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2020 Fall Vol. 37 No. 2, Alumni Affairs School Of Medicine

Medicinews

No abstract provided.

Growth Mindset Messaging In Stigma-Relevant Contexts: Harnessing Benefits Without Costs, Crystal L. Hoyt, Jeni L. Burnette

Jepson School of Leadership Studies articles, book chapters and other publications

Growth mindsets are increasingly used to promote learning, development, and health. The increased popularity resulted in scrutiny and disputes about utility. The current work reviews a perspective critical to the debate. Namely, we focus on emerging research that examines both the favorable and potentially adverse consequences of growth mindset messaging in stigma-relevant contexts. This double-edged sword model merges the mindset perspective with attribution theory and the psychological essentialism literature. In stigmatizing contexts and in isolation, growth mindsets can indirectly predict less positive outcomes, via personal responsibility for the problem, but more positive outcomes, via expectations for the potential to manage …

Tiktok’S Non-Inclusive Beauty Algorithm & Why We Should Care, Priya Melonio

IPHS 200: Programming Humanity

This project will be a meta-analysis of how the popular social media app known as TikTok takes into account image recognition in their machine learning algorithms through the data it analyzes from its users. It will also see how it identifies and pushes the most beautiful to fame and virality. Though we don’t have access to the actual Tiktok algorithm, we are going to use a very similar dataset known as SCUT-FBP5500. We will analyze how it perpetuates toxic western and eastern beauty standards that are only based on far too simple analyses of what is considered beautiful. We will …

Affective Brain Patterns As Multivariate Neural Correlates Of Cardiovascular Disease Risk, Peter J. Gianaros, Thomas E. Kraynak, Dora C.-H. Kuan, James J. Gross, Kateri Mcrae, Ahmad R. Hariri, Stephen B. Manuck, Javier Rasero, Timothy D. Verstynen

Psychology: Faculty Scholarship

This study tested whether brain activity patterns evoked by affective stimuli relate to individual differences in an indicator of pre-clinical atherosclerosis: carotid artery intima-media thickness (CA-IMT). Adults (aged 30–54 years) completed functional magnetic resonance imaging (fMRI) tasks that involved viewing three sets of affective stimuli. Two sets included facial expressions of emotion, and one set included neutral and unpleasant images from the International Affective Picture System (IAPS). Cross-validated, multivariate and machine learning models showed that individual differences in CA-IMT were partially predicted by brain activity patterns evoked by unpleasant IAPS images, even after accounting for age, sex and known cardiovascular …

Illinois Wesleyan Lands Bee Campus Usa Certification, Rachel Mccarthy

News and Events (Discontinued Series)

No abstract provided.

“Something There Is That Doesn’T Love A Wall:” A Reflection On The Constitutional Vulnerabilities Of The Southwest Border Wall, Hope M. Babcock

Georgetown Law Faculty Publications and Other Works

No abstract provided.

Pharmacologic Ire1/Xbp1s Activation Confers Targeted Er Proteostasis Reprogramming, J. M. D. Grandjean, A. Madhavan, L. Cech, B. O. Seguinot, R. J. Paxman, E. Smith, L. Scampavia, E. T. Powers, Christina B. Cooley, L. Plate, T. P. Spicer, J. W. Kelly, R. L. Wiseman

Chemistry Faculty Research

Activation of the IRE1/XBP1s signaling arm of the unfolded protein response (UPR) is a promising strategy to correct defects in endoplasmic reticulum (ER) proteostasis implicated in diverse diseases. However, no pharmacologic activators of this pathway identified to date are suitable for ER proteostasis remodeling through selective activation of IRE1/XBP1s signaling. Here, we use high-throughput screening to identify non-toxic compounds that induce ER proteostasis remodeling through IRE1/XBP1s activation. We employ transcriptional profiling to stringently confirm that our prioritized compounds selectively activate IRE1/XBP1s signaling without activating other cellular stress-responsive signaling pathways. Furthermore, we demonstrate that our compounds improve ER proteostasis of destabilized …

The State Of Altmetrics: A Tenth Anniversary Celebration, Kathy Christian, Euan Adie, Gemma Derrick, Fereshteh Didegah, Paul Groth, Cameron Neylon, Jason Priem, Shenmeng Xu, Zohreh Zahedi, Yin-Leng Theng, Saeed-Ul Hassan, Naif R. Aljohani, Timothy D. Bowen, Vanesh M. Patel, Robin Haunschild, Lutz Bornmann, Mike Taylor, Liesa Ross, Stacy Konkiel

Copyright, Fair Use, Scholarly Communication, etc.

Altmetric’s mission is to help others understand the influence of research online.We collate what people are saying about published research in sources such as the mainstream media, policy documents, social networks, blogs, and other scholarly and non-scholarly forums to provide a more robust picture of the influence and reach of scholarly work. Altmetric works with some of the biggest publishers, funders, businesses and institutions around the world to deliver this data in an accessible and reliable format.

Contents

Altmetrics, Ten Years Later, Euan Adie (Altmetric (founder) & Overton)

Reflections on Altmetrics, Gemma Derrick (University of Lancaster), Fereshteh Didegah (Karolinska Institutet …

Genetic Duties, Jessica L. Roberts, Alexandra L. Foulkes

William & Mary Law Review

Most of our genetic information does not change, yet the results of our genetic tests might. Labs reclassify genetic variants in response to advances in genetic science. As a result, a person who took a test in 2010 could take the same test with the same lab in 2020 and get a different result. However, no legal duty requires labs or physicians to inform patients when a lab reclassifies a variant, even if the reclassification communicates clinically actionable information. This Article considers the need for such duties and their potential challenges. In so doing, it offers much-needed guidance to physicians …

Improving Data For Decision-Making: A Toolkit For Cervical Cancer Prevention And Control Programmes, Elkanah Omenge, Edwin Were, Oliver Rode, Kapten Muthoka, Michael Byczkowski, Heike Sartor, Davy Vanden Broeck, Dietmar Schmidt, Miriam Reuschenbach, Magnus Von Knebel Doeberitz

Obstetrics and Gynaecology, East Africa

Background: Screening of unvaccinated women remains essential to mitigate the high morbidity/mortality of cervical cancer. Here, we compared visual inspection with acetic acid (VIA), recommended by WHO as the most cost-effective screening approach in LMICs, with HPV-based screening, and usage of p16INK4a/Ki-67 dual stain cytology.

Methods: We prospectively enrolled women participating in a VIA-based cervical cancer screening program in two peri-urban health centers of Kenya. Consenting women had a VIA examination preceded by collection of a liquid-based cytology sample from the cervix stored in PreservCyt medium (Hologic®). Analysis of all samples included a hrHPV DNA test and evaluation of a …

Role Of Fine Needle Aspiration Cytology In The Diagnosis Of Parotid Gland Tumors: Analysis Of 193 Cases, Rahim Dhanani, Haissan Iftikhar, Mohammad Sohail Awan, Nida Zahid, Sehrish Nizar Ali Momin

Section of Otolaryngology, Head & Neck Surgery

Introduction: Parotid gland tumors include a wide variety of inflammatory and neoplastic diseases. The majority of these tumors are benign (80%), which usually require superficial parotidectomy, while the incidence of malignant tumors is lower (20%), requiring more radical surgery with or without neck dissection. The diagnosis cannot be established on the basis of clinical history and simple physical examination and requires complementary diagnostic methods. Fine needle aspiration cytology (FNAC) guided by ultrasound is a widely used diagnostic tool to evaluate parotid swellings.
Objective: To determine the sensitivity, specificity, positive and negative predictive values and diagnostic accuracy of FNAC in the …

Many Miles Away: A Cautionary Tale, Charles H. Smith

Faculty/Staff Personal Papers

Reporter Kerry Phillips is in for the surprise of her life: her television station has been contacted on a matter so important that 'scarcely anything could be of greater interest,' and she has been asked to follow up on the story. Little does she know just how interesting her job is about to get!

Church-Based Research: Challenges And Opportunities, David R. Dunaetz

Great Commission Research Journal

Because the church is the body of Christ, research focused on the Great Commission and Jesus’ concern for evangelism and disciple-making needs to be church-based. The goal of such research is to better share God’s love to a world who does not know him by building up a collection of knowledge that will enable us to do so. This research may be both theological (focusing on what the Bible and other theologians have said) and scientific (focusing on collecting new data and interpreting it, especially in light of theology). Church-based scientific research may be either qualitative (exploring broad ideas and …

When Prosecutors Politick: Progressive Law Enforcers Then And Now, Bruce Green, Rebecca Roiphe

Articles & Chapters

A new and recognizable group of reform-minded prosecutors has assumed the mantle of progressive prosecution. The term is hard to define in part because its adherents embrace a diverse set of policies and priorities. In comparing the contemporary movement with Progressive Era prosecutors, this Article has two related goals. First, it seeks to better define progressive prosecution. Second, it uses the historical example to draw some lessons for the current movement. Both groups of prosecutors were elected on a wave of popular support. Unlike today’s mainstream prosecutors who tend to campaign and labor in relative obscurity, these two sets of …

Is Heaven A Zoopolis?, A. G. Holdier

Faith and Philosophy: Journal of the Society of Christian Philosophers

No abstract provided.

Two And Three-Dimensional Radiographic Imaging Of Contrast Agents In Heterogeneous Live Cell Media To Understand Contrast-Induced Toxicity, Fahaneda Hassan, Aldona Gjoni, Subhendra Sarkar

Publications and Research

Radiographic imaging was done using low and high energy radiography equipment. The test hypothesis that macromolecular aggregation changes sample noise in imaging samples for optical imaging methods. Inorganic complexes scatter radiation at the molecular level and may increase the sample noise locally. At high and low photon energies in various x-ray machines, sample and background noise were gathered and compared with those from mammography systems from mammography researchers. The samples with high macromolecular aggregates were prepared using various animal cell compositions and imaged under different conditions that produced different macromolecular dynamics within the samples and thus different image-based sample noise. …

Deep Sea Isopods From The Western Mediterranean: Distribution And Habitat, Joan E. Cartes, Diego F. Figueroa

School of Earth, Environmental, & Marine Sciences Faculty Publications

Isopods are a highly diversified group of deep-sea fauna, with a wide variety of shapes which must reflect a similar great variety of adaptations to the deep environments. The deep Mediterranean, however, has a low diversity of isopods related to its oligotrophy, the thermal stability of deep-water masses (∼12.8 °C below 150 - 200 m) and rather homogeneous geomorphology. The main factor defining isopod habitats in the Balearic Basin is insularity vs mainland influence. Desmosomatidae and Ischnomesidae, examples of epibenthic species (with lack of paddle-shaped legs and non/low-natatory capacity) are mainly linked to mainland areas with higher % organic matter …

The Limits Of Medical X-Pertise: Gender Markers In A Pandemic, Heron Greenesmith, Andy Izenson

Faculty Scholarship

The world changed drastically in 2020. The pandemic has far reaching consequences, and so too do the current civil rights movements and the struggle for gender justice and liberation. This Article seeks to describe a moment in time, a moment of doubt of how one 's gender and race will predict one 's ability to survive the pandemic-not simply COVID-19, but the pandemic writ-large and all the wrenches it has thrown into the health-care machine. How do those of us standing at the edge of a gender revolution navigate these waters? Will our health be the price we pay for …

A Molecular Understanding Of Alphavirus Entry, Autumn C. Holmes, Katherine Basore, Daved H. Fremont, Michael S. Diamond

Open Access Publications

Alphaviruses cause severe human illnesses including persistent arthritis and fatal encephalitis. As alphavirus entry into target cells is the first step in infection, intensive research efforts have focused on elucidating aspects of this pathway, including attachment, internalization, and fusion. Herein, we review recent developments in the molecular understanding of alphavirus entry both in vitro and in vivo and how these advances might enable the design of therapeutics targeting this critical step in the alphavirus life cycle.

Spontaneous Restoration Of Functional Β-Cell Mass In Obese Sm/J Mice, Mario A Miranda, Caryn Carson, Celine L St Pierre, Juan F Macias-Velasco, Jing W Hughes, Marcus Kunzmann, Heather Schmidt, Jessica P Wayhart, Heather A Lawson

Open Access Publications

Maintenance of functional β-cell mass is critical to preventing diabetes, but the physiological mechanisms that cause β-cell populations to thrive or fail in the context of obesity are unknown. High fat-fed SM/J mice spontaneously transition from hyperglycemic-obese to normoglycemic-obese with age, providing a unique opportunity to study β-cell adaptation. Here, we characterize insulin homeostasis, islet morphology, and β-cell function during SM/J's diabetic remission. As they resolve hyperglycemia, obese SM/J mice dramatically increase circulating and pancreatic insulin levels while improving insulin sensitivity. Immunostaining of pancreatic sections reveals that obese SM/J mice selectively increase β-cell mass but not α-cell mass. Obese SM/J …

Optimal Parameter Values For Accurate And Repeatable Nanoindentation Of Human Trabecular Bone, Stephen Matthew Kmak

Master's Theses

Nanoindentation techniques have not been standardized for use on bone tissues, making comparison of bone material properties obtained via nanoindentation across studies difficult and unreliable. This study determined a set of optimal parameter values for thermal drift correction time, dwell time, and loading rate that can be used to obtain accurate and repeatable material properties from human femoral trabecular bone through experimentation and statistical analysis. All testing was conducted using a single nanoindenter on a single trabeculae, with the assumption that material properties within the individual trabeculae were internally consistent. Parameters not of interest during this study, such as ambient …

Key Stakeholders’ Lived Experiences While Implementing An Aligned Curriculum: A Phenomenological Study, Pedro P. Aguas

The Qualitative Report

Furthering innovation in English as a foreign language curriculum has been a concern for the Colombian educational system for many years. Nevertheless, the major attempts at the national level continue to fail. Through this phenomenological study of 12 participants at a an urban public school in grades 6-12 I attempted to answer the phenomenological question, “What were the lived experiences of key stakeholders involved in implementing an aligned curriculum at an urban public school in a northern city in Colombia, South America? “The theoretical framework that guides this study included innovation, the theory of policy attribution, and the learner-centered philosophy. …

Re-Evaluating The Strength Of Pit-Latrine Faecal Sludge From Dynamic Cone Penetrometer Test Data., Yasmine Shafiq, Stuart Haigh, Rochelle Holm, Alison Parker

Faculty and Staff Scholarship

In 2017, 55% of the global population were without safely managed sanitation services. On-site sanitation solutions, such as pit latrines, provide the majority of sanitation coverage across developing countries. Appropriate technologies are required in order to safely empty these latrines without damage to people or the environment. The design of appropriate emptying technologies can be hampered by a lack of knowledge of the mechanical properties of the waste, such as its strength. This paper will develop a calibration for a dynamic cone penetrometer to give accurate measurements of faecal sludge strength against a standard scale, rendering existing data comparable. It …

Distorted Drug Patents, Erika Lietzan

Faculty Publications

Drug patents are distorted. Unlike most other inventors, drug inventors must complete years of testing to the government’s specifications and seek government approval to commercialize their inventions. All the while, the patent term runs. When a drug inventor finally launches a medicine that embodies the invention, only a fraction of the patent life remains. And yet, conventional wisdom holds — and empirical studies show — that patent life is essential to innovation in the pharmaceutical industry, perhaps more so than any other inventive industry. Congress tried to do something about this in 1984, authorizing the Patent and Trademark Office to …

Late Miocene To Late Pliocene (Hemphillian To Blancan) Borophagine Canids (Mammalia: Carnivora) From Idaho, H. Gregory Mcdonald

Western North American Naturalist

While borophagine canids are known from numerous Tertiary faunas across North America, they have not been well documented from the Tertiary faunas of Idaho. Five species represented by 2 genera are now known from Idaho faunas ranging from the latest Clarendonian/earliest Hemphillian to the late Blancan. The earliest records of borophagines in Idaho are Epicyon haydeni from the early Hemphillian Star Valley fauna and Borophagus pugnator from the late Clarendonian/early Hemphillian Poison Creek Formation. Borophagus secundus is present in the late Hemphillian Chalk Hills Formation, and 2 species are present in the Blancan Glenns Ferry Formation: (1) B. hilli …

Trace Metals And The Environment: Studying The Behaviour Of Iceland’S Glacially Sourced Trace Metals, Owen Bailey

Independent Study Project (ISP) Collection

Trace metal contamination in marine ecosystems is a problem for every trophic level, from zooplankton up to humans. The mobility and uptake availability of these metals depend on such environmental parameters as salinity, temperature, and pH, among others. To explore the effects of varying parameters on dissolved metal behaviour, I studied the Jökulsárlón glacial lagoon, into which the Breidamerkurjökull glacier deposits trace metals from volcanic ash through glacial melt. In this study I develop and follow a sampling procedure to analyze trace metal concentrations in the lagoon, while additionally discussing the behaviour and impact of trace metals, focusing on cadmium, …

Impact Of Oer In Teacher Education, Denise Cummings-Clay

Publications and Research

The purpose of this research study, which employed a quantitative research design, was to determine if there was a difference in the grades achieved by students who were enrolled in an entry-level Foundations of Education course using Open Educational Resources (OER) versus the grades achieved by students who used textbooks in other course sections. The goal was to find out whether OER was of the same or higher quality as textbooks in our minority-serving higher education institution. The outcomes revealed that there was no significant difference in grades for course sections that used OER when compared to course sections that …

Lar Inhibitory Peptide Promotes Recovery Of Diaphragm Function And Multiple Forms Of Respiratory Neural Circuit Plasticity After Cervical Spinal Cord Injury., Lan Cheng, Armin Sami, Biswarup Ghosh, Mark W Urban, Nicolette M Heinsinger, Sophia S Liang, George M Smith, Megan C Wright, Shuxin Li, Angelo C Lepore

Farber Institute for Neuroscience Faculty Papers

Chondroitin sulfate proteoglycans (CSPGs), up-regulated in and around the lesion after traumatic spinal cord injury (SCI), are key extracellular matrix inhibitory molecules that limit axon growth and consequent recovery of function. CSPG-mediated inhibition occurs via interactions with axonal receptors, including leukocyte common antigen- related (LAR) phosphatase. We tested the effects of a novel LAR inhibitory peptide in rats after hemisection at cervical level 2, a SCI model in which bulbospinal inspiratory neural circuitry originating in the medullary rostral ventral respiratory group (rVRG) becomes disconnected from phrenic motor neuron (PhMN) targets in cervical spinal cord, resulting in persistent partial-to-complete diaphragm paralysis. …

Orthopedic Principles To Facilitate Enhanced Recovery After Cardiac Surgery, Marc W Gerdisch, Keith B Allen, Yoshifumi Naka, Mark R Bonnell, Kevin P Landolfo, John Grehan, Kendra J Grubb, David J Cohen, T. Sloane Guy, Nirav C Patel, Vinod H Thourani

Department of Surgery Faculty Papers

Enhanced recovery after surgery (ERAS) protocols recognize early postoperative mobilization as a driver of faster postoperative recovery, return to normal activities, and improved long-term patient outcomes. For patients undergoing open cardiac surgery, an opportunity for facilitating earlier mobilization and a return to normal activity lies in the use of improved techniques to stabilize the sternal osteotomy. By following the key orthopedic principles of approximation, compression, and rigid fixation, a more nuanced approach to sternal precaution protocols is possible, which may enable earlier patient mobilization, physical rehabilitation, and recovery.

Breast Carcinoma Metastasis In A Resected Meningioma With Early Diagnosis Of Oligometastatic Disease: A Case Report., Christian Fernandez, Louis Cappelli, Sara Chapin,, Lawrence Kenyon, Christopher J Farrell, Wenyin Shi

Department of Radiation Oncology Faculty Papers

Tumor-to-tumor metastasis describes the ability of primary tumors to metastasize to other primary tumors. These events generally occur in aggressive and widely-metastatic disease, with the appropriate management and significance of these events unknown. A 56-year-old woman with a history of bilateral, localized, invasive lobular breast carcinoma treated with surgery, systemic therapy, and adjuvant radiation presented five and two years post-treatment with progressive neurological symptoms. Imaging revealed an intracranial meningioma, and the patient underwent resection. Pathology revealed metastatic invasive lobular carcinoma cells within the resected meningioma, and the patient was treated with postoperative radiation without sequelae. Subsequent staging scans revealed a …