Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2020

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 30571 - 30600 of 32161

Full-Text Articles in Entire DC Network

A Study Of Using Corncob, Aspen Shaving, Dried Water Hyacinth And Banana Midrib As Bedding For Laboratory Mice, Nantaporn Maytayapirom Jan 2020

A Study Of Using Corncob, Aspen Shaving, Dried Water Hyacinth And Banana Midrib As Bedding For Laboratory Mice, Nantaporn Maytayapirom

Chulalongkorn University Theses and Dissertations (Chula ETD)

A study of using corncob, aspen shaving, dried water hyacinth and banana midrib as bedding for laboratory mice. The objective of this study was to evaluate the physical characteristics (i.e., absorbency and surface moisture), the physiological effects and intracage ammonia level of 4 types of beddings in laboratory mice. This study was divided into two parts. In the first part, the fluid absorption properties of these four beddings were studied using measurement of liquid absorption and the surface moisture. The results showed that the volumetric absorbency of aspen shaving was significantly higher than other beddings. While, the surface moisture showed …

Go to article

Comparison Of Laser Class 1m And Class 4 Applications In Canine Cranial Cruciate Ligament Rupture Evaluated By Clinical Outcomes And Ultrasonography, Noppakrit Ekakaraworapong Jan 2020

Comparison Of Laser Class 1m And Class 4 Applications In Canine Cranial Cruciate Ligament Rupture Evaluated By Clinical Outcomes And Ultrasonography, Noppakrit Ekakaraworapong

Chulalongkorn University Theses and Dissertations (Chula ETD)

Nineteen dogs diagnosed of cranial cruciate ligament rupture were included in this study before TPLO was performed. They were classified into 3 groups which consisted of control, low-level laser therapy class 1M and low-level laser therapy class 4 groups. The number of each group were 4, 8 and 7 dogs, respectively, and the duration of treatment protocol was 4 weeks consecutively. On the first day of the study, dogs were examined and assessed of the clinical signs such as lameness score, synovial fluid analysis, canine brief pain inventory questionnaire (CBPI) and ultrasonographic score. In ultrasonographic monitoring, ultrasonographic scores on synovial …

Go to article

Efficiency And Clinical Outcomes Of Platlet-Rich Plasma Therapy On Caninecoxofemoral Osteoarthritis, Patama Arunrattanakul Jan 2020

Efficiency And Clinical Outcomes Of Platlet-Rich Plasma Therapy On Caninecoxofemoral Osteoarthritis, Patama Arunrattanakul

Chulalongkorn University Theses and Dissertations (Chula ETD)

The purpose of this study was to find out for the optimal technique to prepare plasma with highest platelet concentration in platelet rich plasma (PRP), as well as determine the result of autologous PRP from the dogs with osteoarthritis(OA) condition. It was shown that the PRP could reduce inflammation, cell regeneration, and enhance angiogenesis to support the injured tissue. This study was composed of two phases; the first phase was aimed to find the best centrifugation speed and time that could be able to produce the plasma with the highest platelet concentration by conducting the experiment from a total of …

Go to article

Effects Of Algae-Derived Ss-Glucan Supplementation On Production Performances And Specific Immune Responses In Nursery To Growing Pigs, Sh.Boonnithi Chuaychu Jan 2020

Effects Of Algae-Derived Ss-Glucan Supplementation On Production Performances And Specific Immune Responses In Nursery To Growing Pigs, Sh.Boonnithi Chuaychu

Chulalongkorn University Theses and Dissertations (Chula ETD)

เบต้ากลูแคนเป็นสารเสริมในอาหารสัตว์ที่มีการใช้กันอย่างแพร่หลายในอุตสาหกรรมการเลี้ยงสุกร ถึงแม้ว่าการเสริมสารเบต้ากลูแคนในสูตรอาหารสุกร จะเชื่อว่าสามารถช่วยพัฒนาการเจริญเติบโตและปรับการทำงานของภูมิคุ้มกันในสุกรได้ แต่อย่างไรก็ตาม ในปัจจุบันยังไม่มีข้อมูลการศึกษาที่ชัดเจนเกี่ยวกับผลของการเสริมเบต้ากลูแคนที่สกัดมาจากสาหร่ายต่ออัตราการเจริญเติบโตและการตอบสนองทางภูมิคุ้มกันโดยเฉพาะระบบภูมิคุ้มกันแบบจำเพาะในสุกร ดังนั้นการศึกษานี้จึงมีวัตถุประสงค์เพื่อประเมินผลของการใช้สารเสริมเบต้ากลูแคนจากสาหร่ายในอาหารสุกรต่อประสิทธิภาพการเจริญเติบโตและการตอบสนองทางภูมิคุ้มกันแบบจำเพาะในสุกรอนุบาลและสุกรขุนเล็ก โดยแบ่งสุกรหย่านมสามสายพันธุ์เป็น 3 กลุ่มการทดลอง ได้แก่ กลุ่มควบคุมที่ได้รับอาหารสูตรมาตรฐาน กลุ่มทดลองที่ 2 และ 3 ได้รับอาหารชนิดเดียวกันที่เสริมด้วยสารเสริมเบต้ากลูแคนจากสาหร่ายในปริมาณ 100 และ 200 กรัมต่อตันตามลำดับ จากการทดลอง ไม่พบความแตกต่างอย่างมีนัยสำคัญของประสิทธิภาพการผลิตและอัตราการเจริญเติบโตของสุกรสุกร การทดสอบการตอบสนองของระบบภูมิคุ้มกันที่จำเพาะหลังการฉีดวัคซีน CSFV และ PRRSV พบว่าสุกรที่ได้รับสารเสริมเบต้ากลูแคนจากสาหร่ายในอาหาร มีระดับ neutralizing antibody ต่อ CSFV สูงขึ้นอย่างมีนัยยะสำคัญ นอกจากนี้ พบการเพิ่มขึ้นของจำนวนเซลล์ CD4+(T lymphocytes) และ CD4+CD8+ (putative memory T lymphocytes) ซึ่งสร้างไซโตคายน์ IFN-g+ ที่มีความจำเพาะต่อ CSFV และ PRRSV ในกลุ่มสุกรที่ได้รับสารเสริมเบต้ากลูแคนจากสาหร่ายอีกด้วย จากการศึกษาสรุปได้ว่า ถึงแม้ว่าการให้สารเสริมเบต้ากลูแคนจะไม่สามารถเสริมสมรรถภาพการผลิตของสุกรได้ แต่มีคุณสมบัติทางชีวภาพในการเป็นสารกระตุ้นภูมิคุ้มกันซึ่งอาจเป็นการเพิ่มความต้านทานโรคติดเชื้อไวรัสในสุกรอนุบาลและสุกรขุนเล็กได้

Go to article

Surveillance And Histopathological Study Of Microplastics In Marine Fish From The Gulf Of Thailand, Sirawich Srisiri Jan 2020

Surveillance And Histopathological Study Of Microplastics In Marine Fish From The Gulf Of Thailand, Sirawich Srisiri

Chulalongkorn University Theses and Dissertations (Chula ETD)

Microplastic (MP) problems have been threatened aquatic environment worldwide for decades. This study demonstrated current MP contamination characteristics in marine food fishes from the upper Gulf of Thailand. MPs were found in gastrointestinal tracts of 46.86% of fish samples, which were 1.556±0.47 pieces per fish or 0.035±0.014 pieces per gram of fish bodyweight. No plastics were detected from muscle, liver, kidney or gonad of the fishes. There was a significant relationship between MP contamination and fish species or the fish grouping. Benthic fish had a higher contamination rate than pelagic fish. Fiber-type and blue color were the most abundant MPs …

Go to article

Bacteriophage And Ozone-Nanobubble Based Approaches For Combating Multidrug-Resistant Aeromonas Hydrophila In Nile Tilapia (Oreochromis Niloticus) Culture System, Thanh Dien Le Jan 2020

Bacteriophage And Ozone-Nanobubble Based Approaches For Combating Multidrug-Resistant Aeromonas Hydrophila In Nile Tilapia (Oreochromis Niloticus) Culture System, Thanh Dien Le

Chulalongkorn University Theses and Dissertations (Chula ETD)

Aeromonas hydrophila infection is considered one of the most important bacterial diseases responsible for the loss of millions of dollars in the global freshwater aquaculture industry. Multidrug-resistant (MDR) A. hydrophila is becoming a global issue of concern. Non-antibiotic approaches can minimize the requirement for antimicrobials to combat infectious diseases and antimicrobial resistance. This study aims to investigate the potential application of lytic bacteriophage, ozone nanobubbles (NB-O3), a potential combination of bacteriophage and nanobubble-based technology in combatting MDR A. hydrophila in Nile tilapia. A newly Myoviridae phage pAh6.2TG was isolated, identified, and characterized in this study. The application of this phage …

Go to article

Relationship Between Insulin-Like Growth Factor-1 And Semen Quality In Asian Elephants (Elephas Maximus), Yuqing Yang Jan 2020

Relationship Between Insulin-Like Growth Factor-1 And Semen Quality In Asian Elephants (Elephas Maximus), Yuqing Yang

Chulalongkorn University Theses and Dissertations (Chula ETD)

Evidence has been increasingly suggested that insulin-like growth factor-1 (IGF-1) is related to steroidogenesis and spermatogenesis. This may be conducive to find the causes of poor sperm quality in Asian elephants (Elephas maximus). The present study aimed to investigate whether correlations among serum IGF-1 concentration, serum testosterone level and semen variables exist in elephants. A total of 17 ejaculates (1–3 ejaculates/bull) were collected by performing transrectal massage. Before each ejaculate, blood samples were obtained (n = 17). Subsequently, semen characteristics of each ejaculate were evaluated. Assessments of precision (calculations of the intra- and inter-assay coefficient of variation, CV) and accuracy …

Go to article

Communication Strategy For Conservation Of Thai Food Product : A Case Study Of Moo-Naem, Ananporn Sakulraungsri Jan 2020

Communication Strategy For Conservation Of Thai Food Product : A Case Study Of Moo-Naem, Ananporn Sakulraungsri

Chulalongkorn University Theses and Dissertations (Chula ETD)

The study of Communication strategy for conservation of thai food product : a case study of Moo-Naem consisted of three objectives. 1) To add value to Moo-Naem and communicate the value to its customer; 2) To encourage people to perceive the value of Moo-Naem and purchase Moo-Naem; and 3) To use communication strategy as a tool to conserve Moo-Naem as the traditional and cultural cuisine. Two methodologies were utilized: 1) questionnaire surveys in which the population of the study is the people who lived in Bangkok, Thailand. Simple random sampling method was applied and self-administrated written in Thai and English …

Go to article

The Popularity Of K-Pop In North East India: Case On The Increasing Fame Of Bts Between 14-29 Age Group, Eshani Bora Jan 2020

The Popularity Of K-Pop In North East India: Case On The Increasing Fame Of Bts Between 14-29 Age Group, Eshani Bora

Chulalongkorn University Theses and Dissertations (Chula ETD)

Hallyu Wave or Korean Wave in North East India began in the late 1990s pirated CDs, DVDs, and the Korean TV channel in Manipur due the Revolutionary People's Front ordered a ban on Hindi films and TV channels. The popularity of the Hallyu Wave has been present in the North East ever since due to many physical and cultural similarities. Today, due to the popularity of BTS, a seven-member boy group from South Korea who are the biggest boy group in the world have immensely popularized K-POP to the youth. Due to limited studies on K-POP in North East India, …

Go to article

Pvdf Hollow Fiber Membrane Modification For Dye Wastewater Treatment By Ozonation Membrane Contacting Process, Hanh Le Thi My Jan 2020

Pvdf Hollow Fiber Membrane Modification For Dye Wastewater Treatment By Ozonation Membrane Contacting Process, Hanh Le Thi My

Chulalongkorn University Theses and Dissertations (Chula ETD)

One of the main pollutions from textile wastewater is the dyeing wastewater containing color and organic matters. Among the treatment methods of dye wastewater, ozonation membrane contactor was used as the concept of this research. PVDF membranes were developed by pulse inductively coupled plasma (PICP) and grafted by organosilanes for hydrophobicity enhancement applied for dye wastewater treatment by ozonation membrane contactor. To obtain a stable grafting, the surface of PVDF hollow fiber membrane was activated by the plasma operating condition including two different plasma gases (oxygen and argon), applied voltage and pressure, plasma treatment shot, followed by grafting with four …

Go to article

Assessing Environmental Impact Through Dpsir Framework And Environmental Justice Lenses:A Case Study Of Inland Capture Fisheries In Mahakam River, Etik Sulistiowati Ningsih Jan 2020

Assessing Environmental Impact Through Dpsir Framework And Environmental Justice Lenses:A Case Study Of Inland Capture Fisheries In Mahakam River, Etik Sulistiowati Ningsih

Chulalongkorn University Theses and Dissertations (Chula ETD)

Inland capture fisheries significantly contribute to the achievement of SDG, but most inland capture fisheries are poorly managed or not managed at all. Inland fishery is often facing against the big-scale industrial project. In the Middle Mahakam Area, two dominant natural resources exploited for the industrial project are palm oil and coal mining. Palm oil production, coal mining production, the human population was increasing in the last ten years, and on the opposite, the water quality index is decreasing. However, although many previous studies suggested that fish catches are declining, fisheries statistics show the opposite data. Government statistics show that …

Go to article

Development Of X-Ray Shielding Material From Combination Of Amorphous Cellulose Of Used Paper, Barium Sulphate, And Natural Rubber, Harinate Mungpayaban Jan 2020

Development Of X-Ray Shielding Material From Combination Of Amorphous Cellulose Of Used Paper, Barium Sulphate, And Natural Rubber, Harinate Mungpayaban

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research aimed to fabricate X-ray shielding substrates using amorphous cellulose from office waste paper and eucalyptus pulp mixed with natural rubber to produce the prototypes. The amorphous cellulose was prepared using only the sulfuric acid at 0 °C to rearrange the crystalline chain to the amorphous chain. After that, the barium sulfate/amorphous cellulose composite (Ba/AC) was regenerated using barium chloride solution. The shielding sheets were formulated by mixing vulcanization natural rubber individual with Ba/AC from office waste paper (NR-W), the purified eucalyptus pulp (NR-E), and barium sulfate powder (NR-P). The NR-W and NR-E were shown the predominant attenuation than …

Go to article

Study Of Platelet Production From Megakaryocyte By Using Induced Pluripotent Stem Cell, Jaturawat Pawinwongchai Jan 2020

Study Of Platelet Production From Megakaryocyte By Using Induced Pluripotent Stem Cell, Jaturawat Pawinwongchai

Chulalongkorn University Theses and Dissertations (Chula ETD)

Thrombopoiesis is the process of platelet production from hematopoietic stem cells (HSCs). Glycoproteins (GP) Ib-IX-V that is expressed on the surface of megakaryocytes and platelets binds von Willebrand factor (VWF) plays roles in platelet production. Either the GPIb deficiency or hyper-function can cause macrothrombocytopenia, the molecular mechanisms remain unclear. In this study, the pathogenesis investigations were performed in the human induced pluripotent stem cell (hiPSC) model. CRISPR-Cas9 was used to generate the hiPSCs carrying a gain-of-function GP1BA p.M255V mutation which was described in platelet-type von Willebrand disease (PT-VWD). The GPIb deficiency hiPSCs were previously derived from a Bernard Soulier syndrome …

Go to article

Effect Of Ovalitenone On Non-Small Cell Lung Cancer Cells, Kittipong Sanookpan Jan 2020

Effect Of Ovalitenone On Non-Small Cell Lung Cancer Cells, Kittipong Sanookpan

Chulalongkorn University Theses and Dissertations (Chula ETD)

Cancer metastasis is the major cause of about 90% of cancer deaths. As epithelial-to-mesenchymal transition (EMT) is known for potentiating metastasis. In the present study aimed to elucidate the effect of ovalitenone on the suppression of EMT and metastasis-related behaviors, including cell movement and growth under detached conditions, and cancer stem cells (CSCs), of lung cancer cells. Ovalitenone, as a flavonoid was extracted from roots of Millettia erythrocalyx Gapnep., was the first reported to show the anti-migration activity of H460 and A549 lung cancer cells. Ovalitenone was used at concentrations of 0–200 μM. While it caused no cytotoxic effects on …

Go to article

Prediction Of Arsenic Contamination In Rayong Groundwater Basin Using Machine Learning Based Approaches, Narongpon Sumdang Jan 2020

Prediction Of Arsenic Contamination In Rayong Groundwater Basin Using Machine Learning Based Approaches, Narongpon Sumdang

Chulalongkorn University Theses and Dissertations (Chula ETD)

The present study used three algorithms consisting of Support Vector Machine (SVM), Random Forest (RF), and Artificial Neuron Network (ANN) to locate risk area of arsenic (As)contamination in Rayong coastal aquifers, Thailand. There were three parts in this study consisting of 1) selecting the proper parameters 2) selecting the appropriate model, and 3) constructing the risk map of As. To perform models efficiently, the parameters used to generate the models have to be selected based on the correlation of each hydrochemical parameter with As concentration, which could explain the mechanisms of As release in groundwater. Due to major parameters in …

Go to article

Synergistic Activities Of Antibiotic Combinations Against Carbapenem-Resistant Klebsiella Pneumoniae And Mechanisms Of Carbapenem Resistance In Klebsiella Pneumoniae Clinical Isolates., Netchanok Muhummudaree Jan 2020

Synergistic Activities Of Antibiotic Combinations Against Carbapenem-Resistant Klebsiella Pneumoniae And Mechanisms Of Carbapenem Resistance In Klebsiella Pneumoniae Clinical Isolates., Netchanok Muhummudaree

Chulalongkorn University Theses and Dissertations (Chula ETD)

Carbapenem-resistant Klebsiella pneumoniae (CRKP) has been increasing reported worldwide. The aims of this study were to investigate the mechanisms of carbapenem resistance in K. pneumoniae Thai isolates and study the synergistic activities of antibiotic combinations against CRKP isolates. Two-hundred and forty CRKP clinical isolates were obtained from patients at King Chulalongkorn Memorial Hospital between September 2016 and April 2020. The antibiotic susceptibility testing was determined by agar dilution to imipenem, meropenem, amikacin, fosfomycin, ciprofloxacin and by broth microdilution to colistin. The prevalence rates of resistance to imipenem, meropenem, ciprofloxacin, fosfomycin, amikacin, and colistin were 90.42%, 91.67%, 95.84%, 41.25%, 20%, and …

Go to article

Application Of Phage Display Technology For The Production Of Antibodies Againststreptococcus Suis Serotype 2, Pattarawadee Sulong Jan 2020

Application Of Phage Display Technology For The Production Of Antibodies Againststreptococcus Suis Serotype 2, Pattarawadee Sulong

Chulalongkorn University Theses and Dissertations (Chula ETD)

Streptococcus suis (S. suis) serotype 2 infection is problematic in the swine industry and responsible for most cases of human infection worldwide. Since current multiplex PCR cannot differentiate between serotypes 2 and 1/2, then serotype-specific antibodies (Abs) are required for serotype identification to confirm S. suis serotype 2 infection. This study aimed to generate Abs specific to S. suis serotype 2 by phage display from a human heavy chain variable domain (VH) antibody library. For biopanning, whole cells of S. suis serotype 2 were used as the target antigen. With increasing selection stringency, we could select the VH Abs that …

Go to article

Synthesis Of Nanoscale Zerovalent Iron (Nzvi) Derived From Lignin Containing Wastewater For Arsenic Removal, Phoomipat Jungcharoen Jan 2020

Synthesis Of Nanoscale Zerovalent Iron (Nzvi) Derived From Lignin Containing Wastewater For Arsenic Removal, Phoomipat Jungcharoen

Chulalongkorn University Theses and Dissertations (Chula ETD)

Nanoscale zerovalent iron (nZVI) plays a significant role in environmental remediation including the removal of arsenic from groundwater and drinking water. This study synthesized modified nZVI particles in order to remove arsenic in drinking water. Reductive precipitation under various conditions was used to produce non-modified nZVI (B-nZVI) and lignin-modified nZVI using either 1 g/L lignin solution (L-nZVI) or pulp and paper wastewater (P-nZVI) as the substrate. Ferrous to borohydride molar ratio of 1:1 was found to be the most appropriate ratio for L-nZVI and P-nZVI production since lignin was incorporated into the nZVI structure the most. According to TEM analysis, …

Go to article

Fishermen's Participation In Marine Litter Collection Schemes In Thailand, Phornphavit Thongphaijit Jan 2020

Fishermen's Participation In Marine Litter Collection Schemes In Thailand, Phornphavit Thongphaijit

Chulalongkorn University Theses and Dissertations (Chula ETD)

Marine litter is a global environmental problem that poses various threats to the environment, the economy and society. Its impacts, for example, are the cost of beach cleaning, tourism, the beautiful landscape and etc. Marine litter, which later breaks into microplastics, affects marine lives contributing to the loss of economy to the people who depend on them. Several measures are used to tackle marine litter, including prevention and reduction of waste generation, prevention and reduction of litter reaching the marine environment, and marine litter removal. The latter is essential to clean already-at-sea litter or marine debris. Thailand, among the top …

Go to article

Mechanisms Of Anthocyanin-Enrich Riceberry Rice Extract (Oryza Sativa L.) On The Regulation Of Nutrient Metabolisms And Adipogenesis, Phutthida Kongthitilerd Jan 2020

Mechanisms Of Anthocyanin-Enrich Riceberry Rice Extract (Oryza Sativa L.) On The Regulation Of Nutrient Metabolisms And Adipogenesis, Phutthida Kongthitilerd

Chulalongkorn University Theses and Dissertations (Chula ETD)

Riceberry rice, a new pigmented rice variety from Thailand, contained high anthocyanin content and expressed various biological activities. This study aimed to investigate the anti-obesity effects of Riceberry rice extract (RBE) in 3T3-L1 preadipocytes and to identify the mechanism of RBE and its phytochemicals on insulin secretion from pancreatic INS-1 cells. In 3T3-L1 cells, RBE inhibited preadipocyte proliferation by inducing cell cycle arrest without causing cytotoxicity. During adipogenesis, RBE downregulated transcription factor and adipogenic gene expression leading to the decrease in adipocyte number and triglyceride accumulation. Moreover, RBE reduced glucose uptake by downregulating glucose transporter 4 gene expression and enhanced …

Go to article

Perspectives And Challenges Of Green Hotel In Thailand, Pornwajee Sangmanee Jan 2020

Perspectives And Challenges Of Green Hotel In Thailand, Pornwajee Sangmanee

Chulalongkorn University Theses and Dissertations (Chula ETD)

The hotel business is intense resource consumption such as water, energy, and non-durable products to delight customers, leading to environmental problems. With this regard, the transformation of the green hotel and environmental saving programs can dwindle the hotel property's adverse impacts. The purposes of this paper are 1) to study the perception of hotel practitioners and stakeholders toward the critical challenges of green hotel transformation and 2) to propose the recommendations for green hotel operations and certification scheme in Thailand. The study employed mixed methods to collect the data. The in-depth interviews were along with field observation; the interviews data …

Go to article

City-Wide Greenhouse Gas Mitigation Options To Support Global Climate Goals: Case Studies Of Bangkok, Chiang Mai, And Rayong, Thailand, Sittisak Sugsaisakon Jan 2020

City-Wide Greenhouse Gas Mitigation Options To Support Global Climate Goals: Case Studies Of Bangkok, Chiang Mai, And Rayong, Thailand, Sittisak Sugsaisakon

Chulalongkorn University Theses and Dissertations (Chula ETD)

The action of city on climate mitigation becomes a crucial role. The aims of this study were to quantify greenhouse gases (GHGs) emission, identify feasibility of mitigation options in selected provinces, and to evaluate the performance of local capacity to support Thailand's Nationally Determined Contributed (NDC) and 1.5oC limit pathway. Three provinces, including Bangkok, Chiang Mai and Rayong of Thailand were selected as case studies. The results revealed that stationary energy was the greatest contribution to the city's GHGs emissions in all case studies. Transportation was the second largest emitter in Bangkok and Chiang Mai, whereas IPPU was the second …

Go to article

Effect Of 2-(4"-Hydroxybenzyl)-5-2"-Dihydroxy-3- Methoxystilbene On Apoptosis And Autophagic Cell Death Of Lung Cancer Cells, Sucharat Tungsukruthai Jan 2020

Effect Of 2-(4"-Hydroxybenzyl)-5-2"-Dihydroxy-3- Methoxystilbene On Apoptosis And Autophagic Cell Death Of Lung Cancer Cells, Sucharat Tungsukruthai

Chulalongkorn University Theses and Dissertations (Chula ETD)

The shifting of autophagy, a catabolic process for cell survival, toward death could be a potential mode of anti-cancer drug action. In addition, autophagic cell death (ACD) is an alternative death mechanism in resistant malignant cancer cells. This study, we demonstrated how PE5, a stilbene compound, exhibits potent ACD-promoting activity and apoptosis in lung cancer cells that may offer an opportunity for novel cancer treatment. It was found that PE5 exerted a higher toxic effect toward cancer cells compared with its effect on normal cells. Interestingly, the cell death caused by PE5 was found to be concomitant with dramatic autophagy …

Go to article

Detection Of Arsenite-Oxidizing Bacteria In Groundwater From A Gold Mine Under Different Geochemical Environments, Supeerapat Kraidech Jan 2020

Detection Of Arsenite-Oxidizing Bacteria In Groundwater From A Gold Mine Under Different Geochemical Environments, Supeerapat Kraidech

Chulalongkorn University Theses and Dissertations (Chula ETD)

Millions of people around the world potentially expose to arsenic (As) contaminated groundwater. Besides, the dominant form of As in groundwater is arsenite (As+3) and is more toxic than arsenate (As+5). This study integrated the microbial investigation, geochemical modeling, and multivariate statistical analysis to investigate the arsenite-oxidizing bacteria community from As-contaminated groundwater and its environmental influencing factors in order to understand and further develop the in-situ arsenic bioremediation technology. Microbial investigation was focusing on the detection and identification of native arsenite-oxidizing bacterial community using PCR-DGGE, cloning and sequencing of arsenite oxidase (aoxB) gene amplicons. Nine groundwater samples were collected from …

Go to article

Characterization Of Carbon Storage Regulator A (Csra) Homolog As A Global Gene Regulator In Leptospira Spp., Theerapat Phoka Jan 2020

Characterization Of Carbon Storage Regulator A (Csra) Homolog As A Global Gene Regulator In Leptospira Spp., Theerapat Phoka

Chulalongkorn University Theses and Dissertations (Chula ETD)

Leptospira spp. consist of non-pathogenic and pathogenic species. The bacteria can survive in diverse environments and therefore need mechanisms of rapid adaptation to environmental changes. However, molecular mechanisms of stress response in Leptospira are not fully understood. Carbon Storage Regulator A (CsrA) is a well-characterized, conserved, post-transcriptional global regulator that plays a critical role in response to environmental changes in many bacteria. CsrA has been reported to regulate several pathways such as glycogen metabolism, motility, biofilm formation, and virulence-associated genes. Based on available genomics data of Leptospira spp., we found putative csrA homolog, approximately 50% similarity with csrA of E. …

Go to article

Comparative Evaluation Of Mineral Trioxide Aggregate And Acemannam For Partial Pulpotomy In Permanent Teeth With Incomplete Root Formation, Thuy Tien Vu Jan 2020

Comparative Evaluation Of Mineral Trioxide Aggregate And Acemannam For Partial Pulpotomy In Permanent Teeth With Incomplete Root Formation, Thuy Tien Vu

Chulalongkorn University Theses and Dissertations (Chula ETD)

Mineral trioxide aggregate (MTA), the standard pulp capping material, has disadvantages, including long setting time and high cost. Along this line, acemannan, a polysaccharide extracted from aloe vera, would be a promising biomaterial for vital pulp therapy as it is shown to induce mineralized bridge formation in animal and clinical studies. In this study, the impact of MTA and acemannan sponges on partial pulpotomized permanent teeth has been evaluated. For the research design, fifty immature permanent teeth with caries or accident-induced pulp exposure were collected and assessed. After partial pulpotomy, the teeth were randomly allocated into the treatment group using …

Go to article

The Differential Dendritic Cell Properties In Response To Candida Albicans And Non-Albican Candida Β-Glucan, Truc Thi Huong Dinh Jan 2020

The Differential Dendritic Cell Properties In Response To Candida Albicans And Non-Albican Candida Β-Glucan, Truc Thi Huong Dinh

Chulalongkorn University Theses and Dissertations (Chula ETD)

Increased mortality and antifungal drug resistance of non-albicans Candidiasis patients have become an alarming in health problems nowadays, whereas profound knowledge of their pathogenesis mechanisms is still limited. The immune responses of innate and adaptive immunity play a crucial role in protecting from Candida infections. Dendritic cells (DCs) are the most notable because of their roles in bridging an innate immunity and specific adaptive immunity to eliminate fungal invasion. It is little known about DC functions in non-albicans Candida (NACs) infections. Besides, there is less study on evaluating the DC properties upon the interaction between DCs and NACs-derived ß-glucans. Therefore, …

Go to article

Supply Chain Collaboration For Sustainability In Thailand's Dairy Industry, Virayos Vajirabhoga Jan 2020

Supply Chain Collaboration For Sustainability In Thailand's Dairy Industry, Virayos Vajirabhoga

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study gathered potential 95 variables from a literature review. Through the process of expert review, these were refined into 49 critical variables. Moreover, pilot study, with participation from co-operatives and farmers, aims to develop conceptual frameworks in six areas: performance and commitment, internal and external collaboration, measurement and evaluation, joint operation, sharing and innovation, and negotiation. Furthermore, 26 factors were identified clearly by exploratory factory analysis. The main study was conducted via a paper-based questionnaire with 1,224 respondents nationwide. The proposed 11 hypotheses attempted to identify the structural relationships among the constructs in the model. The result confirmed the …

Go to article

Neutrophil Extracellular Traps (Nets) Formation Of Fcgr2b Deficient Mice In Lupus Mouse Model With Ischemic Reperfusion Injury, Wilasinee Saisorn Jan 2020

Neutrophil Extracellular Traps (Nets) Formation Of Fcgr2b Deficient Mice In Lupus Mouse Model With Ischemic Reperfusion Injury, Wilasinee Saisorn

Chulalongkorn University Theses and Dissertations (Chula ETD)

Acute kidney injury (AKI) caused by renal ischemic reperfusion (I/R) is the most prevalent cause of morbidity and mortality in patients. Neutrophil extracellular traps (NETs) are important for the progression of lupus nephritis after renal I/R injury. Because neutrophils are the first immune cell that respond to tissue damage, neutrophils might be an important cell that determines renal I/R injury. Additionally, NET components, including cell-free DNA, histone, nucleosome, and cytoplasmic protein compartment release the auto-antigens that accelerate lupus disease activity. Therefore, this project aimed to compare NETs formation in several internal organs following renal I/R injury in Fcgr2b deficient (Fcgr2b-/-) …

Go to article

Assessments Of Hydraulic Responses To Climate Variability Of Dominant Trees In Successional Forests In Khao Yai National Park For Environmental Management, Weerapong Unawong Jan 2020

Assessments Of Hydraulic Responses To Climate Variability Of Dominant Trees In Successional Forests In Khao Yai National Park For Environmental Management, Weerapong Unawong

Chulalongkorn University Theses and Dissertations (Chula ETD)

In Southeast Asia, tropical forests have been increasingly threatened by human disturbances and climate change-induced water stress. However, uncertainty remains as to how these forests would respond to environmental changes under water deficit conditions. Here, we conducted a study of seasonal variation in leaf water status and hydraulic properties of dominant tree species across forest successional stages in Khao Yai National Park, Thailand. Specifically, we measured midday leaf water potential (Ψmd) during the wet and dry season, and assessed branch xylem vulnerability at which 50% is lost (P50). The associations between P50 and maximum xylem hydraulic conductivity (Ksmax) and maximum …

Go to article

First Prev Next Last