Digital Commons Network^™

Rapid Assessment Of Breast Tumor Margins Using Deep Ultraviolet Fluorescence Scanning Microscopy, Tongtong Lu, Julie M. Jorns, Mollie Patton, Renee Fisher, Amanda Emmerich, Todd Doehring, Taly Gilat-Schmidt, Dong Hye Ye, Tina Yen, Bing Yu

Biomedical Engineering Faculty Research and Publications

Significance: Re-excision rates for women with invasive breast cancer undergoing breast conserving surgery (or lumpectomy) have decreased in the past decade but remain substantial. This is mainly due to the inability to assess the entire surface of an excised lumpectomy specimen efficiently and accurately during surgery.

Aim: The goal of this study was to develop a deep-ultraviolet scanning fluorescence microscope (DUV-FSM) that can be used to accurately and rapidly detect cancer cells on the surface of excised breast tissue.

Approach: A DUV-FSM was used to image the surfaces of 47 (31 malignant and 16 normal/benign) fresh breast tissue samples stained …

A Size‐Modified Poisson–Boltzmann Ion Channel Model In A Solvent Of Multiple Ionic Species: Application To Voltage‐Dependent Anion Channel, Dexuan Xie, Said H. Audi, Ranjan K. Dash

Biomedical Engineering Faculty Research and Publications

We present a new size‐modified Poisson–Boltzmann ion channel (SMPBIC) model and use it to calculate the electrostatic potential, ionic concentrations, and electrostatic solvation free energy for a voltage‐dependent anion channel (VDAC) on a biological membrane in a solution mixture of multiple ionic species. In particular, the new SMPBIC model adopts a membrane surface charge density and a natural Neumann boundary condition to reflect the charge effect of the membrane on the electrostatics of VDAC. To avoid the singularity difficulties caused by the atomic charges of VDAC, the new SMPBIC model is split into three submodels such that the solution of …

Infographic: Division 1 - Power 5 Football Stars In Stem, Sydney Jones, Leroy Long Iii

Publications

In this infographic, football stars studying degrees in science, technology, engineering, and math (STEM) are showcased. The infographic focuses on racial/ethnic minoritized students who pursue STEM degrees and play football at a university in a National Collegiate Athletic Association (NCAA) Division 1 - Power 5 conference. For each football star, their name, university and major are included. While pursuing majors such as biology, engineering and psychology, these diverse individuals provide counterexamples of who can pursue rigorous majors and high-demand sports.

Transitioning Out Of Leadership: Is There Life After Higher Administration?, Christina M. Frederick, Alvin Y. Wang, Jane S. Halonen

Publications

This article showcases the case histories of three former higher education administrators who stepped down from their responsibilities to rejoin the faculty. From their collective experiences, they extracted the variables that tend to influence the change in professional trajectory. The authors explain how an assortment of cognitive biases can influence the success or failure of downward transitions. We conclude the article with suggestions regarding how to make a successful transition from academic administration back to faculty status.

Pennsylvania’S Covid-19 Response Vs. Homeland Security Frameworks And Research: Masking The Whole Community, Alexander Siedschlag

Publications

This essay offers an intermediate discussion of select policy, strategic, operational, and tactical issues that demonstrate where and how the Commonwealth of Pennsylvania’s novel coronavirus response on the one hand, and homeland security frameworks and research on the other, converge or—more often so—diverge, and how to narrow this gap. Although typically framed as a pandemic owned by the public health sector, the COVID-19 response falls directly within the homeland security mission space, whose core missions include “Ensuring Resilience to Disasters.” In some respects, Pennsylvania’s response exemplifies best practices suggested by research. In other dimensions, it is neither in line with …

Cheater, Cheater: Examination Of Children's Lying For Different Motivations, Tessa Delaney Hendrix

UNF Graduate Theses and Dissertations

The current study examined children’s lie-telling behavior across three motivational contexts. There were 32 children (M = 5.08 years, SD = 0.53) who participated in four experimental paradigms to examine the differences among antisocial and prosocial lying during preschool age years. Children were assessed on overall peer relations and working memory cognitive measures to gain a better understanding of how our social worlds and developmental trajectories affect the types of lies told. Results revealed children’s lie-telling was not uniform across the sequential motivational contexts. Children utilized both lie types depending on the perceived severity or social influence, but at …

Diabetes Risk Status And Physical Activity In Pregnant Women: U.S. Brfss 2011, 2013, 2015, 2017, Bethany Rand

UNF Graduate Theses and Dissertations

Objective: We sought to examine differences in aerobic activity (AA) and muscle-strengthening activity (MSA) by diabetes risk status (DRS) among pregnant women in the United States.

Background: Pregnant women without complications are advised to engage in physical activity (PA) to mitigate adverse outcomes. Differences may exist among pregnant women of diverging diabetes status in meeting national PA recommendations.

Methods: The sample (n=9,597) included pregnant women ages 18-44, who participated in 2011, 2013, 2015, and 2017 Behavioral Risk Factor Surveillance System. Levels of DRS were: no diabetes (ND), high risk for diabetes (HRD) due to self-reported gestational diabetes or …

Basigin As An Immune Mediator In The Cns, Alicia Gonzalez

UNF Graduate Theses and Dissertations

Chronic inflammation is a hallmark of many neurodegenerative disorders. Although the central nervous system (CNS) can stave peripheral pathogens from crossing the blood-brain barrier (BBB) through a network of continuous endothelia, astrocytes, and pericytes, prolonged exposure to a pathogen can comprise this barrier. Basigin, a cell adhesion molecule, is found on the surface of endothelial cells and has been demonstrated to interact with toll-like receptor 4 (TLR4). TLR4 recognizes lipopolysaccharide (LPS), found on the outer membrane of Gram-negative bacteria. The activation of TLR4 produces pro-inflammatory cytokines, like IL-6. The present study aims to address the expression pattern of Basigin gene …

Implementing Welfare Science: Case Studies In Evidence-Based Zoo Management, Marisa Suzanne Spain

UNF Graduate Theses and Dissertations

Animal welfare science is a field that focuses on how we can improve the lives and well-being of animals in human care. Modern welfare science has moved away from simply preventing suffering and on to promoting positive welfare states, a concept that has been coined animal “wellness”. A process called evidence-based zoo management has been implemented in many zoos as a way to promote and ensure wellness. This is the idea that husbandry and housing standards should be evaluated and tested for their efficacy using data rather than relying on traditional best practices. In this manuscript we discuss an informal …

Fggy Carbohydrate Kinase Domain Containing Is Induced During Skeletal Muscle Atrophy And Modulates Map Kinase And Akt Signaling, Anastasia L. Smith

UNF Graduate Theses and Dissertations

Skeletal muscle atrophy can result from a range of physiological conditions, including denervation, immobilization, hindlimb unweighting, and aging. To better characterize the molecular genetic events of atrophy, a microarray was performed using skeletal muscle isolated from mice after 3 and 14 days of denervation and compared to control muscle to identify novel atrophy-induced genes. The microarray revealed that FGGY carbohydrate kinase domain containing (Fggy) is expressed in skeletal muscle and is induced in response to denervation. Bioinformatic analysis of the Fggy gene locus revealed two validated alternative isoforms, that we have termed Fggy-L-552 and Fggy-S-387, which have distinct transcription initiation …

Applications Of Artificial Intelligence To Cryptography, Jonathan Blackledge, Napo Mosola

Articles

This paper considers some recent advances in the field of Cryptography using Artificial Intelligence (AI). It specifically considers the applications of Machine Learning (ML) and Evolutionary Computing (EC) to analyze and encrypt data. A short overview is given on Artificial Neural Networks (ANNs) and the principles of Deep Learning using Deep ANNs. In this context, the paper considers: (i) the implementation of EC and ANNs for generating unique and unclonable ciphers; (ii) ML strategies for detecting the genuine randomness (or otherwise) of finite binary strings for applications in Cryptanalysis. The aim of the paper is to provide an overview on …

Towards A Rapid Screening Of Liver Grafts At The Operating Room Using Mid-Infrared Spectroscopy, David Perezguaita, Marta Moreno Torres, Ramiro Jover, Eugenia Pareja, Bernard Lendl, Julia Kuligowsky, Guillermo Quintas

Articles

The estimation of steatosis in a liver graft is mandatory prior to liver transplantation, as the risk of graft failure increases with the level of infiltrated fat. However, the assessment of liver steatosis before transplantation is typically based on a qualitative or semiquantitative characterization by visual inspection and palpation and histological analysis. Thus, there is an unmet need for transplantation surgeons to have access to a diagnostic tool enabling an in situ fast classification of grafts prior to extraction. In this study, we have assessed an attenuated total reflection−Fourier transform infrared (ATR−FTIR) spectroscopic method compatible with the requirements of an …

Herpes Simplex Virus 1 Targets Irf7 Via Icp0 To Limit Type I Ifn Induction, David Shahnazaryan, Rana Khalil, Claire Wynne, Caroline A Jefferies, Joan Ní Gabhann-Dromgoole, Conor C Murphy

Articles

Herpes simplex keratitis (HSK), caused by herpes simplex virus type 1 (HSV‑1) infection, is the commonest cause of infectious blindness in the developed world. Following infection the virus is initially suspended in the tear film, where it encounters a multi‑pronged immune response comprising enzymes, complement, immunoglobulins and crucially, a range of anti‑viral and pro‑inflammatory cytokines. However, given that HSV‑1 can overcome innate immune responses to establish lifelong latency throughout a susceptible individual’s lifetime, there is significant interest in understanding the mechanisms employed by HSV‑1 to downregulate the anti‑viral type I interferon (IFN) mediated immune responses. This study aimed to investigate …

Dual Contrast In Computed Tomography Allows Earlier Characterization Of Articular Cartilage Over Single Contrast, Abhisek Bhattarai, Behdad Pouran, Janne T.A. Mäkelä, Rubina Shaikh, Miitu K.M. Honkanen, Mithilesh Prakash, Heikki Kröger, Mark W. Grinstaff, Harrie Weinans, Jukka S. Jurvelin, Juha Töyräs

Articles

Cationic computed tomography contrast agents are more sensitive for detecting cartilage degeneration than anionic or non-ionic agents. However, osteoarthritis-related loss of proteoglycans and increase in water content contrarily affect the diffusion of cationic contrast agents, limiting their sensitivity. The quantitative dual-energy computed tomography technique allows the simultaneous determination of the partitions of iodine-based cationic (CA4+) and gadolinium-based non-ionic (gadoteridol) agents in cartilage at diffusion equilibrium. Normalizing the cationic agent partition at diffusion equilibrium with that of the non-ionic agent improves diagnostic sensitivity. We hypothesize that this sensitivity improvement is also prominent during early diffusion time points and that the technique …

Making Sense Of Customary International Law, Monica Hakimi

Faculty Scholarship

This Article addresses a longstanding puzzle about customary international law (CIL): How can it be, at once, so central to the practice of international law — routinely invoked and applied in a broad range of settings — and the source of such persistent confusion and derision? The centrality of CIL suggests that, for the many people who use it, it is not only comprehensible but worthwhile. They presumably use it for a reason. But then, what accounts for all the muddle and disdain?

The Article argues that the problem lies less in the everyday operation of CIL than in the …

Conference On Best Practices For Managing Daubert Questions, Daniel J. Capra, David G. Campbell, Debra A. Livingston, James P. Bassett, Shelly Dick, Traci L. Lovitt, Thomas Marten, Kathryn N. Nester, Thomas D. Schroeder, Elizabeth J. Shapiro, Timothy Lau, Vince Chhabria, John Z. Lee, William H. Orrick Iii, Edmund A. Sargus Jr., Sarah A. Vance, Edward K. Cheng

Faculty Scholarship

This article is a transcript of the Philip D. Reed Lecture Series Conference on Best Practices for Managing Daubert Questions, held on October 25, 2019, at Vanderbilt Law School under the sponsorship of the Judicial Conference Advisory Committee on Evidence Rules. The transcript has been lightly edited and represents the panelists’ individual views only and in no way reflects those of their affiliated firms, organizations, law schools, or the judiciary.

Povos Indígenas, Genocídio E Pademia No Brasil, Fernanda Frizzo Bragato, Marco Antônio Delfino De Almeida, Jocelyn Getgen Kestenbaum

Articles

Indigenous Peoples, Genocide and Pandemics in Brazil

COVID-19 pandemics spreads among Brazilian indigenous communities while they endure the dismantling of protective policies, the current government's hostility, as well as the disproportionate effects in terms of contamination and mortality. This situation has been concerning indigenous organizations and public authorities in Brazil and worldwide. Indigenous peoples are potential victims of genocide, an act characterized both as a criminally punishable conduct and as a State policy capable to generate international State liability. This study intends to investigate whether and how the conditions of susceptibility to the physical destruction met by several Brazilian indigenous …

In Defense Of Empiricism In Family Law, Elizabeth S. Scott

Faculty Scholarship

It is fitting to include an essay defending the application of empirical research to family law and policy in a symposium honoring the scholarly career of Peg Brinig, who is probably the leading empiricist working in family law. While such a defense might seem unnecessary, given the expanding role of behavioral, social, and biological research in shaping the regulation of children and families, prominent scholars recently have raised concerns about the trend toward reliance on empirical science in this field. A part of the criticism is directed at the quality of the science itself and at the lack of sophistication …

Democracy & Religion: Some Variations & Hard Questions, Kent Greenawalt

Faculty Scholarship

The ideas sketched here concern the nonestablishment and free exercise norms expressed in the U.S. Constitution, their application to governmental institutions from legislatures to prisons and the military, the place of religion in the curricula of public schools, and the proper role of religious convictions in lawmaking. A major concern of the essay is the problem of achieving an appropriate balance between governmental neutrality toward religion, as required by the nonestablishment norm, and governmental accommodation of religious practices that would otherwise violate ordinary laws, as required by the free exercise norm. A recurring theme is the complexity of the issues …

Conceptualizing Legal Childhood In The Twenty-First Century, Clare Huntington, Elizabeth S. Scott

Faculty Scholarship

The law governing children is complex, sometimes appearing almost incoherent. The relatively simple framework established in the Progressive Era, in which parents had primary authority over children, subject to limited state oversight, has broken down over the past few decades. Lawmakers started granting children some adult rights and privileges, raising questions about their traditional status as vulnerable, dependent, and legally incompetent beings. As children emerged as legal persons, children’s rights advocates challenged the rationale for parental authority, contending that robust parental rights often harm children. And a wave of punitive reforms in response to juvenile crime in the 1990s undermined …

Summary: Combating Climate Change With Section 115 Of The Clean Air Act, Jonathan Cannon, Ann E. Carlson, Greg Dotson, Michael B. Gerrard, Justin Gundlach, Jayni Foley Hein, Cale Jaffe, Michael A. Livermore, Jason A. Schwartz, Daniel Selmi, Jessica A. Wentz, Philip S. Barnett, Keith J. Benes, Alexandra E. Teitz

Faculty Scholarship

The scale and scope of the climate crisis calls for comprehensive nationwide efforts to reduce greenhouse gas emissions. New legislation, passed by Congress and signed by the President, is the first and best option for climate action at the federal level. This could be a version of the Green New Deal, a carbon tax, sectoral limits, an emissions cap with compliance trading, or another approach. What matters most is that the legislation effectively cut the greenhouse gas emissions driving the world’s temperatures ever higher. Unfortunately, the prospect for federal legislation is uncertain, while strong and decisive action is needed now. …

Coordinating Injunctions, Bert I. Huang

Faculty Scholarship

Consider this scenario: Two judges with parallel cases are each ready to issue an injunction. But their injunctions may clash, ordering incompatible actions by the defendant. Each judge has written an opinion justifying her own intended relief, but the need to avoid conflicting injunctions presses her to make a further choice – “Should I issue the injunction or should I stay it for now?” Each must make this decision in anticipation of what the other will do.

This Article analyzes such a judicial coordination problem, drawing on recent examples including the DACA cases and the “sanctuary cities” cases. It then …

Reframing Affirmative Action: From Diversity To Mobility And Full Participation, Susan P. Sturm

Faculty Scholarship

Legality and efficacy call for reframing the affirmative-action debate within a broader institutional effort to address structural inequality in higher education. Although defending affirmative action as we know it continues to be important and necessary, it is crucial to identify and address the disconnect between affirmative action and higher education's practices that contribute to enduring racial and economic inequality and waning social mobility. There is a persistent and growing gap between higher education’s rhetoric of diversity, opportunity, and mobility and the reality of underparticipation, polarization, and stratification. That gap has racial, gender, and socioeconomic dimensions. The path to shoring up …

The New Restatement Of Children And The Law: Legal Childhood In The Twenty-First Century, Clare Huntington, Elizabeth S. Scott

Faculty Scholarship

This Essay is based on a previous article: Clare Huntington & Elizabeth Scott, Conceptualizing Legal Childhood in the Twenty-First Century, 118 Mich. L. Rev. 1371 (2020) (offering a comprehensive account of the Child Wellbeing framework).

Since the 1960s, the law regulating children has become increasingly complex and uncertain. The relatively simple framework established in the Progressive Era, in which parents had primary authority over children subject to a limited supervisory and protective role of the state, has broken down. Lawmakers have begun to grant children some adult rights and privileges, raising questions about their traditional status as vulnerable, dependent, …

The Integrative Effects Of Global Legal Pluralism, Monica Hakimi

Faculty Scholarship

International lawyers widely understand that legal pluralism is a fact of global life and that it can, in certain settings, be desirable. But many still approach it with some trepidation. A prominent skeptical claim is that pluralist structures lack the integrative resources that unify people around a shared governance project. This claim has been prominent with respect to two kinds of conflicts that are routine in international law: (1) conflicts that play out within a single international legal arrangement, and (2) conflicts that cut across multiple legal arrangements. For both, the skeptical claim is directed at the pluralist structure itself. …

The Proportionality Rule And Mental Health Harm In War, Sarah Knuckey, Alex Moorehead, Audrey Mccalley, Adam Brown

Faculty Scholarship

The foundational international humanitarian law rule of proportionality — that parties to an armed conflict may not attack where civilian harm would be excessive in relation to the anticipated military advantage — is normally interpreted to encompass civilian physical injuries only. Attacks may cause significant mental harms also, yet current interpretations of the law lag behind science in understanding and recognizing these kinds of harms. This article analyzes legal, public health, psychology, and neuroscience research to assess the extent to which mental health harms should and could be taken into account in proportionality assessments.

Youth Decline In Church Growth And Attendance, Marion Diane Jones

Doctoral Dissertations and Projects

Youth attendance in the church has declined in the recent past. The reason for their decline is that they no longer find a church to be socially and spiritually relevant to their lives. The paper seeks to provide a solution to the problem through spiritual formation and increasing the depth of youth programs so that they can remain socially relevant to the lives of the young people. This will be done by encouraging youth people to know who Jesus is and how to have a personal relationship with him through faith.

Fostering Self-Efficacy For Biblical Learning And Doctrinal Awareness With Micro-Teaching In A Brief Course On Bible Study, Robin K. Henson

Doctoral Dissertations and Projects

Self-efficacy for biblical learning was explored in the context of a small group experience focused on how to study the Bible. After first developing a new instrument to measure self-efficacy for biblical learning in a pilot study, ten church attendees participated in a seven-week course designed around the hermeneutical principles of understanding a Scripture passage in textual and historical context, placing the passage in the grand story of God, and relating it to relevant doctrine. The small group process employed micro-teaching as a mechanism to facilitate challenge and mastery experience in learning. Micro-teaching places the student in the role of …

In Vivo Activity Of Copper(Ii), Manganese(Ii), And Silver(I) 1,10-Phenanthroline Chelates, Rafael M. Ghandra, Pauraic Mccarron, Livia Viganor, Mariana Farias Fernandes, Kevin Kavanagh, Malachy Mccann, Marta H. Branquinha, André L.S. Santos, Orla L. Howe, Michael Devereux

Articles

Candida haemulonii is an emerging opportunistic pathogen resistant to most antifungal drugs currently used in clinical arena. Metal complexes containing 1,10-phenanthroline (phen) chelating ligands have well-established anti-Candida activity against different medically relevant species. This study utilized larvae of Galleria mellonella, a widely used model of in vivo infection, to examine C. haemulonii infection characteristics in response to different copper(II), manganese(II), and silver(I) chelates containing phen, which had demonstrated potent anti-C. haemulonii activity in a previous study. The results showed that C. haemulonii virulence was influenced by inoculum size and incubation temperature, and the host G. mellonella immune …

Breastfeeding Practices 2008–2009 Among Chinese Mothers Living In Ireland: A Mixed Methods Study, Qianling Zhou, Katherine Younger, Tanya M. Cassidey, Wenyi Wang, John Kearney

Articles

Background

Migration to another country has a potential influence on breastfeeding practices. A significant difference in breastfeeding rates between Irish nationals and non-nationals has been reported. This study was conducted to explore breastfeeding practices of the Chinese in Ireland, one of the largest Irish ethnic groups, and to explore the influence of living in Ireland on breastfeeding practices. This is the first and the only migration study so far on breastfeeding practices among the Chinese in Ireland.

Methods

A sequential explanatory mixed methods approach was adopted. The first phase was a cross-sectional self-administered retrospective mailed survey, to explore breastfeeding practices …