseri, Mohammad Farahani, Majid Ghasemianpour Bavandi, Shervin Bagherieh, Seyed Amir Mousavi

Future Dental Journal

Statement of the problem: Headgear is most commonly used to correct anteroposterior discrepancies. Headgear can also be used to make more space for teeth to come in. In this instance the headgear is attached to the molars, via molar headgear bands and tubes, and helps to draw these molars backwards in the mouth, opening up space for the front teeth to be moved back using braces and bands. Stress on PDL of molars teeth and soreness of teeth when chewing, or when the teeth touch, is typical. Adults usually feel the soreness 12e24 h later, but younger patients tend to …

Effect Of Incorporating Undoped Or Silver-Doped Photocatalytic Titanium Dioxide On The Antifungal Effect And Dynamic Viscoelastic Properties Of Long-Term Acrylic Denture Liners, Gihan H. Waly

Future Dental Journal

Objectives: The current study aimed to investigate the effect of incorporating undoped or silver-doped titanium dioxide nanoparticles (TiO2-NPs and Ag-doped TiO2-NPs) on the antifungal activity and dynamic viscoelastic properties of soft acrylic denture liners. Materials and methods: One soft acrylic liner material was used (COE-SOFT, GC America, USA). Triphasic TiO2-NPs were purchased from Nanotech, Egypt. Half the amount of the TiO2-NPs was doped with silver (z100 ppm). The efficiency of the doping process was validated by FTRI analysis. Ultraviolet-visible spectrophotometer was used to measure the absorption range of both powders (TiO2-NPs and Agdoped TiO2-NPs). For the antifungal activity test, eight …

Comparative Study Of The Possible Effect Of Bovine And Some Plantbased Milk On Cola-Induced Enamel Erosion On Extracted Human Mandibular First Premolar (Scanning Electron Microscope And X-Ray Microanalysis Evaluation), Nehad M. Abd-Elmonsif

Future Dental Journal

Increased consumption of acidic soft drinks is becoming an important factor in the development of erosive wear. The potential of dairy drinks to protect enamel against dental erosion has been recorded. Recently, the demand for plant based milk beverages has been gaining popularity and used as an alternative to cow's milk. Aim: reveal and compare the possible effects of bovine and three types of plant-based milk on enamel erosion caused by Coca-Cola®. Material and method: 42 extracted premolars were distributed over three groups: Control negative group where teeth were not subjected to any treatment, Control positive group where teeth were …

Identification Of Stiffness Variations In Supporting Substances Of A Human Canine Tooth With A Bracket-Beam-Piezoelectric Sensor And Its Electromechanical Impedance, Hector A. Tinoco

Future Dental Journal

In this paper, an experimental method is described to identify the stiffness variations produced by drillings done in different supporting substances of a human canine tooth. To measure the supporting substances parameters through of a canine, a sensor-actuator systemwas developed. The sensor-actuator device was composed of a stainless steel bracket bonded to a steel wire attached to two piezoelectric transducers, with a concentrated mass attached to the end of the wire. To excite the device, high frequency voltage (between 5 and 10 KHz) was applied through the piezo-transducers, which affects the tooth by means of the vibration of the wire. …