Digital Commons Network^™

Rna Nanoparticles And Method Of Use Thereof, Peixuan Guo, Hui Li, Wei Luo

Pharmaceutical Sciences Faculty Patents

The presently-disclosed subject matter relates to an artificial RNA nanostructure and method of use thereof. In particular, the presently-disclosed subject matter relates to RNA nanoparticles and RNA dendrimers, and methods of disease diagnosis and treatments using the RNA nanostructure and RNA dendrimers.

Effective Number Theory: Counting The Identities Of A Quantum State, Ivan Horváth, Robert Mendris

Anesthesiology Faculty Publications

Quantum physics frequently involves a need to count the states, subspaces, measurement outcomes, and other elements of quantum dynamics. However, with quantum mechanics assigning probabilities to such objects, it is often desirable to work with the notion of a “total” that takes into account their varied relevance. For example, such an effective count of position states available to a lattice electron could characterize its localization properties. Similarly, the effective total of outcomes in the measurement step of a quantum computation relates to the efficiency of the quantum algorithm. Despite a broad need for effective counting, a well-founded prescription has not …

Mucosal Immune System Of African Lungfish, Ryan D. Heimroth

Biology ETDs

Conquering land was an apex moment in the evolution of vertebrates. Physiologically, the first vertebrates to transition to life on land had to adapt in order to survive in an oxygen-rich environment where gravitational forces and limited water prevailed. Several extant vertebrates including anurans and lungfish, survive droughts by undergoing aestivation. Unfavorable environmental conditions trigger lungfish to aestivate. Aestivation is a process of metabolic torpor wherein the fish will encase itself in a mucus cocoon and not move until favorable environmental conditions (food and water) are reintroduced. Aestivation can be reproduced in laboratory settings and, thus, lungfish can be used …

Formal Concept Analysis Applications In Bioinformatics, Sarah Roscoe

School of Computing: Dissertations, Theses, and Student Research

Bioinformatics is an important field that seeks to solve biological problems with the help of computation. One specific field in bioinformatics is that of genomics, the study of genes and their functions. Genomics can provide valuable analysis as to the interaction between how genes interact with their environment. One such way to measure the interaction is through gene expression data, which determines whether (and how much) a certain gene activates in a situation. Analyzing this data can be critical for predicting diseases or other biological reactions. One method used for analysis is Formal Concept Analysis (FCA), a computing technique based …

Minutes, Curriculum Committee Meeting, Tuesday, November 10, 2020, Curriculum Committee

Curriculum Committee Minutes

No abstract provided.

Machine-Based Infants Pain Assessment Tool, Ghadh A. Alzamzmi, Dmitry Goldgof, Yu Sun, Rangachar Kasturi, Terri Ashmeade

USF Patents

A system and method for measuring an infant's pain intensity is presented. The method for assessing an infant's pain intensity based on facial expressions is comprised of three main stages: detection of an infant's face in video sequence followed by preprocessing operations including face alignment; expression segmentation; and expression recognition or classification. Also presented is a multimodal system for assessing an infant's pain intensity using the following classifiers: facial expression classifier; vital sign classifier; crying recognition classifier; body motion classifier and state of arousal classifier. Each classifier generates an individual score, all of which are normalized and weighed to generate …

Compositions And Methods For White To Beige Adipogenesis, Denise Ratzlaff Cooper, Ryan Adam Kirchoffer, Robert Pleasants Sparks, Wayne Charles Guida

USF Patents

Disclosed herein are compositions and methods for transitioning or converting a white adipocyte to a beige adipocyte. The compositions and methods may be used in the treatment of obesity. In some embodiments, the compositions include a compound selected from DC677 and DC761.

New Mechanisms That Control Fact Histone Chaperone And Transcription-Mediated Genome Stability, Angelo Vincenzo De Vivo Diaz

USF Tampa Graduate Theses and Dissertations

The Role of deubiquitinating enzymes (DUBs) in transcription, replication and genome integrity is not one that has been extensively researched. OTU DUBs are a particular class of enzyme with very little known about them.OTUD5 is a cysteine protease in the OTU family responsible to processing lysine 48 and lysine 63 ubiquitin chains. Recently, it has been implicated in to play a role in transcription through its binding partner UBR5. OTUD5 has also been shown to interact with proteins such as PDCD5 and p53, potentially have great importance in cell fate. In this study, I describe new discovered functions for OTUD5 …

Surgical Wound Dehiscence Following Cutaneous Excisions: A Retrospective Study And Review Of The Literature, Jennifer Seyffert, Tanner Harding, Asmi Sanghvi, Nathan Bibliowicz, Martin Yungmann, Shawn Camner, Adam Leavitt, James A. Solomon

GME Publications

Background:

Surgical wound dehiscence (SWD) is the third most common adverse event following dermatologic surgery. There have been no previous studies investigating risk factors for SWD following dermatologic surgery. There are no formal recommendations or standards of care to minimize or prevent SWD following dermatologic surgery.

Purpose:

The purpose of this study was to identify risk factors associated with dermatologic SWD.

Methods:

Multicenter retrospective data mined from EMA electronic medical record were collected from 22,548 matched excisions and postoperative visits performed on patients ≥18 years between January 1, 2019, and September 27, 2019. Matched data analysis was performed using IBM …

The Odorant Receptor Or2w3 On Airway Smooth Muscle Evokes Bronchodilation Via A Cooperative Chemosensory Tradeoff Between Tmem16a And Cftr., Jessie Huang, Hong Lam, Cynthia Koziol-White, Nathachit Limjunyawong, Donghwa Kim, Nicholas Kim, Nikhil Karmacharya, Premraj Rajkumar, Danielle Firer, Nicholas M Dalesio, Joseph Jude, Richard C Kurten, Jennifer L Pluznick, Deepak A. Deshpande, Raymond B Penn, Stephen B Liggett, Reynold A Panettieri, Xinzhong Dong, Steven S An

Center for Translational Medicine Faculty Papers

The recent discovery of sensory (tastant and odorant) G protein-coupled receptors on the smooth muscle of human bronchi suggests unappreciated therapeutic targets in the management of obstructive lung diseases. Here we have characterized the effects of a wide range of volatile odorants on the contractile state of airway smooth muscle (ASM) and uncovered a complex mechanism of odorant-evoked signaling properties that regulate excitation-contraction (E-C) coupling in human ASM cells. Initial studies established multiple odorous molecules capable of increasing intracellular calcium ([Ca2+]i) in ASM cells, some of which were (paradoxically) associated with ASM relaxation. Subsequent studies showed a terpenoid molecule (nerol)-stimulated …

Use Of An Active Canopy Sensor Mounted On An Unmanned Aerial Vehicle To Monitor The Growth And Nitrogen Status Of Winter Wheat, Jie Jiang, Zeyu Zhang, Qiang Cao, Yan Liang, Brian Krienke, Yongchao Tian, Yan Zhu, Weixing Cao, Xiaojun Liu

Department of Agronomy and Horticulture: Faculty Publications

Using remote sensing to rapidly acquire large-area crop growth information (e.g., shoot biomass, nitrogen status) is an urgent demand for modern crop production; unmanned aerial vehicle (UAV) acts as an effective monitoring platform. In order to improve the practicability and efficiency of UAV based monitoring technique, four field experiments involving different nitrogen (N) rates (0–360 kg N ha⁻¹ ) and seven winter wheat (Triticum aestivum L.) varieties were conducted at different eco-sites (Sihong, Rugao, and Xinghua) during 2015–2019. A multispectral active canopy sensor (RapidSCAN CS-45; Holland Scientific Inc., Lincoln, NE, USA) mounted on a multirotor UAV platform was used …

Flame Retardants And Neurodevelopment: An Updated Review Of Epidemiological Literature, Ann M. Vuong, Kimberly Yolton, Kim M. Cecil, Joseph M. Braun, Bruce P. Lanphear, Aimin Chen

School of Public Health Faculty Research

Purpose of Review: Flame retardant (FR) compounds can adversely impact neurodevelopment. This updated literature review summarizes epidemiological studies of FRs and neurotoxicity published since 2015, covering historical (polybrominated biphenyls [PBBs], polychlorinated biphenyls [PCBs]), contemporary (polybrominated diphenyl ethers [PBDEs], hexabromocyclododecane [HBCD], and tetrabromobisphenol A [TBBPA]), and current-use organophosphate FRs (OPFRs) and brominated FRs (2-ethylhexyl 2,3,4,5-tetrabromobezoate [EH-TBB] TBB), bis(2-ethylhexyl) tetrabromophthalate [BEH-TEBP]), focusing on prenatal and postnatal periods of exposure. Recent Findings: Continuing studies on PCBs still reveal adverse associations with child cognition and behavior. Recent studies indicate PBDEs are neurotoxic, particularly for gestational exposures with decreased cognition and increased externalizing behaviors. Findings …

Low-Dose Radiation Therapy (Ldrt) For Covid-19: Benefits Or Risks?, Pataje G. Prasanna, Gayle E. Woloschak, Andrea L. Dicarlo, Jeffrey C. Buchsbaum, Dörthe Schaue, Arnab Chakravarti, Francis A. Cucinotta, Silvia C. Formenti, Chandan Guha, Dale J. Hu, Mohammad K. Khan, David G. Kirsch, Sunil Krishnan, Wolfgang W. Leitner, Brian Marples, William Mcbride, Minesh P. Mehta, Shahin Rafii, Elad Sharon, Julie M. Sullivan, Ralph R. Weichselbaum, Mansoor M. Ahmed, Bhadrasain Vikram, C. Norman Coleman, Kathryn D. Held

Health Physics and Diagnostic Sciences Faculty Research

©2020 by Radiation Research Society. All rights of reproduction in any form reserved. The limited impact of treatments for COVID-19 has stimulated several phase 1 clinical trials of whole-lung low-dose radiation therapy (LDRT; 0.3-1.5 Gy) that are now progressing to phase 2 randomized trials worldwide. This novel but unconventional use of radiation to treat COVID-19 prompted the National Cancer Institute, National Council on Radiation Protection and Measurements and National Institute of Allergy and Infectious Diseases to convene a workshop involving a diverse group of experts in radiation oncology, radiobiology, virology, immunology, radiation protection and public health policy. The workshop was …

Academic Senate - Agenda, 11/10/2020, Academic Senate

Academic Senate Agendas

No abstract provided.

As-905-20 Resolution Opposing The Implementation Of Ab1460/Education Code 89032 (The California State University Ethnic Studies Undergraduate Graduation Requirement) In General Education (Title V), Cal Poly Ethnic Studies Requirement Working Group

Academic Senate Resolutions

Opposing implementation of AB1460, faculty should control the curriculum, request the rescinding of modification to Title V, and reaffirms the Ethnic Studies requirement should be fulfilled as a campus-based university graduation requirement.

Fatigue And Co-Occurring Symptoms In Women With Irritable Bowel Syndrome, Claire Jungyoun Han

Dissertations

The aims of this dissertation study were: [First part of the dissertation study] 1. To explore the relationships among fatigue and co-occurring symptoms (i.e., abdominal pain, depression and anxiety). (1-a) the relationships between abdominal pain and fatigue; and (1-b) whether psychological distress (i.e., depression and anxiety) mediates the effect of abdominal pain on fatigue, across-women and within-woman; and [Second part of the dissertation study] 2. To determine (2-a) if latent classes (i.e. subgroups) of women with IBS could be identified based on the symptom cluster severity of fatigue, abdominal pain, depression and anxiety, (2-b) if these latent classes differed on …

Scholars And Sense

DePaul Magazine

Four DePaul alumni who were the recipients of McNair scholarships have gone on to careers of servies. Pedro Serrano is a public health researcher who most recently has been working on how COVID-19 is affecting people's emotional, physical and mental health. Pascale Ife Williams, a human ecologist, engages is culture and arts initiatives that lift up communities oppressed by institutional inequity. Peter Dziedzic explores interfaith dialogue and religious pluralism as a PhD candidate at Harvard University. Robert Vargas, a tenured sociology professor at the University of Chicago, is using geographic information system mapping software to help governments anticipate and reduce …

Host Density Dependence And Environmental Factors Affecting Laurel Wilt Disease Incidence, Robin A. Choudhury, H. L. Er, M. Hughes, J. A. Smith, G. E. Pruett, J. Konkol, R. C. Ploetz, J. J. Marois, K. A. Marois, A. H. C. Van Bruggen

School of Earth, Environmental, & Marine Sciences Faculty Publications

Host size, density, and distribution, in addition to climate, can affect the likelihood a pathogen will invade and saturate landscapes. Laurel wilt, caused by the vector‐borne pathogen Raffaelea lauricola, has devastated populations of native Lauraceae in the Southeastern US, and continues to spread. We surveyed 87 plots in six coastal islands in South Carolina, Georgia, and North Florida, and one inland site (Archbold Biological Station) in South Florida for laurel wilt‐affected and non‐affected individual plants belonging to the genus Persea. The coastal island sites were surveyed once in 2008 or 2009, and the inland site was surveyed eight …

Kir6.1- And Sur2-Dependent Katp Over-Activity Disrupts Intestinal Motility In Murine Models Of Cantu Syndrome, Nathaniel W York, Helen Parker, Zili Xie, David Tyus, Maham A Waheed, Zihan Yan, Dorothy K Grange, Maria S Remedi, Sarah K England, Hongzhen Hu, Colin G Nichols

Open Access Publications

Cantύ Syndrome (CS), caused by gain-of-function (GOF) mutations in pore-forming (Kir6.1, KCNJ8) and accessory (SUR2, ABCC9) ATP-sensitive potassium (KATP) channel subunit genes, is frequently accompanied by gastrointestinal (GI) dysmotility, and we describe one CS patient who required an implanted intestinal irrigation system for successful stooling. We used gene-modified mice to assess the underlying KATP channel subunits in gut smooth muscle, and to model the consequences of altered KATP channels in CS gut. We show that Kir6.1/SUR2 subunits underlie smooth muscle KATP channels throughout the small intestine and colon. Knock-in mice, carrying human KCNJ8 and ABCC9 CS mutations in the endogenous …

Successful Novice Teachers’ Conceptualizations And Enactments Of The Collaborating Teacher Role: A Dual Case Study, Kia Sarnoff

USF Tampa Graduate Theses and Dissertations

The purpose of this descriptive, exploratory, dual case study was to understand the ways two successful novice middle school mathematics teachers serving as first-year collaborating teachers (CTs) for preservice teachers (PSTs) from the same “Grow Your Own” (GYO) educator preparation program (EPP) where they received their initial preparation conceptualized and enacted their CT roles. The CTs’ perceived impact of being alumni of the same middle school mathematics EPP as their PSTs was also explored. Analysis of interview, observation, and document data collected throughout the PSTs’ initial field experience and the CTs’ first-ever mentoring experience resulted in several key assertions including: …

Opto-Fluidic Manipulation Of Microparticles And Related Applications, Hao Wang

USF Tampa Graduate Theses and Dissertations

Contemporary biomedical technologies introduce many new instruments that are important for diagnosis and treatment of the patients. Instrument that can do rapid detection of bacterial infections, and further direct medical practitioner to prescribe optimal antibiotics is highly desirable. But unfortunately, this instrument is not available yet. Ideally, this instrument has to be portable to be used at point-of-care. This means it has to be small and inexpensive, but still highly accurate. Another critical requirement for the instrument is that the test results have to be available promptly. Because in case of such complications of bacterial infections as sepsis, each additional …

Save Water Drink Wine: Challenges Of Implementing The Ethnography Of The Temecula Valley Wine Industry Into Food-Energy-Water Nexus Decision-Making, Zaida E. Darley

USF Tampa Graduate Theses and Dissertations

This study demonstrates the interrelationships of people, food, energy, and water associated with Temecula Valley’s wine industry and reveals contradictions and biases in how people view these resources, which ultimately shape management and policies. The FEW (Food, Energy, and Water) Nexus is an approach increasingly used by policy- and decision-makers to understand the interrelationship of several resources. However, a FEW Nexus approach often lacks in social aspects that influence environmentally and economically sustainable outcomes, especially in the wine and wine tourism industry. When quantitative and qualitative data are available, the other challenge is which assessment to use. Two assessments often …

Coral Reef Restoration In The Tropical West Atlantic Amid The Covid-19 Pandemic, Linden Cheek

USF Tampa Graduate Theses and Dissertations

Climate change is increasing threats to coasts, both from storm surge and sea level rise. Healthy coral reefs provide reduction in storm surges, wave energy, coastal flooding and everyday erosion, and are found across a variety of spatial scales. Given the state of coral reefs worldwide, active Coral Reef Restoration (CRR) in emerging as a necessary component of coastal protection. CRR can be classified as a nature-based solutions (NbS) for coastal protection that also provides a multitude of ecosystem-based services to both humans and other life. Nearly all literature on coral restoration efforts assume a steady-state of human-ecological interactions, but …

A Framework For Assessing The Reliability, Availability, Maintainability, And Safety (Rams) Of Decentralized Sanitation, Adefunké Adeosun

USF Tampa Graduate Theses and Dissertations

In established industry sectors, Reliability, Availability, Maintainability, and Safety (RAMS) risk assessments are normally used to compare the risks associated with different technologies on process units. Sanitation solutions are split into traditional wastewater treatment which is centralized treatment and can be classified as an established industry, and decentralized treatment such as pit latrines and septic tank systems which are on much smaller scales. Also they can be classified as non-conventional methods such as reinvented advanced decentralized non-sewered sanitation solution techniques exist mainly in two forms as “Single-User Reinvented Toilet (SURT)” systems or “Multiple-User Reinvented Toilet (MURT)” systems. Advanced decentralized non-sewered …

Impacts On Climate Change On Multiple Use Management Of Bureau Of Land Management Land In The Intermountain West, Usa, Elaine M. Brice, Brett A. Miller, Hongchao Zhang, Kirsten Goldstein, Scott N. Zimmer, Guenchik J. Grosklos, Patrick Belmont, Courtney G. Flint, Jennifer E. Givens, Peter B. Adler, Mark W. Brunson, Jordan W. Smith

Environment and Society Faculty Publications

Although natural resource managers are concerned about climate change, many are unable to adequately incorporate climate change science into their adaptation strategies or management plans, and are not always aware of or do not always employ the most current scientific knowledge. One of the most prominent natural resource management agencies in the United States is the Bureau of Land Management (BLM), which is tasked with managing over 248 million acres (>1 million km²) of public lands for multiple, often conflicting, uses. Climate change will affect the sustainability of many of these land uses and could further increase …

Measuring Knowledge Acquisition And Knowledge Creation: A Review Of The Literature, Abdoulaye Kaba, Chennupati K. Ramaiah

Library Philosophy and Practice (e-journal)

This paper presented a review of the literature related to knowledge acquisition and knowledge creation. The paper discussed the nature and types of knowledge, knowledge acquisition, theories and models of knowledge acquisition, in addition to the review of empirical studies measuring knowledge acquisition. For knowledge creation, the paper discussed the definition of knowledge creation, theories and models of knowledge creation, and review of empirical studies measuring knowledge creation. Findings of the review revealed how researchers and scholars have used a variety of variables in investigating and measuring knowledge acquisition and knowledge creation among managers, engineers, and faculty members.

Structural Basis Of Ion Transport And Inhibition In Ferroportin, Yaping Pan, Zhenning Ren, Shuai Gao, Jiemin Shen, Lie Wang, Zhichun Xu, Ye Yu, Preetham Bachina, Hanzhi Zhang, Xiao Fan, Arthur Laganowsky, Nieng Yan, Ming Zhou

Faculty, Staff and Students Publications

Ferroportin is an iron exporter essential for releasing cellular iron into circulation. Ferroportin is inhibited by a peptide hormone, hepcidin. In humans, mutations in ferroportin lead to ferroportin diseases that are often associated with accumulation of iron in macrophages and symptoms of iron deficiency anemia. Here we present the structures of the ferroportin from the primate Philippine tarsier (TsFpn) in the presence and absence of hepcidin solved by cryo-electron microscopy. TsFpn is composed of two domains resembling a clamshell and the structure defines two metal ion binding sites, one in each domain. Both structures are in an outward-facing conformation, and …

Urine Volume Reduction During Long-Duration Cave Exploration By A Light-Weight And Portable Forward Osmosis System, Sebastian Engelhardt, Katey E. Bender, Jörg Vogel, Stephen E. Duirk, Francisco B. Moore, Hazel A. Barton

International Journal of Speleology

The preservation of caves is a challenge during long-duration cave expeditions where human waste can add significant nitrogen to the cave ecosystem. Since the removal of urine that accumulates during a multi-day caving trip is not always feasible due to weight and volume constraints, a light-weight and portable filtration system that is capable of reducing urine volume would be desirable. In this study we tested the Aquaporin Inside hollow fiber membrane in a forward osmosis (FO) setup to evaluate its capability to reduce urine volume while rejecting nitrogenous compounds using different draw solution chemistries and water recovery rates. As a …

Liminal Liberation: Courtesans And Embodied Anxieties In Sixteenth-Century Venice, Mandonesia Carter

LSU Master's Theses

Invectives against the courtesan—a more educated, erudite, and socially elite version of the ordinary prostitute—were commonplace in early modern Venice. A metropolitan center by the sixteenth century, Venice had become one of the most tolerant cities in Europe, allowing the courtesan to rapidly rise far past her social standing. The courtesan, through strategic self-fashioning and self-promotion, blurred the boundaries of gender roles, class roles, and the conventional social hierarchy. This precipitated attacks from critics seeking to provide clarity of the courtesan’s place and protect the interests of their patriarchal society. This thesis examines representations of the sixteenth-century Venetian courtesan in …

Insecticide Resistance Management Approaches And Naturally Derived Toxicants For The Control Of Fall Armyworm, Spodoptera Frugiperda, Sarah Mccomic

LSU Master's Theses

Spodoptera frugiperda, the fall armyworm (FAW), is a major agricultural pest causing billions of dollars in damage annually to staple crops. Agricultural losses stemming from this pest continues to increase as resistance to commercialized insecticide classes evolves and spreads. Considering this, novel chemistries with new modes of action as well as novel resistance management strategies need to be developed to achieve continued control of FAW populations. This project consisted of two main goals. First, we aimed to develop a neurophysiological assay to enable a more precise understanding of pyrethroid and organophosphate resistance at the level of the nerve. We …