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Determination Of Intensity And Socio‐Economic Natural Resources Degradation Factors In Iran Territory, Nasser Ansari, S. J. Sayedaghlaghi, M. H. Ghasemi

IGC Proceedings (1977-2023)

No abstract provided.

Influence Of Exclosure Year On Community Structure And Species Diversity On Typical Steppe, G. L. Shan, Zhu Xu, David R. Kemp, F. Ning

IGC Proceedings (1977-2023)

No abstract provided.

Medical School Watercooler Newsletter - October 29, 2020, Lindsey Lyle

Watercooler Newsletter

This is the October 29, 2020 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• Mayer Mitchell Award to be presented to cancer researcher
• Med School Café to address lung cancer
• MacRae retires after 30 years of service
• USA researchers published in DNA Repair journal
• New citizen to become first physician in her family

Applying Cumulative Effects To Strategically Advance Large-Scale Ecosystem Restoration, Heida L. Diefenderfer, Gregory D. Steyer, Matthew C. Harwell, Andrew J. Loschiavo, Hilary A. Neckles, David M. Burdick, Gary E. Johnson, Kate E. Buenau, Elene Trujillo, John C. Callaway, Ronald M. Thom, Neil K. Ganju, Robert R. Twilley

Jackson Estuarine Laboratory

International efforts to restore degraded ecosystems will continue to expand over the coming decades, yet the factors contributing to the effectiveness of long-term restoration across large areas remain largely unexplored. At large scales, outcomes are more complex and synergistic than the additive impacts of individual restoration projects. Here, we propose a cumulative-effects conceptual framework to inform restoration design and implementation and to comprehensively measure ecological outcomes. To evaluate and illustrate this approach, we reviewed long-term restoration in several large coastal and riverine areas across the US: the greater Florida Everglades; Gulf of Mexico coast; lower Columbia River and estuary; Puget …

Conquer And Prevail Issue 38 Oct 29 2020, Wofford College. Office Of Marketing And Communications

Conquer and Prevail Newsletter

No abstract provided.

The Indiana Statesman, October 29, 2020, Indiana State University

Student Newspaper

Highland Quarters site of shooting; Grad Fair: Campus bookstore event for December graduates; Reusing plastic for the greater good; ISU professors co-author study on climate impact in East Africa

Federal Sentencing Disparities And Marginalized Offenders: Revisiting Cumulative Disadvantage Theory Through Individual-Level Variables, April Terry, Ashley Lockwood

Academic Leadership Journal in Student Research

Over the past several decades, sentencing reforms have claimed to establish guidelines to reduce sentencing disparity; yet, recent studies continue to find discrepancies in sentencing outcomes. The current study explored individual factors using data from the U.S. Sentencing Commission (FY 2010) to further analyze these variables through the lens of cumulative disadvantage theory. The factors included the influence of age, race, sex (gender), offense type, instant offense score, and overall criminal history score on sentencing length (in months). Hierarchical regression revealed being identified as Black, committing fraud/white collar crime or a property offense, and overall criminal history were able to …

High Molecular Weight Adiponectin Levels Are Inversely Associated With Adiposity In Pediatric Brain Tumor Survivors., Rebecca Ronsley, Shahrad Rod Rassekh, Adam Fleming, Brianna Empringham, William Jennings, Carol Portwine, Sarah Burrow, Shayna Zelcer, Donna L Johnston, Lehana Thabane, M Constantine Samaan

Paediatrics Publications

While children with brain tumors are surviving at record rates, survivors are at risk of cardiovascular disease and type 2 diabetes mellitus; these conditions may be driven by excess body fat. Adiponectin in an adipokine that is inversely associated with the fat mass, and has been linked to cardiometabolic risk stratification in the general population. However, adiponectin's profile and determinants in SCBT have not been established. We tested the hypothesis that high molecular weight (HMW) adiponectin levels, the more biologically active form of adiponectin, were associated with adiposity in SCBT similarly to non-cancer controls. Seventy-four SCBT (n = 32 female) …

Combating Acquired Resistance To Mapk Inhibitors In Melanoma By Targeting Abl1/2-Mediated Reactivation Of Mek/Erk/Myc Signaling., Rakshamani Tripathi, Zulong Liu, Aditi Jain,, Anastasia Lyon, Christina Meeks, Dana Richards, Jinpeng Liu, Daheng He, Chi Wang, Marika Nespi, Andrey Rymar, Peng Wang, Melissa Wilson, Rina Plattner

Department of Medical Oncology Faculty Papers

Metastatic melanoma remains an incurable disease for many patients due to the limited success of targeted and immunotherapies. BRAF and MEK inhibitors reduce metastatic burden for patients with melanomas harboring BRAF mutations; however, most eventually relapse due to acquired resistance. Here, we demonstrate that ABL1/2 kinase activities and/or expression are potentiated in cell lines and patient samples following resistance, and ABL1/2 drive BRAF and BRAF/MEK inhibitor resistance by inducing reactivation of MEK/ERK/MYC signaling. Silencing/inhibiting ABL1/2 blocks pathway reactivation, and resensitizes resistant cells to BRAF/MEK inhibitors, whereas expression of constitutively active ABL1/2 is sufficient to promote resistance. Significantly, nilotinib (2^{nd …}

Cellular Taxonomy And Spatial Organization Of The Murine Ventral Posterior Hypothalamus., Laura E Mickelsen, William F Flynn, Kristen Springer, Lydia Wilson, Eric J Beltrami, Mohan Bolisetty, Paul Robson, Alexander C Jackson

Faculty Research 2020

The ventral posterior hypothalamus (VPH) is an anatomically complex brain region implicated in arousal, reproduction, energy balance, and memory processing. However, neuronal cell type diversity within the VPH is poorly understood, an impediment to deconstructing the roles of distinct VPH circuits in physiology and behavior. To address this question, we employed a droplet-based single-cell RNA sequencing (scRNA-seq) approach to systematically classify molecularly distinct cell populations in the mouse VPH. Analysis of >16,000 single cells revealed 20 neuronal and 18 non-neuronal cell populations, defined by suites of discriminatory markers. We validated differentially expressed genes in selected neuronal populations through fluorescence in …

Honokiol Loaded Mpeg-Pcl Micelles For The Treatment Of Age-Related Macular Degeneration, Amna Shahid

USF Tampa Graduate Theses and Dissertations

Age related Macular Degeneration (AMD), a multi-factorial age-related retinal hypoxic disorder resulting in irreversible loss of vision is the foremost cause of blindness in United States. Current treatment strategies used to treat disease involve multiple intraocular injections of Anti – VEGF agents into the vitreous of eye. In addition to the issues of drug localization and targeted delivery, the need to frequently inject drug into the eye raise patient compliance issues. These challenges call for sustained drug delivery system. In this study, a sustained drug delivery system was prepared by loading an anti- HIF agent, honokiol into MPEG-PCL polymer. These …

Atlantic Salmon (Salmo Salar) Neurocranium, Connor Depriest, Nadia Abeido, David Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

9.0 cm in length. Neurocranium scan of an Atlantic Salmon (Salmo salar). Collected from Two Bills Seafood on 04/09/20 by Nadia Abeido and Connor Depriest.

Interdisciplinary Work Highlighted At Covid-19 Research Symposium, Jeff Hansen

Browse All News

No abstract provided.

Comparable Human Reconstitution Following Cesium-137 Versus X-Ray Irradiation Preconditioning In Immunodeficient Nog Mice, Anna Halling Folkmar Andersen, Stine Sofie Frank Nielsen, Rikka Olesen, Jakob Le Fèvre Harslund, Ole S. Søgaard, Lars Østergaard, Paul Denton, Martin Tolstrup

Biology Faculty Publications

Humanized mouse models are used extensively in research involving human pathogens and diseases. However, most of these models require preconditioning. Radio-active sources have been used routinely for this purpose but safety issues have motivated researchers to transition to chemical or X-ray based preconditioning. In this study, we directly compare 350 kV X-ray and Cs-137 low-dose precondition of NOG mice before human stem cell transplantation. Based on flow cytometry data, we found that engraftment of human cells into the mouse bone marrow was similar between radiation sources. Likewise, human engraftment in the peripheral blood was comparable between Cs-137 and three different …

Human T-Cell Leukemia Virus Type 1 And Strongyloides Stercoralis: Partners In Pathogenesis, Adam Dykie, Tharaka Wijesinghe, Arnold B Rabson, Kiran Madugula, Christian Farinas, Sydney Wilson, David Abraham, Pooja Jain

Department of Microbiology and Immunology Faculty Papers

Infection with human T-cell leukemia/lymphoma virus type 1 (HTLV-1) has been associated with various clinical syndromes including co-infection with Strongyloides stercoralis, which is an intestinal parasitic nematode and the leading cause of strongyloidiasis in humans. Interestingly, HTLV-1 endemic areas coincide with regions citing high prevalence of S. stercoralis infection, making these communities optimal for elucidating the pathogenesis of co-infection and its clinical significance. HTLV-1 co-infection with S. stercoralis has been observed for decades in a number of published patient cases and case series; however, the implications of this co-infection remain elusive. Thus far, data suggest that S. stercoralis increases …

Evaluation Of Semi-Quantitative Compared To Quantitative Cultures Of Tracheal Aspirates For The Yield Of Culturable Respiratory Pathogens - A Cross-Sectional Study, Salima Rattani, Joveria Farooqi, Ghazala Jabeen, Saeeda Chandio, Qaiser Kash, Aijaz Khan, Kauser Jabeen

Department of Pathology and Laboratory Medicine

Background: Diagnosis of lower respiratory tract infections (LRTI) depends on the presence of clinical, radiological and microbiological findings. Endotracheal suction aspirate (ETSA) is the commonest respiratory sample sent for culture from intubated patients. Very few studies have compared quantitative and semi-quantitative processing of ETSA cultures for LRTI diagnosis. We determined the diagnostic accuracy of quantitative and semi-quantitative ETSA culture for LRTI diagnosis, agreement between the quantitative and semi quantitative culture techniques and the yield of respiratory pathogens with both methods.
Methods: This was a cross-sectional study conducted at the Aga Khan University clinical laboratory, Karachi, Pakistan. One hundred and seventy-eight …

Combating Acquired Resistance To Mapk Inhibitors In Melanoma By Targeting Abl1/2-Mediated Reactivation Of Mek/Erk/Myc Signaling, Rakshamani Tripathi, Zulong Liu, Aditi Jain, Anastasia Lyon, Christina Meeks, Dana Richards, Jinpeng Liu, Daheng He, Chi Wang, Marika Nespi, Andrey Rymar, Peng Wang, Melissa Wilson, Rina Plattner

Pharmacology and Nutritional Sciences Faculty Publications

Metastatic melanoma remains an incurable disease for many patients due to the limited success of targeted and immunotherapies. BRAF and MEK inhibitors reduce metastatic burden for patients with melanomas harboring BRAF mutations; however, most eventually relapse due to acquired resistance. Here, we demonstrate that ABL1/2 kinase activities and/or expression are potentiated in cell lines and patient samples following resistance, and ABL1/2 drive BRAF and BRAF/MEK inhibitor resistance by inducing reactivation of MEK/ERK/MYC signaling. Silencing/inhibiting ABL1/2 blocks pathway reactivation, and resensitizes resistant cells to BRAF/MEK inhibitors, whereas expression of constitutively active ABL1/2 is sufficient to promote resistance. Significantly, nilotinib (2nd generation …

Neurocognitive Markers Of Passive Suicidal Ideation In Late-Life Depression, Joshua T. Jordan, Christina F. Chick, Camarin E. Rolle, Nathan Hantke, Christine E. Gould, Julie Lutz, Makoto Kawai, Isabelle Cotto, Rosy Karna, Sophia Pirog, Michelle Berk, Keith Sudheimer, Ruth O'Hara, Sherry A. Beaudreau

Psychology | Faculty Scholarship

Objectives: (1) To delineate whether cognitive flexibility and inhibitory ability are neurocognitive markers of passive suicidal ideation (PSI), an early stage of suicide risk in depression and (2) to determine whether PSI is associated with volumetric differences in regions of the prefrontal cortex (PFC) in middle-aged and older adults with depression.

Design: Cross-sectional study.

Setting: University medical school.

Participants: Forty community-dwelling middle-aged and older adults with depression from a larger study of depression and anxiety (NIMH R01 MH091342-05 PI: O'Hara).

Measurements: Psychiatric measures were assessed for the presence of a DSM-5 depressive disorder and PSI. A neurocognitive battery assessed cognitive …

Characterizing The Biophysical Properties And Origin Of Extracellular Matrix In The Breast Tumor Microenvironment, Connor T. King

LSU Master's Theses

Tumors derived from breast tissue possess the ability to manipulate and permanently alter their surrounding tissue. Studies demonstrate that tissues surrounding breast tumors have differences in secreted factors as well as extracellular matrix (ECM) deposition and structure. However, some fundamental gaps exist within this paradigm: specifically, what exacerbates this transformation and are these changes maintained between the subtypes of breast tumors? Therefore, a targeted evaluation of the effects of the tumor on the stromal microenvironment in a subtype specific manner will be invaluable. To determine if tumor aggressiveness and subtype differentially regulate the tumor microenvironment, a model must be constructed …

Spring/Summer 2020: New Faculty Directory, St. Norbert College

St. Norbert College Magazine 2019-2023

Fourteen new faculty members joined the college this year. We’re delighted to introduce them to readers via this new faculty directory.

Edax And Ftir Characterization And Setting Time Of An Experimental Nanoparticle Incorporated Root-End Filling Material, Teena Sheethal Dsouza, Aditya Shetty, Mithra Nidarsh Hegde, Jenitta Emima Packayam

Open Access archive

The evolution of calcium silicate based cements in the field of dentistry has been rewarding. It offers a plethora of advantages with respect to physicochemical and biological properties. However, the extended setting time and limited antibacterial activity in these cements is quite a concern. This study aimed to develop a fast-setting nanoparticle incorporated root-end filling material for use after periapical surgeries. With the incorporation of the silver nanoparticles, and using calcium chloride as the liquid component, the desirable study outcome was achieved. The setting time was significantly reduced when compared to the commercially available root-end filling material.

Challenges And Opportunities For Improving The Landscape For Lewy Body Dementia Clinical Trials., Jennifer G Goldman, Leah K Forsberg, Bradley F Boeve, Melissa J Armstrong, David J Irwin, Tanis J Ferman, Doug Galasko, James E Galvin, Daniel Kaufer, James Leverenz, Carol F Lippa, Karen Marder, Victor Abler, Kevin Biglan, Michael Irizarry, Bill Keller, Leanne Munsie, Masaki Nakagawa, Angela Taylor, Todd Graham

Department of Neurology Faculty Papers

Lewy body dementia (LBD), including dementia with Lewy bodies and Parkinson's disease dementia, affects over a million people in the USA and has a substantial impact on patients, caregivers, and society. Symptomatic treatments for LBD, which can include cognitive, neuropsychiatric, autonomic, sleep, and motor features, are limited with only two drugs (cholinesterase inhibitors) currently approved by regulatory agencies for dementia in LBD. Clinical trials represent a top research priority, but there are many challenges in the development and implementation of trials in LBD. To address these issues and advance the field of clinical trials in the LBDs, the Lewy Body …

Hypogean Communities As Cybernetic Systems: Implications For The Evolution Of Cave Biotas, Aldemaro Romero Jr.

Publications and Research

Ramón Margalef proposed in 1968 that ecosystems could be better understood if they were viewed as cybernetic systems. I tested this hypothesis in the case of hypogean ecosystems using available pieces of evidence. I looked on how information on feedbacks, stability, succession, organization, diversity, and energy flows in the hypogean environment fit the cybernetics hypothesis. The results were that there are convincing arguments that the application of the concept of cybernetics in biospeleology can be beneficial to broadening our understanding of cave biota in terms of their structure. I also make the case that this approach can provide more clarity …

The Colby Echo (2020-10-29), Colby College

The Colby Echo

Published by the students of Colby College since 1877, The Colby Echo is the weekly, editorially independent student-run newspaper of Colby College in Waterville, Maine. Published monthly, 1877-1886; semi-monthly, 1886-1897; and weekly, during the academic year, 1898-present.

Making A First Impression: Exploring What Instructors Do And Say On The First Day Of Introductory Stem Courses, A. Kelly Lane, Clara L. Meaders, J. Kenny Shuman, Mackenzie R. Stetzer, Erin L. Vinson, Brian A. Couch, Michelle K. Smith, Marilyne Stains

School of Biological Sciences: Faculty Publications

Student impressions formed during the first day of class can impact course satisfaction and performance. Despite its potential importance, little is known about how instructors format the first day of class. Here, we report on observations of the first day of class in 23 introductory science, technology, engineering, and math (STEM) courses. We first described how introductory STEM instructors structure their class time by characterizing topics covered on the first day through inductive coding of class videos. We found that all instructors discussed policies and basic information. However, a cluster analysis revealed two groups of instructors who differed primarily in …

Population Genetics Of Rhizophora Apiculata In Peninsular Malaysia Using Microsatellite Markers, Amelia Azman

Student Works (2020-2029)

Rampant illegal logging, overharvesting and deforestation coupled with climate change, pose significant threats to the natural stands of Rhizophora apiculata, or locally known as Bakau Minyak; one of the most economically and ecologically important species of mangroves in Peninsular Malaysia. Despite being a dominant mangrove species, the reduction in the number of R. apiculata in its habitat has resulted in concerns over the long-term survival potential of the species. In Malaysia, genetic information to develop effective guidelines for the conservation and management of mangrove species has been lacking, and hence, further research should be conducted to fill this gap. The …

Pennsylvania’S Covid-19 Response Through The Homeland Security Frameworks And Research Lens – Lessons Learned, Alexander Siedschlag

Publications

• Although typically framed as a pandemic owned by the public health sector, the COVID-19 response falls directly within the homeland security mission space, whose core missions include “Ensuring Resilience to Disasters” (QHSR 2014).
• In some aspects PA’s COVID-19 response is in line with security research.
• In other dimensions, it is neither in line with what research would recommend nor with what the National Preparedness System would foresee.
• The Keystone State has yet to fully make the step from disaster to catastrophe as the characteristic challenge to U.S. emergency management in our century.

Oddpub – A Text-Mining Algorithm To Detect Data Sharing In Biomedical Publications, Nico Riedel, Miriam Kip, Evgeny Bobrov

Copyright, Fair Use, Scholarly Communication, etc.

Open research data are increasingly recognized as a quality indicator and an important resource to increase transparency, robustness and collaboration in science. However, no standardized way of reporting Open Data in publications exists, making it difficult to find shared datasets and assess the prevalence of Open Data in an automated fashion.

We developed ODDPub (Open Data Detection in Publications), a text-mining algorithm that screens biomedical publications and detects cases of Open Data. Using English-language original research publications from a single biomedical research institution (n = 8689) and randomly selected from PubMed (n = 1500) we iteratively developed a …

Kenyon Collegian - October 29, 2020

The Kenyon Collegian

No abstract provided.

Zinc Oxide Based Nanowire Arrays For Selective Detection Of Multiple Gaseous Analytes At Elevated Temperature, Bo Zhang

Doctoral Dissertations

Zinc oxide (ZnO) based nanostructures represent an important class of gas sensor materials, due to their high surface-to-volume ratio, significant surface band structure bending upon gaseous analyte exposures, good mobility of charge carriers, and good structural stability at elevated temperature. Their usually surface-dominant sensing processes entail the important roles played by nanostructure size, defects, morphologies, and surface absorbate energetics and dynamics. In this dissertation, based on ZnO nanowire array as a gas sensing platform, rational decoration of electronic sensitizers, such as Au nanoparticles, and semiconducting oxide, such as Fe₂O₃ nanoparticles, has been employed to boost its electrical …