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2020

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Lanthanide-Doped Lanthanum Hafnate Nanoparticles As Multicolor Phosphors For Warm White Lighting And Scintillators, Santosh K. Gupta, Jose P. Zuniga, Maya Abdou, Melonie P. Thomas, Manisha De Alwis Goonatilleke, Beth S. Guiton, Yuanbing Mao Jan 2020

Lanthanide-Doped Lanthanum Hafnate Nanoparticles As Multicolor Phosphors For Warm White Lighting And Scintillators, Santosh K. Gupta, Jose P. Zuniga, Maya Abdou, Melonie P. Thomas, Manisha De Alwis Goonatilleke, Beth S. Guiton, Yuanbing Mao

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

Designing luminescent materials especially nanomaterials with multifunctional applications is highly challenging and demanding. In this work, we explored pyrochlore La2Hf2O7 nanoparticles (NPs) singly and triply codoped with Eu3+, Tb3+ and Dy3+. Under both ultraviolet and X-ray irradiations, the La2Hf2O7 NPs singly doped with Eu3+, Tb3+ and Dy3+ displayed red, green and yellowish-blue emission, respectively. The concentration quenching study revealed a non-radiative energy transfer in Eu3+ doped La2Hf2O7 NPs, which takes place via dipole-quadrupole mechanism. On the other hand, a dipole-dipole interaction prevails in Tb3+ and Dy3+ doped La2Hf2O7 NPs. Lifetime spectroscopy reveals the stabilization of Eu3+ and Dy3+ ions at …

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Development And Testing Of Artificial Membranes For Rearing Of Rhipicephalus Microplus, The Southern Cattle Fever Tick, Ann T. Vacek, John A. Goolsby, Rupesh R. Kariyat Jan 2020

Development And Testing Of Artificial Membranes For Rearing Of Rhipicephalus Microplus, The Southern Cattle Fever Tick, Ann T. Vacek, John A. Goolsby, Rupesh R. Kariyat

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

The southern cattle fever tick, Rhipicephalus microplus, is a livestock pest worldwide in tropical and subtropical climates, including South Texas, and can vector Babesia spp., the causal agents of bovine babesiosis. Artificial rearing methods for R. microplus are needed, especially for rearing specialist tick parasitoids that are under evaluation for classical biological control. In this study, we tested the efficiency of artificial feeding of R. microplus larvae, nymphs, and adults on a siliconized substrate (goldbeater’s membrane, lens paper, or Hemotek), or on nonsiliconized goldbeater’s membrane or Hemotek. Other variables tested were a warm water bath, incubator, positioning blood above or …

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Improving Educational Experiences Of Students With Disabilities At A Private Postsecondary University, Levenle Jean-Joseph Jan 2020

Improving Educational Experiences Of Students With Disabilities At A Private Postsecondary University, Levenle Jean-Joseph

Theses and Dissertations

The problem addressed in this research study was that students with disabilities were experiencing challenges at a private postsecondary university in the United States that were impacting their educational experience. The purpose of this research study was to discover the challenges individuals with disabilities experience at a private postsecondary university and to find possible resolutions to those challenges. It was anticipated that this research study may improve the education experiences of students with disabilities at a private postsecondary university in the United States. It was equally important to discover (a) challenges experienced by students with a disability in a private …

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Anthelmintic Activity Of Mansoa Alliacea Against Pheretima Posthuma: In Vitro And In Silico Approach, D.S. N. B. K. Prasanth, S. K. Aminabee, Atmakuri Lakshmana Rao, Nayudu Teja, Koti Bhargavi, Chigurupati Monika, Boppudi Pujitha, Tera Sandhya, Agastya Lalitha, Siva Prasad Panda Jan 2020

Anthelmintic Activity Of Mansoa Alliacea Against Pheretima Posthuma: In Vitro And In Silico Approach, D.S. N. B. K. Prasanth, S. K. Aminabee, Atmakuri Lakshmana Rao, Nayudu Teja, Koti Bhargavi, Chigurupati Monika, Boppudi Pujitha, Tera Sandhya, Agastya Lalitha, Siva Prasad Panda

The Thai Journal of Pharmaceutical Sciences

Objectives: Mansoa alliacea has been utilized to remedy many afflictions of humans. Literary works illustrate that it possesses numerous biological activities. Our analysis work aims to distinguish phyto-derived anthelmintic substances from M. alliacea a.

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Investigating Student Perceptions Of The Effectiveness Of A First-Year Experience Online Program On Student Retention, Jennifer P. Bowman-Wilson Jan 2020

Investigating Student Perceptions Of The Effectiveness Of A First-Year Experience Online Program On Student Retention, Jennifer P. Bowman-Wilson

Theses and Dissertations

This applied dissertation is a mixed-methods study designed to collect student perspectives of an online First-Year Experience (FE) course and to determine the overall value of the FE course. The researcher sought to identify what is the value of the FE course to the students enrolled in this online course. In the study’s survey, students will be asked a series of questions designed to determine the overall value of the FE course. For this study, the online FE course survey addressed the following theme areas: Course Content, Overall Satisfaction, Transfer Perceptions, and the participants are the new incoming students (first-year …

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A Critical Narrative Inquiry Into The Lived Experiences Of African American Male K-12 Novice Educators In An Urban School District In Central Alabama, Herbert Leon Blackmon Jan 2020

A Critical Narrative Inquiry Into The Lived Experiences Of African American Male K-12 Novice Educators In An Urban School District In Central Alabama, Herbert Leon Blackmon

All ETDs from UAB

The purpose of this study is to share how African American/Black male K-12 novice educators navigated their own educational journey to become K-12 educators in an urban school district in central Alabama. An urban school district was identified from findings from the Census Bureau and had a school that sat inside an urbanized area and inside a principal city with a population of 250,000 or more. Because of its size, urban school districts were diversified with a large enrollment and an increased number of minority students. By using a qualitative, critical narrative inquiry approach, participants were able to recount their …

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Adapting New Technologies For Evaluating The Ecology And Distribution Of The Diamondback Terrapin (Malaclemys Terrapin) In Alabama, Nicole Mckim Conner Jan 2020

Adapting New Technologies For Evaluating The Ecology And Distribution Of The Diamondback Terrapin (Malaclemys Terrapin) In Alabama, Nicole Mckim Conner

All ETDs from UAB

The diamondback terrapin (Malaclemys terrapin), an emydid turtle that plays an important ecological role in salt marsh ecosystems, has declined over the last century and is listed as a Priority One Species (highest conservation concern) in Alabama. Traditional surveying techniques have been employed to monitor diamondback terrapins on the coast of Alabama throughout the last decade; yet, these techniques can be time-consuming, labor-intensive, and disruptive to terrapins and their habitats. This study evaluated the potential for UAS technology and eDNA methodologies to effectively monitor diamondback terrapin presence, abundance, and/or distribution in salt marsh habitats. UAS-based surveys were conducted in 2017 …

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An Evaluation Of Ontogenetic Allometry Of Defensive And Nutrient Acquisition Properties Of Select Skeletal Components Of The Regular Sea Urchin Lytechinus Variegatus, Raven Amber Edwards Jan 2020

An Evaluation Of Ontogenetic Allometry Of Defensive And Nutrient Acquisition Properties Of Select Skeletal Components Of The Regular Sea Urchin Lytechinus Variegatus, Raven Amber Edwards

All ETDs from UAB

Ontogenetic allometric analyses can provide novel insights into aspects of evolution, ecology, and conservation. For example, a recent study found marine fish exhibit hyperallometric scaling of reproductive output in relation to body size. Accordingly, to sustain fish populations the largest size class of fish should be protected. The present study exploits a model sea urchin to explore allometry to evaluate the ontogeny of skeletal defense and feeding efficiency (Aristotle's lantern). Lytechinus variegatus were sampled from St. Joseph Bay, Florida. A range of different sized late juvenile to adult individuals were measured and then dissected into skeletal components. Skeletal defense was …

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Genome-Wide Mirna Regulation Of Stress Susceptibility Across The Brain In A Rodent Model Of Early Life Stress, Lauren Alexis Allen Mckibben Jan 2020

Genome-Wide Mirna Regulation Of Stress Susceptibility Across The Brain In A Rodent Model Of Early Life Stress, Lauren Alexis Allen Mckibben

All ETDs from UAB

Early life stress (ELS) affects a significant portion of the US population in the form of various types of abuse and neglect, as well as household dysfunction and loss of a loved one, among others. Although these experiences happen early in life, they increase risk for mental health disorders, especially major depression (MDD), across the lifespan. MDD is a debilitating psychiatric disorder marked by periods of depressed mood and loss of pleasure in once enjoyable activities. Patients with MDD also report trouble sleeping, unintentional weight loss or gain, feelings of worthlessness, and suicidal ideation. MDD is associated with annual $100 …

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T Cells In Synucleinopathies, Gregory Paul Williams Jan 2020

T Cells In Synucleinopathies, Gregory Paul Williams

All ETDs from UAB

Synucleinopathies, which include Parkinson disease (PD), dementia with Lewy Bodies (DLB), and multiple system atrophy (MSA), are a collection of neurodegenerative diseases that are in major part defined by the presence of alpha-synuclein (α-syn) rich protein aggregates in the brain. Increasing evidence has highlighted a neuroinflammatory phenotype also associated with these synucleinopathies. This neuroinflammatory phenotype includes the activation of central nervous system (CNS) microglia, increased pro-inflammatory cytokines, and the infiltration of peripheral T cells into the CNS. We sought to further explore the T cell responses associated with PD and MSA. Using two preclinical mouse models of PD and MSA, …

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Co-Factors In Fgf Signaling, Christopher Yanucil Jan 2020

Co-Factors In Fgf Signaling, Christopher Yanucil

All ETDs from UAB

The fibroblast growth factor (FGF) family consists of a group of proteins whose diverse biological functions are mediated by receptor tyrosine kinases, termed FGF receptors (FGFR) 1-4. While paracrine FGFs require heparin sulfate as a co-factor for FGFR bind-ing and signaling, it has been assumed that endocrine FGFs, such as FGF23, do not bind heparin but instead require klotho, a family of transmembrane proteins, as a co-receptor on specific target cells. FGF23 acts as bone-derived hormone that targets tubular epitheli-al cells in the kidney via FGFR1 and α-klotho to reduce renal phosphate uptake. In chron-ic kidney disease (CKD), the kidney …

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Network-Based Analytics For Discovering Gene Modules And Biomarkers In Complex Diseases, Zongliang Yue Jan 2020

Network-Based Analytics For Discovering Gene Modules And Biomarkers In Complex Diseases, Zongliang Yue

All ETDs from UAB

With rapidly increasing novel discoveries of associations between genomic data and complex disease phenotypes, the translation of those associations into knowledge and the identification of critical molecular mechanisms are essential to guild clinical decisions such as the diagnosis of symptomatic individuals, the prediction of disease risk, reproductive genetic counseling, and determining pharmacogenetic profiles for treatment. To decipher the genome of complex diseases, gene-centric analyses focus on detecting molecular mechanisms lead by driver genetics variants, abnormally expressed genes and high-abundance proteins through gene module construction. Additionally, the gene module construction approaches implement systems biology analysis to reveal the causative co-expressed gene …

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Development Of Natural Language Processing Algorithm For Dental Charting, Yi-Fan Zhang Jan 2020

Development Of Natural Language Processing Algorithm For Dental Charting, Yi-Fan Zhang

All ETDs from UAB

Purpose: The purpose was to develop a natural language processing algorithm, which will input data from oral examination transcripts to a structured database. Methods: Four case vignettes were produced for primary, mixed, and permanent dentition patients with varying degree of soft tissue pathology, caries, existing restorations and occlusion relationships. After calibration, dental students were instructed to perform simulated oral examinations based on the case vignettes, using natural language as they would to an assistant who was charting the case. The investigator transcribed the audio recordings of the simulated oral exams. Twenty simulated oral examinations were collected to develop a natural …

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Dietary Nitrate And The Oral Microbiome In Obesity, Health And Exercise, Christian E. Behrens Jan 2020

Dietary Nitrate And The Oral Microbiome In Obesity, Health And Exercise, Christian E. Behrens

All ETDs from UAB

Obesity ranks among the top growing health concerns worldwide. The prevalence of obesity at all life stages continues to rise with nearly 40% of adults and 35% of children/adolescents being affected. Equally troublesome is the increased risk for a number of comorbidities associated with obesity including cardiovascular disease, stroke, type 2 diabetes mellitus, and certain types of cancer. The successful treatment of obesity, particularly long-term, continues to prove challenging and is often met with limited success. This highlights the importance of continued investigation into alternative strategies that may reduce the incidence and severity of obesity and associated pathophysiologies. Regular physical …

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Parents’ Personal Characteristics In Explaining Perceptions Of Infant Temperament, Logan Boe Jan 2020

Parents’ Personal Characteristics In Explaining Perceptions Of Infant Temperament, Logan Boe

All ETDs from UAB

Although a popular topic in developmental psychology research, straightforward ways to interpret measurements of infant temperament (IT) are lacking. Notably, parental personal characteristics, such as psychological distress and regulatory abilities, and resources available to parents may influence parents’ IT reports. The aims of the current project were to: 1) determine if parental characteristics mediate the association between IT and household income; 2) determine if personal resources available to parents (social support, coping, partner satisfaction) moderate the relationships between parental characteristics and IT; and 3) determine which parental characteristics predict differences between mothers’ and fathers’ IT reports. Prenatally, 201 mothers and …

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Measuring Student Attitudes Toward Offenders: The Potential Mediating Role Of Familial Incarceration, Susan Faith Boyd Jan 2020

Measuring Student Attitudes Toward Offenders: The Potential Mediating Role Of Familial Incarceration, Susan Faith Boyd

All ETDs from UAB

Each year hundreds of thousands of ex-offenders are released from U.S. jails and prisons to return to their communities. After release, ex-offenders’ families can play a critical role in helping their loved ones re-adjust to life outside of prison as well as meet the terms of their release; however, the severe financial, emotional, and social hardships associated with reentry have great potential to strengthen or weaken ex-offenders’ family support networks. The current study sought to explore how attitudes toward offenders differ between offenders’ family members and individuals who have never experienced familial incarceration. Adaptations of The Attitudes Toward Prisoners Scale …

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Symbolic Annihilation, The Politics Of (Mis)Representation, And The Stress And Health Of Millennial Black Women, Chenoia Nicole Bryant Jan 2020

Symbolic Annihilation, The Politics Of (Mis)Representation, And The Stress And Health Of Millennial Black Women, Chenoia Nicole Bryant

All ETDs from UAB

The (mis)representation of Black populations in media has been extensively explored and critiqued by several scholars. From their introduction into media through radio to their visi-bility in television and news, the tropes of Black womanhood have carried over from colo-nialist perspectives to present day. Considering race and gender as cultural structures con-straining Black women through the assignment of stereotypical scripts, it is important to consider how, when and where Black women’s agency enters. Negative racialized and gendered stereotypes are informed by culture at large, but Black women’s agency impacts the interpretation of these (mis)representations, offering space for both conformity and …

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Epigenetic Regulation In Cancer And Development, Theodore Busby Jan 2020

Epigenetic Regulation In Cancer And Development, Theodore Busby

All ETDs from UAB

Feedback loops between cellular cues and changes in gene expression mediate the interactions between a multitude of regulatory events that promote development and cancer. Vesicular trafficking is an important process in carrying out signaling events by transporting receptors and ligands to and from the cell surface. GBF1 and BIG1 are large guanine-exchange factors (GEFs) that activate GTPase mediated shuttling of cargo through the Golgi apparatus. This dissertation demonstrates that GBF1 localizes to the cytoplasmic membrane in glioblastoma multiform cells to maintain cell shape and promote migration. Reports have shown that BIG1translocates to the nucleus is hepatocyte carcinoma cell lines in …

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Enhancer Rnas As Regulators Of Gene Expression And Neuronal Function, Nancy Verena Nicole Carullo Jan 2020

Enhancer Rnas As Regulators Of Gene Expression And Neuronal Function, Nancy Verena Nicole Carullo

All ETDs from UAB

Genomic enhancers are cis-regulatory elements in the DNA that exhibit spatial and temporal control over intricate gene expression programs shaping fate and function of heterogeneous cell populations in the developing and adult brain. In addition to their role in cellular development and maintenance, enhancer activity drives transcriptional changes in response to stimulation. Active enhancers are subject to bidirectional transcription that yields non-coding enhancer RNAs (eR-NAs). However, the functional role of eRNAs in transcriptional regulation remains controversial. Therefore, we used primary neuronal cultures to investigate en-hancers and eRNAs in the rat genome. We identified and verified enhancer-gene pairs, characterized their response …

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Obesity-Induced Immune Dysfunction: Implications For Anti- Tumor Immunity And Immunotherapeutic Efficacy, Justin Tyler Gibson Jan 2020

Obesity-Induced Immune Dysfunction: Implications For Anti- Tumor Immunity And Immunotherapeutic Efficacy, Justin Tyler Gibson

All ETDs from UAB

In the US, nearly 40% of adults have obesity. Further, obesity is known toincrease the risk for development, recurrence, and mortality associated with multiple types of cancer. However, despite such high prevalence, the impact of excess body weight on anti-tumor immunity and response to immunotherapeutics remains poorly and incompletely understood. In order to address these deficiencies, we have utilized multiple approaches to study obesity-associated perturbations in the immunogenetic, soluble protein, and cellular profiles of mice bearing mammary tumors and treatment naive human subjects with clear cell renal cell carcinoma (ccRCC). In a pre-clinical murine model of breast cancer, we find …

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Denervation Supersensitivity Of Βeta-Adrenergic Receptors In A Prodromal Model Of Alzheimer's Disease, The Tgf344-Ad Rat, Anthoni Goodman Jan 2020

Denervation Supersensitivity Of Βeta-Adrenergic Receptors In A Prodromal Model Of Alzheimer's Disease, The Tgf344-Ad Rat, Anthoni Goodman

All ETDs from UAB

The central noradrenergic (NA) system is critical for maintenance of attention, behavioral flexibility, spatial navigation, and learning and memory, those cognitive functions lost first in early Alzheimer’s disease (AD). In fact, the locus coeruleus (LC), the major source of norepinephrine (NE) in brain, is the first site of pathological tau accumulation in human AD associated with axon loss throughout forebrain, including hippocampus. The dentate gyrus (DG) is heavily innervated by LC-NA axons, where released norepinephrine (NE) acts on β adrenergic receptors (ARs) at excitatory synapses from entorhinal cortex (EC) to facilitate long-term synaptic plasticity and memory formation. These synapses show …

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Microrna Regulation Of Post-Injury Cardiac Remodeling And Heart Failure, John Clark Henderson Jan 2020

Microrna Regulation Of Post-Injury Cardiac Remodeling And Heart Failure, John Clark Henderson

All ETDs from UAB

Doxorubicin (DOX), an anthracycline, is a widely used chemotherapy agent against various forms of cancer; however, it is also known to induce dose-dependent cardiotoxicity leading to adverse outcomes. Investigating the underlying molecular signaling might have clinical implications. MicroRNAs (miRNAs) have been shown to mediate many diseases and are used as biomarkers for chemotherapy; but currently their role in the regulation of DOX-induced cardiotoxicity is not well understood. Our previous study has shown upregulation of miRNA-377 in the cardiomyocytes (CMs) after cardiac ischemia-reperfusion injury in mice. In this dissertation, we discovered that miR-377 was upregulated in the myocardium after DOX treatment, …

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Il-17 Producing Cd4 T Cells In Spontaneous Germinal Center And Autoantibody Formation In Murine Lupus, Huixian Hong Jan 2020

Il-17 Producing Cd4 T Cells In Spontaneous Germinal Center And Autoantibody Formation In Murine Lupus, Huixian Hong

All ETDs from UAB

IL-23 promotes autoimmune disease, including Th17 CD4 T-cell development and autoantibody (autoAb) production. Here, we show that a deficiency of the p19 component of IL-23 in the autoimmune BXD2 (BXD2-p19−/−) mouse leads to a shift of the follicular T-helper cell program from Tfh-IL-17 to Tfh-IFN-ɣ. Although the germinal center (GC) size and the number of GC B cells remained the same, BXD2-p19−/− mice exhibited a lower class-switch recombination (CSR) in the GC B cells, leading to lower serum levels of IgG2b. Single-cell transcriptomics analysis of GC B cells revealed that while Ifngr1, Il21r and Il4r genes exhibited a synchronized expression …

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Examining The Role Of Neighborhood Quality On The Association Of Mammography Adherence Among Racial/Ethnic Groups, Roman Johnson Jan 2020

Examining The Role Of Neighborhood Quality On The Association Of Mammography Adherence Among Racial/Ethnic Groups, Roman Johnson

All ETDs from UAB

Although several racial/ethnic minority women groups (e.g., Latina, Black, Asian-American, and Native-American women) have lower breast cancer incidence than white women, they are more likely to die from breast cancer. One possible explanation for this discrepancy is racial/ethnic differences in mammography use. Mammography has been shown to contribute to the discovery of tumor proliferation earlier which translates to less breast cancer complications like greater risk of breast cancer-related mortality. Previous studies on racial/ethnic differences in mammography adherence (e.g., annual and biannual mammography adherence) have been inconclusive, and they generally overlook important contextual factors, namely neighborhood quality and geographic location (e.g., …

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Pharmacodynamic Responses And Efficacies Associated With Lrrk2 Inhibition, Kaela Kelly Jan 2020

Pharmacodynamic Responses And Efficacies Associated With Lrrk2 Inhibition, Kaela Kelly

All ETDs from UAB

Parkinson’s disease (PD) is an age-related, progressive, movement disorder pathologically characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and the presence of proteinaceous aggregates, termed Lewy bodies, that are largely comprised of αSynuclein (αSyn). Missense mutations in the leucine-rich repeat kinase (LRRK2) gene are the most common genetic cause of PD and lead to gain-of-function increases in kinase activity. The G2019S-LRRK2 mutation is the most frequent mutation and elevates kinase activity by ~2-3 fold. Genetic and biochemical evidence suggest elevated LRRK2 kinase activity plays a pathogenic role in the development of PD, implicating LRRK2 …

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A Preliminary Analysis On The Effects Of Acute Beetroot Juice Intake On Glycemic And Blood Pressure Control In Type 2 Diabetes, Braxton Linder Jan 2020

A Preliminary Analysis On The Effects Of Acute Beetroot Juice Intake On Glycemic And Blood Pressure Control In Type 2 Diabetes, Braxton Linder

All ETDs from UAB

Cardiometabolic diseases are becoming increasingly prevalent in modern society due to low activity lifestyles and poor nutrition. Inorganic dietary nitrate (diNO3) has shown to potentially improve cardiometabolic health in a number of different populations but remains to be corroborated in humans with type 2 diabetes (T2D). This preliminary analysis aimed to determine the effects of consuming an acute, concentrated dose of diNO3 containing beetroot juice (BRJ) on hemodynamic and glycemic responses in humans with T2D while controlling for pharmacological influences. Three participants with a clinical diagnosis of T2D were recruited into this study. Pulsewave Velocity (PWV) was used to assess …

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Protective Host Responses During Acute And Chronic Lung Exposure To Aspergillus Fumigatus, Joseph Mackel Jan 2020

Protective Host Responses During Acute And Chronic Lung Exposure To Aspergillus Fumigatus, Joseph Mackel

All ETDs from UAB

Aspergillus fumigatus is an environmental airborne fungus that acts as both an opportunistic pathogen and an allergen. In immunocompromised hosts, A. fumigatus can germinate in the lung, cause tissue damage and pneumonia, and disseminate to other organs, causing a disease termed invasive aspergillosis (IA). In severe asthma, sensitization to fungi such as A. fumigatus is associated with more severe disease. Determination of host and fungal factors that drive immunoprotection versus immunopathogenesis in both of these settings will ultimately enable therapeutic modulation of immune responses to improve disease outcomes. In this body of work, we build on recent findings that implicate …

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Gp44, A Minor Protein With A Major Role In Bacteriophage 80Α Infection, Keith Allen Manning Jan 2020

Gp44, A Minor Protein With A Major Role In Bacteriophage 80Α Infection, Keith Allen Manning

All ETDs from UAB

Bacteriophage 80α is a temperate double-stranded DNA phage that infects Staphylococcus aureus and is capable of mobilizing a variety of mobile genetic elements named S. aureus Pathogenicity Islands. The capsid of the mature virion is composed of subunits of the capsid protein, portal protein, and a minor capsid protein gp44 as well as packaged phage genomic DNA. The loss of the gp44 protein completely eliminates the phage titer of 80α but does not eliminate the transduction of the pathogenicity islands. In this dissertation, I show that the minor capsid protein is primarily active in a post-ejection role. Without gp44 the …

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The Role Of The Β-Catenin Signaling Pathway In Modulating The Nucleolar Proteome Of Triple Negative Breast Cancer, Shannon E. Meier Jan 2020

The Role Of The Β-Catenin Signaling Pathway In Modulating The Nucleolar Proteome Of Triple Negative Breast Cancer, Shannon E. Meier

All ETDs from UAB

Previously, abnormal nucleoli were noted as indicators of cancerous lesions andused as a pathologic readout of neoplasia. Nucleolar hypertrophy and increased nucleolar number have been correlated with increased breast cancer (BC) mortality rates. Although various functions of the nucleolus have been investigated, it remains widely understudied in the context of cancer. The nucleolus was initially thought to be solely the site of ribosome biogenesis. However, over half of the proteins found in the nucleolus are associated with other biological functions. It is evident that the nucleolus plays major roles in stress response, DNA repair, and critical cellular aspects that influence …

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Advancing Single Cell And Crispr/Dcas9 Technologies For The Study Of Reward Learning And Addiction, Corey Grant Duke Jan 2020

Advancing Single Cell And Crispr/Dcas9 Technologies For The Study Of Reward Learning And Addiction, Corey Grant Duke

All ETDs from UAB

Drug addiction is a chronic relapsing condition inflicting tremendous harm to individuals and society with ineffective treatment options available to most people. Drugs of abuse elevate dopamine levels in a brain region known as the nucleus accumbens (NAc), and activate gene programs considered essential for producing lasting synaptic and cell state changes which underlie the generation of addictive behavior. These gene expression changes remain poorly understood due to a complex heterogenous cellular architecture, and the rapidly fluctuating nature of the transcriptional processes themselves which make investigation difficult. Recent technical advances increase access to both profiling and manipulating these transcriptional changes …

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