Digital Commons Network^™

The Effects Of E-Vapor On The Pathogenesis Of Rheumatoid Arthritis Mouse Models And Potential Implications For Future Generations, Christiana Daas

Selected Honors Theses

Rheumatoid arthritis is the most prevalent autoimmune disease. Rheumatoid arthritis (RA) has no cure, and the direct cause of the disease is still unknown. The two leading hypotheses concerning its etiology are based on the effects of HLA-DRB1 gene expression, and cigarette smoke. Conjunctively, the use of vaping devices amongst adolescents has increased significantly since introduced in 2007. There is no long-term data on the effects of e-vapor and its aerosols on bodily health. Cigarette smoke is the most noteworthy environmental factor contributing to RA therefore the question is raised as to whether or not vaping relates to rheumatoid arthritis …

Character Displacement In The Midst Of Substantial Background Evolution In Anolis Lizard Island Populations, Ambika Kamath, Nicholas C. Herrmann, Kiyoko M. Gotanda, Kum C. Shim, Jacob Lafond, Gannon Cottone, Heather Falkner, Todd S. Campbell, Yoel E. Stuart

Biology: Faculty Publications and Other Works

Negative interactions between species can generate divergent selection that causes character displacement. However, other processes cause similar divergence. We use spatial and temporal replication across island populations of Anolis lizards to assess the importance of negative interactions in driving trait shifts. Previous work showed that the establishment of Anolis sagrei on islands drove resident Anolis carolinensis to perch higher and evolve larger toepads. To further test the interaction's causality and predictability, we resurveyed a subset of islands nine years later. Anolis sagrei had established on one island between surveys. We found that A. carolinensis on this island now perch higher …

Law And Popular Culture: A Course Book (3rd Edition), Jessica Silbey, Michael Asimow

Books

This book is the reader for a course with the general theme of “Law and Popular Culture” or “Law and Film.” It is about the interface between two these two enormously important subjects. It is suitable for undergraduate and graduate classes or seminars in American studies, criminal justice, political science, film studies, or many other academic programs, as well as in law schools. The course can be taught by anyone interested in law as well as film and television and requires no specialized academic training. This is the third edition of the book which has a new co-author (Jessica M. …

At Three Years, Patients With Acute Lymphoblastic Leukaemia Are Still At Risk For Relapse. Results Of The International Mrc Ukallxii/Ecog E2993 Trial, Chezi Ganzel, Xin V. Wang, Jacob M. Rowe, Susan M. Richards, Georgina Buck, David I. Marks, Mark R. Litzow, Elisabeth M. Paietta, Letizia Foroni, Selina M. Luger, Cheryl L. Willman, Charles G. Mullighan, Kathryn G. Roberts, Peter H. Wiernik, Dan Douer, Hillard M. Lazarus, Martin S. Tallman, Anthony H. Goldstone

Pathology Research and Scholarship

Late relapse [>3 years from complete remission (CR)] in acute lymphoblastic leukaemia (ALL), is unusual. Data from the MRC UKALLXII/ECOG E2993 trial are presented to evaluate the incidence and characteristics of late relapse in adult ALL. Of 1,909 patients, 1,752 (92%) achieved CR and among these 757 (43·2%) relapsed; 691 (91·3%) within three years and 66 (8·7%) beyond. Among these 66 patients, median time to relapse was 47 (37-144) months. Relapse beyond three years occurred in 3·8% of all who achieved CR. The cumulative risk of relapse was 40%, 43% and 45% at three, five and ten years respectively. …

Issue 9, Fall 2020, University Libraries

University Libraries Employee Newsletters

Content:

Employee Spotlight: Carol Kennedy

Welcome to New Employees

• Holly Surbaugh
• Stephanie Moore
• Carol Kennedy

• Arianne Avery
• Olivia Baca
• Brett Nafziger
• Margie Montanez
• Bennett Poulin
• Laura Soito

Leading The Dispersed Church: A Case Study Of Connectivism In Piedmont Chapel, W. Ray Williams

Journal of Applied Christian Leadership

Connectivism is a learning theory first proposed by Siemens and Downes (2005, 2009) as a learning theory for the digital age. This theory proposes that learning may occur external to the learner and teacher; it exists in the multiple complex networks with which the learner associates. In 2020, Corbett and Spinello followed up on Siemen’s work to move connectivism from a learning theory to a leadership theory. Connectivism is a leadership theory that specifically works in modern churches. This theory emphasizes the connectedness of all knowledge and the mutuality of those connections, becoming a tool used to build better teams …

Tools, Techniques And Teamwork: Transferring New Technologies For Wildlife Management, Conservation And Economic Development, John Eisemann, Gail Keirn

United States Department of Agriculture Wildlife Services: Staff Publications

Did you ever wonder who invented radio telemetry? Or breakaway snares? What about the bird repellent methyl anthranilate or the livestock protection collar? These and many other tools used in wildlife damage management resulted from creative thinking by biologists, technicians, researchers and managers working to solve complex wildlife issues. Over the past 90 years, these “aha moments” within the U.S. Department of Agriculture’s Wildlife Services program have ranged from developing novel scare devices, traps and vaccines to exploiting an animal’s visual capabilities to stop unwanted behaviors. Once discovered, these unique ideas may lead to practical, feasible and cost-effective wildlife damage …

What Is Man, That You Are Mindful Of Him? The Harmony Of Substance Dualism And Mbti, Reilly Larose

Philosophy Student Projects

The substance dualist philosophy of mind and the Myers-Briggs Type Indicator share many philosophical commitments which harmonize together. I make the argument in this work that when taken together, both theories aid each other in making their claims meaningful. With such a union, both theories have new directions to explore for mutual gain and open themselves up to consistency of thought in the face of critique.

Circulation,Volume 26, No.1, Center For Coastal Physical Oceanography, Old Dominion University, Sönke Dangendorf

CCPO Circulation

Fall 2020 issue of CCPO Circulation featuring the article, "Understanding the Causes and Impact of Sea Level Rise," by Sönke Dangendorf.

Longwood Magazine 2020 Fall, Longwood University

Alumni Newsletters & Bulletins

No abstract provided.

Population Dynamics Of Waterfowl Wintering In The Mid-Atlantic Region, Usa, Abigail Harris, Thomas Hoke

Fall Showcase for Research and Creative Inquiry

A recent study (Rosenberg et al. 2019) has shown that bird populations in North America are experiencing major declines except for a few groups including waterfowl. However, this study focused only on the summer breeding populations and did not focus on regional dynamics. We utilized data from 62 Christmas Bird Count (CBC) count circles to evaluate population dynamics of common wintering waterfowl in the coastal Mid-Atlantic region (Delaware=7, Maryland=16, Virginia=18, North Carolina=21) since 1950. We found a 36% decline of wintering waterfowl relative abundance compared to 1950s. American wigeon and Canada goose had major population decreases while Snow goose had …

Adios Adjuvant: Combination Immunotherapy For Pediatric Acute Lymphoblastic Leukemia (All) Patients, Arleigh Wood

Fall Showcase for Research and Creative Inquiry

Cancer treatments are shifting from heavy adjuvant therapies to immunological approaches, such as carT cell therapy. By simultaneously administering two known successful treatments for ALL, Blinatumomab and Kymriah, a high rate of remission can be accomplished in pediatric patients with relapsed ALL. Higher rates of remission, prolonged immunity, and less side effects are the projected results based on previously published studies. Combining these two therapies will likely produce more successful results compared to if the drugs were administered independently. This will hopefully translate into a faster return to daily living activities and less chronic effects during such an important developmental …

Factors Contributing To The Decline Of Bees, Coleman Behne

Fall Showcase for Research and Creative Inquiry

Pesticides and parasites are the main causes for the decline in honey bees. This presentation focuses on four of the main factors contributing to bee decline and the stakeholders involved as well as potential solutions.

Do Adults With Bacterial Infections Develop Less Of An Antibiotic Resistance With Iv Antibiotics Than With Oral Antibiotics After A Full Course Of Treatment?, Navvy Stevens, Taylor-Erin Evitts

Fall Showcase for Research and Creative Inquiry

This study was conducted in order to discover if patients develop less of an antibiotic resistance when going through intravenous antibiotics, compared to using oral antibiotics. This concept was created due to the fact that many people that are prescribed oral antibiotics, do not finish the entire prescribed amount. When this occurs, it gives the bacteria that the antibiotics were trying to get rid of, have the chance to adapt and become resistant to the particular antibiotic. By discovering the percentage of people who were prescribed antibiotics that never finished a round of them, it aids in narrowing down what …

2020 Celebration Of Scholarship, Creativity, And Engagement, Todd Bruns, Beth Heldebrandt

Programs

The 2020-2021 academic year is truly extraordinary and higher education’s new, hopefully temporary, normal began on rather short notice in Spring 2020. While our environment has changed, we, as a shared community, are pleased that the important work of faculty continues and evolves as faculty broaden and redefine the boundaries of scholarship, creativity, and innovation in accelerating hybrid and remote environments. And, as new forms and strategies for scholarship and creativity emerge, the core principles of faculty life and student learning remain central to the mission of Eastern Illinois University.

For that reason, our faculty, department chairs, college deans, the …

Fy2021 Faculty Salaries $30-$50,000, Clemson University

Salary Reports

No abstract provided.

Joint Force Quarterly 99 (4th Quarter, October 2020), National Defense University Press

Joint Force Quarterly ARCHIVES

No abstract provided.

Uni Schedule Of Classes, Fall 2020, University Of Northern Iowa

UNI Schedule of Classes

A listing and schedule of the courses being taught as well as policies and procedures concerning attending classes at the University of Northern Iowa.

Cardinal Covid Journal, Calvin Eaton

Cardinal COVID Journal: Prose

No abstract provided.

Data Analytics Beyond Traditional Probabilistic Approach To Uncertainty, Vladik Kreinovich

Departmental Technical Reports (CS)

Data for processing mostly comes from measurements, and measurements are never absolutely accurate: there is always the "measurement error" -- the difference between the measurement result and the actual (unknown) value of the measured quantity. In many applications, it is important to find out how these measurement errors affect the accuracy of the result of data processing. Traditional data processing techniques implicitly assume that we know the probability distributions. In many practical situations, however, we only have partial information about these distributions. In some cases, all we know is the upper bound on the absolute value of the measurement error. …

Why Number Of Color Difference Works Better In Detecting Melanoma Than Number Of Colors: A Possible Fractal-Based Explanation, Julio Urenda, Olga Kosheleva, Vladik Kreinovich

Departmental Technical Reports (CS)

At present, the best way to detect melanoma based on an image of a skin spot is to count the number of different colors in this image. A recent paper has shown that the detection can improve if instead of the number of colors, we use the difference between numbers of colors computed by using different thresholds. In this paper, we provide a possible fractal-based explanation for this empirical fact.

College Of Natural Sciences Newsletter, October 2020, College Of Natural Sciences

College of Natural Sciences Newsletters and Reports

Volume 1. Issue 9

Content:

Dean’s Update P.1
Awards & Recognition P.2
Student Club Spotlight P.3
Open PRAIRIE | Research Overview P.4
Interest in Science | Updates P.5
Where’s Wil? P.6 Art
Competition Announcement P.7

Fall 2020 Gsbms Alumni Connections, New York Medical College

Graduate School of Biomedical Sciences

• Meet the Chair of the Board
• NYMC Receives $594K NIH Shared Instrumentation Grant
• Founder's Dinner Brings NYMC Community Together Virtually
• Six COVID-19 Symposiums Have Addressed "What Have We Learned? How Can We Use What We Have Learned?"
• $100,000 Gift from Henry Saphier, M.D. '61, Will Support Important COVID-19 Research
• NYMC Hosts Writing Workshop to Empower Students to Use Their Written Voice
• NYMC Unveils Free Community Food Pantry

Educational Policies Committee Agenda, October 1, 2020, Utah State University

Educational Policies Committee

Approval of 30 July 2020 and 3 September 2020 Minutes

Subcommittee Reports

• Curriculum Subcommittee
• Academic Standards Subcommittee
• General Education Subcommittee

Other Business

Distorted Drug Patents, Erika Lietzan, Kristina M.L. Acri Née Lybecker

Washington Law Review

Drug patents are distorted. Unlike most other inventors, drug inventors must complete years of testing to the government’s specifications and seek government approval to commercialize their inventions. All the while, the patent term runs. When a drug inventor finally launches a medicine that embodies the invention, only a fraction of the patent life remains. And yet, conventional wisdom holds—and empirical studies show—that patent life is essential to innovation in the pharmaceutical industry, perhaps more so than any other inventive industry. Congress tried to address this in 1984, authorizing the Patent and Trademark Office (PTO) to “restore” a portion of the …

The Dynamic Changes In Cytokine Responses In Covid-19: A Snapshot Of The Current State Of Knowledge, Maja Buszko, Jung Hyun Park, Daniela Verthelyi, Ranjan Sen, Howard A. Young, Amy S. Rosenberg

United States Public Health Resources

The role of cytokines in COVID-19” online symposium was presented on 18 June 2020 by the NIH/FDA Immunology and Cytokine Interest Groups and was purposed to discuss our rapidly changing understanding of COVID-19-related cytokine responses in different stages of infection, including the etiologies, downstream consequences and possible mitigation strategies.

The symposium was opened by Anthony Fauci, Director of the National Institute of Allergy and Infectious Diseases at the US National Institutes of Health (NIAID, NIH), and Janet Woodcock, Director of the Center of Drug Evaluation and Research, Food and Drug Administration (CDER, FDA) and currently leading the therapeutics component of …

Perforin-Deficient Car T Cells Recapitulate Late-Onset Inflammatory Toxicities Observed In Patients, Kazusa Ishii, Marie Pouzolles, Christopher D. Chien, Rebecca A. Erwin-Cohen, M. Eric Kohler, Haiying Qin, Haiyan Lei, Skyler Kuhn, Amanda K. Ombrello, Alina Dulau-Florea, Michael A. Eckhaus, Haneen Shalabi, Bonnie Yates, Daniel A. Lichtenstein, Valérie S. Zimmermann, Taisuke Kondo, Jack F. Shern, Howard A. Young, Naomi Taylor, Nirali N. Shah, Terry J. Fry

United States Public Health Resources

Late-onset inflammatory toxicities resembling hemophagocytic lymphohistiocytosis (HLH) or macrophage activation syndrome (MAS) occur after chimeric antigen receptor T cell (CAR T cell) infusion and represent a therapeutic challenge. Given the established link between perforin deficiency and primary HLH, we investigated the role of perforin in anti-CD19 CAR T cell efficacy and HLH-like toxicities in a syngeneic murine model. Perforin contributed to both CD8+ and CD4+ CAR T cell cytotoxicity but was not required for in vitro or in vivo leukemia clearance. Upon CAR-mediated in vitro activation, perforin-deficient CAR T cells produced higher amounts of proinflammatory cytokines compared with WT CAR …

Dynamics Of Genomic And Immune Responses During Primary Immunotherapy Resistance In Mismatch Repair–Deficient Tumors, Nobuyuki Takahashi, Vinodh N. Rajapakse, Lorinc Pongor, Suresh Kumar, Camille Tlemsani, Rebecca Erwin-Cohen, Howard A. Young, Stephen Hewitt, Jun S. Wei, Javed Khan, Alejandro V. Villarino, Jane B. Trepel, Anish Thomas

United States Public Health Resources

Mismatch repair–deficient (dMMR) cancers generate a substantial number of immunogenic neoantigens, rendering them sensitive to immunotherapy. Yet, there is considerable variability in responses, and roughly one-half of dMMR cancers are refractory to immunotherapy. Here we study a patient with dMMR lung cancer refractory to immunotherapy. The tumor exhibited typical dMMR molecular features, including exceptionally high frameshift insertions and deletions (indels). Despite the treatment inducing abundant intratumoral T-cell infiltrates, it failed to elicit tumor regression, pointing to the T cells lacking cytotoxic activity. A post-treatment tumor demonstrated compound heterozygous frameshift deletions located upstream of the kinase domain in the gene encoding …

Wooster Magazine: Fall 2020, Caitlin Paynich Stanowick

Wooster Magazine: 2011-2020

This fall 2020 issue of Wooster magazine acts as the President’s Annual Report showcasing how undeterred by challenges of pandemic, College of Wooster faculty and staff came together to ensure innovative learning experiences and a strong engaging community endured for students. In addition to the annual financial summary and giving report, the magazine features stories that reflect on the 2019-20 academic year including new learning opportunities for students and innovative academic experiences that open students’ eyes to new perspectives. Featured student stories included Dhwani Parsana ’21 who completed research for her Independent Study with Laura Sirot, associate professor of biology, …

Vol. 96, No. 1 | Fall 2020, Bridgewater College

Bridgewater Magazine

Learning in the Time of COVID