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2020

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Pharmacological Activities Of Psoralidin: A Comprehensive Review Of The Molecular Mechanisms Of Action, Javad Sharifi-Rad, Senem Kamiloglu, Balakyz Yeskaliyeva, Ahmet Beyatli Oct 2020

Pharmacological Activities Of Psoralidin: A Comprehensive Review Of The Molecular Mechanisms Of Action, Javad Sharifi-Rad, Senem Kamiloglu, Balakyz Yeskaliyeva, Ahmet Beyatli

Open Access archive

Analysis of the most relevant studies on the pharmacological properties and molecular mechanisms of psoralidin, a bioactive compound from the seeds of Cullen corylifolium (L.) Medik. confirmed its complex therapeutic potential. In the last years, the interest of the scientific community regarding psoralidin increased, especially after the discovery of its benefits in estrogen-related diseases and as a chemopreventive agent. Growing preclinical pieces of evidence indicate that psoralidin has anticancer, antiosteoporotic, anti-inflammatory, anti-vitiligo, antibacterial, antiviral, and antidepressant-like effects. Here, we provide a comprehensive and critical review of psoralidin on its bioavailability, pharmacological activities with focus on molecular mechanisms and cell signaling …

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Simvastatin Induces Unfolded Protein Response And Enhances Temozolomide-Induced Cell Death In Glioblastoma Cells., Sanaz Dastghaib, Shahla Shojaei, Zohreh Mostafavi-Pour, Pawan Sharma, John B Patterson, Afshin Samali, Pooneh Mokarram, Saeid Ghavami Oct 2020

Simvastatin Induces Unfolded Protein Response And Enhances Temozolomide-Induced Cell Death In Glioblastoma Cells., Sanaz Dastghaib, Shahla Shojaei, Zohreh Mostafavi-Pour, Pawan Sharma, John B Patterson, Afshin Samali, Pooneh Mokarram, Saeid Ghavami

Center for Translational Medicine Faculty Papers

Glioblastoma (GBM) is the most prevalent malignant primary brain tumor with a very poor survival rate. Temozolomide (TMZ) is the common chemotherapeutic agent used for GBM treatment. We recently demonstrated that simvastatin (Simva) increases TMZ-induced apoptosis via the inhibition of autophagic flux in GBM cells. Considering the role of the unfolded protein response (UPR) pathway in the regulation of autophagy, we investigated the involvement of UPR in Simva-TMZ-induced cell death by utilizing highly selective IRE1 RNase activity inhibitor MKC8866, PERK inhibitor GSK-2606414 (PERKi), and eIF2α inhibitor salubrinal. Simva-TMZ treatment decreased the viability of GBM cells and significantly increased apoptotic cell …

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Library And Information Services Of A.C. Joshi Library During Covid – 19 Pandemic: A Study Of Faculty Satisfaction, Harpreet Kaur, Preeti Mahajan Oct 2020

Library And Information Services Of A.C. Joshi Library During Covid – 19 Pandemic: A Study Of Faculty Satisfaction, Harpreet Kaur, Preeti Mahajan

Library Philosophy and Practice (e-journal)

The ongoing pandemic is a global challenge that has resulted in significant morbidity and mortality worldwide. It has severely affected the economy and social integrity of most of the nations. Everyone who has lived through this period of uncertainty has acknowledged the fact that these circumstances have changed the way of life of people across the globe. While there has been a rising concern about the severity of the health challenges faced by the general population, especially vulnerable is the situation of the elderly, the children, health professionals, and also academicians who are braving the mal-effects of this grave onslaught …

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Acute Systemic Inflammatory Response Alters Transcription Profile Of Genes Related To Immune Response And Ca 2+ Homeostasis In Hippocampus; Relevance To Neurodegenerative Disorders, Grzegorz A. Czapski, Yuhai Zhao, Walter J. Lukiw, Joanna B. Strosznajder Oct 2020

Acute Systemic Inflammatory Response Alters Transcription Profile Of Genes Related To Immune Response And Ca 2+ Homeostasis In Hippocampus; Relevance To Neurodegenerative Disorders, Grzegorz A. Czapski, Yuhai Zhao, Walter J. Lukiw, Joanna B. Strosznajder

School of Medicine Faculty Publications

Acute systemic inflammatory response (SIR) triggers an alteration in the transcription of brain genes related to neuroinflammation, oxidative stress and cells death. These changes are also characteristic for Alzheimer’s disease (AD) neuropathology. Our aim was to evaluate gene expression patterns in the mouse hippocampus (MH) by using microarray technology 12 and 96 h after SIR evoked by lipopolysaccharide (LPS). The results were compared with microarray analysis of human postmortem hippocampal AD tissues. It was found that 12 h after LPS administration the expression of 231 genes in MH was significantly altered (FC > 2.0); however, after 96 h only the S100a8 …

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Measurable Residual Disease-Guided Treatment To Prevent Relapse In Acute Myeloid Leukemia And Myelodysplastic Syndrome., Jonathan Pan, Daniel Altman, Lindsay Wilde Oct 2020

Measurable Residual Disease-Guided Treatment To Prevent Relapse In Acute Myeloid Leukemia And Myelodysplastic Syndrome., Jonathan Pan, Daniel Altman, Lindsay Wilde

Department of Medical Oncology Faculty Papers

No abstract provided.

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On The Importance Of Context: Examining The Applicability Of Infertility Insurance Mandates In The United States Using A Mixed-Methods Study Design, Nathanael B. Stanley Oct 2020

On The Importance Of Context: Examining The Applicability Of Infertility Insurance Mandates In The United States Using A Mixed-Methods Study Design, Nathanael B. Stanley

USF Tampa Graduate Theses and Dissertations

Accessibility of infertility services is disproportionately experienced in the United States. Although there exist state-based health insurance mandates for infertility services, these mandates contain language that disqualify people from using them. In order to better understand why these mandates are not able to reduce the financial burden and bridge the income disparity for using infertility services, the purpose of this study is to add context to the applicability of these insurance mandates through qualitative and quantitative inquiry. Using the Glass and McAtee model of risk regulators as an operational paradigm, this research explores the role of environmental context, or “place”, …

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Axonal Blockage With Microscopic Magnetic Stimulation, Hui Ye Oct 2020

Axonal Blockage With Microscopic Magnetic Stimulation, Hui Ye

Biology: Faculty Publications and Other Works

Numerous neurological dysfunctions are characterized by undesirable nerve activity. By providing reversible nerve blockage, electric stimulation with an implanted electrode holds promise in the treatment of these conditions. However, there are several limitations to its application, including poor bio-compatibility and decreased efficacy during chronic implantation. A magnetic coil of miniature size can mitigate some of these problems, by coating it with biocompatible material for chronic implantation. However, it is unknown if miniature coils could be effective in axonal blockage and, if so, what the underlying mechanisms are. Here we demonstrate that a submillimeter magnetic coil can reversibly block action potentials …

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Identifying Genetic Factors That Contribute To The Increased Risk Of Congenital Heart Defects In Infants With Down Syndrome., Cristina E. Trevino, Aaron M. Holleman, Holly Corbitt, Cheryl L. Maslen, Tracie C. Rosser, David J. Cutler, H Richard Johnston, Benjamin L. Rambo-Martin, Jai Oberoi, Kenneth J. Dooley, George T. Capone, Roger H. Reeves, Heather J. Cordell, Bernard D. Keavney, A J Agopian, Elizabeth Goldmuntz, Peter J. Gruber, James O'Brien, Douglas C. Bittel, Lalita Wadhwa, Clifford L. Cua, Jennifer G. Mulle, Michael P. Epstein, Stephanie L. Sherman, Michael E. Zwick Oct 2020

Identifying Genetic Factors That Contribute To The Increased Risk Of Congenital Heart Defects In Infants With Down Syndrome., Cristina E. Trevino, Aaron M. Holleman, Holly Corbitt, Cheryl L. Maslen, Tracie C. Rosser, David J. Cutler, H Richard Johnston, Benjamin L. Rambo-Martin, Jai Oberoi, Kenneth J. Dooley, George T. Capone, Roger H. Reeves, Heather J. Cordell, Bernard D. Keavney, A J Agopian, Elizabeth Goldmuntz, Peter J. Gruber, James O'Brien, Douglas C. Bittel, Lalita Wadhwa, Clifford L. Cua, Jennifer G. Mulle, Michael P. Epstein, Stephanie L. Sherman, Michael E. Zwick

Manuscripts, Articles, Book Chapters and Other Papers

Atrioventricular septal defects (AVSD) are a severe congenital heart defect present in individuals with Down syndrome (DS) at a > 2000-fold increased prevalence compared to the general population. This study aimed to identify risk-associated genes and pathways and to examine a potential polygenic contribution to AVSD in DS. We analyzed a total cohort of 702 individuals with DS with or without AVSD, with genomic data from whole exome sequencing, whole genome sequencing, and/or array-based imputation. We utilized sequence kernel association testing and polygenic risk score (PRS) methods to examine rare and common variants. Our findings suggest that the Notch pathway, particularly …

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Current State Of Sleep-Related Performance Optimization Interventions For The E-Sports Industry, Allison Joy Brager, Guido Simonelli Oct 2020

Current State Of Sleep-Related Performance Optimization Interventions For The E-Sports Industry, Allison Joy Brager, Guido Simonelli

Journal for Sports Neuroscience

Abstract: The e-sports industry is rapidly expanding but despite industry growth, there are existing gaps in knowledge regarding holistic and pharmacological performance enhancement strategies. The current commentary focuses on the current state of performance intervention strategies that target sleep/wake and circadian timing systems. These performance intervention strategies are based on the current state of sleep/wake health and research portfolios of Army research laboratories. The intent is to provide a foundation for future research efforts directly targeting sleep/wake and circadian timing systems in order to optimize and enhance e-sports performance at both the individual and group levels.

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Comparison Of Surgical Out Come Between Virgin Carpal Tunnel Syndrome And Previous Local Steroid Injected Tunnel, Ali Shahad Safi, Hussein Abdradi Alseady Oct 2020

Comparison Of Surgical Out Come Between Virgin Carpal Tunnel Syndrome And Previous Local Steroid Injected Tunnel, Ali Shahad Safi, Hussein Abdradi Alseady

Muthanna Medical Journal

Carpal tunnel syndrome(CTS) is the most commonly occurring peripheral nerve compression neuropathy and its condition characterized by an abnormality of the median nerve function due to compression of the nerve within the carpal tunnel. Surgical release of the transverse carpal ligament is an effective treatment for patients with CTS. Non-steroidal anti-inflammatory drugs, diuretics, vitamin B6 injection, ultrasound therapy, laser therapy, acupuncture, magnetic therapy, bracing and local steroid injections have been used for closed treatment of CTS and effective results in the short-term treatment have been demonstrated clearly only for bracing and local steroid injections. Aim: was to identify the effect …

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Geographic And Intra-Racial Disparities In Early-Onset Colorectal Cancer In The Seer 18 Registries Of The United States, Wesal H. Abualkhair, Meijiao Zhou, Carolina O. Ochoa, Leonel Lacayo, Caitlin Murphy, Xiao Cheng Wu, Jordan J. Karlitz Oct 2020

Geographic And Intra-Racial Disparities In Early-Onset Colorectal Cancer In The Seer 18 Registries Of The United States, Wesal H. Abualkhair, Meijiao Zhou, Carolina O. Ochoa, Leonel Lacayo, Caitlin Murphy, Xiao Cheng Wu, Jordan J. Karlitz

School of Medicine Faculty Publications

Background: Although early-onset colorectal cancer (EOCRC) incidence rates (IRs) are increasing, geographic and intra-racial IR disparities are not well defined. Methods: 2000-2015 Surveillance, Epidemiology, and End Results (SEER) program CRC IR Analysis (170,434 cases) was performed from ages 30 to 60 in four US regions, 18 individual registries, metropolitan and nonmetropolitan locations and stratified by race. Analyses were conducted in 1-year and 5-year age increments. Results: Wide US regional EOCRC IR variations exist: For example, age 45 IRs in the south are 26.8/100,000, 36.0% higher than the West, 19.7/100,000 (p < 0.0001). Disparities magnify between individual registries: EOCRC IRs in highest risk registries were 177-348% (Alaska Natives), 75-200% (Hawaii), 76-128% (Louisiana), and 61-125% (Kentucky) higher than lowest risk registries depending on age. EOCRC IRs are 18.2%-25.6% higher in nonmetropolitan versus metropolitan settings. Wide geographic intra-racial disparities exist. Within the White population, the greatest IR difference (78.8%) was between Kentucky (5.9/100,000) and Los Angeles (3.3/100,000) in 30- to 34-year-olds (p <.0001). Within the Black population, the greatest difference (136.2%) was between rural Georgia (30.7/100,000) and California excluding San Francisco-Oakland/San Jose-Monterey/Los Angeles (13/100,000) in 40- to 44-year-olds (p = 0003). Conclusion: Marked geographic EOCRC disparities exist with disproportionately high IRs in Alaska Natives, Hawaii, and southern registries. Geographic intra-racial disparities are present within White and Black populations. In Blacks, there are disproportionately high EOCRC IRs in rural Georgia. Although vigilance is required in all populations, attention must be paid to these higher risk populations. Potential interventions include assuring early investigation of symptoms, targeting modifiable risk factors and utilizing earlier age 45 screening options supported by some guidelines.

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Remote Sensing To Detect Deterioration Of Flooding Pampa Rangeland By The Use Of Glyphosate, E. J. Jacobo, A. Rodriguez, N. Heinrich, L. Fraschino Oct 2020

Remote Sensing To Detect Deterioration Of Flooding Pampa Rangeland By The Use Of Glyphosate, E. J. Jacobo, A. Rodriguez, N. Heinrich, L. Fraschino

IGC Proceedings (1977-2023)

No abstract provided.

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The Response Of Potentilla Acaulis Population Property To Desertification Grassland In Agro‐Pastoral Ecotone Of Northern China, J. Mi, J. Wang, L. Lin, Kun Wang Oct 2020

The Response Of Potentilla Acaulis Population Property To Desertification Grassland In Agro‐Pastoral Ecotone Of Northern China, J. Mi, J. Wang, L. Lin, Kun Wang

IGC Proceedings (1977-2023)

No abstract provided.

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Predicting Soil Erosion And Deposition Effects On Plant Establishment: A Key To Increasing Restoration Success, J. E. Herrick, D. P. C. Peters, Brandon T. Bestelmeyer, G. S. Okin, N. K. Hansen, Kris M. Havstad Oct 2020

Predicting Soil Erosion And Deposition Effects On Plant Establishment: A Key To Increasing Restoration Success, J. E. Herrick, D. P. C. Peters, Brandon T. Bestelmeyer, G. S. Okin, N. K. Hansen, Kris M. Havstad

IGC Proceedings (1977-2023)

No abstract provided.

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Study On Responses Of Leymus Chinensis Of Degraded Grasslands To Kinds Of Improved Measures, Dan He, Xianglin Li, Liqiang Wan, Feng He Oct 2020

Study On Responses Of Leymus Chinensis Of Degraded Grasslands To Kinds Of Improved Measures, Dan He, Xianglin Li, Liqiang Wan, Feng He

IGC Proceedings (1977-2023)

No abstract provided.

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Reasons Of The Deterioration Of Grassland Eco‐Environment In Inner Mongolia Pasturing Areas, Haishan Oct 2020

Reasons Of The Deterioration Of Grassland Eco‐Environment In Inner Mongolia Pasturing Areas, Haishan

IGC Proceedings (1977-2023)

No abstract provided.

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Use Of Remote Sensing Satellite Images To Predict Pasture Biomass On Waikato Dairy Farms, C. Deanne Waugh, David A. Clark, S. F. Petch, G. Mata, A. Edirisinghe, Z. Ward Oct 2020

Use Of Remote Sensing Satellite Images To Predict Pasture Biomass On Waikato Dairy Farms, C. Deanne Waugh, David A. Clark, S. F. Petch, G. Mata, A. Edirisinghe, Z. Ward

IGC Proceedings (1977-2023)

No abstract provided.

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Rangeland Sustainability Modeling Using Soil Exposure And Soil Moisture Parameters, J. Tibbitts, Keith T. Weber, J. Théau, Temuulen Tsagaan Sankey Oct 2020

Rangeland Sustainability Modeling Using Soil Exposure And Soil Moisture Parameters, J. Tibbitts, Keith T. Weber, J. Théau, Temuulen Tsagaan Sankey

IGC Proceedings (1977-2023)

No abstract provided.

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Effect Of Spatial Resolution On Remotely-Sensed Rangeland Vegetation Indices, J. Théau, Temuulen Tsagaan Sankey, Keith T. Weber, S. Ahmed, J. Tibbitts Oct 2020

Effect Of Spatial Resolution On Remotely-Sensed Rangeland Vegetation Indices, J. Théau, Temuulen Tsagaan Sankey, Keith T. Weber, S. Ahmed, J. Tibbitts

IGC Proceedings (1977-2023)

No abstract provided.

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Monitoring Grassland And Dynamics In Mongolia, Troy Sternberg Oct 2020

Monitoring Grassland And Dynamics In Mongolia, Troy Sternberg

IGC Proceedings (1977-2023)

No abstract provided.

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Monitoring Cattle Utilization And Behavior In A Mediterranean Oak Woodland, I. Schoenbaum, Zalmen Henkin, A. Brosh, J. Kigel, Eugene D. Ungar, Amit Dolev Oct 2020

Monitoring Cattle Utilization And Behavior In A Mediterranean Oak Woodland, I. Schoenbaum, Zalmen Henkin, A. Brosh, J. Kigel, Eugene D. Ungar, Amit Dolev

IGC Proceedings (1977-2023)

No abstract provided.

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The Impact Of Social Stigmas On Sexual Health Seeking Behavior: A Review Of Literature, Jason O. Talley Oct 2020

The Impact Of Social Stigmas On Sexual Health Seeking Behavior: A Review Of Literature, Jason O. Talley

McNair Scholars Research Journal

Studies show a meaningful association between STI/HIV-related stigmas and low adherence to routine STI testing (Morris et al., 2014; Hull et al., 2017). These studies also show that healthcare workers help to facilitate a culture of stigmas among coworkers and patients. According to a national survey, only 16.6% of women and 6.1% of men who participated in the survey had been tested in the last 12 months (Cuffe et al., 2016). Low rates of STI testing contribute to the spread of chlamydia, gonorrhea, HIV, and syphilis (Big-Ideas-HIV-STIs.pdf, n.d.). The motivation for this literature review is to examine how STI and …

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Impacts Of Variation In Food Availability On Spatial Habitat Use In Breeding And Non-Breeding Red Crossbills (Loxia Curvirostra), Liam C. Pendleton Oct 2020

Impacts Of Variation In Food Availability On Spatial Habitat Use In Breeding And Non-Breeding Red Crossbills (Loxia Curvirostra), Liam C. Pendleton

McNair Scholars Research Journal

Movement patterns, habitat use, and reproductive behavior are among many attributes impacted by the distribution of resources within habitats. Our study used radio telemetry to investigate the relationship between food availability and movement patterns of breeding and non-breeding red crossbills (Loxia curvirostra). Crossbills were captured and tracked in different seasons and under conifer seed mast and nonmast conditions. Telemetry data were used to generate statistical models to analyze spatial habitat use. Total linear distance traveled per total area of the home range was used as a comparative measure of activity within home ranges across specimens. We found a …

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A Review Of Late Twentieth-Century Findings On Adolescent Development In Low-Income Single-Parent Households, Shannon K. Hawkins Jr. Oct 2020

A Review Of Late Twentieth-Century Findings On Adolescent Development In Low-Income Single-Parent Households, Shannon K. Hawkins Jr.

McNair Scholars Research Journal

It is generally understood that healthy adolescent development is influenced by a variety of factors. Current research on the effects of family structure on adolescent development have largely grown from data collected in the late twentieth century showing that when children grew up in a two-parent household they experienced significant advantages. According to Amato (2005), these advantages included experiencing a higher standard of living, more effective parenting, more cooperative co-parenting, and closer emotional relationships with both parents. Those who grew up in two-parent households demonstrated superior academic performance (Amato et al., 2015; Amato 2005), suggesting that children from single-parent environments …

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Effect Of Stress On The Health Of African American Women In Low-Income Neighborhoods, Jada C. Childs Oct 2020

Effect Of Stress On The Health Of African American Women In Low-Income Neighborhoods, Jada C. Childs

McNair Scholars Research Journal

Health problems such as obesity are more prevalent in populations of African American women than any other population in the United States. Stress has been found to disproportionately affect the health of African American women when compared to European American women. Factors such as neighborhood environment, socioeconomic status, and familial relationships play a significant role in the stress experienced by these women. This project reviews the current literature on the relationship between various stressors and the health of African American women. The purpose of this research is to increase understanding of the unique stressors that African American women face and …

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Accessibility Of Health Information Provided By The Clinics In The Capricorn Region In The Limpopo Province, South Africa, Maoka Dikotla Dr, Lethabo Ledwaba Mr, Morongoenyane Ntsala Ms Oct 2020

Accessibility Of Health Information Provided By The Clinics In The Capricorn Region In The Limpopo Province, South Africa, Maoka Dikotla Dr, Lethabo Ledwaba Mr, Morongoenyane Ntsala Ms

Library Philosophy and Practice (e-journal)

Health information is a weapon that provides people with much-needed knowledge about self-care management, especially in the rural areas, where only clinics are the key players in the provision and dissemination of such information. The purpose of the study was to investigate the accessibility of health information provided by the clinics in the rural areas of the Capricorn region of the Limpopo Province in South Africa. The study employed the qualitative research method. Face-to-face semi-structured interviews were conducted with the community members who visited the clinics at the time of the data collection. The negative attitude displayed by the healthcare …

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Synthesis, In Vitro, And In Vivo Evaluation Of Novel N-Phenylindazolyl Diarylureas As Potential Anti-Cancer Agents., Lucas N Solano, Grady L Nelson, Conor T Ronayne, Shirisha Jonnalagadda, Sravan K Jonnalagadda, Kaija Kottke, Robert Chitren, Joseph L Johnson, Manoj K Pandey, Subash C. Jonnalagadda, Venkatram R Mereddy Oct 2020

Synthesis, In Vitro, And In Vivo Evaluation Of Novel N-Phenylindazolyl Diarylureas As Potential Anti-Cancer Agents., Lucas N Solano, Grady L Nelson, Conor T Ronayne, Shirisha Jonnalagadda, Sravan K Jonnalagadda, Kaija Kottke, Robert Chitren, Joseph L Johnson, Manoj K Pandey, Subash C. Jonnalagadda, Venkatram R Mereddy

College of Science & Mathematics Departmental Research

Novel N-phenylindazole based diarylureas have been designed, synthesized and evaluated as potential anticancer agents. In vitro cell viability studies of these derivatives illustrate good potency with IC50 values in the range of 0.4–50 μM in several cancer cell lines including murine metastatic breast cancer 4T1, murine glioblastoma GL261, human triple negative breast cancer MDA-MB-231, human pancreatic cancer MIAPaCa-2, and human colorectal cancer cell line WiDr. The ester group in the lead compound 8i was modified to incorporate amino-amides to increase solubility and stability while retaining biological activity. Further in vitro studies reveal that lead candidates inhibit tube length in HUVEC …

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Researchers Find Lead Contamination In Shotgun-Harvested Deer, Rachel Mccarthy Oct 2020

Researchers Find Lead Contamination In Shotgun-Harvested Deer, Rachel Mccarthy

News and Events (Discontinued Series)

No abstract provided.

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Sustainability By Reuse In The Field Of Interior Design And Furniture "Study Applied To The Polytechnic In Damietta", Abeer Swidan Oct 2020

Sustainability By Reuse In The Field Of Interior Design And Furniture "Study Applied To The Polytechnic In Damietta", Abeer Swidan

Mansoura Engineering Journal

Sustainability is the stability of the relationship in both subversive and other living systems, and there are three pillars of sustainability "social, environmental and economic sustainability" and there is ample scientific evidence that humanity is living unsustainably, and human use of natural resources to within sustainable biological systems require to remain diverse and productive over time and for human beings is the ability to long-term maintenance, which in turn depends on the responsible use of natural resources. The research seeks to clarify the importance of applied side of some modern environmental concepts in the field of Interior design and furniture …

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Nsf Provides Funds For Major New Research Instrument At University, Shea Stewart Oct 2020

Nsf Provides Funds For Major New Research Instrument At University, Shea Stewart

University of Mississippi News

New tool will help expand materials research, opportunities for Mississippi researchers

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